Regulation of synthesis of cell-specific ribosomal proteins during differentiation of Dictyostelium discoideum.

abstract：:We have detected a proteolytic mechanism in chloroplasts that selectively and rapidly degrades the imported small subunit of ribulose 1,5-bisphosphate carboxylase when pools of the chloroplast-synthesized large subunit are depleted. This degradation system is constitutively present and appears to be responsible for pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmidt GW,Mishkind ML

更新日期：1983-05-01 00:00:00

abstract：:The efficacy of boron neutron capture therapy (BNCT) for the treatment of intracerebrally implanted rat gliosarcomas was tested. Preferential accumulation of 10B in tumors was achieved by continuous infusion of the sulfhydryl borane dimer, Na4(10)B24H22S2, at a rate of 45-50 micrograms of 10B per g of body weight per ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Joel DD,Fairchild RG,Laissue JA,Saraf SK,Kalef-Ezra JA,Slatkin DN

更新日期：1990-12-01 00:00:00

abstract：:Certain Escherichia coli mutants defective in phosphatidylglycerol biosynthesis accumulate two novel glycolipids, designated X and Y. Lipid X is a diacylglucosamine 1-phosphate bearing beta-hydroxymyristoyl groups at positions 2 and 3, and lipid Y has the same structure as X, except for the additional presence of a pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nishijima M,Amano F,Akamatsu Y,Akagawa K,Tokunaga T,Raetz CR

更新日期：1985-01-01 00:00:00

abstract：:For 2 < k [abstract: see text] we define lifts of cuspidal Poincaré series in S(k)(Gamma(0)(N)) to weight 2 - k harmonic weak Maass forms. This construction answers a question of Dyson by providing the general framework "explaining" Ramanujan's mock theta functions. As an application, we show that the number of partit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bringmann K,Ono K

更新日期：2007-03-06 00:00:00

abstract：:microRNA-146a (miR-146a) has been previously implicated as an essential molecular brake, preventing immune overreaction and malignant transformation by attenuating NF-κB signaling, putatively via repression of the Traf6 and Irak1 genes. The exact contribution of miR-146a-mediated silencing of these genes to the contro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Magilnick N,Reyes EY,Wang WL,Vonderfecht SL,Gohda J,Inoue JI,Boldin MP

更新日期：2017-08-22 00:00:00

abstract：:One of the earliest detectable events during plant-pathogen interaction is a rapid increase in ethylene biosynthesis. This gaseous plant stress hormone may be a signal for plants to activate defense mechanisms against invading pathogens such as bacteria, fungi, and viruses. The effect of ethylene on four plant genes i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ecker JR,Davis RW

更新日期：1987-08-01 00:00:00

abstract：:The homogeneous exchange process whereby IgG molecules adsorbed onto latex particles are replaced by IgG molecules from the bulk solution was studied by means of 125I radiolabeling. The exchange mechanism was investigated on surfaces saturated with either labeled or unlabeled proteins in the presence of a solution of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ball V,Huetz P,Elaissari A,Cazenave JP,Voegel JC,Schaaf P

更新日期：1994-07-19 00:00:00

abstract：:Because it is able to produce desalinated water directly using solar energy with minimum carbon footprint, solar steam generation and desalination is considered one of the most important technologies to address the increasingly pressing global water scarcity. Despite tremendous progress in the past few years, efficien...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li X,Xu W,Tang M,Zhou L,Zhu B,Zhu S,Zhu J

更新日期：2016-12-06 00:00:00

abstract：:DNA vaccines, comprised of plasmid DNA encoding proteins from pathogens, allergens, and tumors, are being evaluated as prophylactic vaccines and therapeutic treatments for infectious diseases, allergies, and cancer; plasmids encoding normal human proteins are likewise being tested as vaccines and treatments for autoim...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu M,Acres B,Balloul JM,Bizouarne N,Paul S,Slos P,Squiban P

更新日期：2004-10-05 00:00:00

abstract：:The archaeological record shows that typically human cultural traits emerged at different times, in different parts of the world, and among different hominin taxa. This pattern suggests that their emergence is the outcome of complex and nonlinear evolutionary trajectories, influenced by environmental, demographic, and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： d'Errico F,Banks WE,Warren DL,Sgubin G,van Niekerk K,Henshilwood C,Daniau AL,Sánchez Goñi MF

更新日期：2017-07-25 00:00:00

abstract：:Public responses where identical T cell receptors (TCRs) are clonally dominant and shared between different individuals are a common characteristic of CD8(+) T cell-mediated immunity. Focusing on TCR sharing, we analyzed approximately 3,400 TCR beta chains (TCRbetas) from mouse CD8(+) T cells responding to the influen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Venturi V,Kedzierska K,Price DA,Doherty PC,Douek DC,Turner SJ,Davenport MP

更新日期：2006-12-05 00:00:00

abstract：:We have constructed an opal suppressor system in Escherichia coli to complement an existing amber suppressor system to study the structural basis of tRNA acceptor identity, particularly the role of middle anticodon nucleotide at position 35. The opal suppressor tRNA contains a UCA anticodon and the mRNA of the suppres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McClain WH,Foss K,Jenkins RA,Schneider J

更新日期：1990-12-01 00:00:00

abstract：:Resistance to the antibiotic fusidic acid (FA) in the human pathogen Staphylococcus aureus usually results from expression of FusB-type proteins (FusB or FusC). These proteins bind to elongation factor G (EF-G), the target of FA, and rescue translation from FA-mediated inhibition by an unknown mechanism. Here we show ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cox G,Thompson GS,Jenkins HT,Peske F,Savelsbergh A,Rodnina MV,Wintermeyer W,Homans SW,Edwards TA,O'Neill AJ

更新日期：2012-02-07 00:00:00

abstract：:For almost a century the plant hormone auxin has been central to theories on apical dominance, whereby the growing shoot tip suppresses the growth of the axillary buds below. According to the classic model, the auxin indole-3-acetic acid is produced in the shoot tip and transported down the stem, where it inhibits bud...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mason MG,Ross JJ,Babst BA,Wienclaw BN,Beveridge CA

更新日期：2014-04-22 00:00:00

abstract：:By affinity chromatography on heparin-Sepharose, two classes of lipoproteins were separated from high density lipoproteins (HDL) isolated from patients with primary or secondary lecithin:cholesterol acyltransferase (LCATase; EC 2.3.1.43) deficiency and from normal subjects. The unretained fraction, HDL(A), was charact...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marcel YL,Vezina C,Emond D,Suzue G

更新日期：1980-05-01 00:00:00

abstract：:Emotional signals are crucial for sharing important information, with conspecifics, for example, to warn humans of danger. Humans use a range of different cues to communicate to others how they feel, including facial, vocal, and gestural signals. We examined the recognition of nonverbal emotional vocalizations, such a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sauter DA,Eisner F,Ekman P,Scott SK

更新日期：2010-02-09 00:00:00

abstract：:Molecular genetic analyses of the young pseudogenes of the immunoglobulin C epsilon genes were carried out to obtain qualitative evidence for the phylogenetic branching pattern of hominoid primates. We found that Old World monkeys had two C epsilon genes, one of which was processed. Among the hominoids examined only t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ueda S,Takenaka O,Honjo T

更新日期：1985-06-01 00:00:00

abstract：:cDNA libraries were constructed from pathogenic (HM-1:IMSS) and nonpathogenic (SAW 1734) isolates of Entamoeba histolytica. A cDNA clone (cEH-P1) specific for pathogenic amoebae was identified by screening with a pool of sera from patients with invasive amoebiasis that had been absorbed with nonpathogenic amoebae. Thi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tannich E,Horstmann RD,Knobloch J,Arnold HH

更新日期：1989-07-01 00:00:00

abstract：:High-throughput biological data, whether generated as sequencing, transcriptional microarrays, proteomic, or other means, continues to require analytic methods that address its high dimensional aspects. Because the computational part of data analysis ultimately identifies shape characteristics in the organization of d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nicolau M,Levine AJ,Carlsson G

更新日期：2011-04-26 00:00:00

abstract：:The three-dimensional structures of the inactive protein precursors (zymogens) of the serine, cysteine, aspartic, and metalloprotease classes of proteolytic enzymes are known. Comparisons of these structures with those of the mature, active proteases reveal that, in general, the preformed, active conformations of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khan AR,Khazanovich-Bernstein N,Bergmann EM,James MN

更新日期：1999-09-28 00:00:00

abstract：:Exposure to 3TC of HIV-1 mutant strains containing non-nucleoside reverse transcriptase inhibitor (NNRTI)-specific mutations in their reverse transcriptase (RT) easily selected for double-mutant viruses that had acquired the characteristic 184-Ile mutation in their RT in addition to the NNRTI-specific mutations. Conve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balzarini J,Pelemans H,Karlsson A,De ClercQ E,Kleim JP

更新日期：1996-11-12 00:00:00

abstract：:Identification of the consensus sequence for termination of replication (ter) in Escherichia coli and the isolation of the ter-binding protein (TBP) allowed us to test their effects on replication forks initiated at the unique origin of the E. coli chromosome (oriC) in a purified enzyme system. Replication was severel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee EH,Kornberg A,Hidaka M,Kobayashi T,Horiuchi T

更新日期：1989-12-01 00:00:00

abstract：:Rabbit corneas denuded of their endothelium were coated with bovine corneal endothelial cells (from steers) previously maintained in tissue culture for short (20 generations) or prolonged (200 generations) periods. When grafted back into female rabbits, the corneal buttons remained clear and showed no edema. In contra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gospodarowicz D,Greenburg G,Alvarado J

更新日期：1979-01-01 00:00:00

abstract：:Some spectinomycin-resistant mutants of Escherichia coli are cold-sensitive. They are unable to assemble both 30S and 50S ribosomal subunits at low temperatures. They accumulate two kinds of incomplete particles, related to 30S and 50S subunits respectively. A single mutation, causing an alteration in a 30S ribosomal ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nashimoto H,Nomura M

更新日期：1970-11-01 00:00:00

abstract：:Persisting (P) cells (murine cells that resemble mast cells and grow continuously in vitro for prolonged periods in the presence of a specific growth factor) did not express detectable levels of Ia antigens (murine class II major histocompatibility antigens) when their growth was supported by partially purified P cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wong GH,Clark-Lewis I,McKimm-Breschkin JL,Schrader JW

更新日期：1982-11-01 00:00:00

abstract：:Watching someone scratch himself can induce feelings of itchiness in the perceiver. This provides a unique opportunity to characterize the neural basis of subjective experiences of itch, independent of changes in peripheral inputs. In this study, we first established that the social contagion of itch is essentially a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holle H,Warne K,Seth AK,Critchley HD,Ward J

更新日期：2012-11-27 00:00:00

abstract：:Visual speech facilitates auditory speech perception, but the visual cues responsible for these benefits and the information they provide remain unclear. Low-level models emphasize basic temporal cues provided by mouth movements, but these impoverished signals may not fully account for the richness of auditory informa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Plass J,Brang D,Suzuki S,Grabowecky M

更新日期：2020-07-21 00:00:00

abstract：:As a direct simulation of a multistep proton transfer reaction involving protein residues, the proton relay shuttle between A and I forms of green fluorescent protein (GFP) is simulated in atomic detail by using a special molecular dynamics simulation technique. Electronic excitation of neutral chromophore in wild-typ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lill MA,Helms V

更新日期：2002-03-05 00:00:00

abstract：:Decisions always involve both facts and values, whereas most science communication focuses only on facts. If science communication is intended to inform decisions, it must be competent with regard to both facts and values. Public participation inevitably involves both facts and values. Research on public participation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dietz T

更新日期：2013-08-20 00:00:00

abstract：:Non-protein-coding RNA genes play an important role in various biological processes. How new RNA genes originated and whether this process is controlled by similar evolutionary mechanisms for the origin of protein-coding genes remains unclear. A young chimeric RNA gene that we term sphinx (spx) provides the first insi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang W,Brunet FG,Nevo E,Long M

更新日期：2002-04-02 00:00:00