miR-146a-Traf6 regulatory axis controls autoimmunity and myelopoiesis, but is dispensable for hematopoietic stem cell homeostasis and tumor suppression.

abstract：:In an investigation to determine how proteins are localized within the nucleus of a cell, we demonstrate that the restriction endonuclease EcoRI is able to enter and function within the nucleus of Saccharomyces cerevisiae when this prokaryotic protein is synthesized in vivo. The EcoRI endonuclease was produced in yeas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barnes G,Rine J

更新日期：1985-03-01 00:00:00

abstract：:Attention to a stimulus enhances both neuronal responses and gamma frequency synchrony in visual area V4, both of which should increase the impact of attended information on downstream neurons. To determine whether gamma synchrony is common throughout the ventral stream, we recorded from neurons in the superficial and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buffalo EA,Fries P,Landman R,Buschman TJ,Desimone R

更新日期：2011-07-05 00:00:00

abstract：:Members of the caspase family of cysteine proteases play central roles in coordinating the stereotypical events that occur during apoptosis. Because the major executioner caspases, caspase-3 and caspase-7, exhibit almost indistinguishable activity toward certain synthetic peptide substrates, this has led to the widesp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walsh JG,Cullen SP,Sheridan C,Lüthi AU,Gerner C,Martin SJ

更新日期：2008-09-02 00:00:00

abstract：:It has been nearly 40 y since it was suggested that genomic methylation patterns could be transmitted via maintenance methylation during S phase and might play a role in the dynamic regulation of gene expression during development [Holliday R, Pugh JE (1975) Science 187(4173):226-232; Riggs AD (1975) Cytogenet Cell Ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bestor TH,Edwards JR,Boulard M

更新日期：2015-06-02 00:00:00

abstract：:Here we test the hypothesis that high-altitude native resident Tibetan women with genotypes for high oxygen saturation of hemoglobin, and thus less physiological hypoxic stress, have higher Darwinian fitness than women with low oxygen saturation genotypes. Oxygen saturation and genealogical data were collected from re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beall CM,Song K,Elston RC,Goldstein MC

更新日期：2004-09-28 00:00:00

abstract：:Cellular telomere length is linked to replicative life span. Telomere repeats are lost in peripheral blood cells in vivo by age, and women show less telomere attrition than men. Previous reports have indicated that telomere length and chromosome-specific telomere-length patterns partly are inherited. The mode of hered...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nordfjäll K,Larefalk A,Lindgren P,Holmberg D,Roos G

更新日期：2005-11-08 00:00:00

abstract：:The E6 protein of the high-risk human papillomaviruses inactivates the tumor suppressor protein p53 by stimulating its ubiquitinylation and subsequent degradation. Ubiquitinylation is a multistep process involving a ubiquitin-activating enzyme, one of many distinct ubiquitin-conjugating enzymes, and in certain cases, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rolfe M,Beer-Romero P,Glass S,Eckstein J,Berdo I,Theodoras A,Pagano M,Draetta G

更新日期：1995-04-11 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) thymidine kinase is currently used as a suicide agent in the gene therapy of cancer. This therapy is based on the preferential phosphorylation of nucleoside analogs by tumor cells expressing HSV-1 thymidine kinase. However, the use of HSV-1 thymidine kinase is limited in part by the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Black ME,Newcomb TG,Wilson HM,Loeb LA

更新日期：1996-04-16 00:00:00

abstract：:The cytosolic concentration of free Ca2+ in bovine neutrophils was monitored by using the intracellular Ca2+ indicator quin2, 2-[[2-bis(acetylamino)-5-methylphenoxy]methyl-6-methoxy-8- bis(acetylamino)]quinoline. Neutrophils at rest have a cytosolic Ca2+ concentration of 85 +/- 5 nM, which in 2-4 min increases to 300-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gennaro R,Pozzan T,Romeo D

更新日期：1984-03-01 00:00:00

abstract：:As a second-order nonlinear optical process, sum-frequency generation is highly surface-specific and accordingly has been developed into a very powerful and versatile surface spectroscopic tool. It has found many unique applications in different disciplines and thus provided many exciting new research opportunities in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shen YR

更新日期：1996-10-29 00:00:00

abstract：:The present paper summarizes future needs in information and tools, technology, infrastructure, training, funding, and bioinformatics, to provide the genomic knowledge and tools for breeding and biotechnological goals in maize. The National Corn Genome Initiative (NCGA) has developed through actions taken by the Natio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coe EH

更新日期：1998-03-03 00:00:00

abstract：:Chromosomes are compacted hundreds of times to fit in the cell, packaged into dynamic folds whose structures are largely unknown. Here, we examine patterns in gene locations to infer large-scale features of bacterial chromosomes. Specifically, we analyzed >100 genomes and identified thousands of gene pairs that displa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wright MA,Kharchenko P,Church GM,Segrè D

更新日期：2007-06-19 00:00:00

abstract：:Understanding the approach to faulting in continental rocks is critical for identifying processes leading to fracturing in geomaterials and the preparation process of large earthquakes. In situ dynamic X-ray imaging and digital volume correlation analysis of a crystalline rock core, under a constant confining pressure...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Renard F,McBeck J,Kandula N,Cordonnier B,Meakin P,Ben-Zion Y

更新日期：2019-08-13 00:00:00

abstract：:During natural fertilization, mammalian spermatozoa must pass through the zona pellucida before reaching the plasma membrane of the oocyte. It is assumed that this step involves partial lysis of the zona by sperm acrosomal enzymes, but there has been no unequivocal evidence to support this view. Here we present eviden...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirose M,Honda A,Fulka H,Tamura-Nakano M,Matoba S,Tomishima T,Mochida K,Hasegawa A,Nagashima K,Inoue K,Ohtsuka M,Baba T,Yanagimachi R,Ogura A

更新日期：2020-02-04 00:00:00

abstract：:Nonsense-mediated mRNA decay (NMD), which degrades transcripts harboring a premature termination codon (PTC), depends on the helicase up-frameshift 1 (UPF1). However, mRNAs that are not NMD targets also bind UPF1. What governs the timing, position, and function of UPF1 binding to mRNAs remains unclear. We provide evid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kurosaki T,Maquat LE

更新日期：2013-02-26 00:00:00

abstract：:Iron-sulfur clusters function as cofactors of a wide range of proteins, with diverse molecular roles in both prokaryotic and eukaryotic cells. Dedicated machineries assemble the clusters and deliver them to the final acceptor molecules in a tightly regulated process. In the prototypical Gram-negative bacterium Escheri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Santos JA,Alonso-García N,Macedo-Ribeiro S,Pereira PJ

更新日期：2014-06-03 00:00:00

abstract：:We examined the MLL genomic translocation breakpoint in acute myeloid leukemia of infant twins. Southern blot analysis in both cases showed two identical MLL gene rearrangements indicating chromosomal translocation. The rearrangements were detectable in the second twin before signs of clinical disease and the intensit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Megonigal MD,Rappaport EF,Jones DH,Williams TM,Lovett BD,Kelly KM,Lerou PH,Moulton T,Budarf ML,Felix CA

更新日期：1998-05-26 00:00:00

abstract：:Growth hormone receptor (GHR) has been demonstrated to be nuclear localized both in vivo and in vitro, but the significance of this observation has remained elusive. Here we show that nuclear GHR is strongly correlated with proliferative status in vivo by using a liver regeneration model. In vitro, nuclear translocati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Conway-Campbell BL,Wooh JW,Brooks AJ,Gordon D,Brown RJ,Lichanska AM,Chin HS,Barton CL,Boyle GM,Parsons PG,Jans DA,Waters MJ

更新日期：2007-08-14 00:00:00

abstract：:Immune responses to several soluble antigens were compared between B6.C-H-2bm12 mutant and wild-type B6 mice by using a lymph node T-cell proliferation assay. B6.C-H-2bm12 mice failed to respond to beef insulin whereas other IA gene-controlled responses, such as response to poly(L-Tyr, L-Glu)--poly(DL-Ala, L-Lys) and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin CC,Rosenthal AS,Passmore HC,Hansen TH

更新日期：1981-10-01 00:00:00

abstract：:The complete nucleotide sequence of the gene for the specific glycoprotein (gp55) of the polycythemic strain of Friend spleen focus-forming virus (SFFV) was derived from the cloned SFFV DNA intermediate. The gp55 gene is present within 1.4 kilobases of the 5' side of the 3'long terminal repeat sequence. The open readi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amanuma H,Katori A,Obata M,Sagata N,Ikawa Y

更新日期：1983-07-01 00:00:00

abstract：:SgrS RNA is a model for the large class of Hfq-associated small RNAs that act to posttranscriptionally regulate bacterial mRNAs. The function of SgrS is well-characterized in nonpathogenic Escherichia coli, where it was originally shown to counteract glucose-phosphate stress by acting as a repressor of the ptsG mRNA, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Papenfort K,Podkaminski D,Hinton JC,Vogel J

更新日期：2012-03-27 00:00:00

abstract：:The catalytic generation of chiral ester enolate equivalents from α,β-unsaturated aldehydes with chiral N-hetereocyclic carbene catalysts makes possible highly enantioselective hetero-Diels-Alder reactions. The reactions proceed under simple, mild conditions with both aliphatic and aromatic substituted enals as substr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaeobamrung J,Kozlowski MC,Bode JW

更新日期：2010-11-30 00:00:00

abstract：:The feasibility of long-term information storage by brain type II Ca2+/calmodulin-dependent protein kinase molecules is explored. Recent evidence indicates that this protein has switch-like properties. Equations are derived showing that a single kinase holoenzyme could form a bistable switch having the stability neces...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lisman JE,Goldring MA

更新日期：1988-07-01 00:00:00

abstract：:Across phyla, the ribosomes-the central molecular machines for translation of genetic information-exhibit an overall preserved architecture and a conserved functional core. The natural heterogeneity of the ribosome periodically phases a debate on their functional specialization and the tissue-specific variations of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amirbeigiarab S,Kiani P,Velazquez Sanchez A,Krisp C,Kazantsev A,Fester L,Schlüter H,Ignatova Z

更新日期：2019-11-05 00:00:00

abstract：:β-Phosphoglucomutase (βPGM) catalyzes isomerization of β-D-glucose 1-phosphate (βG1P) into D-glucose 6-phosphate (G6P) via sequential phosphoryl transfer steps using a β-D-glucose 1,6-bisphosphate (βG16BP) intermediate. Synthetic fluoromethylenephosphonate and methylenephosphonate analogs of βG1P deliver novel step 1 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jin Y,Bhattasali D,Pellegrini E,Forget SM,Baxter NJ,Cliff MJ,Bowler MW,Jakeman DL,Blackburn GM,Waltho JP

更新日期：2014-08-26 00:00:00

abstract：:In many of their compounds the transition metals have covalence 9, forming nine bonds with use of nine hybrid spd bond orbitals. A set of maximum-valence single-bond radii is formulated for use in these compounds. These radii are in reasonably good agreement with observed bond lengths. Quadruple bonds between two tran...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pauling L

更新日期：1975-10-01 00:00:00

abstract：:Most teenage fears subside with age, a change that may reflect brain maturation in the service of refined fear learning. Whereas adults clearly demarcate safe situations from real dangers, attenuating fear to the former but not the latter, adolescents' immaturity in prefrontal cortex function may limit their ability t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lau JY,Britton JC,Nelson EE,Angold A,Ernst M,Goldwin M,Grillon C,Leibenluft E,Lissek S,Norcross M,Shiffrin N,Pine DS

更新日期：2011-03-15 00:00:00

abstract：:Studies by several investigators have shown that 12-0-tetradecanoylphorbol-13-acetate (TPA) is an extraordinarily potent stimulator of differentiation of cultured human promyelocytic leukemia cells in vitro. In the present study, TPA was administered to humans by i.v. infusion without irreversible toxicity, and it was...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Han ZT,Zhu XX,Yang RY,Sun JZ,Tian GF,Liu XJ,Cao GS,Newmark HL,Conney AH,Chang RL

更新日期：1998-04-28 00:00:00

abstract：:Crystals of myosin subfragment 1 from avian skeletal muscle have been grown reproducibly. They diffract x-rays to at least 4.5-A resolution. The subfragment 1 crystallizes in space group P2(1)2(1)2(1) where a = 107 A, b = 117 A, and c = 278 A. The cell dimensions and intensity distribution on x-ray diffraction photogr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rayment I,Winkelmann DA

更新日期：1984-07-01 00:00:00

abstract：:Biogeochemical reactions occur unevenly in space and time, but this heterogeneity is often simplified as a linear average due to sparse data, especially in subsurface environments where access is limited. For example, little is known about the spatial variability of groundwater denitrification, an important process in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kolbe T,de Dreuzy JR,Abbott BW,Aquilina L,Babey T,Green CT,Fleckenstein JH,Labasque T,Laverman AM,Marçais J,Peiffer S,Thomas Z,Pinay G

更新日期：2019-02-12 00:00:00