Chromosomal periodicity of evolutionarily conserved gene pairs.

abstract：:Increased intestinal permeability has been observed in numerous human autoimmune diseases, including type-1 diabetes (T1D) and its' animal model, the BB-wor diabetic prone rat. We have recently described zonulin, a protein that regulates intercellular tight junctions. The objective of this study was to establish wheth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watts T,Berti I,Sapone A,Gerarduzzi T,Not T,Zielke R,Fasano A

更新日期：2005-02-22 00:00:00

abstract：:Severe hearing loss during early development is associated with deficits in speech and language acquisition. Although functional studies have shown a deafness-induced alteration of synaptic strength, it is not known whether long-term synaptic plasticity depends on auditory experience. In this study, sensorineural hear...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kotak VC,Breithaupt AD,Sanes DH

更新日期：2007-02-27 00:00:00

abstract：:From our current understanding of the genetic basis of development and pattern formation in Drosophila and vertebrates it is commonly thought that clusters of Hox genes sculpt the morphology of animals in specific body regions. Based on Hox gene conservation throughout the animal kingdom it is proposed that these gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kmita-Cunisse M,Loosli F,Bièrne J,Gehring WJ

更新日期：1998-03-17 00:00:00

abstract：:We demonstrate here that yeast killer viruses, previously thought to be transmitted only by cytoplasmic mixing during division, mating, or other induced forms of cell fusion, are capable of extracellular transmission. Viral particles from standard K1 and K2 killer strains were used to inoculate sensitive cells of Sacc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： el-Sherbeini M,Bostian KA

更新日期：1987-06-01 00:00:00

abstract：:Calcium-dependent protein kinases (CDPKs) comprise the major group of Ca2+-regulated kinases in plants and protists. It has long been assumed that CDPKs are activated, like other Ca2+-regulated kinases, by derepression of the kinase domain (KD). However, we found that removal of the autoinhibitory domain from Toxoplas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ingram JR,Knockenhauer KE,Markus BM,Mandelbaum J,Ramek A,Shan Y,Shaw DE,Schwartz TU,Ploegh HL,Lourido S

更新日期：2015-09-08 00:00:00

abstract：:In a recently discovered class of oncogenes, GTPase-inhibiting mutations constitutively activate alpha subunits of signal-transducing guanine nucleotide-binding proteins (G proteins). Somatic mutations in a subclass of endocrine tumors are found in the arginine-179 codon of the alpha subunit of Gi2 (alpha i2), creatin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pace AM,Wong YH,Bourne HR

更新日期：1991-08-15 00:00:00

abstract：:Prion diseases are characterized by an accumulation of PrP(Sc), a misfolded isoform of the normal cellular prion protein, PrP(C). We previously reported the bioactivity of acridine-based compounds against PrP(Sc) replication in scrapie-infected neuroblastoma cells and now report the improved potency of bis-acridine co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： May BC,Fafarman AT,Hong SB,Rogers M,Deady LW,Prusiner SB,Cohen FE

更新日期：2003-03-18 00:00:00

abstract：:An improved electron cloud bolometer is analyzed. In this device the cloud temperature is read out not via thermal noise induced by the electrons in a coupled LC circuit but via shift in their axial oscillation frequency in the Penning trap confining them. This shift occurs because as the electron cloud expands with i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dehmelt H

更新日期：1994-07-05 00:00:00

abstract：:A sensitive in vitro crosslinking technique using a photoactive derivative of the chimeric activator LexA-E2F-1 was used to identify yeast proteins that might influence the response of RNA polymerase II to transcriptional activators. We found that a novel yeast protein, Xtc1p, could be covalently crosslinked to the ac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Emili A,Kobayashi R,Ingles CJ

更新日期：1998-09-15 00:00:00

abstract：:Amber suppressor tRNA genes were constructed by site-specific mutagenesis of the anticodons of human lysine-inserting tRNA (tRNA(Lys)) and glutamine-inserting tRNA (tRNA(Gln)) genes, and a Xenopus laevis tyrosine-inserting tRNA (tRNA(Tyr)) gene. As previous in vitro studies in prokaryotes have shown that substitution ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ho YS,Kan YW

更新日期：1987-04-01 00:00:00

abstract：:Conflicting data have been reported with regard to the infectability, dysfunction, and depletion of dendritic cells (DCs) in human immunodeficiency virus (HIV) disease. These discrepancies could potentially be explained by the existence of multiple subsets of cells with dendritic morphology in peripheral blood. The is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weissman D,Li Y,Ananworanich J,Zhou LJ,Adelsberger J,Tedder TF,Baseler M,Fauci AS

更新日期：1995-01-31 00:00:00

abstract：:Bone mineralization is an essential step during the embryonic development of vertebrates, and bone serves vital functions in human physiology. To systematically identify unique gene functions essential for osteogenesis, we performed a forward genetic screen in zebrafish and isolated a mutant, no bone (nob), that does ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huitema LF,Apschner A,Logister I,Spoorendonk KM,Bussmann J,Hammond CL,Schulte-Merker S

更新日期：2012-12-26 00:00:00

abstract：:An emergent viral pathogen termed severe fever with thrombocytopenia syndrome virus (SFTSV) is responsible for thousands of clinical cases and associated fatalities in China, Japan, and South Korea. Akin to other phleboviruses, SFTSV relies on a viral glycoprotein, Gc, to catalyze the merger of endosomal host and vira...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Halldorsson S,Behrens AJ,Harlos K,Huiskonen JT,Elliott RM,Crispin M,Brennan B,Bowden TA

更新日期：2016-06-28 00:00:00

abstract：:ERK6, a mitogen-activated protein (MAP) kinase-related serine/threonine kinase, is highly expressed in human skeletal muscle and appears to function as a signal transducer during differentiation of myoblasts to myotubes. In transfected 293 cells, activation of the 45-kDa enzyme results in tyrosine-phosphorylated 46- a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lechner C,Zahalka MA,Giot JF,Møller NP,Ullrich A

更新日期：1996-04-30 00:00:00

abstract：:Malignant melanoma has one of the highest mortality rates of any cancer because of its aggressive nature and high metastatic potential. Clinical staging of the disease at the time of diagnosis is very important for the prognosis and outcome of melanoma treatment. In this study, we designed and synthesized the 18F-labe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pyo A,Kim DY,Kim H,Lim D,Kwon SY,Kang SR,Kim HS,Bom HS,Min JJ

更新日期：2020-06-09 00:00:00

abstract：:Transcriptional network evolution is central to the development of complex biological systems. Networks can evolve through variation of master regulators and/or by changes in regulation of genes within networks. To gain insight into meaningful evolutionary differences in large networks, it is essential to address the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jegga AG,Inga A,Menendez D,Aronow BJ,Resnick MA

更新日期：2008-01-22 00:00:00

abstract：:Efforts to understand the dramatic declines in mortality over the past century have focused on life expectancy. However, understanding changes in disparity in age of death is important to understanding mechanisms of mortality improvement and devising policy to promote health equity. We derive a novel decomposition of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seligman B,Greenberg G,Tuljapurkar S

更新日期：2016-07-26 00:00:00

abstract：:Groundwater-dependent species are among the least-known components of global biodiversity, as well as some of the most vulnerable because of rapid groundwater depletion at regional and global scales. The karstic Edwards-Trinity aquifer system of west-central Texas is one of the most species-rich groundwater systems in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Devitt TJ,Wright AM,Cannatella DC,Hillis DM

更新日期：2019-02-12 00:00:00

abstract：:In recent years, advertisers and magazine editors have been widely criticized for taking digital photo retouching to an extreme. Impossibly thin, tall, and wrinkle- and blemish-free models are routinely splashed onto billboards, advertisements, and magazine covers. The ubiquity of these unrealistic and highly idealize...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kee E,Farid H

更新日期：2011-12-13 00:00:00

abstract：:Metal-catalyzed oxidation results in loss of function and structural alteration of proteins. The oxidative process affects a variety of side amino acid groups, some of which are converted to carbonyl compounds. Spectrophotometric measurement of these moieties, after their reaction with 2,4-dinitrophenylhydrazine, is a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Requena JR,Chao CC,Levine RL,Stadtman ER

更新日期：2001-01-02 00:00:00

abstract：:Triton X-100-solubilized high-density microsomes from insulin-treated rat adipocytes exhibit a marked increase in serine/threonine and tyrosine kinase activities toward exogenous histone when compared to controls. The insulin-dependent activation of microsomal histone kinase activities occurs within the physiological ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu KT,Khalaf N,Czech MP

更新日期：1987-06-01 00:00:00

abstract：:The design, realization, and test performances of an electronic junction based on single-electron phenomena that works in the air at room temperature are hereby reported. The element consists of an electrochemically etched sharp tungsten stylus over whose tip a nanometer-size crystal was synthesized. Langmuir-Blodgett...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Facci P,Erokhin V,Carrara S,Nicolini C

更新日期：1996-10-01 00:00:00

abstract：:The molecular chaperone Hsp90 is a protein folding machine that is conserved from bacteria to man. Human, cytosolic Hsp90 is dedicated to folding of chiefly signal transduction components. The chaperoning mechanism of Hsp90 is controlled by ATP and various cochaperones, but is poorly understood and controversial. Here...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karagöz GE,Duarte AM,Ippel H,Uetrecht C,Sinnige T,van Rosmalen M,Hausmann J,Heck AJ,Boelens R,Rüdiger SG

更新日期：2011-01-11 00:00:00

abstract：:The history of the genus Pan is a topic of enduring interest. Chimpanzees (Pan troglodytes) are often divided into subspecies, but the population structure and genetic history of chimpanzees across Africa remain unclear. Some population genetics studies have led to speculation that, until recently, this species consti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gonder MK,Locatelli S,Ghobrial L,Mitchell MW,Kujawski JT,Lankester FJ,Stewart CB,Tishkoff SA

更新日期：2011-03-22 00:00:00

abstract：:We performed combinatorial peptide library screening in vivo on a novel human prostate cancer xenograft that is androgen-independent and induces a robust osteoblastic reaction in bonelike matrix and soft tissue. We found two peptides, PKRGFQD and SNTRVAP, which were enriched in the tumors, targeted the cell surface of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mandelin J,Cardó-Vila M,Driessen WH,Mathew P,Navone NM,Lin SH,Logothetis CJ,Rietz AC,Dobroff AS,Proneth B,Sidman RL,Pasqualini R,Arap W

更新日期：2015-03-24 00:00:00

abstract：:Escherichia coli fMet-tRNAfMet alters the pattern of promoter selection of E. coli RNA polymerase (RNA nucleotidyltransferase, nucleosidetriphosphate:RNA nucleotidyltransferase; EC 2.7.7.6), affecting RNA synthesis from the rRNA, suIII+tRNA, and lac promoters in different ways. The in vitro synthesis of the stable RNA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Debenham PG,Pongs O,Travers AA

更新日期：1980-02-01 00:00:00

abstract：:Insulin-degrading enzyme (IDE) selectively degrades the monomer of amyloidogenic peptides and contributes to clearance of amyloid β (Aβ). Thus, IDE retards the progression of Alzheimer's disease. IDE possesses an enclosed catalytic chamber that engulfs and degrades its peptide substrates; however, the molecular mechan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McCord LA,Liang WG,Dowdell E,Kalas V,Hoey RJ,Koide A,Koide S,Tang WJ

更新日期：2013-08-20 00:00:00

abstract：:Maltose-binding protein (MBP) is a two-domain protein that undergoes a ligand-mediated conformational rearrangement from an "open" to a "closed" structure on binding to maltooligosaccharides. To characterize the energy landscape associated with this transition, we have generated five variants of MBP with mutations loc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Millet O,Hudson RP,Kay LE

更新日期：2003-10-28 00:00:00

abstract：:Hox genes are conserved transcription factor-encoding genes that specify the identity of body regions in bilaterally symmetrical animals. In the cricket Gryllus bimaculatus, a member of the hemimetabolous insect group Orthoptera, the induction of a subset of mesodermal cells to form the primordial germ cells (PGCs) is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barnett AA,Nakamura T,Extavour CG

更新日期：2019-08-13 00:00:00

abstract：:Chemical coding in the sympathetic nervous system involves both noradrenergic and, for a minority of neurons, cholinergic neurotransmission. The expression of the cholinergic phenotype in the developing sympathetic nervous system was examined to determine if coding for cholinergic transmission occurs before or after i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schäfer MK,Schütz B,Weihe E,Eiden LE

更新日期：1997-04-15 00:00:00