Selective loss of antigen-specific Ir gene function in IA mutant B6.C-H-2bm12 is an antigen presenting cell defect.

abstract：:Reactive oxygen species, the by-products of oxidative energy metabolism, are considered a main proximate cause of aging. Accordingly, overexpression of the enzyme Cu-Zn superoxide dismutase 1 (SOD1) can lengthen lifespan of Drosophila melanogaster in the laboratory. However, the role of SOD1 as a main determinant of l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parker JD,Parker KM,Sohal BH,Sohal RS,Keller L

更新日期：2004-03-09 00:00:00

abstract：:Prenylated Rab GTPases regulate intracellular vesicle trafficking in eukaryotic cells by associating with specific membranes and recruiting a multitude of Rab-specific effector proteins. Prenylation, membrane delivery, and recycling of all 60 members of the Rab GTPase family are regulated by two related molecules, Rab...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu YW,Tan KT,Waldmann H,Goody RS,Alexandrov K

更新日期：2007-07-24 00:00:00

abstract：:Incorporation of 2-acyl spin-labeled lecithin into the phosphatidylcholine protein from bovine liver results in an immobilization of the spin-label at the methyl and the carboxyl terminal end of the acyl chain. The nitroxide group on the protein-bound lecithin molecule is not accessible to ascorbate. This suggests tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Devaux PF,Moonen P,Bienvenue A,Wirtz KW

更新日期：1977-05-01 00:00:00

abstract：:The Amazon rainforest is the Earth's largest reservoir of plant and animal diversity, and it has been subjected to especially high rates of land use change, primarily to cattle pasture. This conversion has had a strongly negative effect on biological diversity, reducing the number of plant and animal species and homog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rodrigues JL,Pellizari VH,Mueller R,Baek K,Jesus Eda C,Paula FS,Mirza B,Hamaoui GS Jr,Tsai SM,Feigl B,Tiedje JM,Bohannan BJ,Nüsslein K

更新日期：2013-01-15 00:00:00

abstract：:Saccharomyces cerevisiae strains harboring a nonreciprocal, bridge-induced translocation (BIT) between chromosomes VIII and XV exhibited an abnormal phenotype comprising elongated buds and multibudded, unevenly nucleated pseudohyphae. In these cells, we found evidence of molecular effects elicited by the translocation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nikitin D,Tosato V,Zavec AB,Bruschi CV

更新日期：2008-07-15 00:00:00

abstract：:Tissue kallikrein (TK) is a serine protease synthetized in renal tubular cells located upstream from the collecting duct where renal potassium balance is regulated. Because secretion of TK is promoted by K+ intake, we hypothesized that this enzyme might regulate plasma K+ concentration ([K+]). We showed in wild-type m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： El Moghrabi S,Houillier P,Picard N,Sohet F,Wootla B,Bloch-Faure M,Leviel F,Cheval L,Frische S,Meneton P,Eladari D,Chambrey R

更新日期：2010-07-27 00:00:00

abstract：:The mosquito midgut plays a central role in the sporogonic development of malaria parasites. We have found that polyclonal sera, produced against mosquito midguts, blocked the passage of Plasmodium falciparum ookinetes across the midgut, leading to a significant reduction of infections in mosquitoes. Anti-midgut mAbs ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lal AA,Patterson PS,Sacci JB,Vaughan JA,Paul C,Collins WE,Wirtz RA,Azad AF

更新日期：2001-04-24 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-alpha) stimulated the phosphorylation of a 28-kDa protein (p28) in the ME-180 line of human cervical carcinoma cells. The effect of TNF-alpha on the phosphorylation state of p28 was rapid (4-fold increase within 15 min) and persistent, remaining above the basal level for at least 2 hr....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marino MW,Pfeffer LM,Guidon PT Jr,Donner DB

更新日期：1989-11-01 00:00:00

abstract：:Clustered DNA damage induced by ionizing radiation is refractory to repair and may trigger carcinogenic events for reasons that are not well understood. Here, we used an in situ method to directly monitor induction and repair of clustered DNA lesions in individual cells. We showed, consistent with biophysical modeling...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Asaithamby A,Hu B,Chen DJ

更新日期：2011-05-17 00:00:00

abstract：:Chromosome 3p and 1p deletions are among the most frequent genetic changes in human lung cancer and although candidate tumor suppressor genes have been identified in these regions, no causative correlations have been drawn between deletion or mutation of these and lung carcinogenesis. We identify XPC and Gadd45a as ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hollander MC,Philburn RT,Patterson AD,Velasco-Miguel S,Friedberg EC,Linnoila RI,Fornace AJ Jr

更新日期：2005-09-13 00:00:00

abstract：:DNA delivery of IL-12 has shown promise in reducing the toxic side effects associated with administration of recombinant human (h)IL-12 protein while maintaining the ability to inhibit tumor growth and abolish tumor metastases in animal models. We have developed a more potent version of IL-12 by using DNA shuffling an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leong SR,Chang JC,Ong R,Dawes G,Stemmer WP,Punnonen J

更新日期：2003-02-04 00:00:00

abstract：:Most current gene transfer methods function satisfactorily in specialized systems involving established cell lines but are often not applicable with nonadherent, primary hematopoietic cells, which are notoriously difficult to transfect. To approach this problem, we have investigated an alternative method of gene trans...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zenke M,Steinlein P,Wagner E,Cotten M,Beug H,Birnstiel ML

更新日期：1990-05-01 00:00:00

abstract：:To understand the evolution of a Theory of Mind, we need to understand the selective factors that might have jumpstarted its initial evolution. We argue that a subconscious, reflexive appreciation of others' intentions, emotions, and perspectives is at the roots of even the most complex forms of Theory of Mind and tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seyfarth RM,Cheney DL

更新日期：2013-06-18 00:00:00

abstract：:The 5' flanking regions of the mouse renin genes (Ren1d and Ren2d) contain putative negative control and cAMP responsive elements. Sequence analysis shows additionally that these putative control elements in the Ren2d gene are interrupted by a 160-base-pair insertion. To document the functions of these elements, we is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakamura N,Burt DW,Paul M,Dzau VJ

更新日期：1989-01-01 00:00:00

abstract：:Many ion channels exhibit a slow stochastic switching between distinct modes of gating activity. This feature of channel behavior has pronounced implications for the dynamics of ionic currents and the signaling pathways that they regulate. A canonical example is the inositol 1,4,5-trisphosphate receptor (IP3R) channel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bicknell BA,Goodhill GJ

更新日期：2016-09-06 00:00:00

abstract：:A majority of the total protein synthesis in host cell cytoplasm is inhibited by cycloheximide. Because leghemoglobin represents a large proportion of total cellular protein in the nodule, this observation suggests that leghemoglobin may be translated on the 80S-type ribosomes. Analysis of the nascent peptides isolate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Verma DP,Bal AK

更新日期：1976-11-01 00:00:00

abstract：:The study of gene family members has been aided by the isolation of related genes on the basis of DNA homology. We have adapted the polymerase chain reaction to screen animal genomes very rapidly and reliably for likely gene family members. Using conserved amino acid sequences to design degenerate oligonucleotide prim...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kamb A,Weir M,Rudy B,Varmus H,Kenyon C

更新日期：1989-06-01 00:00:00

abstract：:Alzheimer's disease (AD) neuropathological hallmarks include senile plaques with aggregated amyloid beta as a major component, neurofibrillary tangles (NFT) containing truncated and hyperphosphorylated Tau, extensive neuronal loss, and chronic neuroinflammation. However, the key molecular mechanism that dominates the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang H,Liu X,Chen S,Ye K

更新日期：2018-12-26 00:00:00

abstract：:Prions are mammalian proteins (PrPs) with a unique pathogenic property: a nonendogenous isoform PrP(Sc) can catalyze conversion of the endogenous PrP(C) isoform into additional PrP(Sc). In this work, we demonstrate that PrP(C) helix 1 has certain properties (hydrophilicity, charge distribution) that make it unique amo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morrissey MP,Shakhnovich EI

更新日期：1999-09-28 00:00:00

abstract：:Two-dimensional gel electrophoresis of immunoprecipitated human HLA-DR antigens from cells expressing the HLA-DR4 haplotype shows distinct clustering of beta-chain patterns. Six unique electrophoretic variants were observed among 17 HLA-DR4 homozygous cell lines (HCL) analyzed. These patterns correlate precisely with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nepom BS,Nepom GT,Mickelson E,Antonelli P,Hansen JA

更新日期：1983-11-01 00:00:00

abstract：:A key feature of immune evasion for African trypanosomes is the functional specialization of their surface membrane in an invagination known as the flagellar pocket (FP), the cell's sole site of endocytosis and exocytosis. The FP membrane is biochemically distinct yet continuous with those of the cell body and the fla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gadelha C,Rothery S,Morphew M,McIntosh JR,Severs NJ,Gull K

更新日期：2009-10-13 00:00:00

abstract：:Repetitive brain stimulation protocols induce plasticity in the stimulated site in brain slice models. Recent evidence from network models has indicated that additional plasticity-related changes occur in nonstimulated remote regions. Despite increasing use of brain stimulation protocols in experimental and clinical s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Abe M,Fukuyama H,Mima T

更新日期：2014-03-25 00:00:00

abstract：:Cytotactin is an extracellular matrix protein that is dynamically and transiently expressed in a place-dependent fashion during development by glial cells, fibroblasts, and several other cell types. In the present study, the effects of cytotactin on cell proliferation were examined in fibroblastic cells in culture. NI...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crossin KL

更新日期：1991-12-15 00:00:00

abstract：:The study of development has relied primarily on the isolation of mutations in genes with specific functions in development and on the comparison of their expression patterns in normal and mutant phenotypes. Comparative evolutionary analyses can complement these approaches. Phylogenetic analyses of Sonic hedgehog (Shh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zardoya R,Abouheif E,Meyer A

更新日期：1996-11-12 00:00:00

abstract：:Extracellular growth and differentiation factors induce changes in gene expression in the nucleus by initiating a series of protein associations that alter the subcellular localization of intracellular signaling proteins. Initial events involve receptor homo- or heterodimerization and subsequent recruitment of cytosol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Belshaw PJ,Ho SN,Crabtree GR,Schreiber SL

更新日期：1996-05-14 00:00:00

abstract：:The exemplary search capabilities of flying insects have established them as one of the most diverse taxa on Earth. However, we still lack the fundamental ability to quantify, represent, and predict trajectories under natural contexts to understand search and its applications. For example, flying insects have evolved ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaushik PK,Renz M,Olsson SB

更新日期：2020-06-02 00:00:00

abstract：:The acid-sensing ion channel 1a (ASIC1a) is abundantly expressed in the amygdala complex and other brain regions associated with fear. Studies of mice with a disrupted ASIC1 gene suggested that ASIC1a may contribute to learned fear. To test this hypothesis, we generated mice overexpressing human ASIC1a by using the pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wemmie JA,Coryell MW,Askwith CC,Lamani E,Leonard AS,Sigmund CD,Welsh MJ

更新日期：2004-03-09 00:00:00

abstract：:Much recent attention in the study of adaptation of organismal form has centered on developmental regulation. As such, the highly conserved respiratory machinery of eukaryotic cells might seem an unlikely target for selection supporting novel morphologies. We demonstrate that a dramatic molecular evolutionary rate inc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jobson RW,Nielsen R,Laakkonen L,Wikström M,Albert VA

更新日期：2004-12-28 00:00:00

abstract：:A way to assess specific CD8+ T-cell activity in a skin test analogous to the conventional delayed-type hypersensitivity (DTH) reaction for CD4+ T cells is presented. Local injection of viral class I binding peptides caused a specific CD8+ T-cell-mediated DTH in footpads of virally infected mice. The DTH was inducible...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kündig TM,Althage A,Hengartner H,Zinkernagel RM

更新日期：1992-08-15 00:00:00

abstract：:Unrestrained 53BP1 activity at DNA double-strand breaks (DSBs) hampers DNA end resection and upsets DSB repair pathway choice. RNF169 acts as a molecular rheostat to limit 53BP1 deposition at DSBs, but how this fine balance translates to DSB repair control remains undefined. In striking contrast to 53BP1, ChIP analyse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： An L,Dong C,Li J,Chen J,Yuan J,Huang J,Chan KM,Yu CH,Huen MSY

更新日期：2018-08-28 00:00:00