Ribosome clearance by FusB-type proteins mediates resistance to the antibiotic fusidic acid.

abstract：:An oligomeric intermediate in the biosynthetic pathway of peptidoglycan was isolated from B. megaterium. The oligomer has been identified as [disaccharide(pentapeptide)]12 pyrophosphoryl undecaprenol. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fuchs-Cleveland E,Gilvarg C

更新日期：1976-11-01 00:00:00

abstract：:Twice each year, millions of night-migratory songbirds migrate thousands of kilometers. To find their way, they must process and integrate spatiotemporal information from a variety of cues including the Earth's magnetic field and the night-time starry sky. By using sensory-driven gene expression, we discovered that ni...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mouritsen H,Feenders G,Liedvogel M,Wada K,Jarvis ED

更新日期：2005-06-07 00:00:00

abstract：:X-ray structures of bovine heart cytochrome c oxidase have suggested that the enzyme, which reduces O(2) in a process coupled with a proton pumping process, contains a proton pumping pathway (H-pathway) composed of a hydrogen bond network and a water channel located in tandem across the enzyme. The hydrogen bond netwo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shimokata K,Katayama Y,Murayama H,Suematsu M,Tsukihara T,Muramoto K,Aoyama H,Yoshikawa S,Shimada H

更新日期：2007-03-06 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disorder of uncertain pathogenesis characterized by a loss of substantia nigra pars compacta (SNpc) dopaminergic (DA) neurons, and can be modeled by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Both inflammatory processes and oxidative stress may c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu DC,Teismann P,Tieu K,Vila M,Jackson-Lewis V,Ischiropoulos H,Przedborski S

更新日期：2003-05-13 00:00:00

abstract：:A single-chain Fv (scFv) fusion phage library derived from random combinations of VH and VL (variable heavy and light chains) domains in the antibody repertoire of a vaccinated melanoma patient was previously used to isolate clones that bind specifically to melanoma cells. An unexpected finding was that one of the clo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cai X,Garen A

更新日期：1997-08-19 00:00:00

abstract：:Major breakthroughs have recently been reported that can help overcome two inherent drawbacks of NMR: the lack of sensitivity and the limited memory of longitudinal magnetization. Dynamic nuclear polarization (DNP) couples nuclear spins to the large reservoir of electrons, thus making it possible to detect dilute endo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vasos PR,Comment A,Sarkar R,Ahuja P,Jannin S,Ansermet JP,Konter JA,Hautle P,van den Brandt B,Bodenhausen G

更新日期：2009-11-03 00:00:00

abstract：:We have recently shown that the expression of nestin, the neural stem cell marker protein, is expressed in bulge-area stem cells of the hair follicle. We used transgenic mice with GFP expression driven by the nestin regulatory element [nestin-driven GFP (ND-GFP)]. The ND-GFP stem cells give rise to the outer-root shea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amoh Y,Li L,Katsuoka K,Penman S,Hoffman RM

更新日期：2005-04-12 00:00:00

abstract：:The helical ribosome structures of Mycoplasma gallisepticum have been analyzed by optical diffraction and the rotational symmetry technique. The helix repeat (510 A) is composed of 10 ribosomes in 3 turns. The rotational studies show some ribosome fine structure. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maniloff J

更新日期：1971-01-01 00:00:00

abstract：:We posit that feasible reversal of the growth of atmospheric CH(4) and other trace gases would provide a vital contribution toward averting dangerous anthropogenic interference with global climate. Such trace gas reductions may allow stabilization of atmospheric CO(2) at an achievable level of anthropogenic CO(2) emis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hansen J,Sato M

更新日期：2004-11-16 00:00:00

abstract：:Gyrate atrophy (GA), a recessive eye disease involving progressive loss of vision due to chorioretinal degeneration, is associated with a deficiency of the mitochondrial enzyme ornithine aminotransferase (OATase; ornithine-oxo-acid aminotransferase; L-ornithine:2-oxo-acid aminotransferase, EC 2.6.1.13) with consequent...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramesh V,McClatchey AI,Ramesh N,Benoit LA,Berson EL,Shih VE,Gusella JF

更新日期：1988-06-01 00:00:00

abstract：:Posttranslational modifications (PTMs) of α-synuclein (α-syn), e.g., phosphorylation, play an important role in modulating α-syn pathology in Parkinson's disease (PD) and α-synucleinopathies. Accumulation of phosphorylated α-syn fibrils in Lewy bodies and Lewy neurites is the histological hallmark of these diseases. H...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao K,Lim YJ,Liu Z,Long H,Sun Y,Hu JJ,Zhao C,Tao Y,Zhang X,Li D,Li YM,Liu C

更新日期：2020-08-18 00:00:00

abstract：:The coupling of calcium transport to ATP hydrolysis in rabbit muscle sarcoplasmic reticulum vesicles was determined under steady-state conditions in the presence of 5 mM oxalate and using various concentrations of vesicles to modulate the concentration of free Ca2+ in the medium. This experimental approach takes advan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gafni A,Boyer PD

更新日期：1985-01-01 00:00:00

abstract：:Assembly of light-harvesting complexes requires synchronization of chlorophyll (Chl) biosynthesis with biogenesis of light-harvesting Chl a/b-binding proteins (LHCPs). The chloroplast signal recognition particle (cpSRP) pathway is responsible for transport of nucleus-encoded LHCPs in the stroma of the plastid and thei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang P,Liang FC,Wittmann D,Siegel A,Shan SO,Grimm B

更新日期：2018-04-10 00:00:00

abstract：:Establishing a timeline for the evolution of novelties is a common, unifying goal at the intersection of evolutionary and developmental biology. Analyses of gene regulatory networks (GRNs) provide the ability to understand the underlying genetic and developmental mechanisms responsible for the origin of morphological ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thompson JR,Erkenbrack EM,Hinman VF,McCauley BS,Petsios E,Bottjer DJ

更新日期：2017-06-06 00:00:00

abstract：:Remembering and discriminating objects based on their previously learned values are essential for goal-directed behaviors. While the cerebral cortex is known to contribute to object recognition, surprisingly little is known about its role in retaining long-term object-value associations. To address this question, we t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ghazizadeh A,Griggs W,Leopold DA,Hikosaka O

更新日期：2018-02-27 00:00:00

abstract：:All cell functions that involve membrane deformation or a change in cell shape (e.g., endocytosis, exocytosis, cell motility, and cytokinesis) are regulated by membrane tension. While molecular contacts between the plasma membrane and the underlying actin cytoskeleton are known to make significant contributions to mem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nambiar R,McConnell RE,Tyska MJ

更新日期：2009-07-21 00:00:00

abstract：:Protein tyrosine phosphorylation and dephosphorylation are key regulatory events in T-cell receptor (TCR) signaling. We investigated the role of the tyrosine phosphatase SHPTP1 in TCR signaling by analysis of TCR signal transduction in motheaten (me/me) mice, which lack SHPTP1 expression. As revealed by flow cytometri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lorenz U,Ravichandran KS,Burakoff SJ,Neel BG

更新日期：1996-09-03 00:00:00

abstract：:Alu elements are a family of interspersed repeats that have mobilized throughout primate genomes by retroposition from a few "master" genes. Among the 500,000 Alu elements in the human genome are members of the human-specific subfamily that are not fixed in the human species; that is, not all chromosomes carry an Alu ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Batzer MA,Stoneking M,Alegria-Hartman M,Bazan H,Kass DH,Shaikh TH,Novick GE,Ioannou PA,Scheer WD,Herrera RJ

更新日期：1994-12-06 00:00:00

abstract：:Phosphatidylinositol (3,4,5)-triphosphate (PtdInsP(3)) mediates intracellular signaling for directional sensing and pseudopod extension at the leading edge of migrating cells during chemotaxis. How this PtdInsP(3) signal is translated into remodeling of the actin cytoskeleton is poorly understood. Here, using a proteo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang P,Wang Y,Sesaki H,Iijima M

更新日期：2010-06-29 00:00:00

abstract：:The MAK16 gene was first defined as a gene whose mutation resulted in loss of M1 double-stranded RNA virus-like particles. The mak16-1 mutation also produces temperature-sensitive cell growth. We report here that mak16-1 cells arrest at the nonpermissive temperature in G1 phase, such that they are mating competent. We...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wickner RB

更新日期：1988-08-01 00:00:00

abstract：:Rod-shaped "ghosts" that are free of murein have been isolated from E. coli. The shape of these "ghosts" is maintained by a unit membrane soluble in sodium dodecyl sulfate. Ghosts consist of about 20-30% phospholipid (almost exclusively phosphatidylethanolamine) and 50-60% protein; a large fraction of the remaining ma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Henning U,Rehn K,Hoehn B

更新日期：1973-07-01 00:00:00

abstract：:The complete amino acid sequence for human erythrocyte band 4.2 has been derived from the nucleotide sequence of a full-length 2.35-kilobase (kb) cDNA. The 2.35-kb cDNA was isolated from a human reticulocyte cDNA library made in the expression vector lambda gt11. Of the 2348 base pairs (bp), 2073 bp encode 691 amino a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Korsgren C,Lawler J,Lambert S,Speicher D,Cohen CM

更新日期：1990-01-01 00:00:00

abstract：:An argument is presented in favor of the hypothesis that, bovine carboxypeptidases A and B fit by and large, the concept of homology on the levels of both amino acid sequence and three-dimensional structure. Two peptide sequences from carboxypeptidases A and B, comprising 46 amino acid residues, display structural hom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bradshaw RA,Neurath H,Walsh KA

更新日期：1969-06-01 00:00:00

abstract：:Interleukin 2 (IL-2)-deficient (IL-2-/-) mice develop hemolytic anemia and chronic inflammatory bowel disease. Importantly, the induction of disease in IL-2-deficient mice is critically dependent on CD4+ T cells. We have studied the requirements of T cells from IL-2-deficient mice for costimulation with B7 antigens. S...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Razi-Wolf Z,Höllander GA,Reiser H

更新日期：1996-04-02 00:00:00

abstract：:A five-helix secondary structural model is proposed for eukaryotic cytoplasmic 5S rRNA. All available sequence data are consistent with this model including those from Chlorella 5S rRNA whose sequence is revised by data included here. Various architectural features of eukaryotic 5S rRNA are summarized in terms of this...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luehrsen KR,Fox GE

更新日期：1981-04-01 00:00:00

abstract：:Early events in both T-cell receptor (CD3)- and CD4-induced signal transduction pathways include tyrosine phosphorylation of protein substrates, the generation of phosphatidylinositol-phosphate breakdown products, and the mobilization of intracellular Ca2+. Oxidative stress in T cells mediated by sulfhydryl-reactive n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kanner SB,Kavanagh TJ,Grossmann A,Hu SL,Bolen JB,Rabinovitch PS,Ledbetter JA

更新日期：1992-01-01 00:00:00

abstract：:The long QT syndrome (LQTS) is a heritable disorder that predisposes to sudden cardiac death. LQTS is caused by mutations in ion channel genes including HERG and KCNE1, but the precise mechanisms remain unclear. To clarify this situation we injected adenoviral vectors expressing wild-type or LQT mutants of HERG and KC...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoppe UC,Marbán E,Johns DC

更新日期：2001-04-24 00:00:00

abstract：:The multisubunit enzyme aspartate transcarbamylase consists of six copies of two types of polypeptide chains, catalytic (C) and regulatory (R). A complex formed by the partial dissociation of this enzyme has been isolated. This species, which has the structure C(6)R(4), is a likely intermediate in the stepwise dissoci...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Evans DR,Pastra-Landis SC,Lipscomb WN

更新日期：1974-04-01 00:00:00

abstract：:Proteolipid protein (PLP) is the major myelin membrane protein of the central nervous system. We have isolated a copy of an alternatively spliced PLP gene transcript from a mouse brain cDNA library that was screened for PLP-related sequences. The encoded 241-amino acid protein differs from PLP by an internal deletion ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nave KA,Lai C,Bloom FE,Milner RJ

更新日期：1987-08-01 00:00:00

abstract：:A further study is made of the intertwining operators for the representations of the simple Lie groups of real rank one. We extend and apply this to the higher rank case, obtaining various results dealing with reducibility of principal series and existence of complementary series. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knapp AW,Stein EM

更新日期：1970-05-01 00:00:00