Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness.

abstract：:Human T cell clones were analyzed for their susceptibility to activation-induced cell death (AICD) in response to CD3/T cell receptor ligation. AICD was observed only in Th1 clones and was Fas-mediated, whereas Th2 clones resisted AICD. Analysis of a panel of Th0 clones, characterized by their ability to secrete both ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Varadhachary AS,Perdow SN,Hu C,Ramanarayanan M,Salgame P

更新日期：1997-05-27 00:00:00

abstract：:The p2b domain of Rous sarcoma virus (RSV) Gag and the p6 domain of HIV-1 Gag contain late assembly (L) domains that engage the ESCRT membrane fission machinery and are essential for virus release. We now show that the PPXY-type RSV L domain specifically recruits the BAR domain protein PACSIN2 into virus-like particle...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Popov S,Popova E,Inoue M,Wu Y,Göttlinger H

更新日期：2018-07-03 00:00:00

abstract：:A major goal for developmental biologists is to define the behaviors and molecular contents of differentiating cells. We have devised a strategy for isolating cells from diverse embryonic regions and stages in the zebrafish, using computer-guided laser photoconversion of injected Kaede protein and flow cytometry. This...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown JL,Snir M,Noushmehr H,Kirby M,Hong SK,Elkahloun AG,Feldman B

更新日期：2008-08-26 00:00:00

abstract：:Short oxygen-halogen interactions have been known in organic chemistry since the 1950s and recently have been exploited in the design of supramolecular assemblies. The present survey of protein and nucleic acid structures reveals similar halogen bonds as potentially stabilizing inter- and intramolecular interactions t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Auffinger P,Hays FA,Westhof E,Ho PS

更新日期：2004-11-30 00:00:00

abstract：:Pathologic ocular angiogenesis is a leading cause of blindness, influenced by both dysregulated lipid metabolism and inflammation. Retinoic-acid-receptor-related orphan receptor alpha (RORα) is a lipid-sensing nuclear receptor with diverse biologic function including regulation of lipid metabolism and inflammation; ho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun Y,Liu CH,SanGiovanni JP,Evans LP,Tian KT,Zhang B,Stahl A,Pu WT,Kamenecka TM,Solt LA,Chen J

更新日期：2015-08-18 00:00:00

abstract：:Thiostrepton (TSR), an archetypal bimacrocyclic thiopeptide antibiotic that arises from complex posttranslational modifications of a genetically encoded precursor peptide, possesses a quinaldic acid (QA) moiety within the side-ring system of a thiopeptide-characteristic framework. Focusing on selective engineering of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zheng Q,Wang S,Duan P,Liao R,Chen D,Liu W

更新日期：2016-12-13 00:00:00

abstract：:The chemotherapeutic drug Taxol is known to interact within a specific site on beta-tubulin. Although the general location of the site has been defined by photoaffinity labeling and electron crystallography, the original data were insufficient to make an absolute determination of the bound conformation. We have now co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Snyder JP,Nettles JH,Cornett B,Downing KH,Nogales E

更新日期：2001-04-24 00:00:00

abstract：:The genome of a thermophilic fungus, Thermomyces lanuginosus, contains a tandemly arranged cluster of sequences that are approximately equal to 50% homologous with the cytoplasmic 5S RNA and that are selectable by hybridization techniques. Unlike typical pseudogenes, these sequences are not truncated; rather, they bea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wong WM,Abrahamson JL,Nazar RN

更新日期：1984-03-01 00:00:00

abstract：:Conventional markets can underprovide ecosystem services. Deliberate creation of a market for ecosystem services [e.g., a payments for ecosystem services (PES) scheme] can close the gap. The new ecosystem service market alters behaviors and quantities of ecosystem service provided and reveals prices for the ecosystems...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Adamowicz W,Calderon-Etter L,Entem A,Fenichel EP,Hall JS,Lloyd-Smith P,Ogden FL,Regina JA,Rouhi Rad M,Stallard RF

更新日期：2019-03-19 00:00:00

abstract：:Kampo formulations are traditional herbal medications used in China and Japan for many centuries to treat diarrheal diseases such as cholera. Our studies were undertaken to identify and verify by chemical synthesis the active components that inhibited cholera toxin (CT), the virulence factor secreted by Vibrio cholera...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oi H,Matsuura D,Miyake M,Ueno M,Takai I,Yamamoto T,Kubo M,Moss J,Noda M

更新日期：2002-03-05 00:00:00

abstract：:Previous work showed that cultured human pancreatic cancer cells overexpress the epidermal growth factor (EGF) receptor. In the present study, we sought to determine whether some of these cell lines produce transforming growth factor alpha (TGF-alpha). Utilizing a radiolabeled TGF-alpha cDNA in hybridization experimen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith JJ,Derynck R,Korc M

更新日期：1987-11-01 00:00:00

abstract：:As sensors, wireless communication devices, personal health monitoring systems, and autonomous microelectromechanical systems (MEMS) become distributed and smaller, there is an increasing demand for miniaturized integrated power sources. Although thin-film batteries are well-suited for on-chip integration, their energ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ning H,Pikul JH,Zhang R,Li X,Xu S,Wang J,Rogers JA,King WP,Braun PV

更新日期：2015-05-26 00:00:00

abstract：:Four 12-O-tetradecanoyl-13-O-acetylphorbol-type tumor promoters--teleocidin, phorbol ester, aplysiatoxin, and ingenol ester--are superposed in an attempt to understand their common biological activity on the assumption that they may bind to the same receptor site. A method using three-dimensional computer graphics was...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Itai A,Kato Y,Tomioka N,Iitaka Y,Endo Y,Hasegawa M,Shudo K,Fujiki H,Sakai S

更新日期：1988-06-01 00:00:00

abstract：:Calpains are Ca(2+)-dependent intracellular proteases. We show here that calpain-generated natural C-terminal fragments of proteins that include G protein-coupled receptors, transmembrane ion channels, transcriptional regulators, apoptosis controllers, kinases, and phosphatases (Phe-GluN2a, Lys-Ica512, Arg-Ankrd2, Tyr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Piatkov KI,Oh JH,Liu Y,Varshavsky A

更新日期：2014-03-04 00:00:00

abstract：:Phylogenetic analysis of Plasmodium parasites has indicated that their modern-day distribution is a result of a series of human-mediated dispersals involving transport between Africa, Europe, America, and Asia. A major outstanding question is the phylogenetic affinity of the malaria causing parasites Plasmodium vivax ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gelabert P,Sandoval-Velasco M,Olalde I,Fregel R,Rieux A,Escosa R,Aranda C,Paaijmans K,Mueller I,Gilbert MT,Lalueza-Fox C

更新日期：2016-10-11 00:00:00

abstract：:The mechanisms that are essential for the maintenance of nutrient status in breast milk are unclear. Our data demonstrate that the intestine via hypoxia-inducible factor (HIF)-2α is an essential regulatory mechanism for maintaining the quality of breast milk. During lactation, intestinal HIF-2α is highly increased, le...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramakrishnan SK,Anderson ER,Martin A,Centofanti B,Shah YM

更新日期：2015-07-14 00:00:00

abstract：:We have screened about 1.4 million colonies of Escherichia coli K-12 for their ability to grow on nutrient agar at 30 degrees and 41 degrees. Among the 2266 temperature-sensitive mutants found, 110 were defective in DNA synthesis but not in protein synthesis at 41 degrees. Three of these dna mutations mapped at two pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sevastopoulos CG,Wehr CT,Glaser DA

更新日期：1977-08-01 00:00:00

abstract：:In many cell-signaling pathways, information is transmitted by the diffusion of messenger molecules. Diffusion coefficients characterize the messenger's spatial range and the characteristic times of signal propagation. Inside cells, particles usually diffuse in the presence of immobile binding sites (or traps). It is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pando B,Dawson SP,Mak DO,Pearson JE

更新日期：2006-04-04 00:00:00

abstract：:An enhancer specific to erythroid cells was identified previously in the 3' flanking sequence of the chicken adult beta-globin gene and shown to act on the beta-globin promoter. This enhancer lies between the adult beta-globin gene and the embryonic epsilon-globin gene, about equidistant from the two promoters. To det...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nickol JM,Felsenfeld G

更新日期：1988-04-01 00:00:00

abstract：:Estrogen receptors (ERs) protect pancreatic islet survival in mice through rapid extranuclear actions. ERalpha also enhances insulin synthesis in cultured islets. Whether ERalpha stimulates insulin synthesis in vivo and, if so, through which mechanism(s) remain largely unknown. To address these issues, we generated a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wong WP,Tiano JP,Liu S,Hewitt SC,Le May C,Dalle S,Katzenellenbogen JA,Katzenellenbogen BS,Korach KS,Mauvais-Jarvis F

更新日期：2010-07-20 00:00:00

abstract：:Transfer of organelle DNA into the nuclear genome has been significant in eukaryotic evolution, because it appears to be the origin of many nuclear genes. Most studies on organelle DNA transfer have been restricted to evolutionary events but experimental systems recently became available to monitor the process in real...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang CY,Ayliffe MA,Timmis JN

更新日期：2004-06-29 00:00:00

abstract：:Activation of protein kinase C (PKC) by phorbol ester facilitates hormonal secretion and transmitter release, and phorbol ester-induced synaptic potentiation (PESP) is a model for presynaptic facilitation. A variety of PKC isoforms are expressed in the central nervous system, but the isoform involved in the PESP has n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saitoh N,Hori T,Takahashi T

更新日期：2001-11-20 00:00:00

abstract：:Excess activation of glutamate receptors and production of free radicals including nitric oxide may result in severe and irreversible damage to the mammalian central nervous system (CNS), but endogenous defense systems that protect neurons from these insults are poorly understood. Here, we purified and isolated a neur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kume T,Asai N,Nishikawa H,Mano N,Terauchi T,Taguchi R,Shirakawa H,Osakada F,Mori H,Asakawa N,Yonaga M,Nishizawa Y,Sugimoto H,Shimohama S,Katsuki H,Kaneko S,Akaike A

更新日期：2002-03-05 00:00:00

abstract：:Electron spectroscopic imaging, a new technique that permits the quantitative detection of the spatial distributions of atomic elements at high resolution, has been applied to the epiphyseal zone of hypertrophy in the mouse for the visualization of calcium, phosphorus, and sulfur. Longitudinally sectioned epiphyseal g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arsenault AL,Ottensmeyer FP

更新日期：1983-03-01 00:00:00

abstract：:In vivo expression technology (IVET) has been used to identify > 100 Salmonella typhimurium genes that are specifically expressed during infection of BALB/c mice and/or murine cultured macrophages. Induction of these genes is shown to be required for survival in the animal under conditions of the IVET selection. One c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heithoff DM,Conner CP,Hanna PC,Julio SM,Hentschel U,Mahan MJ

更新日期：1997-02-04 00:00:00

abstract：:Species-specific colors and patterns on animal body surfaces are determined primarily by neural-crest-derived pigment cells in the skin (chromatophores). However, even closely related species display widely differing patterns. These contrasting aspects of chromatophores (i.e., the fixed developmental control within sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fukamachi S,Sugimoto M,Mitani H,Shima A

更新日期：2004-07-20 00:00:00

abstract：:Genetic variation in the serotonin transporter gene (SLC6A4) is associated with vulnerability to affective disorders and pharmacotherapy efficacy. We recently identified sequence polymorphisms in the common marmoset SLC6A4 repeat region (AC/C/G and CT/T/C) associated with individual differences in anxiety-like trait, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Santangelo AM,Sawiak SJ,Fryer T,Hong Y,Shiba Y,Clarke HF,Riss PJ,Ferrari V,Tait R,Suckling J,Aigbirhio FI,Roberts AC

更新日期：2019-07-16 00:00:00

abstract：:We have used X-ray diffraction on the rhombohedral phospholipid phase to reconstruct stalk structures in different pure lipids and lipid mixtures with unprecedented resolution, enabling a quantitative analysis of geometry, as well as curvature and hydration energies. Electron density isosurfaces are used to study shap...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aeffner S,Reusch T,Weinhausen B,Salditt T

更新日期：2012-06-19 00:00:00

abstract：:IFN-gamma treatment of cells leads to tyrosine phosphorylation of signal transducer and activator of transcription (STAT) 1 followed by dimerization through a reciprocal Src homology 2-phosphotyrosine interaction near the -COOH end of each monomer, forming a parallel structure that accumulates in the nucleus to drive ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhong M,Henriksen MA,Takeuchi K,Schaefer O,Liu B,ten Hoeve J,Ren Z,Mao X,Chen X,Shuai K,Darnell JE Jr

更新日期：2005-03-15 00:00:00

abstract：:Maximum likelihood estimators and other direct optimization-based estimators dominated statistical estimation and prediction for decades. Yet, the principled foundations supporting their dominance do not apply to the discrete high-dimensional inference problems of the 21st century. As it is well known, statistical dec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carvalho LE,Lawrence CE

更新日期：2008-03-04 00:00:00