Night-vision brain area in migratory songbirds.

abstract：:Previous studies have shown that Delta-mediated Notch signaling regulates the number of early differentiating neurons. However, the role of Notch activation and Jagged-mediated signaling during late neurogenesis remains poorly defined. In the developing spinal cord of zebrafish, GABAergic Kolmer-Agduhr (KA'') cells an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeo SY,Chitnis AB

更新日期：2007-04-03 00:00:00

abstract：:The DNA in chromatin of isolated thymus nuclei, and in two different preparations of deoxyribonucleoprotein extracted from chromatin, has been digested with DNase. By variation of the time of reaction and the concentration of enzyme, and by comparison of the action of the enzyme on (protein-free) DNA with its action o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mirsky AE

更新日期：1971-12-01 00:00:00

abstract：:Gaseous HCl generated from a variety of sources is ubiquitous in both outdoor and indoor air. Oxides of nitrogen (NO(y)) are also globally distributed, because NO formed in combustion processes is oxidized to NO(2), HNO(3), N(2)O(5) and a variety of other nitrogen oxides during transport. Deposition of HCl and NO(y) o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raff JD,Njegic B,Chang WL,Gordon MS,Dabdub D,Gerber RB,Finlayson-Pitts BJ

更新日期：2009-08-18 00:00:00

abstract：:We have developed a coevolutionary method for the computational design of HIV-1 protease inhibitors selected for their ability to retain efficacy in the face of protease mutation. For HIV-1 protease, typical drug design techniques are shown to be ineffective for the design of resistance-evading inhibitors: An inhibito...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rosin CD,Belew RK,Morris GM,Olson AJ,Goodsell DS

更新日期：1999-02-16 00:00:00

abstract：:The Escherichia coli cytosolic homotetrameric protein SecB is known to be involved in protein export across the plasma membrane. A currently prevalent view holds that SecB functions exclusively as a chaperone interacting nonspecifically with unfolded proteins, not necessarily exported proteins, whereas a contrary view...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watanabe M,Blobel G

更新日期：1995-10-24 00:00:00

abstract：:Control of iron homeostasis is essential for healthy central nervous system function: iron deficiency is associated with cognitive impairment, yet iron overload is thought to promote neurodegenerative diseases. Specific genetic markers have been previously identified that influence levels of transferrin, the protein t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jahanshad N,Kohannim O,Hibar DP,Stein JL,McMahon KL,de Zubicaray GI,Medland SE,Montgomery GW,Whitfield JB,Martin NG,Wright MJ,Toga AW,Thompson PM

更新日期：2012-04-03 00:00:00

abstract：:By the use of a rapid radioautographic screening procedure, two mutants of Bacillus brevis ATCC 8185 that have lost the ability to produce gramicidin have been isolated. These mutants produced normal levels of tyrocidine and sporulated at the same frequency as the parent strain. Their spores, however, were more heat-s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mukherjee PK,Paulus H

更新日期：1977-02-01 00:00:00

abstract：:X-ray studies on human insulins prepared by semisynthetic and biosynthetic methods have recently been undertaken. Human insulin differs from porcine insulin only at the COOH terminus of the B-chain. The present study reports the crystal structure of 4-zinc human insulin, which is used clinically as a slow-acting prepa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith GD,Swenson DC,Dodson EJ,Dodson GG,Reynolds CD

更新日期：1984-11-01 00:00:00

abstract：:Here we describe two mammalian transcription factors selectively expressed in the central nervous system. Both proteins, neuronal PAS domain protein (NPAS) 1 and NPAS2, are members of the basic helix-loop-helix-PAS family of transcription factors. cDNAs encoding mouse and human forms of NPAS1 and NPAS2 have been isola...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou YD,Barnard M,Tian H,Li X,Ring HZ,Francke U,Shelton J,Richardson J,Russell DW,McKnight SL

更新日期：1997-01-21 00:00:00

abstract：:Members of the ras gene family are activated as oncogenes in many different human cancers. To systematically determine the frequency at which such genes might be involved in the neoplastic process affecting a specific target tissue, urothelial cells, we surveyed a large series of urinary tract tumors for ras oncogenes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fujita J,Srivastava SK,Kraus MH,Rhim JS,Tronick SR,Aaronson SA

更新日期：1985-06-01 00:00:00

abstract：:Donor DNA molecules carrying Tn1 or Tn3 deletion mutants do not need to replicate in order to participate in replicon fusion recombination events during which the Tn1/Tn3 element is duplicated. We have assayed Tn1 delta Ap-mediated replicon fusion events involving plasmid R388 and the bacteriophage lambda-derived plas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Muster CJ,Shapiro JA,MacHattie LA

更新日期：1983-04-01 00:00:00

abstract：:Many bacteria use N-acyl homoserine lactone (AHL) signals to coordinate the behavior of individual cells in a local population. The successful infection of eukaryotic hosts by bacteria seems to depend particularly on such AHL-mediated "quorum-sensing" regulation. We have used proteome analysis to show that a eukaryoti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mathesius U,Mulders S,Gao M,Teplitski M,Caetano-Anolles G,Rolfe BG,Bauer WD

更新日期：2003-02-04 00:00:00

abstract：:A mechanism of ion transport across membranes is reported. Microbial transport of Fe(3+) generally delivers iron, a growth-limiting nutrient, to cells via highly specific siderophore-mediated transport systems. In contrast, iron transport in the fresh water bacterium Aeromonas hydrophila is found to occur by means of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stintzi A,Barnes C,Xu J,Raymond KN

更新日期：2000-09-26 00:00:00

abstract：:There is now abundant evidence to substantiate an important role of hepatitis C virus (HCV) core protein in cellular gene expression as well as in the viral cycle. Thus the subcellular localization of this protein has important implications. However, several studies have shown controversial results: the HCV core has b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barba G,Harper F,Harada T,Kohara M,Goulinet S,Matsuura Y,Eder G,Schaff Z,Chapman MJ,Miyamura T,Bréchot C

更新日期：1997-02-18 00:00:00

abstract：:Different experimental structures of the same protein or of proteins with high sequence similarity contain many small variations. Here we construct ensembles of "high-sequence similarity Protein Data Bank" (HSP) structures and consider the extent to which such ensembles represent the structural heterogeneity of the na...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Best RB,Lindorff-Larsen K,DePristo MA,Vendruscolo M

更新日期：2006-07-18 00:00:00

abstract：:The paucity of knowledge about cardiomyocyte maturation is a major bottleneck in cardiac regenerative medicine. In development, cardiomyocyte maturation is characterized by orchestrated structural, transcriptional, and functional specializations that occur mainly at the perinatal stage. Sarcomeres are the key cytoskel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guo Y,Cao Y,Jardin BD,Sethi I,Ma Q,Moghadaszadeh B,Troiano EC,Mazumdar N,Trembley MA,Small EM,Yuan GC,Beggs AH,Pu WT

更新日期：2021-01-12 00:00:00

abstract：:Four polyimidazoles were used in the binding and cleavage studies with poly(U). The two polydisperse polyvinylimidazoles were previously described by others, while the other two new polymers of polyethyleneimines were prepared by cationic polymerization of oxazolines. The latter had imidazole units attached to each ni...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheng L,Abhilash KG,Breslow R

更新日期：2012-08-07 00:00:00

abstract：:The MLL (mixed-lineage leukemia) gene is involved in many chromosomal translocations associated with acute myeloid and lymphoid leukemia. We previously identified a transcriptional repression domain in MLL, which contains a region with homology to DNA methyltransferase. In chromosomal translocations, the MLL repressio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xia ZB,Anderson M,Diaz MO,Zeleznik-Le NJ

更新日期：2003-07-08 00:00:00

abstract：:HIV-1 envelope glycoprotein is the primary target for HIV-1-specific antibodies. The native HIV-1 envelope spike on the virion surface is a trimer, but trimeric gp140 and monomeric gp120 currently are believed to induce comparable immune responses. Indeed, most studies on the immunogenicity of HIV-1 envelope oligomers...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kovacs JM,Nkolola JP,Peng H,Cheung A,Perry J,Miller CA,Seaman MS,Barouch DH,Chen B

更新日期：2012-07-24 00:00:00

abstract：:The effect of cytoplasm upon the expression of tumorigenicity was examined with a pair of mouse and a pair of Chinese hamster cell lines, in intraspecies cybrids formed by reciprocal fusions between either tumorigenic or nontumorigenic cells and cytoplasms derived from them. With the mouse cells, 3T3 and the simian vi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Howell AN,Sager R

更新日期：1978-05-01 00:00:00

abstract：:The self-association of Toll/interleukin-1 receptor/resistance protein (TIR) domains has been implicated in signaling in plant and animal immunity receptors. Structure-based studies identified different TIR-domain dimerization interfaces required for signaling of the plant nucleotide-binding oligomerization domain-lik...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang X,Bernoux M,Bentham AR,Newman TE,Ve T,Casey LW,Raaymakers TM,Hu J,Croll TI,Schreiber KJ,Staskawicz BJ,Anderson PA,Sohn KH,Williams SJ,Dodds PN,Kobe B

更新日期：2017-03-07 00:00:00

abstract：:The DNA sequence of 178 base pairs preceding the first structural gene of the threonine operon of Escherichia coli has been determined. A region of perfect 2-fold rotational symmetry, involving 28 base pairs, precedes the first structural gene. The structural similarity of this sequence to known RNA polymerase termina...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gardner JF

更新日期：1979-04-01 00:00:00

abstract：:Among the tRNA population of the archaeal parasite Nanoarchaeum equitans are five species assembled from separate 5' and 3' tRNA halves and four species derived from tRNA precursors containing introns. In both groups an intervening sequence element must be removed during tRNA maturation. A bulge-helix-bulge (BHB) moti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Randau L,Calvin K,Hall M,Yuan J,Podar M,Li H,Söll D

更新日期：2005-12-13 00:00:00

abstract：:Micrometeorites with diameter approximately 100-200 microm dominate the flux of extraterrestrial matter on Earth. The vast majority of micrometeorites are chemically, mineralogically, and isotopically related to carbonaceous chondrites, which amount to only 2.5% of meteorite falls. Here, we report the discovery of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gounelle M,Chaussidon M,Morbidelli A,Barrat JA,Engrand C,Zolensky ME,McKeegan KD

更新日期：2009-04-28 00:00:00

abstract：:Heat shock locus V (HslV; also called ClpQ) is the proteolytic core of the ATP-dependent protease HslVU in Escherichia coli. It has sequence similarity with the beta-type subunits of the eukaryotic and archaebacterial proteasomes. Unlike these particles, which display 72-point symmetry, it is a dimer of hexamers with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bochtler M,Ditzel L,Groll M,Huber R

更新日期：1997-06-10 00:00:00

abstract：:Excitation of HbCO by a single 6-psec 530-nm pulse results in photodissociation with a first-order constant of 0.89 X 10(11) sec-1. The kinetics of photodissociation, monitored by following absorbance changes in the Soret band at 440 nm, are interpreted as corresponding to predissociation followed by a corssing into a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Noe LJ,Eisert WG,Rentzepis PM

更新日期：1978-02-01 00:00:00

abstract：:The hippocampus and cerebellum are critically involved in trace eyeblink classical conditioning (EBCC). The mechanisms underlying the hippocampal-cerebellar interaction during this task are not well-understood, although hippocampal theta (3-7 Hz) oscillations are known to reflect a favorable state for EBCC. Two groups...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoffmann LC,Berry SD

更新日期：2009-12-15 00:00:00

abstract：:Multiple biological processes involve the stretching of nucleic acids (NAs). Stretching forces induce local changes in the molecule structure, inhibiting or promoting the binding of proteins, which ultimately affects their functionality. Understanding how a force induces changes in the structure of NAs at the atomic l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marin-Gonzalez A,Vilhena JG,Perez R,Moreno-Herrero F

更新日期：2017-07-03 00:00:00

abstract：:Accurately estimating human mobility and gauging its relationship with virus transmission is critical for the control of COVID-19 spreading. Using mobile device location data of over 100 million monthly active samples, we compute origin-destination travel demand and aggregate mobility inflow at each US county from Mar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xiong C,Hu S,Yang M,Luo W,Zhang L

更新日期：2020-11-03 00:00:00

abstract：:Many physical and chemical properties of the light rare-earths and actinides are governed by the active role of f electrons, and despite intensive efforts the details of the mechanisms of phase stability and transformation are not fully understood. A prominent example which has attracted a lot of interest, both experi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krisch M,Farber DL,Xu R,Antonangeli D,Aracne CM,Beraud A,Chiang TC,Zarestky J,Kim DY,Isaev EI,Ahuja R,Johansson B

更新日期：2011-06-07 00:00:00