Temporal-prefrontal cortical network for discrimination of valuable objects in long-term memory.

abstract：:In the nitrogen-fixing symbiosis between legume hosts and rhizobia, the bacteria are engulfed by a plant cell membrane to become intracellular organelles. In the model legume Medicago truncatula, internalization and differentiation of Sinorhizobium (also known as Ensifer) meliloti is a prerequisite for nitrogen fixati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim M,Chen Y,Xi J,Waters C,Chen R,Wang D

更新日期：2015-12-08 00:00:00

abstract：:Laminin, an ∼800-kDa heterotrimeric protein, is a major functional component of the extracellular matrix, contributing to tissue development and maintenance. The unique architecture of laminin is not currently amenable to determination at high resolution, as its flexible and narrow segments complicate both crystalliza...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Armony G,Jacob E,Moran T,Levin Y,Mehlman T,Levy Y,Fass D

更新日期：2016-11-22 00:00:00

abstract：:Senescent cell antigen (SCA), an aging antigen, is a protein that appears on old cells and marks them for removal by the immune system in mammals. It is derived from band 3, a ubiquitous membrane transport protein found in diverse cell types and tissues. We have used synthetic peptides to identify aging antigenic site...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kay MM,Marchalonis JJ,Hughes J,Watanabe K,Schluter SF

更新日期：1990-08-01 00:00:00

abstract：:The size and metabolic rate of cells affect processes from the molecular to the organismal level. We present a quantitative, theoretical framework for studying relationships among cell volume, cellular metabolic rate, body size, and whole-organism metabolic rate that helps reveal the feedback between these levels of o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Savage VM,Allen AP,Brown JH,Gillooly JF,Herman AB,Woodruff WH,West GB

更新日期：2007-03-13 00:00:00

abstract：:The polyomavirus enhancer is composed of multiple DNA sequence elements serving as binding sites for proteins present in mouse nuclear extracts that activate transcription and DNA replication. We have identified three such proteins and their binding sites and correlate them with enhancer function. Mutation of nucleoti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martin ME,Piette J,Yaniv M,Tang WJ,Folk WR

更新日期：1988-08-01 00:00:00

abstract：:S-nitrosation is a posttranslational, oxidative addition of NO to cysteine residues of proteins that has been proposed as a cGMP-independent signaling pathway [Hess DT, Matsumoto A, Kim SO, Marshall HE, Stamler JS (2005) Nat Rev Mol Cell Biol 6:150-166]. A paradox of S-nitrosation is that only a small set of reactive ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitchell DA,Morton SU,Fernhoff NB,Marletta MA

更新日期：2007-07-10 00:00:00

abstract：:Pathologic extraskeletal bone formation, or heterotopic ossification (HO), occurs following mechanical trauma, burns, orthopedic operations, and in patients with hyperactivating mutations of the type I bone morphogenetic protein receptor ACVR1 (Activin type 1 receptor). Extraskeletal bone forms through an endochondral...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Agarwal S,Loder S,Brownley C,Cholok D,Mangiavini L,Li J,Breuler C,Sung HH,Li S,Ranganathan K,Peterson J,Tompkins R,Herndon D,Xiao W,Jumlongras D,Olsen BR,Davis TA,Mishina Y,Schipani E,Levi B

更新日期：2016-01-19 00:00:00

abstract：:Pre-mRNA splicing requires the bridging of the 5' and 3' ends of the intron. In yeast, this bridging involves interactions between the WW domains in the splicing factor PRP40 and a proline-rich domain in the branchpoint binding protein, BBP. Using a proline-rich domain derived from formin (a product of the murine limb...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bedford MT,Reed R,Leder P

更新日期：1998-09-01 00:00:00

abstract：:Group A Streptococcus (GAS) and other bacterial pathogens are known to interact with integrins as an initial step in a complex pathway of bacterial ingestion by host cells. Efficient GAS invasion depends on the interaction of bound fibronectin (Fn) with integrins and activation of integrin signaling. TGF-beta1 regulat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang B,Li S,Southern PJ,Cleary PP

更新日期：2006-02-14 00:00:00

abstract：:Genetic variation in the peptide-binding groove of the highly polymorphic HLA class I molecules has repeatedly been associated with HIV-1 control and progression to AIDS, accounting for up to 12% of the variation in HIV-1 set point viral load (spVL). This suggests a key role in disease control for HLA presentation of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arora J,McLaren PJ,Chaturvedi N,Carrington M,Fellay J,Lenz TL

更新日期：2019-01-15 00:00:00

abstract：:Using currently available gene fusion techniques, we have constructed plasmids that direct the overproduction of the carboxyl-terminal two-thirds of DNA polymerase I, corresponding to the proteolytically derived "Klenow fragment." We have obtained overproduction amounting to several percent of the cellular protein usi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Joyce CM,Grindley ND

更新日期：1983-04-01 00:00:00

abstract：:Thyrotropin-releasing hormone (TRH) binds to specific receptors on GH4C1 pituitary tumor cells. A fluorescently labeled analog of TRH was synthesized by coupling pGlu-His-ProNH(CH2)6NH2 to fluorescein isothiocyanate. The fluorescein-labeled peptide (FL-TRH) stimulated prolactin synthesis and release by GH4C1 cultures ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Halpern J,Hinkle PM

更新日期：1981-01-01 00:00:00

abstract：:Network theory provides a powerful tool for the representation and analysis of complex systems of interacting agents. Here, we investigate the U.S. House of Representatives network of committees and subcommittees, with committees connected according to "interlocks," or common membership. Analysis of this network revea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Porter MA,Mucha PJ,Newman ME,Warmbrand CM

更新日期：2005-05-17 00:00:00

abstract：:Bacteriophage lambda integrates into the chromosome of its Escherichia coli host by means of a site-specific recombination between a locus on the phage chromosome (phage att site) and a locus on the bacterial chromosome (bacterial att site). The nucleotide sequence of four lambda att sites altered in site-specific rec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoess RH,Landy A

更新日期：1978-11-01 00:00:00

abstract：:Recent studies have indicated that mammalian cells contain a cytosolic protein disaggregation machinery comprised of Hsc70, DnaJ homologs, and Hsp110 proteins, the last of which acts to accelerate a rate-limiting step of nucleotide exchange of Hsc70. We tested the ability of transgenic overexpression of a Thy1 promote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nagy M,Fenton WA,Li D,Furtak K,Horwich AL

更新日期：2016-05-10 00:00:00

abstract：:Indirect reciprocity is a mechanism for cooperation based on shared moral systems and individual reputations. It assumes that members of a community routinely observe and assess each other and that they use this information to decide who is good or bad, and who deserves cooperation. When information is transmitted pub...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hilbe C,Schmid L,Tkadlec J,Chatterjee K,Nowak MA

更新日期：2018-11-27 00:00:00

abstract：:The distribution of enkephalin-like immunoreactivity within the avian retina was studied by immunofluorescence and immunoperoxidase techniques with antiserum to [Met5]enkephalin and [Leu5]enkephalin. Formaldehyde-fixed retinae were sectioned and incubated in antiserum to either [Met5]- or [Leu5]enkephalin. Specificity...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brecha N,Karten HJ,Laverack C

更新日期：1979-06-01 00:00:00

abstract：:We have isolated and partially characterized an endonuclease involved in processing the 5' end of 16S rRNA of Escherichia coli. A mutant strain that is deficient in this enzyme accumulates a new precursor of 16S rRNA, named 16.3S rRNA. This rRNA has the 3' end of mature 16S rRNA but is about 60 nucleotides longer at t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dahlberg AE,Dahlberg JE,Lund E,Tokimatsu H,Rabson AB,Calvert PC,Reynolds F,Zahalak M

更新日期：1978-08-01 00:00:00

abstract：:Combinatorial transcription codes generate the myriad of cell types during development and thus likely provide crucial insights into directed differentiation of stem cells to a specific cell type. The LIM complex composed of Isl1 and Lhx3 directs the specification of spinal motor neurons (MNs) in embryos. Here, we rep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee S,Cuvillier JM,Lee B,Shen R,Lee JW,Lee SK

更新日期：2012-02-28 00:00:00

abstract：:Type 2 diabetes is preceded by the development of insulin resistance, in which the action of insulin is impaired, largely in skeletal muscles. Caveolin-3 (Cav3) is a muscle-specific subtype of caveolin, an example of a scaffolding protein found within membranes. Cav is also known as growth signal inhibitor, although i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oshikawa J,Otsu K,Toya Y,Tsunematsu T,Hankins R,Kawabe J,Minamisawa S,Umemura S,Hagiwara Y,Ishikawa Y

更新日期：2004-08-24 00:00:00

abstract：:A calmodulin-neomycin-resistance fusion gene was introduced into Trypanosoma brucei by electroporation, and stably transformed cell lines were obtained. In all of the transformants, the fusion gene had integrated into the host genome at the cognate locus, evidently by homologous recombination within flanking calmoduli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eid J,Sollner-Webb B

更新日期：1991-03-15 00:00:00

abstract：:In the realm of protein-protein interactions, the assembly process of homooligomers plays a fundamental role because the majority of proteins fall into this category. A comprehensive understanding of this multistep process requires the characterization of the driving molecular interactions and the transient intermedia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barducci A,Bonomi M,Prakash MK,Parrinello M

更新日期：2013-12-03 00:00:00

abstract：:Kinesin-73 cDNA was shown to encode a kinesin heavy chain protein that contains an N-terminal motor domain and a long central region that lacks extensive coiled-coils. The amino acid sequence of the motor domain of kinesin-73 protein is most closely related to the motor domains of Caenorhabditis elegans unc-104 and mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li HP,Liu ZM,Nirenberg M

更新日期：1997-02-18 00:00:00

abstract：:Insulin resistance is a key factor in the etiology of type 2 diabetes. Insulin-stimulated glucose uptake is mediated by the glucose transporter 4 (GLUT4), which is expressed mainly in skeletal muscle and adipose tissue. Insulin-stimulated translocation of GLUT4 from its intracellular compartment to the plasma membrane...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baeza-Raja B,Li P,Le Moan N,Sachs BD,Schachtrup C,Davalos D,Vagena E,Bridges D,Kim C,Saltiel AR,Olefsky JM,Akassoglou K

更新日期：2012-04-10 00:00:00

abstract：:The transcription factor zinc-finger protein Miz1 represses TNF-α-induced JNK activation and the repression is relieved upon TNF-α stimulation. However, the underlying mechanism is incompletely understood. Here we report that Miz1 interferes with the ubiquitin conjugating enzyme (E2) Ubc13 for binding to the RING doma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu J,Yan J,Jiang S,Wen J,Chen L,Zhao Y,Lin A

更新日期：2012-01-03 00:00:00

abstract：:Diphtheria toxin ( DTx ) is an extremely potent inhibitor of protein synthesis. It is secreted as a linear polypeptide, which is cleaved to produce disulfide-linked A and B fragments. Fragment A, the inhibitor of protein synthesis, requires fragment B, the recognition subunit, for entry into intact cells. Fragment B h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zalman LS,Wisnieski BJ

更新日期：1984-06-01 00:00:00

abstract：:Normal myeloid precursors and MGI(+)D(+) myeloid leukemic cells can be induced to differentiate to mature cells by the normal protein inducer MGI. The sequence of differentiation is the induction of C3 and Fc rosettes, C3 and Fc immune phagocytosis (IP), synthesis and secretion of lysozyme, and formation of mature mac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lotem J,Sachs L

更新日期：1977-12-01 00:00:00

abstract：:Chronic, low grade, sterile inflammation frequently accompanies aging and age-related diseases. Cellular senescence is associated with the production of proinflammatory chemokines, cytokines, and extracellular matrix (ECM) remodeling proteases, which comprise the senescence-associated secretory phenotype (SASP). We fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu M,Tchkonia T,Ding H,Ogrodnik M,Lubbers ER,Pirtskhalava T,White TA,Johnson KO,Stout MB,Mezera V,Giorgadze N,Jensen MD,LeBrasseur NK,Kirkland JL

更新日期：2015-11-17 00:00:00

abstract：:A cloned complementary DNA sequence has been isolated from a human placental cDNA library in the bacteriophage expression vector lambda gt11 after screening with polyclonal antibodies against human placental aromatase-system cytochrome P-450 (P-450Arom). A single recombinant clone, lambda hAROM1, was characterized by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Evans CT,Ledesma DB,Schulz TZ,Simpson ER,Mendelson CR

更新日期：1986-09-01 00:00:00

abstract：:Glucagon-like peptide 1 (GLP-1) is a hormone derived from the preproglucagon molecule and is secreted by intestinal L cells. It is the most potent stimulator of glucose-induced insulin secretion and also suppresses in vivo acid secretion by gastric glands. A cDNA for the GLP-1 receptor was isolated by transient expres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thorens B

更新日期：1992-09-15 00:00:00