Activation of the polyomavirus enhancer by a murine activator protein 1 (AP1) homolog and two contiguous proteins.

abstract：:Viral shells are self-assembled protein nanocontainers with remarkable material properties. They combine simplicity of construction with toughness and complex functionality. These properties make them interesting for bionanotechnology. To date we know little about how virus structure determines assembly pathways and s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ivanovska IL,Miranda R,Carrascosa JL,Wuite GJ,Schmidt CF

更新日期：2011-08-02 00:00:00

abstract：:Specific Ca2+ binding and Ca2+ activation of ATPase activity in scallop myosin require a regulatory light chain (RLC) from regulated (molluscan or vertebrate smooth) myosin; hybrids containing vertebrate skeletal RLCs do not bind Ca2+ and their ATPase activity is inhibited. Chimeras between scallop and chicken skeleta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jancso A,Szent-Györgyi AG

更新日期：1994-09-13 00:00:00

abstract：:Lod scores provide a method to unify linkage tests based on identity by descent and identity in marker state while permitting selection of the most informative individuals through their disease-related phenotypes and markers in relatives. After parametric lods are reviewed, a nonparametric approach that depends on a s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morton NE

更新日期：1996-04-16 00:00:00

abstract：:Escherichia coli K12 2320(lambda)-15B has a mutation that results in ochre suppressor activity.(1) This mutation concomitantly causes a decreased growth rate in rich medium, an increased sensitivity to streptomycin,(1) and the production of some altered 30S ribosomes which are differentially sensitive to RNase.(2) The...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gartner TK,Orias E,Lannan JE,Beeson J,Reid PJ

更新日期：1969-03-01 00:00:00

abstract：:Redistribution of specialized molecules in migrating cells develops asymmetry between two opposite cell poles, the leading edge and the uropod. We show that acquisition of a motile phenotype in T lymphocytes results in the asymmetric redistribution of ganglioside GM3- and GM1-enriched raft domains to the leading edge ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gómez-Móuton C,Abad JL,Mira E,Lacalle RA,Gallardo E,Jiménez-Baranda S,Illa I,Bernad A,Mañes S,Martínez-A C

更新日期：2001-08-14 00:00:00

abstract：:The heterogeneous RNA of the HeLa cell nucleus contains short internal poly(A) sequences which, in contrast to the longer poly(A) sequences at the 3' ends, are not found in messenger RNA of the cytoplasm. A distinct origin for each of these homologous sequences is evident when the effects of actinomycin D and 3'-deoxy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakazato H,Edmonds M,Kopp DW

更新日期：1974-01-01 00:00:00

abstract：:Chondroitin sulfate proteoglycans (CSPGs) represent a major barrier to regenerating axons in the central nervous system (CNS), but the structural diversity of their polysaccharides has hampered efforts to dissect the structure-activity relationships underlying their physiological activity. By taking advantage of our a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown JM,Xia J,Zhuang B,Cho KS,Rogers CJ,Gama CI,Rawat M,Tully SE,Uetani N,Mason DE,Tremblay ML,Peters EC,Habuchi O,Chen DF,Hsieh-Wilson LC

更新日期：2012-03-27 00:00:00

abstract：:Chromosomal RNA, which is a component of the chromosomes of higher organisms, and whose participation is required for sequence-specific interaction of chromosomal proteins with chromosomal DNA, occurs in chromosomes bound to DNA. We have found that the DNA sequences to which chromosomal RNA binds are repetitive ones. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sivolap YM,Bonner J

更新日期：1971-02-01 00:00:00

abstract：:The receptor for granulocyte-macrophage colony-stimulating factor (GM-CSF) is composed of an alpha and beta subunit, which together form the high-affinity receptor. The alpha subunit by itself binds ligand at low affinity, whereas the isolated beta subunit does not bind GM-CSF. It is generally believed that the high-a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ding DX,Rivas CI,Heaney ML,Raines MA,Vera JC,Golde DW

更新日期：1994-03-29 00:00:00

abstract：:Investigation of retinal neurochemistry in a well-defined chick model of form-deprivation myopia indicated that dopamine and its metabolite 3,4-dihydroxyphenylacetic acid are reduced in myopic as compared to control eyes. The reduction in retinal dopamine is evident only during light adaptation and is accompanied by a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stone RA,Lin T,Laties AM,Iuvone PM

更新日期：1989-01-01 00:00:00

abstract：:The organization and allelic recombination of the merozoite surface protein-1 gene of Plasmodium vivax (PvMsp-1), the most widely prevalent human malaria parasite, were evaluated in complete nucleotide sequences of 40 isolates from various geographic areas. Alignment of 31 distinct alleles revealed the mosaic organiza...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Putaporntip C,Jongwutiwes S,Sakihama N,Ferreira MU,Kho WG,Kaneko A,Kanbara H,Hattori T,Tanabe K

更新日期：2002-12-10 00:00:00

abstract：:We carried out a large-scale screen to identify interactions between integral membrane proteins of Saccharomyces cerevisiae by using a modified split-ubiquitin technique. Among 705 proteins annotated as integral membrane, we identified 1,985 putative interactions involving 536 proteins. To ascribe confidence levels to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller JP,Lo RS,Ben-Hur A,Desmarais C,Stagljar I,Noble WS,Fields S

更新日期：2005-08-23 00:00:00

abstract：:Colonization of land by plants was a major transition on Earth, but the developmental and genetic innovations required for this transition remain unknown. Physiological studies and the fossil record strongly suggest that the ability of the first land plants to form symbiotic associations with beneficial fungi was one ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Delaux PM,Radhakrishnan GV,Jayaraman D,Cheema J,Malbreil M,Volkening JD,Sekimoto H,Nishiyama T,Melkonian M,Pokorny L,Rothfels CJ,Sederoff HW,Stevenson DW,Surek B,Zhang Y,Sussman MR,Dunand C,Morris RJ,Roux C,Wong GK

更新日期：2015-10-27 00:00:00

abstract：:A 16-base-pair palindrome from the Agrobacterium tumefaciens octopine synthase gene functions as a constitutive enhancer in plant protoplasts. Degenerate oligonucleotide mutagenesis provided single base substitutions at every position in the element and a number of multiple base substitutions. The effects of these cha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Singh K,Tokuhisa JG,Dennis ES,Peacock WJ

更新日期：1989-05-01 00:00:00

abstract：:Cytokines such as interleukin 4 (IL-4) play a key role in the regulation of immune responses, but little is known about how their multiple activities are regulated in vivo. In this report, we demonstrated that an IL-4-binding protein (IL-4BP) is constitutively present in the biological fluids of mice (serum, ascites, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fernandez-Botran R,Vitetta ES

更新日期：1990-06-01 00:00:00

abstract：:It is unknown whether cross-regulatory interactions between homeotic genes, which have been shown to play an important role in the maintenance of their expression domains during Drosophila development, are also important during mammalian development. We have analyzed here the expression of Hox genes in Hoxa-1 (Hox-1.6...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dollé P,Lufkin T,Krumlauf R,Mark M,Duboule D,Chambon P

更新日期：1993-08-15 00:00:00

abstract：:The Esx secretion pathway is conserved across Gram-positive bacteria. Esx-1, the best-characterized system, is required for virulence of Mycobacterium tuberculosis, although its precise function during infection remains unclear. Esx-3, a paralogous system present in all mycobacterial species, is required for growth in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Siegrist MS,Unnikrishnan M,McConnell MJ,Borowsky M,Cheng TY,Siddiqi N,Fortune SM,Moody DB,Rubin EJ

更新日期：2009-11-03 00:00:00

abstract：:Spontaneous reciprocal mitotic recombination in the yeast Saccharomyces cerevisiae, associated with heteroallelic recombination, occurs almost exclusively at the two-strand stage and involves recombination of unduplicated chromosomes (i.e., during G1) or the unduplicated regions of chromosomes during the S phase of mi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Esposito MS

更新日期：1978-09-01 00:00:00

abstract：:The use of proteasome inhibitors to target cancer's dependence on altered protein homeostasis has been greatly limited by intrinsic and acquired resistance. Analyzing data from thousands of cancer lines and tumors, we find that those with suppressed expression of one or more 19S proteasome subunits show intrinsic prot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsvetkov P,Sokol E,Jin D,Brune Z,Thiru P,Ghandi M,Garraway LA,Gupta PB,Santagata S,Whitesell L,Lindquist S

更新日期：2017-01-10 00:00:00

abstract：:Superantigens such as the staphylococcal enterotoxins can play an important role in exacerbation of autoimmune disorders such as experimental allergic encephalomyelitis (EAE) in mice. In fact, superantigens can reactivate EAE in PL/J mice that have been sensitized to rat myelin basic protein (MBP). The T-cell subset p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Soos JM,Hobeika AC,Butfiloski EJ,Schiffenbauer J,Johnson HM

更新日期：1995-06-20 00:00:00

abstract：:We demonstrate that the BC200 RNA gene, which encodes a neural small cytoplasmic RNA, is a member of the most prodigious family of interspersed repetitive DNA and that its product represents an example of a primate tissue-specific RNA polymerase III transcript. The BC200 RNA gene is an early monomeric member and one o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martignetti JA,Brosius J

更新日期：1993-12-15 00:00:00

abstract：:L-2-hydroxyglutarate (L-2HG) has emerged as a putative oncometabolite that is capable of inhibiting enzymes involved in metabolism, chromatin modification, and cell differentiation. However, despite the ability of L-2HG to interfere with a broad range of cellular processes, this molecule is often characterized as a me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li H,Chawla G,Hurlburt AJ,Sterrett MC,Zaslaver O,Cox J,Karty JA,Rosebrock AP,Caudy AA,Tennessen JM

更新日期：2017-02-07 00:00:00

abstract：:The fdhF gene encoding the 80-kDa selenopolypeptide subunit of formate dehydrogenase H from Escherichia coli contains an in-frame TGA codon at amino acid position 140, which encodes selenocysteine. We have analyzed how this UGA "sense codon" is discriminated from a UGA codon signaling polypeptide chain termination. De...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zinoni F,Heider J,Böck A

更新日期：1990-06-01 00:00:00

abstract：:The MYC family of cellular oncogenes includes c-Myc, N-myc, and L-myc, which encode transcriptional regulators involved in the control of cell proliferation and death. Accordingly, these genes become aberrantly activated and expressed in specific types of cancers. For example, c-Myc translocations occur frequently in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gostissa M,Ranganath S,Bianco JM,Alt FW

更新日期：2009-02-17 00:00:00

abstract：:We performed label-free observation of molecular dynamics in apoptotic cells by Raman microscopy. Dynamic changes in cytochrome c distribution at the Raman band of 750 cm(-1) were observed after adding an apoptosis inducer to the cells. The comparison of mitochondria fluorescence images and Raman images of cytochrome ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okada M,Smith NI,Palonpon AF,Endo H,Kawata S,Sodeoka M,Fujita K

更新日期：2012-01-03 00:00:00

abstract：:Mitochondrial function and ambulatory activity were monitored after feeding old rats acetyl-L-carnitine (ALCAR). Young (3-5 mo) and old (22-28 mo) rats were given a 1.5% (wt/vol) solution of ALCAR in their drinking water for 1 mo, were sacrificed, and their liver parenchymal cells were isolated. ALCAR supplementation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hagen TM,Ingersoll RT,Wehr CM,Lykkesfeldt J,Vinarsky V,Bartholomew JC,Song MH,Ames BN

更新日期：1998-08-04 00:00:00

abstract：:Climate change is increasing fire activity in the western United States, which has the potential to accelerate climate-induced shifts in vegetation communities. Wildfire can catalyze vegetation change by killing adult trees that could otherwise persist in climate conditions no longer suitable for seedling establishmen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davis KT,Dobrowski SZ,Higuera PE,Holden ZA,Veblen TT,Rother MT,Parks SA,Sala A,Maneta MP

更新日期：2019-03-26 00:00:00

abstract：:Although tumor necrosis factor (TNF) initially came to prominence because of its anti-tumor activity, most attention is now focused on its proinflammatory actions. TNF appears to play a critical role in both early and late events involved in inflammation, from localizing the noxious agent and amplifying the cellular a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marino MW,Dunn A,Grail D,Inglese M,Noguchi Y,Richards E,Jungbluth A,Wada H,Moore M,Williamson B,Basu S,Old LJ

更新日期：1997-07-22 00:00:00

abstract：:The introduction of foreign genes into early mouse embryos and embryonic stem (ES) cells is invaluable for the analysis of gene function and regulation in the living animal. The use of vectors derived from retroviruses as gene transfer vehicles in this setting has had limited success because of silencing of transgene ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pfeifer A,Ikawa M,Dayn Y,Verma IM

更新日期：2002-02-19 00:00:00

abstract：:The c-myc protooncogene has been implicated in control of growth and differentiation of mammalian cells. For instance, growth arrest is often preceded by reduction in c-myc mRNA and gene transcription. To elucidate the mechanisms of control of c-myc gene transcription, we have begun to characterize the interaction of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duyao MP,Buckler AJ,Sonenshein GE

更新日期：1990-06-01 00:00:00