Discrete fracture patterns of virus shells reveal mechanical building blocks.

abstract：:This distance between a base next to the anticodon of tRNA and the 3' CpCpA terminus of the molecule has been estimated by singlet-singlet energy transfer experiments. The energy donor was the Y base of unknown structure found in yeast tRNA(phe). Three different energy acceptors were used: acriflavine, proflavinyl ace...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beardsley K,Cantor CR

更新日期：1970-01-01 00:00:00

abstract：:The Arabidopsis thaliana AtHKT1 protein, a Na(+)/K(+) transporter, is capable of mediating inward Na(+) currents in Xenopus laevis oocytes and K(+) uptake in Escherichia coli. HKT1 proteins are members of a superfamily of K(+) transporters. These proteins have been proposed to contain eight transmembrane segments and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kato Y,Sakaguchi M,Mori Y,Saito K,Nakamura T,Bakker EP,Sato Y,Goshima S,Uozumi N

更新日期：2001-05-22 00:00:00

abstract：:The protooncogene src encodes two proteins, designated pp60c-src+ and pp60c-src.pp60c-src+ is expressed only in neurons, whereas pp60c-src is expressed in neuronal and nonneuronal cells. pp60c-src+ differs from pp60c-src in that it contains an insert of 6 amino acids. To study the evolutionary conservation of the 6-am...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang XM,Martinez R,Le Beau J,Wiestler O,Walter G

更新日期：1989-06-01 00:00:00

abstract：:High-affinity nuclear binding sites for 17 beta-estradiol (17 beta E2) were recently found in bone cells; however, the mechanism by which estrogen exerts its effect on bone in vivo is still unknown. To study if estrogen acts on bone directly, we used an experimental model in which test substances are infused locally i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takano-Yamamoto T,Rodan GA

更新日期：1990-03-01 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is a genetic disorder caused by loss of the protein dystrophin. In humans, DMD has early onset, causes developmental delays, muscle necrosis, loss of ambulation, and death. Current animal models have been challenged by their inability to model the early onset and severity of the disea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hughes KJ,Rodriguez A,Flatt KM,Ray S,Schuler A,Rodemoyer B,Veerappan V,Cuciarone K,Kullman A,Lim C,Gutta N,Vemuri S,Andriulis V,Niswonger D,Barickman L,Stein W,Singhvi A,Schroeder NE,Vidal-Gadea AG

更新日期：2019-02-26 00:00:00

abstract：:Vertebrates can modulate the sound levels entering their inner ears in the face of intense external sound or during their own vocalizations. Middle ear muscle contractions restrain the motion of the middle ear ossicles, attenuating the transmission of low-frequency sound and thereby protecting the hair cells in the in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gridi-Papp M,Feng AS,Shen JX,Yu ZL,Rosowski JJ,Narins PM

更新日期：2008-08-05 00:00:00

abstract：:Neurodegenerative diseases and noxious stimuli to the brain enhance transcription of serum- and glucocorticoid-induced kinase-1 (SGK1). Here, we report that the SGK1 gene encodes a brain-specific additional isoform, SGK1.1, which exhibits distinct regulation, properties, and functional effects. SGK1.1 decreases expres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arteaga MF,Coric T,Straub C,Canessa CM

更新日期：2008-03-18 00:00:00

abstract：:Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors are an established treatment in estrogen receptor-positive breast cancer and are currently in clinical development in melanoma, a tumor that exhibits high rates of CDK4 activation. We analyzed melanoma cells with acquired resistance to the CDK4/6 inhibitor palbociclib an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： AbuHammad S,Cullinane C,Martin C,Bacolas Z,Ward T,Chen H,Slater A,Ardley K,Kirby L,Chan KT,Brajanovski N,Smith LK,Rao AD,Lelliott EJ,Kleinschmidt M,Vergara IA,Papenfuss AT,Lau P,Ghosh P,Haupt S,Haupt Y,Sanij E,

更新日期：2019-09-03 00:00:00

abstract：:We have isolated CaKRE9, a gene from Candida albicans, that is a functional homologue of the Saccharomyces cerevisiae KRE9 gene involved in beta-1,6-glucan synthesis. Disruption of the CaKRE9 gene in C. albicans shows that CaKre9p is required for the synthesis or assembly of this fungal polymer. Homozygous null disrup...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lussier M,Sdicu AM,Shahinian S,Bussey H

更新日期：1998-08-18 00:00:00

abstract：:Sequence-specific gene silencing by short hairpin (sh) RNAs has recently emerged as an indispensable tool for understanding gene function and a promising avenue for drug discovery. However, a wider biomedical use of this approach is hindered by the lack of straightforward methods for achieving uniform expression of sh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khandelia P,Yap K,Makeyev EV

更新日期：2011-08-02 00:00:00

abstract：:(3)H-actinomycin D, a guanine-binding agent, labels fixed human chromosomes nonrandomly. Actinomycin D added in G2 inhibits secondary constrictions and breaks chromosomes. There is some tendency for label to be concentrated at the ends of chromosomes and near the centromere. Labeling with (3)H-thymidine in the late st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miles CP

更新日期：1970-03-01 00:00:00

abstract：:Phytohormones have essential roles in coordinately regulating a large array of developmental processes. Studies have revealed that brassinosteroids (BRs) and abscisic acid (ABA) interact to regulate hundreds of expression in genes, governing many biological processes. However, whether their interaction is through modi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang S,Cai Z,Wang X

更新日期：2009-03-17 00:00:00

abstract：:There exists a properly embedded minimal surface of genus one with a single end asymptotic to the end of the helicoid. This genus-one helicoid is constructed as the limit of a continuous one-parameter family of screw-motion invariant minimal surfaces, also asymptotic to the helicoid, that have genus equal to one in th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weber M,Hoffman D,Wolf M

更新日期：2005-11-15 00:00:00

abstract：:Transient expression of either alpha or alpha + beta subunits of the high-conductance Ca2+-activated K+ (maxi-K) channel has been achieved in COS-1 cells. Expression has been studied using charybdotoxin (ChTX), a peptidyl inhibitor that binds in the pore on the alpha subunit. Although some properties of monoiodotyrosi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hanner M,Schmalhofer WA,Munujos P,Knaus HG,Kaczorowski GJ,Garcia ML

更新日期：1997-04-01 00:00:00

abstract：:Drosophila heteroneura and D. silvestris are sympatric species living on the island of Hawaii, while D. planitibia is allopatric on the nearby island of Maui. A pronounced ethological isolation is found between the sympatric species, and none between allopatric ones, except that D. planitibia females discriminate agai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ahearn JN,Carson HL,Dobzhansky T,Kaneshiro KY

更新日期：1974-03-01 00:00:00

abstract：:Soluble epoxide hydrolase (sEH) is an emerging therapeutic target in a number of diseases that have inflammation as a common underlying cause. sEH limits tissue levels of cytochrome P450 (CYP) epoxides derived from omega-6 and omega-3 polyunsaturated fatty acids (PUFA) by converting these antiinflammatory mediators in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： López-Vicario C,Alcaraz-Quiles J,García-Alonso V,Rius B,Hwang SH,Titos E,Lopategi A,Hammock BD,Arroyo V,Clària J

更新日期：2015-01-13 00:00:00

abstract：:Mild oxidation of human serum low-density lipoprotein (LDL) converts the apoprotein from a nearly homogeneous component of high apparent molecular weight to a mixture of apparently lower molecular weight polypeptide components, as characterized by sodium dodecyl sulfate/polyacrylamide gel electrophoresis. This protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schuh J,Fairclough GF Jr,Haschemeyer RH

更新日期：1978-07-01 00:00:00

abstract：:Regulation of the turnover of triglycerides in adipose tissue requires the continuous provision of 3-glycerophosphate, which may be supplied by the metabolism of glucose or by glyceroneogenesis, the de novo synthesis of 3-glycerophosphate from sources other than hexoses or glycerol. The importance of glyceroneogenesis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olswang Y,Cohen H,Papo O,Cassuto H,Croniger CM,Hakimi P,Tilghman SM,Hanson RW,Reshef L

更新日期：2002-01-22 00:00:00

abstract：:Fourier transform infrared (FTIR) spectroscopy provides a unique molecular fingerprint of tissue from endogenous sources of light absorption; however, specific molecular components of the overall FTIR signature of precancer have not been characterized. In attenuated total reflectance mode, infrared light penetrates on...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang TD,Triadafilopoulos G,Crawford JM,Dixon LR,Bhandari T,Sahbaie P,Friedland S,Soetikno R,Contag CH

更新日期：2007-10-02 00:00:00

abstract：:The chemosmotic model provides a framework for visualizing energy-coupled reactions (vectorial reaction sequences, membrane-dependent gradient formation, and charge separation of reacting species) and a mechanism for energy coupling (indirect coupling between the driving and driven reaction sequences mediated by a mem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Green DE

更新日期：1981-04-01 00:00:00

abstract：:The hereditary hearing-vision loss disease Usher syndrome (USH) is caused by defects in several proteins, most of which form an integrated protein network called Usher interactome. Harmonin/Ush1C is a master scaffold in the assembly of the Usher protein complexes, because harmonin is known to bind to every protein in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pan L,Yan J,Wu L,Zhang M

更新日期：2009-04-07 00:00:00

abstract：:Murine hematopoietic blast colony-forming cells (BL-CFCs) are able to generate up to 30,000 progeny blast cells within 10 d in agar cultures. Contained in these populations are large numbers of lineage-committed progenitor cells in the granulocytic and macrophage lineages. Sequential analyses of blast colonies reveale...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Metcalf D,Ng A,Mifsud S,Di Rago L

更新日期：2010-09-14 00:00:00

abstract：:Fermions need to satisfy the Pauli exclusion principle: no two can be in the same state. This restriction is most compactly expressed in a second quantization formalism by the requirement that the creation and annihilation operators of the electrons satisfy anticommutation relations. The usual classical limit of quant...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levine RD

更新日期：2000-02-29 00:00:00

abstract：:We have shown that 3-nitropropionate, an isoelectronic analogue of succinate, is a suicide inactivator of succinate dehydrogenase [succinate:(acceptor) oxidoreductase, EC 1.3.99.1] as follows. (i) When rat liver mitochondria oxidize succinate in the presence of 3-nitropropionate carbanion, the rate of O(2) consumption...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alston TA,Mela L,Bright HJ

更新日期：1977-09-01 00:00:00

abstract：:A common genetic mutation found in clear cell renal cell carcinoma (CC-RCC) is the loss of the von Hippel-Lindau (VHL) gene, which results in stabilization of hypoxia-inducible factors (HIFs), and contributes to cancer progression and metastasis. CUB-domain-containing protein 1 (CDCP1) was shown to promote metastasis ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Razorenova OV,Finger EC,Colavitti R,Chernikova SB,Boiko AD,Chan CK,Krieg A,Bedogni B,LaGory E,Weissman IL,Broome-Powell M,Giaccia AJ

更新日期：2011-02-01 00:00:00

abstract：:A metabolite of estradiol, 2-methoxyestradiol (2ME), inhibits angiogenesis in the chicken embryo chorioallantoic membrane assay. Since 2ME causes mitotic perturbations, we examined its interactions with tubulin. In our standard 1.0 M glutamate system (plus 1.0 mM MgCl2 at 37 degrees C), superstoichiometric concentrati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： D'Amato RJ,Lin CM,Flynn E,Folkman J,Hamel E

更新日期：1994-04-26 00:00:00

abstract：:Class I major histocompatibility complex (MHC) antigens are confronted with an apparently insurmountable dilemma. Each should show a binding preference to a common enough variety of nonapeptides, so that one relevant nonapeptide can be found in at least every other viral protein to provoke a cytotoxic T-cell response....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohno S

更新日期：1992-05-15 00:00:00

abstract：:The mitochondrial genome of the S-type male-sterile cytoplasm of maize contains two linear episomes, S1 (6397 base pairs) and S2 (5453 base pairs). The S2 episome contains two large unidentified open reading frames, URF1 (3512 base pairs) and URF2 (1017 base pairs). We have demonstrated that a polypeptide with an appa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zabala G,O'brien-Vedder C,Walbot V

更新日期：1987-11-01 00:00:00

abstract：:Morphogenesis often yields organs with robust size and shapes, whereas cell growth and deformation feature significant spatiotemporal variability. Here, we investigate whether tissue responses to mechanical signals contribute to resolve this apparent paradox. We built a model of growing tissue made of fiber-like mater...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fruleux A,Boudaoud A

更新日期：2019-02-05 00:00:00

abstract：:The assembly of actin monomers into filaments and networks plays vital roles throughout eukaryotic biology, including intracellular transport, cell motility, cell division, determining cellular shape, and providing cells with mechanical strength. The regulation of actin assembly and modulation of filament mechanical p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kang H,Bradley MJ,McCullough BR,Pierre A,Grintsevich EE,Reisler E,De La Cruz EM

更新日期：2012-10-16 00:00:00