Abstract:
:We have isolated CaKRE9, a gene from Candida albicans, that is a functional homologue of the Saccharomyces cerevisiae KRE9 gene involved in beta-1,6-glucan synthesis. Disruption of the CaKRE9 gene in C. albicans shows that CaKre9p is required for the synthesis or assembly of this fungal polymer. Homozygous null disruptants of CaKRE9 grow poorly on galactose and fail to form hyphae in serum, and, in growth medium containing glucose, the gene is essential. Thus, the CaKRE9 gene product is a potentially useful candidate as a target for fungal-specific drugs.
journal_name
Proc Natl Acad Sci U S Aauthors
Lussier M,Sdicu AM,Shahinian S,Bussey Hdoi
10.1073/pnas.95.17.9825subject
Has Abstractpub_date
1998-08-18 00:00:00pages
9825-30issue
17eissn
0027-8424issn
1091-6490journal_volume
95pub_type
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