当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > Protein kinase LKB1 regulates polarized dendrite formation of adult hippocampal newborn neurons.

Protein kinase LKB1 regulates polarized dendrite formation of adult hippocampal newborn neurons.

Abstract：

:Adult-born granule cells in the dentate gyrus of the rodent hippocampus are important for memory formation and mood regulation, but the cellular mechanism underlying their polarized development, a process critical for their incorporation into functional circuits, remains unknown. We found that deletion of the serine-threonine protein kinase LKB1 or overexpression of dominant-negative LKB1 reduced the polarized initiation of the primary dendrite from the soma and disrupted its oriented growth toward the molecular layer. This abnormality correlated with the dispersion of Golgi apparatus that normally accumulated at the base and within the initial segment of the primary dendrite, and was mimicked by disrupting Golgi organization via altering the expression of Golgi structural proteins GM130 or GRASP65. Thus, besides its known function in axon formation in embryonic pyramidal neurons, LKB1 plays an additional role in regulating polarized dendrite morphogenesis in adult-born granule cells in the hippocampus.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Huang W,She L,Chang XY,Yang RR,Wang L,Ji HB,Jiao JW,Poo MM

doi

10.1073/pnas.1321454111

subject

Has Abstract

pub_date

2014-01-07 00:00:00

pages

469-74

issue

1

eissn

0027-8424

issn

1091-6490

pii

1321454111

journal_volume

111

pub_type

杂志文章

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