Adiponectin is critical in determining susceptibility to depressive behaviors and has antidepressant-like activity.

abstract：:Acquisition of acetylcholine receptors during differentiation of a clonal myoblast cell line was monitored with a neurotoxin isolated from venom of the Indian Cobra Naja naja. Toxin bound specifically and reversibly to acetylcholine receptors of the differentiated cells. Specificity of the binding reaction was assayed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patrick J,Heinemann SF,Lindstrom J,Schubert D,Steinbach JH

更新日期：1972-10-01 00:00:00

abstract：:Motion detection is typically spared in blindsight, which results from damage to the striate cortex (area V1) of the brain that is sufficient to eliminate conscious visual awareness and severely reduce sensitivity to luminance contrast, especially for high spatial and low temporal frequencies. Here we show that the di...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Azzopardi P,Hock HS

更新日期：2011-01-11 00:00:00

abstract：:Zinc is an essential micronutrient for all living organisms. When facing a shortage in zinc supply, plants adapt by enhancing the zinc uptake capacity. The molecular regulators controlling this adaptation are not known. We present the identification of two closely related members of the Arabidopsis thaliana basic-regi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Assunção AG,Herrero E,Lin YF,Huettel B,Talukdar S,Smaczniak C,Immink RG,van Eldik M,Fiers M,Schat H,Aarts MG

更新日期：2010-06-01 00:00:00

abstract：:A fundamental, yet underexplored, materials system is the interface between biological molecules and inorganic surfaces. In an elemental approach to this problem, we have systematically examined the adhesion of amino acids to a series of inorganic surfaces including metals, insulators, and semiconductors. Significant ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Willett RL,Baldwin KW,West KW,Pfeiffer LN

更新日期：2005-05-31 00:00:00

abstract：:The DC and DX subregions of the human major histocompatibility complex (MHC) have been cloned from a cosmid library made from a human B-cell line, Priess. The DC subregion, 48 kilobases, includes the DC alpha and DC beta genes. A second DC-like region, the DX subregion, 35 kilobases, contains the DX alpha gene and a n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okada K,Boss JM,Prentice H,Spies T,Mengler R,Auffray C,Lillie J,Grossberger D,Strominger JL

更新日期：1985-05-01 00:00:00

abstract：:The ability to be synchronized by light-dark cycles is a fundamental property of circadian clocks. Although there are indications that circadian clocks are extremely light-sensitive and that they can be set by the low irradiances that occur at dawn and dusk, this has not been shown on the cellular level. Here, we demo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bachleitner W,Kempinger L,Wülbeck C,Rieger D,Helfrich-Förster C

更新日期：2007-02-27 00:00:00

abstract：:Water dynamics in concentrated ionic solutions plays an important role in a number of material and energy conversion processes such as the charge transfer at the electrolyte-electrode interface in aqueous rechargeable ion batteries. One long-standing puzzle is that all electrolytes, regardless of their "structure-maki...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Q,Wu T,Chen C,Mukamel S,Zhuang W

更新日期：2017-09-19 00:00:00

abstract：:Rapamycin is an immunosuppressive immunophilin ligand reported as having neurotrophic activity. We show that modification of rapamycin at the mammalian target of rapamycin (mTOR) binding region yields immunophilin ligands, WYE-592 and ILS-920, with potent neurotrophic activities in cortical neuronal cultures, efficacy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruan B,Pong K,Jow F,Bowlby M,Crozier RA,Liu D,Liang S,Chen Y,Mercado ML,Feng X,Bennett F,von Schack D,McDonald L,Zaleska MM,Wood A,Reinhart PH,Magolda RL,Skotnicki J,Pangalos MN,Koehn FE,Carter GT,Abou-Gharbia M

更新日期：2008-01-08 00:00:00

abstract：:Light chain allotypic determinants were demonstrated on the surface of peripheral blood lymphocytes of rabbits. By means of a combined immunofluorescent and autoradiographic technique, a great majority of the individual lymphocytes of rabbits heteroxygous at the b locus were shown to have detectable quantities of only...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davie JM,Paul WE,Mage RG,Goldman MB

更新日期：1971-02-01 00:00:00

abstract：:Oligothiophenes incorporating MM quadruple bonds have been prepared from the reactions between Mo(2)(TiPB)(4) (TiPB = 2,4,6-triisopropyl benzoate) and 3',4'-dihexyl-2,2'-:5',2''-terthiophene-5,5''-dicarboxylic acid. The oligomers of empirical formula Mo(2)(TiPB)(2)(O(2)C(Th)-C(4)(n-hexyl)(2)S-(Th)CO(2)) are soluble in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burdzinski GT,Chisholm MH,Chou PT,Chou YH,Feil F,Gallucci JC,Ghosh Y,Gustafson TL,Ho ML,Liu Y,Ramnauth R,Turro C

更新日期：2008-10-07 00:00:00

abstract：:Murine embryonal carcinoma (EC) cells are refractory to infection by retroviruses because retroviral long terminal repeat (LTR) enhancers have little activity in EC cells. A previous report described the isolation of clonal EC cell lines that express the integrated neomycin-resistance gene (neo) linked to the Moloney ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taketo M,Tanaka M

更新日期：1987-06-01 00:00:00

abstract：:The x-ray sensitive hamster cell line xrs-6 is deficient in DNA double-strand break (DSB) repair and exhibits impaired V(D)J recombination. The molecular defect in this line is in the 80-kDa subunit of the Ku autoantigen, a protein that binds to DNA ends and recruits the DNA-dependent protein kinase to DNA. Using an I...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liang F,Romanienko PJ,Weaver DT,Jeggo PA,Jasin M

更新日期：1996-08-20 00:00:00

abstract：:We are designing simple peptide ion channels as model systems for the study of the physical principles controlling conduction through ion-channel proteins. Here we report on an uncharged peptide, Ac-(Leu-Ser-Ser-Leu-Leu-Ser-Leu)3-CONH2, designed to form an aggregate of parallel, amphiphilic, membrane-spanning alpha-he...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kienker PK,DeGrado WF,Lear JD

更新日期：1994-05-24 00:00:00

abstract：:Cocaine exposure in utero causes severe alterations in the development of the central nervous system. To study the basis of these teratogenic effects in vitro, we have used cocultures of neurons and glial cells from mouse embryonic brain. Cocaine selectively affected embryonic neuronal cells, causing first a dramatic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nassogne MC,Evrard P,Courtoy PJ

更新日期：1995-11-21 00:00:00

abstract：:Intracellular transport is based on molecular motors that pull cargos along cytoskeletal filaments. One motor species always moves in one direction, e.g., conventional kinesin moves to the microtubule plus end, whereas cytoplasmic dynein moves to the microtubule minus end. However, many cellular cargoes are observed t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Müller MJ,Klumpp S,Lipowsky R

更新日期：2008-03-25 00:00:00

abstract：:Evidence is given for the existence of an electron transport pathway to oxygen in the thylakoid membranes of chloroplasts (chlororespiration). Plastoquinone is shown to be a redox carrier common to both photosynthetic and chlororespiratory pathways. It is shown that, in dark-adapted chloroplasts, an electrochemical gr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bennoun P

更新日期：1982-07-01 00:00:00

abstract：:Maternal infections during pregnancy are associated with increased risk of neurodevelopmental disorders, although the precise mechanisms remain to be elucidated. Previously, we established a maternal immune activation (MIA) model using swine, which results in altered social behaviors of piglet offspring. These behavio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Antonson AM,Lawson MA,Caputo MP,Matt SM,Leyshon BJ,Johnson RW

更新日期：2019-10-01 00:00:00

abstract：:Heterotrimeric G proteins function as molecular relays that mediate signal transduction from heptahelical receptors in the cell membrane to intracellular effector proteins. Crystallographic studies have demonstrated that guanine nucleotide exchange on the Galpha subunit causes specific conformational changes in three ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oldham WM,Van Eps N,Preininger AM,Hubbell WL,Hamm HE

更新日期：2007-05-08 00:00:00

abstract：:Protein delivery to restricted plasma membrane domains is exquisitely regulated at different stages of the cell trafficking machinery. Traffic control involves the recognition of export/retention/retrieval signals in the endoplasmic reticulum (ER)/Golgi complex that will determine protein fate. A splice variant (SV), ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zarei MM,Eghbali M,Alioua A,Song M,Knaus HG,Stefani E,Toro L

更新日期：2004-07-06 00:00:00

abstract：:Separation of cells is a critical process for studying cell properties, disease diagnostics, and therapeutics. Cell sorting by acoustic waves offers a means to separate cells on the basis of their size and physical properties in a label-free, contactless, and biocompatible manner. The separation sensitivity and effici...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ding X,Peng Z,Lin SC,Geri M,Li S,Li P,Chen Y,Dao M,Suresh S,Huang TJ

更新日期：2014-09-09 00:00:00

abstract：:A fundamental question in the study of human language acquisition centers around apportioning explanatory force between the experience of the learner and the core knowledge that allows learners to represent that experience. We provide a previously unidentified kind of data identifying children's contribution to langua...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Han CH,Musolino J,Lidz J

更新日期：2016-01-26 00:00:00

abstract：:Cancer patients and tumor-bearing mice possess serum antibodies that recognize antigens expressed by cancer cells at the time of diagnosis. After diagnosis, cancers progress to more aggressive stages, most often by acquiring new genetic changes that can give rise to new proteins, some of which are antigenic. However, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spiotto MT,Reth MA,Schreiber H

更新日期：2003-04-29 00:00:00

abstract：:Phosphatidylcholine (PC) is the major glycerophospholipid in eukaryotic cells and is an essential component in all cellular membranes. The biochemistry of de novo PC synthesis by the Kennedy pathway is well established, but less is known about the physiological functions of PC. We identified two unrelated patients wit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Payne F,Lim K,Girousse A,Brown RJ,Kory N,Robbins A,Xue Y,Sleigh A,Cochran E,Adams C,Dev Borman A,Russel-Jones D,Gorden P,Semple RK,Saudek V,O'Rahilly S,Walther TC,Barroso I,Savage DB

更新日期：2014-06-17 00:00:00

abstract：:Imprinted gene expression associated with Prader-Willi syndrome (PWS) and Angelman syndrome (AS) is controlled by two imprinting centers (ICs), the PWS-IC and the AS-IC. The PWS-IC operates in cis to activate transcription of genes that are expressed exclusively from the paternal allele. We have created a conditional ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DuBose AJ,Smith EY,Johnstone KA,Resnick JL

更新日期：2012-02-28 00:00:00

abstract：:Inherited colorectal cancer syndromes in humans exhibit regional specificity for tumor formation. By using mice with germline mutations in the adenomatous polyposis coli gene (Apc) and/or DNA mismatch repair genes, we have analyzed the genetic control of tumor regionality in the mouse small intestine. In C57BL/6 mice ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haigis KM,Hoff PD,White A,Shoemaker AR,Halberg RB,Dove WF

更新日期：2004-06-29 00:00:00

abstract：:We have long known that language is lateralized to the left hemisphere (LH) in most neurologically healthy adults. In contrast, findings on lateralization of function during development are more complex. As in adults, anatomical, electrophysiological, and neuroimaging studies in infants and children indicate LH latera...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olulade OA,Seydell-Greenwald A,Chambers CE,Turkeltaub PE,Dromerick AW,Berl MM,Gaillard WD,Newport EL

更新日期：2020-09-22 00:00:00

abstract：:Mutations in the dystrophin gene cause Duchenne muscular dystrophy (DMD) most commonly through loss of protein expression. In a small subpopulation of patients, missense mutations can cause DMD, Becker muscular dystrophy, or X-linked cardiomyopathy. Nearly one-half of disease-causing missense mutations are located in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Henderson DM,Lee A,Ervasti JM

更新日期：2010-05-25 00:00:00

abstract：:There is great interest in understanding the mechanisms of expression underlying long-term potentiation (LTP). They are agreed to involve an increase in synaptic efficacy, which is described by three multiplicative parameters: p, the probability of neurotransmitter release; n, the number of active release sites; and q...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schulz PE

更新日期：1997-05-27 00:00:00

abstract：:Protein tyrosine phosphorylation and dephosphorylation are key regulatory events in T-cell receptor (TCR) signaling. We investigated the role of the tyrosine phosphatase SHPTP1 in TCR signaling by analysis of TCR signal transduction in motheaten (me/me) mice, which lack SHPTP1 expression. As revealed by flow cytometri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lorenz U,Ravichandran KS,Burakoff SJ,Neel BG

更新日期：1996-09-03 00:00:00

abstract：:This paper describes the state of the art in applications of voice-processing technologies. In the first part, technologies concerning the implementation of speech recognition and synthesis algorithms are described. Hardware technologies such as microprocessors and DSPs (digital signal processors) are discussed. Softw...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakatsu R,Suzuki Y

更新日期：1995-10-24 00:00:00