The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I.

abstract：:Phytohormones have essential roles in coordinately regulating a large array of developmental processes. Studies have revealed that brassinosteroids (BRs) and abscisic acid (ABA) interact to regulate hundreds of expression in genes, governing many biological processes. However, whether their interaction is through modi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang S,Cai Z,Wang X

更新日期：2009-03-17 00:00:00

abstract：:Factors that elevate amyloid-beta (Abeta) peptide levels are associated with an increased risk for Alzheimer's disease. Insulysin has been identified as one of several proteases potentially involved in Abeta degradation based on its hydrolysis of Abeta peptides in vitro. In this study, in vivo levels of brain Abeta40 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller BC,Eckman EA,Sambamurti K,Dobbs N,Chow KM,Eckman CB,Hersh LB,Thiele DL

更新日期：2003-05-13 00:00:00

abstract：:Metallic nanoscale structures are capable of supporting surface plasmon polaritons (SPPs), propagating collective electron oscillations with tight spatial confinement at the metal surface. SPPs represent one of the most promising structures to beat the diffraction limit imposed by conventional dielectric optics. Ag na...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan R,Pausauskie P,Huang J,Yang P

更新日期：2009-12-15 00:00:00

abstract：:A climate/vegetation model simulates episodic wetter and drier periods at the 21,000-y precession period in eastern North Africa, the Arabian Peninsula, and the Levant over the past 140,000 y. Large orbitally forced wet/dry extremes occur during interglacial time, ∼130 to 80 ka, and conditions between these two extrem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kutzbach JE,Guan J,He F,Cohen AS,Orland IJ,Chen G

更新日期：2020-02-04 00:00:00

abstract：:An association of the dopamine receptor D4 (DRD4) gene located on chromosome 11p15.5 and attention deficit/hyperactivity disorder (ADHD) has been demonstrated and replicated by multiple investigators. A specific allele [the 7-repeat of a 48-bp variable number of tandem repeats (VNTR) in exon 3] has been proposed as an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Swanson J,Oosterlaan J,Murias M,Schuck S,Flodman P,Spence MA,Wasdell M,Ding Y,Chi HC,Smith M,Mann M,Carlson C,Kennedy JL,Sergeant JA,Leung P,Zhang YP,Sadeh A,Chen C,Whalen CK,Babb KA,Moyzis R,Posner MI

更新日期：2000-04-25 00:00:00

abstract：:Despite being engineered to avoid renal clearance, many cationic polymer (polycation)-based siRNA nanoparticles that are used for systemic delivery are rapidly eliminated from the circulation. Here, we show that a component of the renal filtration barrier--the glomerular basement membrane (GBM)--can disassemble cation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zuckerman JE,Choi CH,Han H,Davis ME

更新日期：2012-02-21 00:00:00

abstract：:Bacteriophage lambda encodes a number of genes involved in the recombinational repair of DNA double-strand breaks. The product of one of these genes, rap, has been purified. Truncated Rap proteins that copurify with the full-length form are derived, at least in part, from a rho-dependent transcription terminator locat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharples GJ,Corbett LM,Graham IR

更新日期：1998-11-10 00:00:00

abstract：:Relative cerebral glucose metabolism was examined with positron-emission tomography (PET) as a measure of neuronal activation during performance of the classically conditioned eyeblink response in 12 young adult subjects. Each subject received three sessions: (i) a control session with PET scan in which unpaired prese...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Logan CG,Grafton ST

更新日期：1995-08-01 00:00:00

abstract：:We tested a theoretical prediction that patterns of excitatory input activity that consistently fail to activate target neurons sufficiently to induce synaptic potentiation will instead cause a specific synaptic depression. To realize this situation experimentally, the Schaffer collateral projection to area CA1 in rat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dudek SM,Bear MF

更新日期：1992-05-15 00:00:00

abstract：:In this paper we report a time-course study of development of experimental allergic encephalomyelitis in Lewis rats, by monitoring neuroendocrine regulation of the hypothalamus-pituitary-adrenal axis through corticotropin-releasing hormone mRNA expression, inflammatory cellular infiltrate, macrophagic and neuronal nit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Calzà L,Giardino L,Pozza M,Micera A,Aloe L

更新日期：1997-04-01 00:00:00

abstract：:In response to environmental stresses, the mammalian serine threonine kinases PERK, GCN2, HRI, and PKR phosphorylate the regulatory serine 51 of the eukaryotic translation initiation factor 2α (eIF2α) to inhibit global protein synthesis. Plasmodium, the protozoan that causes malaria, expresses three eIF2α kinases: IK1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang M,Mishra S,Sakthivel R,Rojas M,Ranjan R,Sullivan WJ Jr,Fontoura BM,Ménard R,Dever TE,Nussenzweig V

更新日期：2012-03-06 00:00:00

abstract：:G protein-coupled receptors (GPCRs) are seven-transmembrane proteins that transmit diverse extracellular signals across a membrane. Herpesvirus genomes encode multiple GPCRs implicated in viral pathogenesis. Kaposi sarcoma-associated herpesvirus GPCR (kGPCR) activates proliferative pathways and, when expressed in endo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,Lu X,Zhu L,Shen Y,Chengedza S,Feng H,Wang L,Jung JU,Gutkind JS,Feng P

更新日期：2013-07-02 00:00:00

abstract：:Despite an important role in vascular development and repair, the origin of endothelial progenitors remains unknown. Accumulating evidence indicates that cells derived from the hematopoietic system participate in angiogenesis. However, the identity and functional role of these cells remain controversial. Here we show ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bailey AS,Willenbring H,Jiang S,Anderson DA,Schroeder DA,Wong MH,Grompe M,Fleming WH

更新日期：2006-08-29 00:00:00

abstract：:Intrinsically disordered proteins (IDPs) are characterized by a lack of defined structure. Instead, they populate ensembles of rapidly interconverting conformations with marginal structural stabilities. Changes in solution conditions such as temperature and crowding agents consequently affect IDPs more than their fold...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wicky BIM,Shammas SL,Clarke J

更新日期：2017-09-12 00:00:00

abstract：:Cisplatin is a chemotherapeutic drug used to treat a variety of cancers. Both intrinsic and acquired resistance to cisplatin, as well as toxicity, limit its effectiveness. Molecular mechanisms that underlie cisplatin resistance are poorly understood. Here we demonstrate that deletion of the yeast CTR1 gene, which enco...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishida S,Lee J,Thiele DJ,Herskowitz I

更新日期：2002-10-29 00:00:00

abstract：:An 125I-labeled synthetic analog of bovine parathyroid hormone, [8-norleucine,18-norleucine,34-tyrosine]PTH-(1-34) amide ([Nle]PTH-(1-34)-NH2), purified by high-pressure liquid chromatography (HPLC), was employed to label the parathyroid hormone (PTH) receptor in cell lines derived from PTH target tissues: the ROS 17/...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wright BS,Tyler GA,O'Brien R,Caporale LH,Rosenblatt M

更新日期：1987-01-01 00:00:00

abstract：:Sterigmatocystin (ST), a potent hepatocarcinogen, was covalently bound to calf thymus DNA by incubation in the presence of phenobarbital-induced rat liver microsomes. Acid hydrolysis of ST-modified DNA liberated a major guanine-containing adduct, present in DNA at an estimated level of 1 ST residue per 100-150 nucleot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Essigmann JM,Barker LJ,Fowler KW,Francisco MA,Reinhold VN,Wogan GN

更新日期：1979-01-01 00:00:00

abstract：:This paper identifies all statistically significant dyad symmetry combinations in the Epstein-Barr virus genome. The distribution of long dyad symmetry pairings emphasizes two regions, the 5' third of the 3.1-kilobase-pair (kbp) repeat and the oriP region, the latter essential for Epstein-Barr virus replication during...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karlin S

更新日期：1986-09-01 00:00:00

abstract：:The discipline-wide effort to database the fossil record at the occurrence level has made it possible to estimate marine invertebrate extinction and origination rates with much greater accuracy. The new data show that two biotic mechanisms have hastened recoveries from mass extinctions and confined diversity to a rela...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alroy J

更新日期：2008-08-12 00:00:00

abstract：:The Cdc28 protein kinase functions in the G1 to S phase transition of the cell cycle of the budding yeast Saccharomyces cerevisiae. This is in contrast with observations of the homologous protein kinase from a variety of metazoans, where activity and function are associated with the G2 to M phase transition. We presen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reed SI,Wittenberg C

更新日期：1990-08-01 00:00:00

abstract：:During cytokinesis, a cleavage furrow generated by actomyosin ring contraction is restructured into the midbody, a platform for the assembly of the abscission machinery that controls the final separation of daughter cells. The polymerization state of F-actin is important during assembly, ingression, disassembly, and c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Terry SJ,Donà F,Osenberg P,Carlton JG,Eggert US

更新日期：2018-02-27 00:00:00

abstract：:Gene-environment interactions are important determinants of cancer risk. Traditionally, gene-environment interactions are thought to contribute to tumor-suppressor-gene penetrance by facilitating or inhibiting the acquisition of additional somatic mutations required for tumorigenesis. Here, we demonstrate that a disti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cook JD,Davis BJ,Cai SL,Barrett JC,Conti CJ,Walker CL

更新日期：2005-06-14 00:00:00

abstract：:Children whose parents divorce tend to have worse educational outcomes than children whose parents stay married. However, not all children respond identically to their parents divorcing. We focus on how the impact of parental divorce on children's education varies by how likely or unlikely divorce was for those parent...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brand JE,Moore R,Song X,Xie Y

更新日期：2019-04-09 00:00:00

abstract：:The history of the genus Pan is a topic of enduring interest. Chimpanzees (Pan troglodytes) are often divided into subspecies, but the population structure and genetic history of chimpanzees across Africa remain unclear. Some population genetics studies have led to speculation that, until recently, this species consti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gonder MK,Locatelli S,Ghobrial L,Mitchell MW,Kujawski JT,Lankester FJ,Stewart CB,Tishkoff SA

更新日期：2011-03-22 00:00:00

abstract：:Genomic clones and cDNA plasmids were isolated for the intermediate filament protein vimentin from chicken. The identity of the various clones was determined both by mRNA selection [Paterson, B. M. & Roberts, B. E. (1981) in Gene Amplification and Analysis, Structural Analysis or Nucleic Acids, eds. Chirikjian, J. G. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zehner ZE,Paterson BM

更新日期：1983-02-01 00:00:00

abstract：:Reactive oxygen species (ROS) mediate abscisic acid (ABA) signaling in guard cells. To dissect guard cell ABA-ROS signaling genetically, a cell type-specific functional genomics approach was used to identify 2 MAPK genes, MPK9 and MPK12, which are preferentially and highly expressed in guard cells. To provide genetic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jammes F,Song C,Shin D,Munemasa S,Takeda K,Gu D,Cho D,Lee S,Giordo R,Sritubtim S,Leonhardt N,Ellis BE,Murata Y,Kwak JM

更新日期：2009-12-01 00:00:00

abstract：:Two mutations are described that alter the pattern of inheritance of chloroplast genes in Chlamydomonas. The mutant gene mat-1 linked to the mating type allele mt(-) greatly increases the frequency of exceptional zygotes, i.e., zygotes that transmit chloroplast genes from the mt(-) (male) parent. In some crosses, 80-9...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sager R,Ramanis Z

更新日期：1974-12-01 00:00:00

abstract：:Ecological interactions shape adaptations through coevolution not only between pairs of species but also through entire multispecies assemblages. Local coevolution can then be further altered through spatial processes that have been formally partitioned in the geographic mosaic theory of coevolution. A major current c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Medeiros LP,Garcia G,Thompson JN,Guimarães PR Jr

更新日期：2018-11-20 00:00:00

abstract：:Many groups of insects are specialists in exploiting sensory cues to locate food resources or conspecifics. To achieve orientation, bees and ants analyze the polarization pattern of the sky, male moths orient along the females' odor plume, and cicadas, grasshoppers, and crickets use acoustic signals to locate singing ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poulet JF,Hedwig B

更新日期：2005-10-25 00:00:00

abstract：:Circulating exosomal microRNA (miR) represents a new class of blood-based biomarkers for cancer liquid biopsy. The detection of miR at a very low concentration and with single-base discrimination without the need for sophisticated equipment, large volumes, or elaborate sample processing is a challenge. To address this...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Canady TD,Li N,Smith LD,Lu Y,Kohli M,Smith AM,Cunningham BT

更新日期：2019-09-24 00:00:00