African climate response to orbital and glacial forcing in 140,000-y simulation with implications for early modern human environments.

Abstract:

:A climate/vegetation model simulates episodic wetter and drier periods at the 21,000-y precession period in eastern North Africa, the Arabian Peninsula, and the Levant over the past 140,000 y. Large orbitally forced wet/dry extremes occur during interglacial time, ∼130 to 80 ka, and conditions between these two extremes prevail during glacial time, ∼70 to 15 ka. Orbital precession causes high seasonality in Northern Hemisphere (NH) insolation at ∼125, 105, and 83 ka, with stronger and northward extended summer monsoon rains in North Africa and the Arabian Peninsula and increased winter rains in the Mediterranean Basin. The combined effects of these two seasonally distinct rainfall regimes increase vegetation and narrow the width of the Saharan-Arabian desert and semidesert zones. During the opposite phase of the precession cycle (∼115, 95, and 73 ka), NH seasonality is low, and decreased summer insolation and increased winter insolation cause monsoon and storm track rains to decrease and the width of the desert zone to increase. During glacial time (∼70 to 15 ka), forcing from large ice sheets and lowered greenhouse gas concentrations combine to increase winter Mediterranean storm track precipitation; the southward retreat of the northern limit of summer monsoon rains is relatively small, thereby limiting the expansion of deserts. The lowered greenhouse gas concentrations cause the near-equatorial zone to cool and reduce convection, causing drier climate with reduced forest cover. At most locations and times, the simulations agree with environmental observations. These changing regional patterns of climate/vegetation could have influenced the dispersal of early humans through expansions and contractions of well-watered corridors.

authors

Kutzbach JE,Guan J,He F,Cohen AS,Orland IJ,Chen G

doi

10.1073/pnas.1917673117

subject

Has Abstract

pub_date

2020-02-04 00:00:00

pages

2255-2264

issue

5

eissn

0027-8424

issn

1091-6490

pii

1917673117

journal_volume

117

pub_type

杂志文章
  • Chlorine activation indoors and outdoors via surface-mediated reactions of nitrogen oxides with hydrogen chloride.

    abstract::Gaseous HCl generated from a variety of sources is ubiquitous in both outdoor and indoor air. Oxides of nitrogen (NO(y)) are also globally distributed, because NO formed in combustion processes is oxidized to NO(2), HNO(3), N(2)O(5) and a variety of other nitrogen oxides during transport. Deposition of HCl and NO(y) o...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0904195106

    authors: Raff JD,Njegic B,Chang WL,Gordon MS,Dabdub D,Gerber RB,Finlayson-Pitts BJ

    更新日期:2009-08-18 00:00:00

  • Monarch butterflies (Danaus plexippus L.) use a magnetic compass for navigation.

    abstract::Fall migratory monarch butterflies, tested for their directional responses to magnetic cues under three conditions, amagnetic, normal, and reversed magnetic fields, showed three distinct patterns. In the absence of a magnetic field, monarchs lacked directionality as a group. In the normal magnetic field, monarchs orie...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章,收录出版

    doi:10.1073/pnas.96.24.13845

    authors: Etheredge JA,Perez SM,Taylor OR,Jander R

    更新日期:1999-11-23 00:00:00

  • Src tyrosine kinase phosphorylation of nuclear receptor HNF4α correlates with isoform-specific loss of HNF4α in human colon cancer.

    abstract::Src tyrosine kinase has long been implicated in colon cancer but much remains to be learned about its substrates. The nuclear receptor hepatocyte nuclear factor 4α (HNF4α) has just recently been implicated in colon cancer but its role is poorly defined. Here we show that c-Src phosphorylates human HNF4α on three tyros...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1106799109

    authors: Chellappa K,Jankova L,Schnabl JM,Pan S,Brelivet Y,Fung CL,Chan C,Dent OF,Clarke SJ,Robertson GR,Sladek FM

    更新日期:2012-02-14 00:00:00

  • Quantum chaos on a critical Fermi surface.

    abstract::We compute parameters characterizing many-body quantum chaos for a critical Fermi surface without quasiparticle excitations. We examine a theory of [Formula: see text] species of fermions at nonzero density coupled to a [Formula: see text] gauge field in two spatial dimensions and determine the Lyapunov rate and the b...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1618185114

    authors: Patel AA,Sachdev S

    更新日期:2017-02-21 00:00:00

  • Detection and localization of virus-specific DNA by in situ hybridization of cells during infection and rapid transformation by the murine sarcoma-leukemia virus.

    abstract::Cytological preparations of interphase nuclei and chromosomes from mouse 3T6 cells prepared at various times after infection with the murine sarcomaleukemia virus complex were hybridized with the [(3)H]DNA product of the viral RNA-directed DNA polymerase. While uninfected nuclei had an average of 4 autoradiographic gr...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.71.9.3418

    authors: Loni MC,Green M

    更新日期:1974-09-01 00:00:00

  • Trait changes in a harvested population are driven by a dynamic tug-of-war between natural and harvest selection.

    abstract::Selective harvest of large individuals should alter natural adaptive landscapes and drive evolution toward reduced somatic growth and increased reproductive investment. However, few studies have simultaneously considered the relative importance of artificial and natural selection in driving trait changes in wild popul...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0705908104

    authors: Edeline E,Carlson SM,Stige LC,Winfield IJ,Fletcher JM,James JB,Haugen TO,Vøllestad LA,Stenseth NC

    更新日期:2007-10-02 00:00:00

  • Message passing on networks with loops.

    abstract::Message passing is a fundamental technique for performing calculations on networks and graphs with applications in physics, computer science, statistics, and machine learning, including Bayesian inference, spin models, satisfiability, graph partitioning, network epidemiology, and the calculation of matrix eigenvalues....

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1914893116

    authors: Cantwell GT,Newman MEJ

    更新日期:2019-11-19 00:00:00

  • Membrane domains and flagellar pocket boundaries are influenced by the cytoskeleton in African trypanosomes.

    abstract::A key feature of immune evasion for African trypanosomes is the functional specialization of their surface membrane in an invagination known as the flagellar pocket (FP), the cell's sole site of endocytosis and exocytosis. The FP membrane is biochemically distinct yet continuous with those of the cell body and the fla...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0909289106

    authors: Gadelha C,Rothery S,Morphew M,McIntosh JR,Severs NJ,Gull K

    更新日期:2009-10-13 00:00:00

  • Higher-Order Curvature and Local Solvability of D(theta).

    abstract::Let E and F be vector bundles and D:E --> F an operator of order k. We associate a sequence of invariants ((l))(D), l >/= 0 with D which generalize the concept of curvature in a natural way. In the case where D = D(theta) is the differential operator of a connection theta on a vector bundle E, ((1))(D(theta)) is the c...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.70.3.797

    authors: Knapp RE

    更新日期:1973-03-01 00:00:00

  • Lagging adaptation to warming climate in Arabidopsis thaliana.

    abstract::If climate change outpaces the rate of adaptive evolution within a site, populations previously well adapted to local conditions may decline or disappear, and banked seeds from those populations will be unsuitable for restoring them. However, if such adaptational lag has occurred, immigrants from historically warmer c...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1406314111

    authors: Wilczek AM,Cooper MD,Korves TM,Schmitt J

    更新日期:2014-06-03 00:00:00

  • Life cycle air quality impacts of conventional and alternative light-duty transportation in the United States.

    abstract::Commonly considered strategies for reducing the environmental impact of light-duty transportation include using alternative fuels and improving vehicle fuel economy. We evaluate the air quality-related human health impacts of 10 such options, including the use of liquid biofuels, diesel, and compressed natural gas (CN...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1406853111

    authors: Tessum CW,Hill JD,Marshall JD

    更新日期:2014-12-30 00:00:00

  • Diurnal down-regulation of ethylene biosynthesis mediates biomass heterosis.

    abstract::Heterosis is widely applied in agriculture; however, the underlying molecular mechanisms for superior performance are not well understood. Ethylene biosynthesis and signaling genes are shown to be down-regulated in Arabidopsis interspecific hybrids. Ethylene is a plant hormone that promotes fruit ripening and maturati...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1722068115

    authors: Song Q,Ando A,Xu D,Fang L,Zhang T,Huq E,Qiao H,Deng XW,Chen ZJ

    更新日期:2018-05-22 00:00:00

  • Prospects for fungus identification using CO1 DNA barcodes, with Penicillium as a test case.

    abstract::DNA barcoding systems employ a short, standardized gene region to identify species. A 648-bp segment of mitochondrial cytochrome c oxidase 1 (CO1) is the core barcode region for animals, but its utility has not been tested in fungi. This study began with an examination of patterns of sequence divergences in this gene ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0611691104

    authors: Seifert KA,Samson RA,Dewaard JR,Houbraken J,Lévesque CA,Moncalvo JM,Louis-Seize G,Hebert PD

    更新日期:2007-03-06 00:00:00

  • Histone H4 Lys 20 monomethylation by histone methylase SET8 mediates Wnt target gene activation.

    abstract::Histone methylation has an important role in transcriptional regulation. However, unlike H3K4 and H3K9 methylation, the role of H4K20 monomethylation (H4K20me-1) in transcriptional regulation remains unclear. Here, we show that Wnt3a specifically stimulates H4K20 monomethylation at the T cell factor (TCF)-binding elem...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1009353108

    authors: Li Z,Nie F,Wang S,Li L

    更新日期:2011-02-22 00:00:00

  • Programmable motion of DNA origami mechanisms.

    abstract::DNA origami enables the precise fabrication of nanoscale geometries. We demonstrate an approach to engineer complex and reversible motion of nanoscale DNA origami machine elements. We first design, fabricate, and characterize the mechanical behavior of flexible DNA origami rotational and linear joints that integrate s...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1408869112

    authors: Marras AE,Zhou L,Su HJ,Castro CE

    更新日期:2015-01-20 00:00:00

  • Kinetic analysis of a complete poxvirus transcriptome reveals an immediate-early class of genes.

    abstract::Vaccinia virus is the prototypic orthopoxvirus and was the vaccine used to eradicate smallpox, yet the expression profiles of many of its genes remain unknown. Using a genome tiling array approach, we simultaneously measured the expression levels of all 223 annotated vaccinia virus genes during infection and determine...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0711573105

    authors: Assarsson E,Greenbaum JA,Sundström M,Schaffer L,Hammond JA,Pasquetto V,Oseroff C,Hendrickson RC,Lefkowitz EJ,Tscharke DC,Sidney J,Grey HM,Head SR,Peters B,Sette A

    更新日期:2008-02-12 00:00:00

  • A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated.

    abstract::The beta 2-adrenergic receptor (beta 2AR) can be constitutively activated by mutations in the third intracellular loop. Whereas the wild-type receptor exists predominantly in an inactive conformation (R) in the absence of agonist, the mutant receptor appears to spontaneously adopt an active conformation (R*). We now d...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.91.7.2699

    authors: Pei G,Samama P,Lohse M,Wang M,Codina J,Lefkowitz RJ

    更新日期:1994-03-29 00:00:00

  • Complex genetic interactions underlying expression differences between Drosophila races: analysis of chromosome substitutions.

    abstract::Regulation of gene expression is usually separated into cis and trans components. The separation may become artificial if much of the variation in expression is under multigenic and epistatic (e.g., cis-by-trans) control. There is hence a need to quantify the relative contribution of cis, trans, and cis-by-trans effec...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0711774105

    authors: Wang HY,Fu Y,McPeek MS,Lu X,Nuzhdin S,Xu A,Lu J,Wu ML,Wu CI

    更新日期:2008-04-29 00:00:00

  • Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury.

    abstract::Traumatic brain injury (TBI) causes neuronal apoptosis, inflammation, and reactive astrogliosis, which contribute to secondary tissue loss, impaired regeneration, and associated functional disabilities. Here, we show that up-regulation of cell cycle components is associated with caspase-mediated neuronal apoptosis and...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0500989102

    authors: Di Giovanni S,Movsesyan V,Ahmed F,Cernak I,Schinelli S,Stoica B,Faden AI

    更新日期:2005-06-07 00:00:00

  • Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells.

    abstract::The thymus provides multiple microenvironments that are essential for the development and repertoire selection of T lymphocytes. The thymic cortex induces the generation and positive selection of T lymphocytes, whereas the thymic medulla establishes self-tolerance among the positively selected T lymphocytes. Cortical ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1301799110

    authors: Ohigashi I,Zuklys S,Sakata M,Mayer CE,Zhanybekova S,Murata S,Tanaka K,Holländer GA,Takahama Y

    更新日期:2013-06-11 00:00:00

  • Genetic requirements for mycobacterial survival during infection.

    abstract::Despite the importance of tuberculosis as a public health problem, we know relatively little about the molecular mechanisms used by the causative organism, Mycobacterium tuberculosis, to persist in the host. To define these mechanisms, we have mutated virtually every nonessential gene of M. tuberculosis and determined...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2134250100

    authors: Sassetti CM,Rubin EJ

    更新日期:2003-10-28 00:00:00

  • Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice.

    abstract::Defining prospective pathways by which zoonoses evolve and emerge as human pathogens is critical for anticipating and controlling both natural and deliberate pandemics. However, predicting tenable pathways of animal-to-human movement has been hindered by challenges in identifying reservoir species, cultivating zoonoti...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0808116105

    authors: Becker MM,Graham RL,Donaldson EF,Rockx B,Sims AC,Sheahan T,Pickles RJ,Corti D,Johnston RE,Baric RS,Denison MR

    更新日期:2008-12-16 00:00:00

  • Chiral plasmons without magnetic field.

    abstract::Plasmons, the collective oscillations of interacting electrons, possess emergent properties that dramatically alter the optical response of metals. We predict the existence of a new class of plasmons-chiral Berry plasmons (CBPs)-for a wide range of 2D metallic systems including gapped Dirac materials. As we show, in t...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1519086113

    authors: Song JC,Rudner MS

    更新日期:2016-04-26 00:00:00

  • Conserved behavioral circuits govern high-speed decision-making in wild fish shoals.

    abstract::To evade their predators, animals must quickly detect potential threats, gauge risk, and mount a response. Putative neural circuits responsible for these tasks have been isolated in laboratory studies. However, it is unclear whether and how these circuits combine to generate the flexible, dynamic sequences of evasion ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1809140115

    authors: Hein AM,Gil MA,Twomey CR,Couzin ID,Levin SA

    更新日期:2018-11-27 00:00:00

  • Repression by hematin of porphyrin biosynthesis in erythrocyte precursors in congenital erythropoietic porphyria.

    abstract::Hematin administered intravenously in a patient with congenital erythropoietic porphyria evidently entered erythrocyte precursors in the bone marrow, producing the well-known negative feedback repression of porphyrin biosynthesis with marked decline of porphyrin concentrations in urine, circulating plasma, and erythro...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.71.2.278

    authors: Watson CJ,Bossenmaier I,Cardinal R,Petryka ZJ

    更新日期:1974-02-01 00:00:00

  • An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.

    abstract::Four macrocyclic cystine-knot peptides of 29-31 residues, kalata, circulin A and B (CirA and CirB), and cyclopsychotride, have been isolated from coffee plants but have undetermined physiological functions. These macrocycles and 10 of their analogs prepared by chemical synthesis were tested against nine strains of mic...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.96.16.8913

    authors: Tam JP,Lu YA,Yang JL,Chiu KW

    更新日期:1999-08-03 00:00:00

  • IL-15 in tumor microenvironment causes rejection of large established tumors by T cells in a noncognate T cell receptor-dependent manner.

    abstract::A major challenge of cancer immunotherapy is the persistence and outgrowth of subpopulations that lose expression of the target antigen. IL-15 is a potent cytokine that can promote organ-specific autoimmunity when up-regulated on tissue cells. Here we report that T cells eradicated 2-wk-old solid tumors that expressed...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1301022110

    authors: Liu RB,Engels B,Schreiber K,Ciszewski C,Schietinger A,Schreiber H,Jabri B

    更新日期:2013-05-14 00:00:00

  • The anti-tetanus immune response of neonatal mice is augmented by retinoic acid combined with polyriboinosinic:polyribocytidylic acid.

    abstract::Neonates are highly susceptible to infectious diseases and, in general, respond poorly to conventional vaccines due to immaturity of the immune system. In the present study, we hypothesized that the anti-tetanus toxoid (TT) vaccine response of neonatal mice could be enhanced by retinoic acid (RA), a bioactive retinoid...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0506438102

    authors: Ma Y,Ross AC

    更新日期:2005-09-20 00:00:00

  • Inhibitor of intramembrane protease RseP blocks the σE response causing lethal accumulation of unfolded outer membrane proteins.

    abstract::The outer membrane (OM) of Gram-negative bacteria forms a robust permeability barrier that blocks entry of toxins and antibiotics. Most OM proteins (OMPs) assume a β-barrel fold, and some form aqueous channels for nutrient uptake and efflux of intracellular toxins. The Bam machine catalyzes rapid folding and assembly ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1806107115

    authors: Konovalova A,Grabowicz M,Balibar CJ,Malinverni JC,Painter RE,Riley D,Mann PA,Wang H,Garlisi CG,Sherborne B,Rigel NW,Ricci DP,Black TA,Roemer T,Silhavy TJ,Walker SS

    更新日期:2018-07-10 00:00:00

  • Competition for mates and the improvement of nonsexual fitness.

    abstract::Competition for mates can be a major source of selection, not just on secondary sexual traits but across the genome. Mate competition strengthens selection on males via sexual selection, which typically favors healthy, vigorous individuals and, thus, all genetic variants that increase overall quality. However, recent ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1805435115

    authors: Yun L,Chen PJ,Kwok KE,Angell CS,Rundle HD,Agrawal AF

    更新日期:2018-06-26 00:00:00