Diurnal down-regulation of ethylene biosynthesis mediates biomass heterosis.

abstract：:An acid extract of pedal ganglia of the mollusc Mytilus edulis was fractionated by high-pressure liquid chromatography with a reverse-phase column. Peak fractions with retention times of those of [Met]- and [Leu]enkephalin were subjected to binding assays in both invertebrate and vertebrate tissues. The results showed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leung MK,Stefano GB

更新日期：1984-02-01 00:00:00

abstract：:We have made direct, quantitative measurements of the lateral motion and age-dependent distribution of acetylcholine receptors (AChR) on the surface of rat myotubes in primary culture. AChR were fluorescently marked with tetramethylrhodamine-labeled alpha-bungarotoxin and AChR lateral motion was measured by the fluore...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Axelrod D,Ravdin P,Koppel DE,Schlessinger J,Webb WW,Elson EL,Podleski TR

更新日期：1976-12-01 00:00:00

abstract：:Recent epidemics demonstrate the global threat of Zika virus (ZIKV), a flavivirus transmitted by mosquitoes. Although infection is usually asymptomatic or mild, newborns of infected mothers can display severe symptoms, including neurodevelopmental abnormalities and microcephaly. Given the large-scale spread, symptom s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Esswein SR,Gristick HB,Jurado A,Peace A,Keeffe JR,Lee YE,Voll AV,Saeed M,Nussenzweig MC,Rice CM,Robbiani DF,MacDonald MR,Bjorkman PJ

更新日期：2020-05-05 00:00:00

abstract：:The Arabidopsis thaliana disease resistance genes RPS2 and RPM1 belong to a class of plant disease resistance genes that encode proteins that contain an N-terminal tripartite nucleotide binding site (NBS) and a C-terminal tandem array of leucine-rich repeats. RPS2 and RPM1 confer resistance to strains of the bacterial...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leister RT,Ausubel FM,Katagiri F

更新日期：1996-12-24 00:00:00

abstract：:The present paper summarizes future needs in information and tools, technology, infrastructure, training, funding, and bioinformatics, to provide the genomic knowledge and tools for breeding and biotechnological goals in maize. The National Corn Genome Initiative (NCGA) has developed through actions taken by the Natio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coe EH

更新日期：1998-03-03 00:00:00

abstract：:The breast and ovarian cancer suppressor BRCA2 controls the enzyme RAD51 during homologous DNA recombination (HDR) to preserve genome stability. BRCA2 binds to RAD51 through 8 conserved BRC repeat motifs dispersed in an 1127-residue region (BRCA2([BRC1-8])). Here, we show that BRCA2([BRC1-8]) exerts opposing effects o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shivji MK,Mukund SR,Rajendra E,Chen S,Short JM,Savill J,Klenerman D,Venkitaraman AR

更新日期：2009-08-11 00:00:00

abstract：:Staphylococcal protein A (SpA) is anchored to the cell wall envelope of Staphylococcus aureus by sortase A, which links the threonyl (T) of its C-terminal LPXTG motif to peptidoglycan cross-bridges (i.e., Gly5). SpA binds the Fcγ domains of IgG and protects staphylococci from opsonophagocytic clearance. Moreover, SpA ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Becker S,Frankel MB,Schneewind O,Missiakas D

更新日期：2014-01-28 00:00:00

abstract：:The steady-state level and synthesis of a pair of polypeptides of Mr 33,000 and 35,000 in chicken embryo fibroblasts (CEF) transformed by Rous sarcoma virus (RSV) are significantly decreased relative to normal CEF; however, the decrease is more pronounced in the case of the Mr 35,000 polypeptide. These polypeptides ha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hendricks M,Weintraub H

更新日期：1981-09-01 00:00:00

abstract：:Frame-shift mutations at microsatellites occur as a time-dependent function of polymerase errors followed by failure of postreplicational mismatch repair. A cell-culture system was developed that allows identification of intermediate mutant cells that carry the mutation on a single DNA strand after the initial DNA pol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gasche C,Chang CL,Natarajan L,Goel A,Rhees J,Young DJ,Arnold CN,Boland CR

更新日期：2003-02-18 00:00:00

abstract：:Host-seeking behavior by parasitic nematodes relies heavily on chemical cues emanating from potential hosts. Nonspecific cues for Strongyloides stercoralis, a nematode that infects humans and a few other mammals, include carbon dioxide and sodium chloride; however, the characteristic species specificity of this parasi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Safer D,Brenes M,Dunipace S,Schad G

更新日期：2007-01-30 00:00:00

abstract：:Whether G protein-coupled receptors signal from endosomes to control important pathophysiological processes and are therapeutic targets is uncertain. We report that opioids from the inflamed colon activate δ-opioid receptors (DOPr) in endosomes of nociceptors. Biopsy samples of inflamed colonic mucosa from patients an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jimenez-Vargas NN,Gong J,Wisdom MJ,Jensen DD,Latorre R,Hegron A,Teng S,DiCello JJ,Rajasekhar P,Veldhuis NA,Carbone SE,Yu Y,Lopez-Lopez C,Jaramillo-Polanco J,Canals M,Reed DE,Lomax AE,Schmidt BL,Leong KW,Vanner SJ,

更新日期：2020-06-30 00:00:00

abstract：:Recent evidence indicates a specific role for vascular endothelial growth factor a (Vegfa) during artery development in both zebrafish and mouse embryos, whereas less is known about signals that govern vein formation. In zebrafish, loss of vegfa blocks segmental artery formation and reduces artery-specific gene expres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Covassin LD,Villefranc JA,Kacergis MC,Weinstein BM,Lawson ND

更新日期：2006-04-25 00:00:00

abstract：:A series of hairpin pyrrole-imidazole polyamide-fluorescein conjugates were synthesized and assayed for cellular localization. Thirteen cell lines, representing 11 human cancers, one human transformed kidney cell line, and one murine leukemia cell line, were treated with 5 microM polyamide-fluorescein conjugates for 1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Best TP,Edelson BS,Nickols NG,Dervan PB

更新日期：2003-10-14 00:00:00

abstract：:A temperature-sensitive (ts) mutant, GA 907/7, was isolated after mutagen treatment of avian myeloblastosis virus. When bone marrow cells or secondary yolk sac macrophages were infected with GA 907/7, the expression of transformation was greatly reduced at 41 degrees C. The results of temperature-shift experiments sug...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moscovici MG,Moscovici C

更新日期：1983-03-01 00:00:00

abstract：:We study the dynamic network of e-mail traffic and find that it develops self-organized coherent structures similar to those appearing in many nonlinear dynamic systems. Such structures are uncovered by a general information theoretic approach to dynamic networks based on the analysis of synchronization among trios of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eckmann JP,Moses E,Sergi D

更新日期：2004-10-05 00:00:00

abstract：:New advances in polarized light microscopy were used to image Congo red-stained cerebral amyloidosis in sharp relief. The rotating-polarizer method was used to separate the optical effects of transmission, linear birefringence, extinction, linear dichroism, and orientation of the electric dipole transition moments and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jin LW,Claborn KA,Kurimoto M,Geday MA,Maezawa I,Sohraby F,Estrada M,Kaminksy W,Kahr B

更新日期：2003-12-23 00:00:00

abstract：:The five alpha genes of herpes simplex virus 1 are the first set of genes to be expressed after infection. Previous studies have shown that alpha genes resident in eukaryotic cells are induced by infection with herpes simplex virus 1 or 2 but not by other herpesviruses and indicate that the alpha trans-inducing factor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pellett PE,McKnight JL,Jenkins FJ,Roizman B

更新日期：1985-09-01 00:00:00

abstract：:The consumption of garlic is inversely correlated with the progression of cardiovascular disease, although the responsible mechanisms remain unclear. Here we show that human RBCs convert garlic-derived organic polysulfides into hydrogen sulfide (H(2)S), an endogenous cardioprotective vascular cell signaling molecule. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benavides GA,Squadrito GL,Mills RW,Patel HD,Isbell TS,Patel RP,Darley-Usmar VM,Doeller JE,Kraus DW

更新日期：2007-11-13 00:00:00

abstract：:Chemokines and their receptors are key factors in the onset and progression of AIDS. Among them, accumulating evidence strongly indicates the involvement of IL-8 and its receptors, CXCR1 and CXCR2, in AIDS-related conditions. Through extensive investigation of genetic variations of the human CXCR1-CXCR2 locus, we iden...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vasilescu A,Terashima Y,Enomoto M,Heath S,Poonpiriya V,Gatanaga H,Do H,Diop G,Hirtzig T,Auewarakul P,Lauhakirti D,Sura T,Charneau P,Marullo S,Therwath A,Oka S,Kanegasaki S,Lathrop M,Matsushima K,Zagury JF,Matsuda

更新日期：2007-02-27 00:00:00

abstract：:Inflammatory destruction of insulin-producing beta cells in the pancreatic islets is the hallmark of insulin-dependent diabetes mellitus, a spontaneous autoimmune disease of non-obese diabetic mice resembling human juvenile (type I) diabetes. Histochemical analysis of diabetic pancreata revealed that mononuclear cells...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weiss L,Slavin S,Reich S,Cohen P,Shuster S,Stern R,Kaganovsky E,Okon E,Rubinstein AM,Naor D

更新日期：2000-01-04 00:00:00

abstract：:Here we show how a simple inorganic salt can spontaneously form autocatalytic sets of replicating inorganic molecules that work via molecular recognition based on the {PMo12} ≡ [PMo12O40]3- Keggin ion, and {Mo36} ≡ [H3Mo57M6(NO)6O183(H2O)18]22- cluster. These small clusters are able to catalyze their own formation via...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miras HN,Mathis C,Xuan W,Long DL,Pow R,Cronin L

更新日期：2020-05-19 00:00:00

abstract：:Gamma-band synchronization adjusts the timing of excitatory and inhibitory inputs to a neuron. Neurons in the visual cortex are selective for stimulus orientation because of dynamic interactions between excitatory and inhibitory inputs. We hypothesized that these interactions and hence also orientation selectivity var...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Womelsdorf T,Lima B,Vinck M,Oostenveld R,Singer W,Neuenschwander S,Fries P

更新日期：2012-03-13 00:00:00

abstract：:Cells are dynamical systems of biomolecular interactions that process information from their environment to mount diverse yet specific responses. A key property of many self-organized systems is that of criticality: a state of a system in which, on average, perturbations are neither dampened nor amplified, but are pro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nykter M,Price ND,Aldana M,Ramsey SA,Kauffman SA,Hood LE,Yli-Harja O,Shmulevich I

更新日期：2008-02-12 00:00:00

abstract：:Sulfonated gallium(III) corroles are intensely fluorescent macrocyclic compounds that spontaneously assemble with carrier proteins to undergo cell entry. We report in vivo imaging and therapeutic efficacy of a tumor-targeted corrole noncovalently assembled with a heregulin-modified protein directed at the human epider...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Agadjanian H,Ma J,Rentsendorj A,Valluripalli V,Hwang JY,Mahammed A,Farkas DL,Gray HB,Gross Z,Medina-Kauwe LK

更新日期：2009-04-14 00:00:00

abstract：:In systemic lupus erythematosus (SLE), T helper cells exhibit increased and prolonged expression of cell-surface CD40 ligand (CD154), spontaneously overproduce interleukin-10 (IL-10), but underproduce interferon-gamma (IFN-gamma). We tested the hypothesis that the imbalance of these gene products reflects skewed expre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mishra N,Brown DR,Olorenshaw IM,Kammer GM

更新日期：2001-02-27 00:00:00

abstract：:L-Fucose and D-galactose in low concentrations (0.27 or 2.7 mM) inhibited the induction of active Na+ channels in mouse and human neuroblastoma cells when the monosaccharides were added to the culture medium for 4 days with the inducing agent dimethyl sulfoxide. Active Na+ ionophores were determined by measurement of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giovanni MY,Kessel D,Glick MC

更新日期：1981-02-01 00:00:00

abstract：:Bovine milk lipoprotein lipase was subjected to amino acid sequence analysis. The first 19 amino-terminal residues were Asp-Arg-Ile-Thr-Gly-Gly-Lys-Asp-Phe-Arg-Asp-Ile-Glu-Ser-Lys-Phe-Ala-Leu- Arg. In addition, reversed-phase high-performance liquid chromatography of a tryptic digest of reduced and alkylated lipase re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ben-Avram CM,Ben-Zeev O,Lee TD,Haaga K,Shively JE,Goers J,Pedersen ME,Reeve JR Jr,Schotz MC

更新日期：1986-06-01 00:00:00

abstract：:Although cells express hundreds of metalloenzymes, the mechanisms by which apoenzymes receive their metal cofactors are largely unknown. Poly(rC)-binding proteins PCBP1 and PCBP2 are multifunctional adaptor proteins that bind iron and deliver it to ferritin for storage or to prolyl and asparagyl hydroxylases to metall...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frey AG,Nandal A,Park JH,Smith PM,Yabe T,Ryu MS,Ghosh MC,Lee J,Rouault TA,Park MH,Philpott CC

更新日期：2014-06-03 00:00:00

abstract：:Tridymite, a low-pressure, high-temperature (>870 °C) SiO2 polymorph, was detected in a drill sample of laminated mudstone (Buckskin) at Marias Pass in Gale crater, Mars, by the Chemistry and Mineralogy X-ray diffraction instrument onboard the Mars Science Laboratory rover Curiosity The tridymitic mudstone has ∼40 wt....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morris RV,Vaniman DT,Blake DF,Gellert R,Chipera SJ,Rampe EB,Ming DW,Morrison SM,Downs RT,Treiman AH,Yen AS,Grotzinger JP,Achilles CN,Bristow TF,Crisp JA,Des Marais DJ,Farmer JD,Fendrich KV,Frydenvang J,Graff TG,Mo

更新日期：2016-06-28 00:00:00

abstract：:Marine Archaea are important players among microbial plankton and significantly contribute to biogeochemical cycles, but details regarding their community structure and long-term seasonal activity and dynamics remain largely unexplored. In this study, we monitored the interannual archaeal community composition of abun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hugoni M,Taib N,Debroas D,Domaizon I,Jouan Dufournel I,Bronner G,Salter I,Agogué H,Mary I,Galand PE

更新日期：2013-04-09 00:00:00