Specific monosaccharide inhibition of active sodium channels in neuroblastoma cells.

abstract：:A diverse range of neural cell types is generated from a pool of dividing stem and progenitor cells in an orderly manner during development. Little is known of the molecular and cellular biology underpinning the intrinsic control of this process. We have used a nonbiased method to purify populations of neural progenit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Livesey FJ,Young TL,Cepko CL

更新日期：2004-02-03 00:00:00

abstract：:Chlorarachniophytes are amoeboid algae with unusual chloroplasts. Instead of the usual two membranes that surround the chloroplasts of plants, green algae, and red algae, the chloroplasts of chlorarachniophytes have four bounding membranes. The extra membranes may reflect an unusual origin of chlorarachniophyte chloro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McFadden GI,Gilson PR,Hofmann CJ,Adcock GJ,Maier UG

更新日期：1994-04-26 00:00:00

abstract：:Electrically excitable cells harness voltage-coupled calcium influx to transmit intracellular signals, typically studied in neurons and cardiomyocytes. Despite intense study in higher organisms, investigations of voltage and calcium signaling in bacteria have lagged due to their small size and a lack of sensitive tool...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bruni GN,Weekley RA,Dodd BJT,Kralj JM

更新日期：2017-08-29 00:00:00

abstract：:The human immunodeficiency virus 1 (HIV-1) long terminal repeat (LTR) sequences were inserted into adenovirus in place of the E1 region. The HIV-1 LTR contained in this recombinant adenovirus responds to trans-activation by tatIII in a HeLa cell line constitutively expressing that HIV-1 gene product. In addition, the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rice AP,Mathews MB

更新日期：1988-06-01 00:00:00

abstract：:Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell prolymphocytic leukemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28. The crystal structure of human recombinant MTCP-1 protein has been determined at 2.0 A r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu ZQ,Du Bois GC,Song SP,Kulikovskaya I,Virgilio L,Rothstein JL,Croce CM,Weber IT,Harrison RW

更新日期：1998-03-31 00:00:00

abstract：:The bacterial pathogen Streptococcus pneumoniae is a major public health concern, being responsible for more than 1.5 million deaths annually through pneumonia, meningitis, and septicemia. Available vaccines target only a subset of serotypes, so vaccination is often accompanied by a rise in the frequency of nonvaccine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Obolski U,Lourenço J,Thompson C,Thompson R,Gori A,Gupta S

更新日期：2018-03-20 00:00:00

abstract：:It is a well known fact that stirring keeps particles suspended in fluids. This is apparent, for instance, when shaking medicine flasks, when agitating tea deposits in a mug, or when heavy winds fill the air with dust particles. The commonplace nature of such observations makes it easy to accept that this feature will...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruiz J,Macías D,Peters F

更新日期：2004-12-21 00:00:00

abstract：:The FKBP12-rapamycin-associated protein (FRAP; also called RAFT1/mTOR) regulates translation initiation and entry into the cell cycle. Depriving cells of amino acids or treating them with the small molecule rapamycin inhibits FRAP and results in rapid dephosphorylation and inactivation of the translational regulators ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peterson RT,Desai BN,Hardwick JS,Schreiber SL

更新日期：1999-04-13 00:00:00

abstract：:Light activates rod outer segment (ROS) phosphodiesterase (PDEase), as shown by previous biochemical and physiological studies. We have further investigated the role of PDEase in this system by injecting trypsin-activated PDEase, purified from bovine ROS, into single ROS of the isolated retina of the toad Bufo marinus...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shimoda Y,Hurley JB,Miller WH

更新日期：1984-01-01 00:00:00

abstract：:In vitro, polynucleotide phosphorylase of Escherichia coli can both synthesize RNA by using nucleotide diphosphates as precursors and exonucleolytically degrade RNA in the presence of inorganic phosphate. However, because of the high in vivo concentration of inorganic phosphate in exponentially growing cells, it has b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mohanty BK,Kushner SR

更新日期：2000-10-24 00:00:00

abstract：:Targeted disruption of the pp60(src) (Src) gene has implicated this tyrosine kinase in osteoclast-mediated bone resorption and as a therapeutic target for the treatment of osteoporosis and other bone-related diseases. Herein we describe the discovery of a nonpeptide inhibitor (AP22408) of Src that demonstrates in vivo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shakespeare W,Yang M,Bohacek R,Cerasoli F,Stebbins K,Sundaramoorthi R,Azimioara M,Vu C,Pradeepan S,Metcalf C 3rd,Haraldson C,Merry T,Dalgarno D,Narula S,Hatada M,Lu X,van Schravendijk MR,Adams S,Violette S,Smith J,

更新日期：2000-08-15 00:00:00

abstract：:High-pressure single-crystal X-ray diffraction method with precise control of hydrostatic conditions, typically with helium or neon as the pressure-transmitting medium, has significantly changed our view on what happens with low-density silica phases under pressure. Coesite is a prototype material for pressure-induced...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu W,Wu X,Liang Y,Liu C,Miranda CR,Scandolo S

更新日期：2017-12-05 00:00:00

abstract：:G-protein-coupled receptors (GPCRs) have recently joined the list of cell surface receptors that dimerize. Dimerization has been shown to alter the ligand-binding, signaling, and trafficking properties of these receptors. Recent studies have shown that GPCRs heterodimerize with closely related members, resulting in th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jordan BA,Trapaidze N,Gomes I,Nivarthi R,Devi LA

更新日期：2001-01-02 00:00:00

abstract：:The mechanosensory hair cells of the inner ear are required for hearing and balance and have a distinctive apical structure, the hair bundle, that converts mechanical stimuli into electrical signals. This structure comprises a single cilium, the kinocilium, lying adjacent to an ensemble of actin-based projections know...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Honda A,Kita T,Seshadri SV,Misaki K,Ahmed Z,Ladbury JE,Richardson GP,Yonemura S,Ladher RK

更新日期：2018-08-14 00:00:00

abstract：:The heterodisaccharide lactose (1,4-O-beta-D-galactopyranosyl-D-glucose) induces cellulase formation in the ascomycete Hypocrea jecorina (= Trichoderma reesei). Lactose assimilation is slow, and the assimilation of its beta-D-galactose moiety depends mainly on the operation of a recently described reductive pathway an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fekete E,Seiboth B,Kubicek CP,Szentirmai A,Karaffa L

更新日期：2008-05-20 00:00:00

abstract：:Antagonists of growth hormone-releasing hormone (GH-RH) inhibit the growth of various tumors through mechanisms that involve the suppression of the insulin-like growth factor I and/or insulin-like growth factor II levels or secretion. In the present study, we tested the hypothesis that the tumor inhibition is associat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kiaris H,Schally AV

更新日期：1999-01-05 00:00:00

abstract：:Ultrastructural immunocytochemical studies of the expression of major histocompatibility complex class I antigens in the placentas of inbred rats were performed using placentas derived from natural matings and from embryo transfers into females made pseudopregnant by mechanical stimulation. The studies utilized the WF...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kanbour-Shakir A,Zhang X,Rouleau A,Armstrong DT,Kunz HW,Macpherson TA,Gill TJ 3rd

更新日期：1990-01-01 00:00:00

abstract：:Cell cycle progression is tightly regulated by cyclin-dependent kinases (CDKs). The ankyrin-repeat protein p19INK4d functions as a key regulator of G1/S transition; however, its molecular mode of action is unknown. Here, we combine cell and structural biology methods to unravel the mechanism by which p19INK4d controls...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kumar A,Gopalswamy M,Wolf A,Brockwell DJ,Hatzfeld M,Balbach J

更新日期：2018-03-27 00:00:00

abstract：:Separation of cells is a critical process for studying cell properties, disease diagnostics, and therapeutics. Cell sorting by acoustic waves offers a means to separate cells on the basis of their size and physical properties in a label-free, contactless, and biocompatible manner. The separation sensitivity and effici...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ding X,Peng Z,Lin SC,Geri M,Li S,Li P,Chen Y,Dao M,Suresh S,Huang TJ

更新日期：2014-09-09 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF), a cognate ligand for the tyrosine kinase receptor B (TrkB) receptor, mediates neuronal survival, differentiation, synaptic plasticity, and neurogenesis. However, BDNF has a poor pharmacokinetic profile that limits its therapeutic potential. Here we report the identification of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jang SW,Liu X,Yepes M,Shepherd KR,Miller GW,Liu Y,Wilson WD,Xiao G,Blanchi B,Sun YE,Ye K

更新日期：2010-02-09 00:00:00

abstract：:The nuclear receptor REV-ERBα integrates the circadian clock with hepatic glucose and lipid metabolism by nucleating transcriptional comodulators at genomic regulatory regions. An interactomic approach identified O-GlcNAc transferase (OGT) as a REV-ERBα-interacting protein. By shielding cytoplasmic OGT from proteasoma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berthier A,Vinod M,Porez G,Steenackers A,Alexandre J,Yamakawa N,Gheeraert C,Ploton M,Maréchal X,Dubois-Chevalier J,Hovasse A,Schaeffer-Reiss C,Cianférani S,Rolando C,Bray F,Duez H,Eeckhoute J,Lefebvre T,Staels B,Lef

更新日期：2018-11-20 00:00:00

abstract：:Nitric oxide (NO) plays diverse and significant roles in biological processes despite its cytotoxicity, raising the question of how biological systems control the action of NO to minimize its cytotoxicity in cells. As a great example of such a system, we found a possibility that NO-generating nitrite reductase (NiR) f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Terasaka E,Yamada K,Wang PH,Hosokawa K,Yamagiwa R,Matsumoto K,Ishii S,Mori T,Yagi K,Sawai H,Arai H,Sugimoto H,Sugita Y,Shiro Y,Tosha T

更新日期：2017-09-12 00:00:00

abstract：:Adenosine has been identified in the anterior pituitary gland and is secreted from cultured folliculostellate (FS) cells. To determine whether adenosine controls the secretion of anterior pituitary hormones in vitro, adenosine was incubated with anterior pituitaries. It stimulated prolactin (PRL) release at the lowest...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu WH,Kimura M,Walczewska A,Porter JC,McCann SM

更新日期：1998-06-23 00:00:00

abstract：:Progressive myoclonus epilepsy of Univerricht-Lundborg type is a clinically defined entity among the progressive myoclonus epilepsies. It is an autosomal recessive disorder. The underlying biochemical defect is unknown. We used linkage analysis to localize the gene in 12 families with the aid of polymorphic DNA marker...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lehesjoki AE,Koskiniemi M,Sistonen P,Miao J,Hästbacka J,Norio R,de la Chapelle A

更新日期：1991-05-01 00:00:00

abstract：:In eukaryotic cells the concentration of dNTP is highest in S phase and lowest in G1 phase and is controlled by ribonucleotide reductase (RNR). RNR activity is eliminated in all eukaryotes in G1 phase by a variety of mechanisms: transcriptional regulation, small inhibitory proteins, and protein degradation. After acti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chabes A,Stillman B

更新日期：2007-01-23 00:00:00

abstract：:The voltage-dependent gating of the colicin channel involves a substantial structural rearrangement that results in the transfer of about 35% of the 200 residues in its pore-forming domain across the membrane. This transfer appears to represent an unusual type of protein translocation that does not depend on a large, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Slatin SL,Nardi A,Jakes KS,Baty D,Duché D

更新日期：2002-02-05 00:00:00

abstract：:L203 and L227 are mouse monoclonal antibodies specific for human HLA-DR antigens. Their reactivity with multiple, structurally different, HLA-DR antigens was examined by using radioiodinated human lymphoblastoid cells and cell lines, heterozygous or homozygous at the HLA-D locus. Antibody L203 precipitates DR antigens...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Finn OJ,Levy R

更新日期：1982-04-01 00:00:00

abstract：:The mid-winter development of refractoriness to melatonin (Mel) triggers recrudescence of the atrophied reproductive apparatus of rodents. As a consequence, over-wintering animals become reproductively competent just before the onset of spring conditions favorable for breeding. The neural target tissues that cease to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Freeman DA,Zucker I

更新日期：2001-05-22 00:00:00

abstract：:The product of the Escherichia coli secB gene is required for efficient export of proteins across the cytoplasmic membrane. The studies described in this report show that in wild-type growing cells, SecB protein associates with precursor forms of exported proteins, such as the periplasmic maltose-binding protein (MBP)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kumamoto CA

更新日期：1989-07-01 00:00:00

abstract：:Grain growth under shear annealing is crucial for controlling the properties of polycrystalline materials. However, their microscopic kinetics are not well understood because individual atomic trajectories are difficult to track. Here, we study grain growth with single-particle kinetics in colloidal polycrystals using...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li W,Peng Y,Zhang Y,Still T,Yodh AG,Han Y

更新日期：2020-09-29 00:00:00