Adenosine acts by A1 receptors to stimulate release of prolactin from anterior-pituitaries in vitro.

abstract：:Arsenate is an abundant oxyanion that, because of its ability to mimic the phosphate group, is toxic to cells. Arsenate reductase (EC; encoded by the arsC gene in bacteria) participates to achieve arsenate resistance in both prokaryotes and yeast by reducing arsenate to arsenite; the arsenite is then exported by a spe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bennett MS,Guan Z,Laurberg M,Su XD

更新日期：2001-11-20 00:00:00

abstract：:A "projection function," P(x,z), is defined as the partial integral of the molecular electron density, rho(x,y,z), over the region -infinity < y < +infinity. The projection provides a three-dimensional representation of molecular electron distributions. Chemically useful information can be discerned from graphical dis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Streitwieser A,Collins JB,McKelvey JM,Grier D,Sender J,Toczko AG

更新日期：1979-06-01 00:00:00

abstract：:E12 and E47 are two non-tissue-specific helix-loop-helix (HLH) transcription factors encoded by the E2A gene. Previous studies suggested that they are involved in regulation of differentiation in many tissue types including muscle, blood, and nerve through direct heterodimer interactions with tissue-specific HLH prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhuang Y,Kim CG,Bartelmez S,Cheng P,Groudine M,Weintraub H

更新日期：1992-12-15 00:00:00

abstract：:The ever-increasing global need for potable water requires practical, sustainable approaches for purifying abundant alternative sources such as seawater, high-salinity processed water, or underground reservoirs. Evaporation-based solutions are of particular interest for treating high salinity water, since conventional...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dongare PD,Alabastri A,Neumann O,Nordlander P,Halas NJ

更新日期：2019-07-02 00:00:00

abstract：:A theory is proposed to study the sensitivity of cylindrical explosives. Using the equations governing the conservation of mass, energy, and momentum, the equation of state, and Newtonian mechanics, we have derived the expression D = D(o)e(-a2/d), in which the apparent length of the reaction zone, a, takes into accoun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eyring H,Walker FE,Ma SM,Coon N

更新日期：1980-05-01 00:00:00

abstract：:Immunological memory is a hallmark of adaptive immunity, and understanding T cell memory will be central to the development of effective cell-mediated vaccines. The characteristics and functions of CD4 memory cells have not been well defined. Here we demonstrate that the increased size of the secondary response is sol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： MacLeod MK,McKee A,Crawford F,White J,Kappler J,Marrack P

更新日期：2008-09-23 00:00:00

abstract：:One-half of pituitary-intact or sham-operated rats survive infection with 10(9) colony-forming units of Salmonella typhimurium, whereas rats without a pituitary gland all die within a few days. When the dose of S. typhimurium is reduced 600-fold, 15-25% of the hypophysectomized rats survive, and the survival rate is s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Edwards CK 3rd,Yunger LM,Lorence RM,Dantzer R,Kelley KW

更新日期：1991-03-15 00:00:00

abstract：:Size has a profound effect on the structure of the brain. Many brain structures scale allometrically, that is, their relative size changes systematically as a function of brain size. Here we use independent contrasts analysis to examine the scaling of frontal cortex in 43 species of mammals including 25 primates and 1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bush EC,Allman JM

更新日期：2004-03-16 00:00:00

abstract：:The role of intraspecific and interspecific interactions in structuring biotic communities at fine spatial scales is well documented, but the signature of species interactions at coarser spatial scales is unclear. We present evidence that species interactions may be a significant factor in mediating the regional assem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gotelli NJ,Graves GR,Rahbek C

更新日期：2010-03-16 00:00:00

abstract：:Visual receptive fields (RFs) were mapped inside and outside the cortical representation of the optic disk in the striate cortex (area V1) of anesthetized and paralyzed Cebus monkeys. Unexpectedly, most cells were found to be binocularly driven, and the RFs mapped with contralateral-eye stimulation progressed in a top...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fiorani Júnior M,Rosa MG,Gattass R,Rocha-Miranda CE

更新日期：1992-09-15 00:00:00

abstract：:Insertion of the transposon Tn5 into the T-region of the octopine Ti plasmid of Agrobacterium tumefaciens gives rise to crown gall tumors having altered morphology. Three loci within the T-DNA that control tumor morphology have been detected [Garfinkel, D. J., Simpson, R. B., Ream, L. W., White, F. F., Gordon, M. P. &...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Akiyoshi DE,Morris RO,Hinz R,Mischke BS,Kosuge T,Garfinkel DJ,Gordon MP,Nester EW

更新日期：1983-01-01 00:00:00

abstract：:A cDNA for parafusin, an evolutionarily conserved phosphoglycoprotein involved in exocytosis, has been cloned and sequenced from a unicellular eukaryote, Paramecium tetraurelia. A Paramecium cDNA library was screened with an oligonucleotide probe synthesized to an internal amino acid sequence of isolated parafusin. Th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Subramanian SV,Wyroba E,Andersen AP,Satir BH

更新日期：1994-10-11 00:00:00

abstract：:We determined the complete mtDNA sequence of the centipede Lithobius forficatus and found that only one of the 22 inferred tRNA genes encodes a fully paired aminoacyl acceptor stem. The other 21 genes encode tRNAs with up to five mismatches in these stems, and some of these overlap extensively with the downstream gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lavrov DV,Brown WM,Boore JL

更新日期：2000-12-05 00:00:00

abstract：:Reactive oxygen species (ROS)-mediated oxidative stress and DNA damage have recently been recognized as contributing to the efficacy of most bactericidal antibiotics, irrespective of their primary macromolecular targets. Inhibitors of targets involved in both combating oxidative stress as well as being required for in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tiwari S,van Tonder AJ,Vilchèze C,Mendes V,Thomas SE,Malek A,Chen B,Chen M,Kim J,Blundell TL,Parkhill J,Weinrick B,Berney M,Jacobs WR Jr

更新日期：2018-09-25 00:00:00

abstract：:Object recognition is challenging because the same object can produce vastly different images, mixing signals related to its identity with signals due to its image attributes, such as size, position, rotation, etc. Previous studies have shown that both signals are present in high-level visual areas, but precisely how ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ratan Murty NA,Arun SP

更新日期：2018-04-03 00:00:00

abstract：:Using single-cell sequence analysis, we discovered that a high proportion of cells in tissues as diverse as buccal epithelium and heart muscle contain high proportions of clonal mutant mtDNA expanded from single initial mutant mtDNA molecules. We demonstrate that intracellular clonal expansion of somatic point mutatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nekhaeva E,Bodyak ND,Kraytsberg Y,McGrath SB,Van Orsouw NJ,Pluzhnikov A,Wei JY,Vijg J,Khrapko K

更新日期：2002-04-16 00:00:00

abstract：:Previous studies have shown that Delta-mediated Notch signaling regulates the number of early differentiating neurons. However, the role of Notch activation and Jagged-mediated signaling during late neurogenesis remains poorly defined. In the developing spinal cord of zebrafish, GABAergic Kolmer-Agduhr (KA'') cells an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeo SY,Chitnis AB

更新日期：2007-04-03 00:00:00

abstract：:The pathways that allow quiescent disseminated cancer cells to survive during prolonged dormancy periods are unknown. Here, we identify the transcription factor ATF6alpha as a pivotal survival factor for quiescent but not proliferative squamous carcinoma cells. ATF6alpha is essential for the adaptation of dormant cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schewe DM,Aguirre-Ghiso JA

更新日期：2008-07-29 00:00:00

abstract：:The techniques of electrophoresis were used in a search for evidence of mutation affecting protein structure, the indicators being hemoglobin and a set of serum proteins and erythrocyte enzymes. Among 94,796 locus tests on Amerindians from Central and South America, there was no evidence for mutation. Among 105,649 lo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Neel JV,Mohrenweiser HW,Meisler MH

更新日期：1980-10-01 00:00:00

abstract：:Positive allosteric modulation of the mu-opioid receptor (MOPr), the site of action of all clinically used opioids, represents a potential approach for the management of pain. We recently reported on positive allosteric modulators of MOPr (mu-PAMs), a class A G protein coupled receptor (GPCR). This study was designed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Livingston KE,Traynor JR

更新日期：2014-12-23 00:00:00

abstract：:A model for the chain melting phase transition in dilute aqueous phospholipid bilayer dispersions is presented. This model includes interactions between head groups, between hydrocarbon chains, and within the chains. The head groups are modeled as hard disks which are constrained to lie on a two-dimensional surface se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jacobs RE,Hudson B,Andersen HC

更新日期：1975-10-01 00:00:00

abstract：:Herpes simplex virus 1 (HSV-1) infection induces transcription of the chloramphenicol acetyltransferase (CAT) gene directed by the long terminal repeat (LTR) of human immunodeficiency virus (HIV) in both transiently and permanently transfected cells containing the HIV-LTR/CAT hybrid gene. To define the mechanism by wh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mosca JD,Bednarik DP,Raj NB,Rosen CA,Sodroski JG,Haseltine WA,Hayward GS,Pitha PM

更新日期：1987-11-01 00:00:00

abstract：:Polycyclic aromatic hydrocarbons and related species have been suggested to play a key role in the astrochemical evolution of the interstellar medium, but the formation mechanism of even their simplest building block--the aromatic benzene molecule--has remained elusive for decades. Here we demonstrate in crossed molec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jones BM,Zhang F,Kaiser RI,Jamal A,Mebel AM,Cordiner MA,Charnley SB

更新日期：2011-01-11 00:00:00

abstract：:The Amazon rainforest is the Earth's largest reservoir of plant and animal diversity, and it has been subjected to especially high rates of land use change, primarily to cattle pasture. This conversion has had a strongly negative effect on biological diversity, reducing the number of plant and animal species and homog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rodrigues JL,Pellizari VH,Mueller R,Baek K,Jesus Eda C,Paula FS,Mirza B,Hamaoui GS Jr,Tsai SM,Feigl B,Tiedje JM,Bohannan BJ,Nüsslein K

更新日期：2013-01-15 00:00:00

abstract：:The concept of contagion has steadily expanded from its original grounding in epidemic disease to describe a vast array of processes that spread across networks, notably social phenomena such as fads, political opinions, the adoption of new technologies, and financial decisions. Traditional models of social contagion ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ugander J,Backstrom L,Marlow C,Kleinberg J

更新日期：2012-04-17 00:00:00

abstract：:There is pronounced seasonal plasticity in the morphology of the neural circuits that regulate song behavior in adult songbirds, primarily in response to changes in plasma testosterone (T) levels. Most song nuclei have androgen receptors. Afferent input from the telencephalic nucleus HVc (also known as the "high vocal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brenowitz EA,Lent K

更新日期：2002-09-17 00:00:00

abstract：:Failure of embryo implantation accounts for a significant percentage of female infertility. Exquisitely coordinated molecular programs govern the interaction between the competent blastocyst and the receptive uterus. Decidualization, the rapid proliferation and differentiation of endometrial stromal cells into decidua...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haller M,Yin Y,Ma L

更新日期：2019-09-24 00:00:00

abstract：:Choroideremia is an X-linked hereditary retinal degeneration resulting from mutations in the Rab escort protein-1 (REP1). The Rep1 protein facilitates posttranslational modification of Rab proteins, which regulate intracellular trafficking in the retinal pigment epithelium (RPE) and photoreceptors and are likely invol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krock BL,Bilotta J,Perkins BD

更新日期：2007-03-13 00:00:00

abstract：:Expression of alphavbeta3- or alphavbeta5-integrins and selectins is widespread on blood cells and endothelial cells. Here we report that human tumor cells injected s.c. into mice lacking beta3- or beta3/beta5-integrins or various selectins show enhanced tumor growth compared with growth in control mice. There was inc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taverna D,Moher H,Crowley D,Borsig L,Varki A,Hynes RO

更新日期：2004-01-20 00:00:00

abstract：:The motility of cilia and flagella is powered by dynein ATPases associated with outer doublet microtubules. However, a flagellar kinesin-like protein that may function as a motor associates with the central pair complex. We determined that Chlamydomonas reinhardtii central pair kinesin Klp1 is a phosphoprotein and, li...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yokoyama R,O'toole E,Ghosh S,Mitchell DR

更新日期：2004-12-14 00:00:00