Formation of benzene in the interstellar medium.

abstract：:CSB/ERCC6 belongs to an orphan subfamily of SWI2/SNF2-related chromatin remodelers and plays crucial roles in gene expression, DNA damage repair, and the maintenance of genome integrity. The molecular basis of chromatin remodeling by Cockayne syndrome B protein (CSB) is not well understood. Here we investigate the mol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang W,Xu J,Limbo O,Fei J,Kassavetis GA,Chong J,Kadonaga JT,Russell P,Li B,Wang D

更新日期：2019-03-26 00:00:00

abstract：:Excess activation of glutamate receptors and production of free radicals including nitric oxide may result in severe and irreversible damage to the mammalian central nervous system (CNS), but endogenous defense systems that protect neurons from these insults are poorly understood. Here, we purified and isolated a neur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kume T,Asai N,Nishikawa H,Mano N,Terauchi T,Taguchi R,Shirakawa H,Osakada F,Mori H,Asakawa N,Yonaga M,Nishizawa Y,Sugimoto H,Shimohama S,Katsuki H,Kaneko S,Akaike A

更新日期：2002-03-05 00:00:00

abstract：:gC1qR is one of the C1q receptors implicated in the regulation of innate and adaptive immunity. We found that gC1qR inhibits RIG-I and MDA5-dependent antiviral signaling. Double stranded RNA and virus trigger the translocation of gC1qR to the mitochondrial outer membrane leading to the interaction of gC1qR with the RI...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu L,Xiao N,Liu F,Ren H,Gu J

更新日期：2009-02-03 00:00:00

abstract：:Sensitive optical signal detection can often be confounded by the presence of a significant background, and, as such, predetection background suppression is substantively important for weak signal detection. In this paper, we present a novel optical structure design, termed surface-wave-enabled darkfield aperture (SWE...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zheng G,Cui X,Yang C

更新日期：2010-05-18 00:00:00

abstract：:The auditory and motor neural systems are closely intertwined, enabling people to carry out tasks such as playing a musical instrument whose mapping between action and sound is extremely sophisticated. While the dorsal auditory stream has been shown to mediate these audio-motor transformations, little is known about h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wollman I,Penhune V,Segado M,Carpentier T,Zatorre RJ

更新日期：2018-06-26 00:00:00

abstract：:The superficial gray layer of the superior colliculus contains a map that represents the visual field, whereas the underlying intermediate gray layer contains a vector map of the saccades that shift the direction of gaze. These two maps are aligned so that a particular region of the visual field is represented directl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee PH,Helms MC,Augustine GJ,Hall WC

更新日期：1997-11-25 00:00:00

abstract：:Sunlight exposure is strongly indicated as one of the important etiologic agents in human cutaneous malignant melanoma. However, because of the absence of good animal models, it has not been possible to estimate the wavelengths or wavelength regions involved. We have developed a useful animal model from crosses and ba...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Setlow RB,Woodhead AD,Grist E

更新日期：1989-11-01 00:00:00

abstract：:The importance of Gly-93 and Gly-94 in transmembrane segment M1 of the Na+,K+-ATPase for interaction with Na+ and K+ was demonstrated by functional analysis of mutants Gly-93-Ala and Gly-94-Ala. In the crystal structures of the Ca2+-ATPase, the corresponding residues, Asp-59 and Leu-60, are located exactly where M1 be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Einholm AP,Toustrup-Jensen M,Andersen JP,Vilsen B

更新日期：2005-08-09 00:00:00

abstract：:Interindividual differences in hepatic metabolism, which are mainly due to genetic polymorphism in its gene, have a large influence on individual drug efficacy and adverse reaction. Hepatocyte-like cells (HLCs) differentiated from human induced pluripotent stem (iPS) cells have the potential to predict interindividual...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takayama K,Morisaki Y,Kuno S,Nagamoto Y,Harada K,Furukawa N,Ohtaka M,Nishimura K,Imagawa K,Sakurai F,Tachibana M,Sumazaki R,Noguchi E,Nakanishi M,Hirata K,Kawabata K,Mizuguchi H

更新日期：2014-11-25 00:00:00

abstract：:Compartmentalization of biomolecules within lipid membranes is a fundamental requirement of living systems and an essential feature of many pharmaceutical therapies. However, applications of membrane-enclosed solutions of proteins, DNA, and other biologically active compounds have been limited by the difficulty of for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stachowiak JC,Richmond DL,Li TH,Liu AP,Parekh SH,Fletcher DA

更新日期：2008-03-25 00:00:00

abstract：:In many eukaryotic systems during immune responses, mitogen-activated protein kinases (MAPKs) link cytoplasmic signaling to chromatin events by targeting transcription factors, chromatin remodeling complexes, and the RNA polymerase machinery. So far, knowledge on these events is scarce in plants and no attempts have b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rayapuram N,Jarad M,Alhoraibi HM,Bigeard J,Abulfaraj AA,Völz R,Mariappan KG,Almeida-Trapp M,Schlöffel M,Lastrucci E,Bonhomme L,Gust AA,Mithöfer A,Arold ST,Pflieger D,Hirt H

更新日期：2021-01-19 00:00:00

abstract：:The rugged folding-energy landscapes of RNAs often display many competing minima. How do RNAs discriminate among competing conformations in their search for the native state? By using optical tweezers, we show that the folding-energy landscape can be manipulated to control the fate of an RNA: individual RNA molecules ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li PT,Bustamante C,Tinoco I Jr

更新日期：2007-04-24 00:00:00

abstract：:A rapid and convenient method has been devised to determine the binding sites for proteins on RNA. The procedure is an adaptation of one used to map DNA-protein complexes by protection against nuclease digestion. The method uses the cytotoxic ribonuclease alpha-sarcin, which hydrolyzes purines in both single- and doub...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huber PW,Wool IG

更新日期：1984-01-01 00:00:00

abstract：:Oncogene-induced senescence (OIS) is a critical tumor-suppressing mechanism that restrains cancer progression at premalignant stages, in part by causing telomere dysfunction. Currently it is unknown whether this proliferative arrest presents a stable and therefore irreversible barrier to cancer progression. Here we de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patel PL,Suram A,Mirani N,Bischof O,Herbig U

更新日期：2016-08-23 00:00:00

abstract：:Let t --> gamma(t) be a homogeneous curve in R(n). For suitable f, define [unk](f)(x) = sup(h > 0)|(1/h) [unk](0) (h)f(x - gamma(t)) dt|. Then parallel[unk](f) parallel(p)

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stein EM

更新日期：1976-07-01 00:00:00

abstract：:The elongated three-helix bundle domains spectrin R16 and R17 fold some two to three orders of magnitude more slowly than their homologue R15. We have shown that this slow folding is due, at least in part, to roughness in the free-energy landscape of R16 and R17. We have proposed that this roughness is due to a frustr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wensley BG,Kwa LG,Shammas SL,Rogers JM,Browning S,Yang Z,Clarke J

更新日期：2012-10-30 00:00:00

abstract：:The chemical speciation of arsenic in sediments and porewaters of aquifers is the critical factor that determines whether dissolved arsenic accumulates to potentially toxic levels. Sequestration of arsenic in solid phases, which may occur by adsorption or precipitation processes, controls dissolved concentrations. We ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Day PA,Vlassopoulos D,Root R,Rivera N

更新日期：2004-09-21 00:00:00

abstract：:We present an adaptation of the hydroxyl radical DNA "footprinting" technique that permits high-resolution mapping of protected regions of RNA. Hydroxyl radical cleaves RNA independently of base sequence and secondary structure of the RNAs examined and allows resolution of protected regions at the single nucleotide le...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang XD,Padgett RA

更新日期：1989-10-01 00:00:00

abstract：:Recent studies have shown that orthotopic (transurethral) transplantation of human bladder cancer cell lines into nude mice permits tumor growth that accurately reflects their clinical malignant status in the original host. Thus, such a system allows a unique opportunity to analyze the genetic events involved in the c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Theodorescu D,Cornil I,Fernandez BJ,Kerbel RS

更新日期：1990-11-01 00:00:00

abstract：:Anisotropic expansion of plant cells requires organized arrays of cortical microtubules. Mutations in microtubule-associated proteins and a particular mutation in alpha-tubulins were reported to cause abnormal microtubule arrays and result in helical growth in Arabidopsis thaliana. However, the way in which these muta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishida T,Kaneko Y,Iwano M,Hashimoto T

更新日期：2007-05-15 00:00:00

abstract：:The notion that tRNA and 5S rRNA interact through evolutionarily conserved complementary sequences has been tested by nucleolytic modification of the 5S rRNA, using the modified rRNA to reconstitute the large ribosomal subunit, and assaying for poly(uridylic acid)-directed polyphenylalanine synthesis. The 5S rRNA sequ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pace B,Matthews EA,Johnson KD,Cantor CR,Pace NR

更新日期：1982-01-01 00:00:00

abstract：:The Escherichia coli gene encoding protein n' has been isolated and named priA for primosomal protein A. Protein n' is absolutely required for the conversion of single-stranded phi X174 DNA to the duplex replicative form in an in vitro-reconstituted system. The gene maps to 88.7 minutes on the chromosome adjacent to t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee EH,Masai H,Allen GC Jr,Kornberg A

更新日期：1990-06-01 00:00:00

abstract：:It has long been recognized that a suite of proteins exists in coral skeletons that is critical for the oriented precipitation of calcium carbonate crystals, yet these proteins remain poorly characterized. Using liquid chromatography-tandem mass spectrometry analysis of proteins extracted from the cell-free skeleton o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Drake JL,Mass T,Haramaty L,Zelzion E,Bhattacharya D,Falkowski PG

更新日期：2013-03-05 00:00:00

abstract：:We stabilize nematic droplets with handles against surface tension-driven instabilities, using a yield-stress material as outer fluid, and study the complex nematic textures and defect structures that result from the competition between topological constraints and the elasticity of the nematic liquid crystal. We uncov...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pairam E,Vallamkondu J,Koning V,van Zuiden BC,Ellis PW,Bates MA,Vitelli V,Fernandez-Nieves A

更新日期：2013-06-04 00:00:00

abstract：:TP53 (p53) is a tumor suppressor whose functions are lost or altered in most malignancies. p53 homozygous knockout (p53-/-) mice uniformly die of spontaneous malignancy, typically T-cell lymphoma. RALBP1 (RLIP76, Rlip) is a stress-protective, mercapturic acid pathway transporter protein that also functions as a Ral ef...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Awasthi S,Tompkins J,Singhal J,Riggs AD,Yadav S,Wu X,Singh S,Warden C,Liu Z,Wang J,Slavin TP,Weitzel JN,Yuan YC,Awasthi M,Srivastava SK,Awasthi YC,Singhal SS

更新日期：2018-04-10 00:00:00

abstract：:Vertebrate primary cilium is a Hedgehog signaling center but the extent of its involvement in other signaling systems is less well understood. This report delineates a mechanism by which fibroblast growth factor (FGF) controls primary cilia. Employing proteomic approaches to characterize proteins associated with the F...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kunova Bosakova M,Nita A,Gregor T,Varecha M,Gudernova I,Fafilek B,Barta T,Basheer N,Abraham SP,Balek L,Tomanova M,Fialova Kucerova J,Bosak J,Potesil D,Zieba J,Song J,Konik P,Park S,Duran I,Zdrahal Z,Smajs D,Jans

更新日期：2019-03-05 00:00:00

abstract：:Galectin-3 is a glycan-binding protein (GBP) that binds β-galactoside glycan structures to orchestrate a variety of important biological events, including the activation of hepatic stellate cells and regulation of immune responses. While the requisite glycan epitopes needed to bind galectin-3 have long been elucidated...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Joeh E,O'Leary T,Li W,Hawkins R,Hung JR,Parker CG,Huang ML

更新日期：2020-11-03 00:00:00

abstract：:X-ray structures of bovine heart cytochrome c oxidase have suggested that the enzyme, which reduces O(2) in a process coupled with a proton pumping process, contains a proton pumping pathway (H-pathway) composed of a hydrogen bond network and a water channel located in tandem across the enzyme. The hydrogen bond netwo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shimokata K,Katayama Y,Murayama H,Suematsu M,Tsukihara T,Muramoto K,Aoyama H,Yoshikawa S,Shimada H

更新日期：2007-03-06 00:00:00

abstract：:The stress inoculation hypothesis presupposes that brief intermittent stress exposure early in life induces the development of subsequent stress resistance in human and nonhuman primates. Rodent studies, however, suggest a role for maternal care rather than stress exposure per se (i.e., the maternal mediation hypothes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parker KJ,Buckmaster CL,Sundlass K,Schatzberg AF,Lyons DM

更新日期：2006-02-21 00:00:00

abstract：:Freshwater planarian flatworms are capable of regenerating complete organisms from tiny fragments of their bodies; the basis for this regenerative prowess is an experimentally accessible stem cell population that is present in the adult planarian. The study of these organisms, classic experimental models for investiga...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Newmark PA,Reddien PW,Cebrià F,Sánchez Alvarado A

更新日期：2003-09-30 00:00:00