Integrated spatial electron populations in molecules: The electron projection function.

abstract：:Xenopus laevis oocytes were injected with poly(A)+-mRNA isolated from chorionating follicular epithelium of the domesticated silk moth (Bombyx mori). On two-dimensional gel electrophoresis, the resultant translation products comigrated with authentic, secreted, chorion standards, demonstrating that the frog oocyte sys...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bock SC,Tiemeier DC,Mester K,Wu M,Goldsmith MR

更新日期：1982-02-01 00:00:00

abstract：:Orchids employing sexual deceit attract males of their pollinator species through specific volatile signals that mimic female-released sex pheromones. One of these signals proved to be 2-ethyl-5-propylcyclohexan-1,3-dione (chiloglottone1), a new natural product that was shown to be most important in the relations betw...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Franke S,Ibarra F,Schulz CM,Twele R,Poldy J,Barrow RA,Peakall R,Schiestl FP,Francke W

更新日期：2009-06-02 00:00:00

abstract：:Pheromone biosynthesis-activating neuropeptide (PBAN) regulates sex pheromone biosynthesis in female Helicoverpa (Heliothis) zea. Two oligonucleotide probes representing two overlapping amino acid regions of PBAN were used to screen 2.5 x 10(5) recombinant plaques, and a positive recombinant clone was isolated. Sequen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davis MT,Vakharia VN,Henry J,Kempe TG,Raina AK

更新日期：1992-01-01 00:00:00

abstract：:Caenorhabditis elegans sqv mutants are defective in vulval epithelial invagination and have a severe reduction in hermaphrodite fertility. The gene sqv-7 encodes a multitransmembrane hydrophobic protein resembling nucleotide sugar transporters of the Golgi membrane. A Golgi vesicle enriched fraction of Saccharomyces c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berninsone P,Hwang HY,Zemtseva I,Horvitz HR,Hirschberg CB

更新日期：2001-03-27 00:00:00

abstract：:We recently have shown that mice deficient for the 86-kDa component (Ku80) of the DNA-dependent protein kinase exhibit growth retardation and a profound deficiency in V(D)J (variable, diversity, and joining) recombination. These defects may be related to abnormalities in DNA metabolism that arise from the inability of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nussenzweig A,Sokol K,Burgman P,Li L,Li GC

更新日期：1997-12-09 00:00:00

abstract：:Protein 4.1R (4.1R) is a multifunctional component of the red cell membrane. It forms a ternary complex with actin and spectrin, which defines the nodal junctions of the membrane-skeletal network, and its attachment to the transmembrane protein glycophorin C creates a bridge between the protein network and the membran...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Salomao M,Zhang X,Yang Y,Lee S,Hartwig JH,Chasis JA,Mohandas N,An X

更新日期：2008-06-10 00:00:00

abstract：:Plasmodium parasites must complete development in the mosquito vector for transmission to occur. The mosquito innate immune response is remarkably efficient in limiting parasite numbers. Previous work has identified a LPS-induced TNFα transcription factor (LITAF)-like transcription factor, LITAF-like 3 (LL3), which si...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith RC,Barillas-Mury C,Jacobs-Lorena M

更新日期：2015-06-30 00:00:00

abstract：:It is commonly accepted that some of the latest dates for Neanderthal fossils and Mousterian industries are found south of the Ebro valley in Iberia at ca. 36 ka calBP (calibrated radiocarbon date ranges). In contrast, to the north of the valley the Mousterian disappears shortly before the Proto-Aurignacian appears at...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wood RE,Barroso-Ruíz C,Caparrós M,Jordá Pardo JF,Galván Santos B,Higham TF

更新日期：2013-02-19 00:00:00

abstract：:The antitumor effect of doxorubicin (DOX) conjugated to a biodegradable dendrimer was evaluated in mice bearing C-26 colon carcinomas. An asymmetric biodegradable polyester dendrimer containing 8-10 wt % DOX was prepared. The design of the dendrimer carrier optimized blood circulation time through size and molecular a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee CC,Gillies ER,Fox ME,Guillaudeu SJ,Fréchet JM,Dy EE,Szoka FC

更新日期：2006-11-07 00:00:00

abstract：:We applied an innovation framework to sustainable livestock development research projects in Africa and Asia. The focus of these projects ranged from pastoral systems to poverty and ecosystems services mapping to market access by the poor to fodder and natural resource management to livestock parasite drug resistance....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kristjanson P,Reid RS,Dickson N,Clark WC,Romney D,Puskur R,Macmillan S,Grace D

更新日期：2009-03-31 00:00:00

abstract：:To address the significance of human immunodeficiency virus (HIV) replication in peripheral blood mononuclear cells (PBMCs), we have used reverse transcriptase-initiated PCR to measure HIV-1 mRNA expression in PBMC specimens collected from a cohort of HIV-infected individuals during a long-term prospective study. We f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saksela K,Stevens C,Rubinstein P,Baltimore D

更新日期：1994-02-01 00:00:00

abstract：:LMB-7 [B3(Fv)-PE38] is a single-chain immunotoxin constructed from the murine monoclonal antibody B3 and a truncated from of Pseudomonas exotoxin PE38. Antibody B3 recognizes a carbohydrate epitope found on solid tumors that frequently invade the intrathecal space and cause neoplastic meningitis. We tested the therape...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pastan IH,Archer GE,McLendon RE,Friedman HS,Fuchs HE,Wang QC,Pai LH,Herndon J,Bigner DD

更新日期：1995-03-28 00:00:00

abstract：:We partially purified a preparation from Escherichia coli that proteolytically degrades the enzyme glutamine synthetase [L-glutamate:ammonia ligase (ADP-forming), EC 6.3.1.2]. The degradation is at least a two-step process. First, the glutamine synthetase undergoes an oxidative modification. This modification leads to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levine RL,Oliver CN,Fulks RM,Stadtman ER

更新日期：1981-04-01 00:00:00

abstract：:Reproducible quantification of large biological cohorts is critical for clinical/pharmaceutical proteomics yet remains challenging because most prevalent methods suffer from drastically declined commonly quantified proteins and substantially deteriorated quantitative quality as cohort size expands. MS2-based data-inde...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shen X,Shen S,Li J,Hu Q,Nie L,Tu C,Wang X,Poulsen DJ,Orsburn BC,Wang J,Qu J

更新日期：2018-05-22 00:00:00

abstract：:Epstein-Barr virus (EBV) latent infection membrane protein 1 (LMP1)-induced NF-kappaB activation is important for infected cell survival. LMP1 activates NF-kappaB, in part, by engaging tumor necrosis factor (TNF) receptor-associated factors (TRAFs), which also mediate NF-kappaB activation from LTbetaR and CD40. LTbeta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luftig M,Yasui T,Soni V,Kang MS,Jacobson N,Cahir-McFarland E,Seed B,Kieff E

更新日期：2004-01-06 00:00:00

abstract：:Seed development in plants involves the coordinated growth of the embryo, endosperm, and maternal tissue. Several genes have been identified that influence seed size by acting maternally, such as AUXIN RESPONSE FACTOR2, APETALA2, and DA1. However, given the lack of gain-of-function effects of these genes on seed size,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Adamski NM,Anastasiou E,Eriksson S,O'Neill CM,Lenhard M

更新日期：2009-11-24 00:00:00

abstract：:In rodent models of Parkinson disease in which transplants of dissociated rodent and human embryonic mesencephalic tissue, rich in dopamine neurons, have been studied, only 5-20% of the dopamine neurons survive the implantation procedure. We have investigated the effects of inhibiting free radical generation with two ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakao N,Frodl EM,Duan WM,Widner H,Brundin P

更新日期：1994-12-20 00:00:00

abstract：:The mechanism of nuclear DNA replication in radicles of germinating cotton (Gossypium barbadense) was investigated. Pulse-labeling with [(3)H]thymidine indicates that replication intermediates are of small molecular weight (4-10S) and behave as if single-stranded. Prolonged labeling indicates that intermediates are of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clay WF,Bartels PG,Katterman FR

更新日期：1976-09-01 00:00:00

abstract：:The complex cooperative behavior exhibited by wild chimpanzees generates considerable theoretical and empirical interest, yet we know very little about the mechanisms responsible for its evolution. Here, we investigate the influence of kinship on the cooperative behavior of male chimpanzees living in an unusually larg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Langergraber KE,Mitani JC,Vigilant L

更新日期：2007-05-08 00:00:00

abstract：:Examination of old human lenses indicates that low-molecular-weight alpha crystallin is not present in the inner 30-40%, the nucleus, of the lens. The remainder of such lenses, the periphery, contains normal levels of this protein. This finding is in marked contrast to observations in young lenses, where a large quant...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roy D,Spector A

更新日期：1976-10-01 00:00:00

abstract：:Extended defects are known to have critical influences in achieving desired material performance. However, the nature of extended defect generation is highly elusive due to the presence of multiple nucleation mechanisms with close energetics. A strategy to design extended defects in a simple and clean way is thus high...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Z,Guo H,Shao S,Saghayezhian M,Li J,Fittipaldi R,Vecchione A,Siwakoti P,Zhu Y,Zhang J,Plummer EW

更新日期：2018-09-18 00:00:00

abstract：:A Chinese hamster ovary cell (CHO) mutant (strain 58), defective in CDP-choline synthetase (cholinephosphate cytidylyltransferase; CTP:cholinephosphate cytidylyltransferase, EC 2.7.7.15), is temperature sensitive for growth and contains less than half of the normal amount of phosphatidylcholine under nonpermissive con...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Esko JD,Nishijima M,Raetz CR

更新日期：1982-03-01 00:00:00

abstract：:Corticotropin (ACTH) and melanotropin (MSH) peptides (melanocortins) are produced not only in the pituitary but also in the brain, with highest concentrations in the arcuate nucleus of the hypothalamus and the commisural nucleus of the solitary tract. We have identified a receptor for MSH and ACTH peptides that is spe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roselli-Rehfuss L,Mountjoy KG,Robbins LS,Mortrud MT,Low MJ,Tatro JB,Entwistle ML,Simerly RB,Cone RD

更新日期：1993-10-01 00:00:00

abstract：:The global prevalence of prediabetes and type 2 diabetes (T2D) is increasing, and it is contributing to the susceptibility to diabetes and its related epidemic in offspring. Although the impacts of paternal impaired fasting blood glucose and glucose intolerance on the metabolism of offspring have been well established...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wei Y,Yang CR,Wei YP,Zhao ZA,Hou Y,Schatten H,Sun QY

更新日期：2014-02-04 00:00:00

abstract：:The hetR gene plays a very important role in cell differentiation of heterocystous cyanobacteria. To understand the mechanism of the hetR gene product in regulation of heterocyst differentiation, the recombinant HetR protein (rHetR) was overproduced in Escherichia coli. Purified rHetR was unstable and degraded easily ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou R,Wei X,Jiang N,Li H,Dong Y,Hsi KL,Zhao J

更新日期：1998-04-28 00:00:00

abstract：:The core protein of a small chondroitin/dermatan sulfate proteoglycan expressed by human fibroblasts and present in extracellular matrices in association with collagen has been cloned from a lambda gt11 fibroblast cDNA library. cDNA clones were isolated by use of antibodies specific for the intact proteoglycan and ant...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krusius T,Ruoslahti E

更新日期：1986-10-01 00:00:00

abstract：:The photoproduct of carbon monoxide myoglobin generated at 4 K and lower has a resonance Raman spectrum characteristic of a high-spin heme but in which the high-frequency core size-sensitive lines are at lower frequency than those in the deoxy preparation. Such differences are not detected in the photoproduct generate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rousseau DL,Argade PV

更新日期：1986-03-01 00:00:00

abstract：:The sense of body ownership represents a fundamental aspect of our self-awareness, but is disrupted in many neurological, psychiatric, and psychological conditions that are also characterized by disruption of skin temperature regulation, sometimes in a single limb. We hypothesized that skin temperature in a specific l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moseley GL,Olthof N,Venema A,Don S,Wijers M,Gallace A,Spence C

更新日期：2008-09-02 00:00:00

abstract：:ALS is a terminal disease of motor neurons that is characterized by accumulation of proteinaceous deposits in affected cells. Pathological deposition of mutated Cu/Zn superoxide dismutase (SOD1) accounts for ∼20% of the familial ALS (fALS) cases. However, understanding the molecular link between mutation and disease h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ivanova MI,Sievers SA,Guenther EL,Johnson LM,Winkler DD,Galaleldeen A,Sawaya MR,Hart PJ,Eisenberg DS

更新日期：2014-01-07 00:00:00

abstract：:Tumor necrosis factor (TNF) is a macrophage product under active study as an anticancer drug. However, this agent can be very toxic and has been implicated in the pathogenesis of endotoxic shock. After intravenous injection of human recombinant TNF (4 micrograms/g), growing rats showed an unusual constellation of phys...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kettelhut IC,Fiers W,Goldberg AL

更新日期：1987-06-01 00:00:00