Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: the effects of ionizing radiation on growth, survival, and development.

abstract：:We have developed a homologous in vitro transcription system that requires (i) 2,3,7,8-tetrachlorodibenzo-p-dioxin (called TCDD or dioxin), (ii) the Ah receptor, and (iii) a dioxin-responsive enhancer for activity. Unfractionated nuclear extracts from mouse hepatoma cells contain an inhibitor and fail to direct transc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wen LP,Koeiman N,Whitlock JP Jr

更新日期：1990-11-01 00:00:00

abstract：:Humans speak, monkeys grunt, and ducks quack. How do we come to know which vocalizations animals produce? Here we explore this question by asking whether young infants expect humans, but not other animals, to produce speech, and further, whether infants have similarly restricted expectations about the sources of vocal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vouloumanos A,Druhen MJ,Hauser MD,Huizink AT

更新日期：2009-11-03 00:00:00

abstract：:Certain complex phenotypes appear repeatedly across diverse species due to processes of evolutionary conservation and convergence. In some contexts like developmental body patterning, there is increased appreciation that common molecular mechanisms underlie common phenotypes; these molecular mechanisms include highly ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rittschof CC,Bukhari SA,Sloofman LG,Troy JM,Caetano-Anollés D,Cash-Ahmed A,Kent M,Lu X,Sanogo YO,Weisner PA,Zhang H,Bell AM,Ma J,Sinha S,Robinson GE,Stubbs L

更新日期：2014-12-16 00:00:00

abstract：:Colloidal and sol-gel procedures have been used to prepare heterogeneous catalysts consisting of platinum metal particles with narrow size distributions and well defined shapes dispersed on high-surface-area silica supports. The overall procedure was developed in three stages. First, tetrahedral and cubic colloidal me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee I,Morales R,Albiter MA,Zaera F

更新日期：2008-10-07 00:00:00

abstract：:The influence of speech production on speech perception is well established in adults. However, because adults have a long history of both perceiving and producing speech, the extent to which the perception-production linkage is due to experience is unknown. We addressed this issue by asking whether articulatory confi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bruderer AG,Danielson DK,Kandhadai P,Werker JF

更新日期：2015-11-03 00:00:00

abstract：:The aldosterone-induced augmentation of Na+ transport in toad bladder was analyzed by comparing the hormonal actions on the transepithelial short-circuit current and on the amiloride-sensitive 22Na+ uptake in isolated membrane vesicles. Incubating bladders with 0.5 microM aldosterone for 3 hr evoked more than a 2-fold...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Asher C,Garty H

更新日期：1988-10-01 00:00:00

abstract：:Androgen receptor (AR) target genes direct development and survival of the prostate epithelial lineage, including prostate cancer (PCa). Thus, endocrine therapies that inhibit the AR ligand-binding domain (LBD) are effective in treating PCa. AR transcriptional reactivation is central to resistance, as evidenced by the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nyquist MD,Li Y,Hwang TH,Manlove LS,Vessella RL,Silverstein KA,Voytas DF,Dehm SM

更新日期：2013-10-22 00:00:00

abstract：:We have identified a major T-cell epitope, amino acids 48-54 (DRAHYNI, in one-letter code) in the E7 open reading frame protein of human papillomavirus (HPV) type 16. Lymph node cells from mice immunized with synthetic peptides containing DRAHYNI proliferated and produced interleukin when challenged in vitro with pept...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tindle RW,Fernando GJ,Sterling JC,Frazer IH

更新日期：1991-07-01 00:00:00

abstract：:By Southern blotting and hybridization analysis using 32P-labeled poly(dT-dG) . poly(dC-dA) as a probe, we have found, in eukaryotic genomes, a huge number of stretches of dT-dG alternating sequence, a sequence that has been shown to adopt the Z-DNA conformation under some conditions. This sequence was found in all eu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hamada H,Petrino MG,Kakunaga T

更新日期：1982-11-01 00:00:00

abstract：:Microstructural, δ(13)C isotope and C/N ratio investigations were conducted on excavated material from the black Younger Dryas boundary in Lommel, Belgium, aiming for a characterisation of the carbon content and structures. Cubic diamond nanoparticles are found in large numbers. The larger ones with diameters around o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tian H,Schryvers D,Claeys P

更新日期：2011-01-04 00:00:00

abstract：:Cleavage of the hemagglutinin (HA) in tissue culture systems has been correlated with virulence of avian influenza viruses. To examine the structural requirements for cleavage of the HA, the HA gene from a virulent H5 influenza virus was expressed in mammalian cells (CV-1), and the cleavage site of the HA was explored...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kawaoka Y,Webster RG

更新日期：1988-01-01 00:00:00

abstract：:The central questions of bacterial ecology and evolution require a method to consistently demarcate, from the vast and diverse set of bacterial cells within a natural community, the groups playing ecologically distinct roles (ecotypes). Because of a lack of theory-based guidelines, current methods in bacterial systema...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koeppel A,Perry EB,Sikorski J,Krizanc D,Warner A,Ward DM,Rooney AP,Brambilla E,Connor N,Ratcliff RM,Nevo E,Cohan FM

更新日期：2008-02-19 00:00:00

abstract：:Addition of a 0.5 M KCl wash fraction from rabbit reticulocyte ribosomes causes a 3- to 10-fold increase in the extent of translation of natural mRNAs by Krebs-cell lysates. In the presence of the wash fraction, 1 pmol of rabbit or mouse 10S RNA directs the incorporation of 80 pmol of leucine into rabbit globin. The a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Metafora S,Terada M,Dow LW,Marks PA,Bank A

更新日期：1972-05-01 00:00:00

abstract：:Pathogen exit is a key stage in the spread and propagation of infectious disease, with the fecal-oral route being a common mode of disease transmission. However, it is poorly understood which molecular pathways provide the major modes for intracellular pathogen exit and fecal-oral transmission in vivo. Here, we use th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Szumowski SC,Botts MR,Popovich JJ,Smelkinson MG,Troemel ER

更新日期：2014-06-03 00:00:00

abstract：:Developmental and physiological responses are regulated by light throughout the entire life cycle of higher plants. To sense changes in the light environment, plants have developed various photoreceptors, including the red/far-red light-absorbing phytochromes and blue light-absorbing cryptochromes. A wide variety of p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bognár LK,Hall A,Adám E,Thain SC,Nagy F,Millar AJ

更新日期：1999-12-07 00:00:00

abstract：:An expression for the equilibrium of the mean phenotypic value of a quantitative character is derived for a model in which the fitness of an individual depends on its own phenotype and the mean phenotypic value of a group of related individuals. When selection is weak the equilibrium mean is well predicted by Hamilton...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boyd R,Richerson PJ

更新日期：1980-12-01 00:00:00

abstract：:Small noncoding microRNAs (miRNAs) can contribute to cancer development and progression and are differentially expressed in normal tissues and cancers. From a large-scale miRnome analysis on 540 samples including lung, breast, stomach, prostate, colon, and pancreatic tumors, we identified a solid cancer miRNA signatur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Volinia S,Calin GA,Liu CG,Ambs S,Cimmino A,Petrocca F,Visone R,Iorio M,Roldo C,Ferracin M,Prueitt RL,Yanaihara N,Lanza G,Scarpa A,Vecchione A,Negrini M,Harris CC,Croce CM

更新日期：2006-02-14 00:00:00

abstract：:The nucleus accumbens (NAc) regulates motivated behavior by, in part, processing excitatory synaptic projections from several brain regions. Among these regions, the prefrontal cortex (PFC) and basolateral amygdala, convey executive control and affective states, respectively. Whereas glutamatergic synaptic transmissio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suska A,Lee BR,Huang YH,Dong Y,Schlüter OM

更新日期：2013-01-08 00:00:00

abstract：:Exposure of cholera toxin to membrane particles prepared from sarcoma 180 cells gives rise to a variety of fragments which are capable of activating adenylate cyclase [ATP:pyrophosphate-lyase (cyclizing), EC 4.6.1.1]. A major component of these fragments has an apparent molecular weight in the 8,000-10,000 range. The ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matuo Y,Wheeler MA,Bitensky MW

更新日期：1976-08-01 00:00:00

abstract：:Transgenic mice harboring the int-2/Fgf-3 protooncogene under transcriptional control of the mouse mammary tumor virus (MMTV) promoter/enhancer exhibit a dramatic, benign hyperplasia of the mammary gland. In one int-2 transgenic line (TG.NX), this growth disturbance is evoked by pregnancy and regresses after parturiti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee FS,Lane TF,Kuo A,Shackleford GM,Leder P

更新日期：1995-03-14 00:00:00

abstract：:The enormous complexity of biological networks has led to the suggestion that networks are built of modules that perform particular functions and are "reused" in evolution in a manner similar to reusable domains in protein structures or modules of electronic circuits. Analysis of known biological networks has revealed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spirin V,Gelfand MS,Mironov AA,Mirny LA

更新日期：2006-06-06 00:00:00

abstract：:We have recently discovered that cationic cholesterol derivatives characterized by guanidinium polar headgroups are very efficient for gene transfection in vitro and in vivo. In spite of being based on some rationale at the molecular level, the development of these new synthetic vectors was nevertheless empirical. Ind...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pitard B,Oudrhiri N,Vigneron JP,Hauchecorne M,Aguerre O,Toury R,Airiau M,Ramasawmy R,Scherman D,Crouzet J,Lehn JM,Lehn P

更新日期：1999-03-16 00:00:00

abstract：:Phycobilisomes isolated from eight different species of cyanobacteria contain in addition to the light-harvesting phycobiliproteins, a small number of colorless polypeptides with molecular weights higher than those of the chromopolypeptide subunits of the phycobiliproteins. In the phycobilisomes of the species examin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de Marsac NT,Cohen-bazire G

更新日期：1977-04-01 00:00:00

abstract：:Recently, a 29-residue cyclic peptide was synthesized (TrPepz) that was reported to possess nearly the same catalytic activity and specificity as the pancreatic serine protease, trypsin, for hydrolysis of a small ester substrate, N-tosyl-L-arginine methyl ester (TAME), and small and large peptides [Atassi, M. Z. & Man...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wells JA,Fairbrother WJ,Otlewski J,Laskowski M Jr,Burnier J

更新日期：1994-05-10 00:00:00

abstract：:The Escherichia coli cytosolic homotetrameric protein SecB is known to be involved in protein export across the plasma membrane. A currently prevalent view holds that SecB functions exclusively as a chaperone interacting nonspecifically with unfolded proteins, not necessarily exported proteins, whereas a contrary view...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watanabe M,Blobel G

更新日期：1995-10-24 00:00:00

abstract：:We have studied the effect of the cholinergic agonist carbachol on the spontaneous release of glutamate in cultured rat hippocampal cells. Spontaneous excitatory postsynaptic currents (sEPSCs) through glutamatergic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type channels were recorded by means of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bouron A,Reuter H

更新日期：1997-10-28 00:00:00

abstract：:Chromatin becomes reorganized during mitosis each cell cycle. To identify genes potentially involved in these supramolecular events, we have used a colony-color assay to screen temperature-sensitive mutants of Saccharomyces cerevisiae. When a sequence that mediates attachment to the nuclear matrix in vitro was inserte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fishel BR,Sperry AO,Garrard WT

更新日期：1993-06-15 00:00:00

abstract：:We show in climate model experiments that large-scale afforestation in northern mid-latitudes warms the Northern Hemisphere and alters global circulation patterns. An expansion of dark forests increases the absorption of solar energy and increases surface temperature, particularly in regions where the land surface is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Swann AL,Fung IY,Chiang JC

更新日期：2012-01-17 00:00:00

abstract：:The successful treatment of cancer by boron neutron-capture therapy (BNCT) requires the selective concentration of boron-10 within malignant tumors. The potential of liposomes to deliver boron-rich compounds to tumors has been assessed by the examination of the biodistribution of boron delivered by liposomes in tumor-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shelly K,Feakes DA,Hawthorne MF,Schmidt PG,Krisch TA,Bauer WF

更新日期：1992-10-01 00:00:00

abstract：:G proteins are activated when they associate with G protein-coupled receptors (GPCRs), often in response to agonist-mediated receptor activation. It is generally thought that agonist-induced receptor-G protein association necessarily promotes G protein activation and, conversely, that activated GPCRs do not interact w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okashah N,Wright SC,Kawakami K,Mathiasen S,Zhou J,Lu S,Javitch JA,Inoue A,Bouvier M,Lambert NA

更新日期：2020-09-01 00:00:00