An analysis of the gene expression program of mammalian neural progenitor cells.

abstract：:Despite substantial evidence that nitric oxide (NO) and/or endogenous S-nitrosothiols (SNOs) exert protective effects in a variety of cardiovascular diseases, the molecular details are largely unknown. Here we show that following left coronary artery ligation, mice with a targeted deletion of the S-nitrosoglutathione ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lima B,Lam GK,Xie L,Diesen DL,Villamizar N,Nienaber J,Messina E,Bowles D,Kontos CD,Hare JM,Stamler JS,Rockman HA

更新日期：2009-04-14 00:00:00

abstract：:Immune function is an energetically costly physiological activity that potentially diverts calories away from less immediately essential life tasks. Among developing organisms, the allocation of energy toward immune function may lead to tradeoffs with physical growth, particularly in high-pathogen, low-resource enviro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Urlacher SS,Ellison PT,Sugiyama LS,Pontzer H,Eick G,Liebert MA,Cepon-Robins TJ,Gildner TE,Snodgrass JJ

更新日期：2018-04-24 00:00:00

abstract：:How do firing patterns in a cortical circuit change when inhibitory neurons are excited? We virally expressed an excitatory designer receptor exclusively activated by a designer drug (Gq-DREADD) in all inhibitory interneuron types of the CA1 region of the hippocampus in the rat. While clozapine N-oxide (CNO) activatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rogers S,Rozman PA,Valero M,Doyle WK,Buzsáki G

更新日期：2021-01-12 00:00:00

abstract：:We have examined the effect of diphtheria toxin, Pseudomonas aeruginosa exotoxin A, and cycloheximide on the CV-1 cell cytoskeleton. Within a few hours after producing an inhibition of cellular protein synthesis, all these agents specifically disrupted the organization of the vimentin filament system with no discernab...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharpe AH,Chen LB,Murphy JR,Fields BN

更新日期：1980-12-01 00:00:00

abstract：:Like many physiological ligands, several viruses and toxins enter mammalian cells through receptor-mediated endocytosis. Once internalized, the nucleic acids of several viruses and the toxic subunit of diphtheria toxin gain access to the cytosol of the host cell through an acidic intracellular compartment. In this rep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Merion M,Schlesinger P,Brooks RM,Moehring JM,Moehring TJ,Sly WS

更新日期：1983-09-01 00:00:00

abstract：:Realizing the goal of the Paris Agreement to limit global warming to 2 °C by the end of this century will most likely require deployment of carbon-negative technologies. It is particularly important that China, as the world's top carbon emitter, avoids being locked into carbon-intensive, coal-fired power-generation te...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu X,Cao L,Wang H,Peng W,Xing J,Wang S,Cai S,Shen B,Yang Q,Nielsen CP,McElroy MB

更新日期：2019-04-23 00:00:00

abstract：:Human gene MAGE-1 encodes tumor-specific antigens that are recognized on melanoma cells by autologous cytolytic T lymphocytes. This gene is expressed in a significant proportion of tumors of various histological types, but not in normal tissues except male germ-line cells. We reported previously that reporter genes dr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Smet C,De Backer O,Faraoni I,Lurquin C,Brasseur F,Boon T

更新日期：1996-07-09 00:00:00

abstract：:Neurofibromin gene (NF1) mutation causes neurofibromatosis type 1 (NF1), a disorder in which brain white matter deficits identified by neuroimaging are common, yet of unknown cellular etiology. In mice, Nf1 loss in adult oligodendrocytes causes myelin decompaction and increases oligodendrocyte nitric oxide (NO) levels...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Asleh J,Shofty B,Cohen N,Kavushansky A,López-Juárez A,Constantini S,Ratner N,Kahn I

更新日期：2020-09-08 00:00:00

abstract：:In the majority of human tumors, expression of the c-MYC oncogene becomes constitutive. Here, we report that c-MYC directly regulates the expression of AP4 via CACGTG motifs in the first intron of the AP4 gene. Induction of AP4 was required for c-MYC-mediated cell cycle reentry of anti-estrogen arrested breast cancer ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jung P,Menssen A,Mayr D,Hermeking H

更新日期：2008-09-30 00:00:00

abstract：:The extent to which stratospheric intrusions on synoptic scales influence the tropospheric ozone (O3) levels remains poorly understood, because quantitative detection of stratospheric air has been challenging. Cosmogenic 35S mainly produced in the stratosphere has the potential to identify stratospheric air masses at ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin M,Su L,Shaheen R,Fung JC,Thiemens MH

更新日期：2016-10-04 00:00:00

abstract：:Perception and cognition in infants have been traditionally investigated using habituation paradigms, assuming that babies' memories in laboratory contexts are best constructed after numerous repetitions of the very same stimulus in the absence of interference. A crucial, yet open, question regards how babies deal wit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benavides-Varela S,Siugzdaite R,Gómez DM,Macagno F,Cattarossi L,Mehler J

更新日期：2017-07-18 00:00:00

abstract：:A chimeric mouse-human antibody has been created that recognizes an antigen found on the surface of cells from many carcinomas. Immunoglobulin constant (C) domains of the mouse monoclonal antibody L6, C gamma 2a and C kappa, were substituted by the human C gamma 1 and C kappa by recombining cDNA modules encoding varia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu AY,Robinson RR,Hellström KE,Murray ED Jr,Chang CP,Hellström I

更新日期：1987-05-01 00:00:00

abstract：:Multiplex assays, involving the simultaneous use of multiple circulating tumor DNA (ctDNA) markers, can improve the performance of liquid biopsies so that they are highly predictive of cancer recurrence. We have developed a single-tube methylation-specific quantitative PCR assay (mqMSP) that uses 10 different methylat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jin S,Zhu D,Shao F,Chen S,Guo Y,Li K,Wang Y,Ding R,Gao L,Ma W,Lu T,Li D,Zhang Z,Cai S,Liang X,Song H,Ji L,Li J,Zheng Z,Jiang F,Wu X,Luan J,Zhang H,Yang Z,Cantor CR,Xu C,Ding C

更新日期：2021-02-02 00:00:00

abstract：:Macrophage migration inhibition factor (MIF) is one of a class of lymphocyte-derived mediator substances (lymphokines) which plays a role in the mechanism of cellular immunity. A variety of other soluble factors produced by non-lymphoid cells have been shown to have effects on macrophage mobility similar to that of MI...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yoshida T,Bigazzi P,Cohen S

更新日期：1975-04-01 00:00:00

abstract：:We report here studies of tryptophan (Trp) solvation dynamics in water and in the Pyrococcus furiosus rubredoxin protein, including the native and its apo and denatured forms. We also report results on energy transfer from Trp to the iron-sulfur [Fe-S] cluster. Trp fluorescence decay with the onset of solvation dynami...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhong D,Pal SK,Zhang D,Chan SI,Zewail AH

更新日期：2002-01-08 00:00:00

abstract：:HetR is an essential regulator of heterocyst development in cyanobacteria. Many mutations in HetR render Anabaena incapable of nitrogen fixation. The protein binds to a DNA palindrome upstream of hetP and other genes. We have determined the crystal structures of HetR complexed with palindromic DNA targets, 21, 23, and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim Y,Ye Z,Joachimiak G,Videau P,Young J,Hurd K,Callahan SM,Gornicki P,Zhao J,Haselkorn R,Joachimiak A

更新日期：2013-05-07 00:00:00

abstract：:Amino acid residues that are critical in maintaining the framework structure of immunoglobulin heavy- and light-chain variable (V) regions are strongly conserved in the V alpha and V beta proteins of the alpha beta T-cell antigen receptor (TCR alpha beta). Consequently, it has been proposed that TCR alpha beta has a c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gahm SJ,Fowlkes BJ,Jameson SC,Gascoigne NR,Cotterman MM,Kanagawa O,Schwartz RH,Matis LA

更新日期：1991-11-15 00:00:00

abstract：:Granulocyte-colony stimulating factor (G-CSF) promotes mobilization of CD11b(+)Gr1(+) myeloid cells and has been implicated in resistance to anti-VEGF therapy in mouse models. High G-CSF production has been associated with a poor prognosis in cancer patients. Here we show that activation of the RAS/MEK/ERK pathway reg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Phan VT,Wu X,Cheng JH,Sheng RX,Chung AS,Zhuang G,Tran C,Song Q,Kowanetz M,Sambrone A,Tan M,Meng YG,Jackson EL,Peale FV,Junttila MR,Ferrara N

更新日期：2013-04-09 00:00:00

abstract：:Fall migratory monarch butterflies, tested for their directional responses to magnetic cues under three conditions, amagnetic, normal, and reversed magnetic fields, showed three distinct patterns. In the absence of a magnetic field, monarchs lacked directionality as a group. In the normal magnetic field, monarchs orie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Etheredge JA,Perez SM,Taylor OR,Jander R

更新日期：1999-11-23 00:00:00

abstract：:Neonates suffer high morbidity and mortality in infection, presumably because of the lack of a fully developed adaptive and innate immune system. Evidence of poor innate responses in neonates has been shown by using a model that sensitizes the host to Toll-like receptor (TLR)-mediated inflammation with d-galactosamine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao J,Kim KD,Yang X,Auh S,Fu YX,Tang H

更新日期：2008-05-27 00:00:00

abstract：:Neural crest stem cells can be isolated from differentiated cultures of human pluripotent stem cells, but the process is inefficient and requires cell sorting to obtain a highly enriched population. No specific method for directed differentiation of human pluripotent cells toward neural crest stem cells has yet been r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Menendez L,Yatskievych TA,Antin PB,Dalton S

更新日期：2011-11-29 00:00:00

abstract：:The major Hsp70 of the mitochondrial matrix (Ssc1 in yeast) is critically important for the translocation of proteins from the cytosol, across the mitochondrial inner membrane, and into the matrix. Tim44, a peripheral inner membrane protein with limited sequence similarity to the J domain of J-type cochaperones, tethe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： D'Silva PD,Schilke B,Walter W,Andrew A,Craig EA

更新日期：2003-11-25 00:00:00

abstract：:The Etruscans, the only preclassical European population that has been genetically characterized so far, share only two haplotypes with their modern geographic counterparts, the Tuscans, who, nonetheless, appear to be their closest relatives. We modeled 10 demographic scenarios spanning the last 2,500 years and tested...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Belle EM,Ramakrishnan U,Mountain JL,Barbujani G

更新日期：2006-05-23 00:00:00

abstract：:Within the trimeric HIV-1 envelope (Env) spike, the first and second variable loops (V1V2 region) and the third variable loop (V3) of the gp120 subunit play dual roles in antibody recognition, because they contain neutralization epitopes and also participate in epitope masking. The spatial relationships between V1V2 a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu L,Cimbro R,Lusso P,Berger EA

更新日期：2011-12-13 00:00:00

abstract：:Although pain is a prevalent nonmotor symptom in Parkinson's disease (PD), it is undertreated, in part because of our limited understanding of the underlying mechanisms. Considering that the basal ganglia are implicated in pain sensation, and that their synaptic outputs are controlled by the subthalamic nucleus (STN),...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luan Y,Tang D,Wu H,Gu W,Wu Y,Cao JL,Xiao C,Zhou C

更新日期：2020-05-05 00:00:00

abstract：:The influence of language familiarity upon speaker identification is well established, to such an extent that it has been argued that "Human voice recognition depends on language ability" [Perrachione TK, Del Tufo SN, Gabrieli JDE (2011) Science 333(6042):595]. However, 7-mo-old infants discriminate speakers of their ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fleming D,Giordano BL,Caldara R,Belin P

更新日期：2014-09-23 00:00:00

abstract：:Ultraviolet photosensitivity of the single-stranded forms of poly(A) and poly(dA) is compared. In contrast to poly(A), poly(dA) is rather sensitive to ultraviolet irradiation. Relatively low doses of ultraviolet light lead to characteristic changes of the ultraviolet and circular dichroism spectra of poly(dA), suggest...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pörschke D

更新日期：1973-09-01 00:00:00

abstract：:A juvenile male zebra finch, Taeniopygia guttata, kept singly with its father develops a fairly complete imitation of the father's song. The imitation is less complete when other male siblings are present, possibly because as imitation commences, model abundance increases. Here we examine the consequences of allowing ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tchernichovski O,Lints T,Mitra PP,Nottebohm F

更新日期：1999-10-26 00:00:00

abstract：:A conformational isoform of the mammalian prion protein (PrP(Sc)) is the sole component of the infectious pathogen that causes the prion diseases. We have obtained X-ray fiber diffraction patterns from infectious prions that show cross-beta diffraction: meridional intensity at 4.8 A resolution, indicating the presence...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wille H,Bian W,McDonald M,Kendall A,Colby DW,Bloch L,Ollesch J,Borovinskiy AL,Cohen FE,Prusiner SB,Stubbs G

更新日期：2009-10-06 00:00:00

abstract：:The 24-hr intracarotid infusion of plasma-treated glycyl-L-glutamine (3 microM) produced significant enhancement of the monomeric G1 and tetrameric G4 forms of acetylcholinesterase of the cat superior cervical ganglion 48 hr after denervation, in comparison with denervated, noninfused controls. No significant effect o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koelle GB,Skau KA,Thampi NS,Hymel DM,Han MS

更新日期：1988-08-01 00:00:00