当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > Oxidative capacity of muscle and mitochondria: correlation of physiological, biochemical, and morphometric characteristics.

Oxidative capacity of muscle and mitochondria: correlation of physiological, biochemical, and morphometric characteristics.

Abstract：

:The oxidative capacity of cat skeletal muscles (soleus, gracilis, and gracilis chronically stimulated for 28 days) was derived from the total mitochondrial content in the muscle, the surface area of mitochondrial inner membranes, and respiratory activities of isolated mitochondria. Mitochondrial content was estimated by standard morphometry. The surface area of mitochondrial inner membranes per unit volume of mitochondria was estimated by a stereological method. The respiratory activities of isolated mitochondria were measured biochemically, using pyruvate/malate, glutamate/malate, succinate, or cytochrome c as substrate. Structurally and functionally, mitochondria from the three muscle types showed nearly identical characteristics. Oxidative activity was dependent on substrate; with succinate, 5.8 ml of O2 per min per ml of mitochondria was the rate most likely to represent physiological conditions. Oxidative activities of 3.1 ml.min-1.ml-1 with pyruvate/malate and 14.5 ml.min-1.ml-1 with cytochrome c as substrates were theoretical lower and upper bounds. The oxidative capacity of each of the three muscles was thus in direct proportion to the total volume of mitochondria in the muscle. The respiratory capacity of isolated mitochondria was very near to the maximal oxygen uptake rate of mitochondria that is commonly estimated in intact muscles of a wide variety of animals.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Schwerzmann K,Hoppeler H,Kayar SR,Weibel ER

doi

10.1073/pnas.86.5.1583

subject

Has Abstract

pub_date

1989-03-01 00:00:00

pages

1583-7

issue

5

eissn

0027-8424

issn

1091-6490

journal_volume

86

pub_type

杂志文章

相关文献

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA文献大全
  • agr receptor mutants reveal distinct modes of inhibition by staphylococcal autoinducing peptides.

    abstract：:Through the agr quorum-sensing system, staphylococci secrete unique autoinducing peptides (AIPs) and detect their concentration via the AgrC transmembrane receptor, coordinating local bacterial population density with global changes in gene expression. Unique AIP and AgrC variants exist within and between species, and...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0807760106

    authors： Geisinger E,Muir TW,Novick RP

    更新日期：2009-01-27 00:00:00

  • Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis.

    abstract：:Insig-1 and -2 are closely related proteins of the endoplasmic reticulum (ER) that block proteolytic activation of sterol regulatory element-binding proteins (SREBPs), transcription factors that activate the synthesis of cholesterol and fatty acids in liver and other organs. When cellular cholesterol levels are high, ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0130116100

    authors： Yabe D,Komuro R,Liang G,Goldstein JL,Brown MS

    更新日期：2003-03-18 00:00:00

  • Membrane-bound MinDE complex acts as a toggle switch that drives Min oscillation coupled to cytoplasmic depletion of MinD.

    abstract：:The Escherichia coli Min system self-organizes into a cell-pole to cell-pole oscillator on the membrane to prevent divisions at the cell poles. Reconstituting the Min system on a lipid bilayer has contributed to elucidating the oscillatory mechanism. However, previous in vitro patterns were attained with protein densi...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1600644113

    authors： Vecchiarelli AG,Li M,Mizuuchi M,Hwang LC,Seol Y,Neuman KC,Mizuuchi K

    更新日期：2016-03-15 00:00:00

  • A channeled tRNA cycle during mammalian protein synthesis.

    abstract：:In earlier studies it was shown that the mammalian translation system is highly organized in vivo and that the intermediates in the process, aminoacyl-tRNAs, are channeled--i.e., they are directly transferred from the aminoacyl-tRNA synthetases to the elongation factor to the ribosomes without dissociating into the ce...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.92.16.7158

    authors： Stapulionis R,Deutscher MP

    更新日期：1995-08-01 00:00:00

  • A 40-base-pair sequence in the 3' end of the beta-actin gene regulates beta-actin mRNA transcription during myogenesis.

    abstract：:In an earlier report, evidence was presented that the down-regulation of beta-actin mRNA during myogenesis was controlled by a region 3' to the promoter of the gene. In this paper we report the location of this regulatory sequence, determined by deletion analysis and the use of chimeric genes, transfected stably into ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.85.5.1389

    authors： DePonti-Zilli L,Seiler-Tuyns A,Paterson BM

    更新日期：1988-03-01 00:00:00

  • Adenovirus-vectored vaccine containing multidimensionally conserved parts of the HIV proteome is immunogenic in rhesus macaques.

    abstract：:An effective vaccine that can protect against HIV infection does not exist. A major reason why a vaccine is not available is the high mutability of the virus, which enables it to evolve mutations that can evade human immune responses. This challenge is exacerbated by the ability of the virus to evolve compensatory mut...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.2022496118

    authors： Murakowski DK,Barton JP,Peter L,Chandrashekar A,Bondzie E,Gao A,Barouch DH,Chakraborty AK

    更新日期：2021-02-02 00:00:00

  • Prefusion structure of syntaxin-1A suggests pathway for folding into neuronal trans-SNARE complex fusion intermediate.

    abstract：:The assembly of the three neuronal soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor (SNARE) proteins synaptobrevin 2, syntaxin-1A, and SNAP-25 is the key step that leads to exocytotic fusion of synaptic vesicles. In the fully assembled SNARE complex, these three proteins form a coiled-coil ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1314699110

    authors： Liang B,Kiessling V,Tamm LK

    更新日期：2013-11-26 00:00:00

  • Stability of local rings of dimension 2.

    abstract：:The notion of stability of a local ring arises naturally in investigating completed moduli spaces via geometric invariant theory. A scheme corresponding to a boundary point of a moduli space of nonsingular varieties cannot have unstable singular points. This paper reports some results concerning the stability of surfa...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.75.9.4085

    authors： Shah J

    更新日期：1978-09-01 00:00:00

  • Cloning and characterization of a cDNA encoding the rat brain glucose-transporter protein.

    abstract：:Antibody raised against the human erythrocyte glucose transporter identified a recombinant lambda gt11 bacteriophage in a cDNA library prepared from immunoselected polysomal RNA from adult rat brain. The cDNA predicts a 492-amino acid protein that demonstrates 97.6% identity to the human hepatoma hexose carrier. The t...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.83.16.5784

    authors： Birnbaum MJ,Haspel HC,Rosen OM

    更新日期：1986-08-01 00:00:00

  • Engineering RNA sequence specificity of Pumilio repeats.

    abstract：:Puf proteins bind RNA sequence specifically and regulate translation and stability of target mRNAs. A "code" for RNA recognition has been deduced from crystal structures of the Puf protein, human Pumilio1, where each of eight repeats binds an RNA base via a combination of three side chains at conserved positions. Here...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0606294103

    authors： Cheong CG,Hall TM

    更新日期：2006-09-12 00:00:00

  • Linking genome and proteome by mass spectrometry: large-scale identification of yeast proteins from two dimensional gels.

    abstract：:The function of many of the uncharacterized open reading frames discovered by genomic sequencing can be determined at the level of expressed gene products, the proteome. However, identifying the cognate gene from minute amounts of protein has been one of the major problems in molecular biology. Using yeast as an examp...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.93.25.14440

    authors： Shevchenko A,Jensen ON,Podtelejnikov AV,Sagliocco F,Wilm M,Vorm O,Mortensen P,Shevchenko A,Boucherie H,Mann M

    更新日期：1996-12-10 00:00:00

  • L-735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor.

    abstract：:To date, numerous inhibitors of the human immunodeficiency virus type 1 protease have been reported, but few have been studied extensively in humans, primarily as a consequence of poor oral bioavailability in animal models. L-735,524 represents a class of human immunodeficiency virus type 1 protease inhibitors, termed...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.91.9.4096

    authors： Vacca JP,Dorsey BD,Schleif WA,Levin RB,McDaniel SL,Darke PL,Zugay J,Quintero JC,Blahy OM,Roth E

    更新日期：1994-04-26 00:00:00

  • Effect of phenotypic variation on kin selection.

    abstract：:An expression for the equilibrium of the mean phenotypic value of a quantitative character is derived for a model in which the fitness of an individual depends on its own phenotype and the mean phenotypic value of a group of related individuals. When selection is weak the equilibrium mean is well predicted by Hamilton...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.77.12.7506

    authors： Boyd R,Richerson PJ

    更新日期：1980-12-01 00:00:00

  • Demonstration of inter- and intraspecies differences in serotonin binding sites by antibodies from an autistic child.

    abstract：:Serotonin (5-HT) binding sites from bovine and rat cerebral cortex membranes share pharmacological properties that allow both to be subclassified by the same criteria. We show here that [3H]5-HT binding sites from human cortex also possess pharmacological properties that follow the same subclassification scheme as for...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.82.2.612

    authors： Todd RD,Ciaranello RD

    更新日期：1985-01-01 00:00:00

  • Protein kinase D1 is essential for Ras-induced senescence and tumor suppression by regulating senescence-associated inflammation.

    abstract：:Oncogene-induced senescence (OIS) is an initial barrier to tumor development. Reactive oxygen species (ROS) is critical for oncogenic Ras OIS, but the downstream effectors to mediate ROS signaling are still relatively elusive. Senescent cells develop a senescence-associated secretory phenotype (SASP). However, the mec...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1310972111

    authors： Wang P,Han L,Shen H,Wang P,Lv C,Zhao G,Niu J,Xue L,Wang QJ,Tong T,Chen J

    更新日期：2014-05-27 00:00:00

  • C NMR chemical shift correlations in application of "tool of increasing electron demand" to stable long-lived carbocations: Comprehensive evaluation.

    abstract：:The reliability of (13)C NMR chemical shift correlations in the application of the "tool of increasing electron demand" to stable long-lived carbocationic systems is demonstrated by a comprehensive analysis of 22 stable aryl-substituted carbocationic systems. The observation of slopes of less than unity in such chemic...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.78.4.1998

    authors： Olah GA,Berrier AL,Prakash GK

    更新日期：1981-04-01 00:00:00

  • Characterization of tumor necrosis factor-deficient mice.

    abstract：:Although tumor necrosis factor (TNF) initially came to prominence because of its anti-tumor activity, most attention is now focused on its proinflammatory actions. TNF appears to play a critical role in both early and late events involved in inflammation, from localizing the noxious agent and amplifying the cellular a...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.94.15.8093

    authors： Marino MW,Dunn A,Grail D,Inglese M,Noguchi Y,Richards E,Jungbluth A,Wada H,Moore M,Williamson B,Basu S,Old LJ

    更新日期：1997-07-22 00:00:00

  • Community-based conservation in a globalized world.

    abstract：:Communities have an important role to play in biodiversity conservation. However, community-based conservation as a panacea, like government-based conservation as a panacea, ignores the necessity of managing commons at multiple levels, with vertical and horizontal interplay among institutions. The study of conservatio...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0702098104

    authors： Berkes F

    更新日期：2007-09-25 00:00:00

  • Coincidence cloning of Alu PCR products.

    abstract：:Coincidence cloning allows the isolation of sequences held in common by two genomic DNA populations. Human DNA from two human-hamster hybrid cell lines was amplified by Alu-repeat primers (Alu PCR) and the products originating from the shared human chromosomal region were cloned. To achieve this, human sequences were ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.88.15.6765

    authors： Aslanidis C,de Jong PJ

    更新日期：1991-08-01 00:00:00

  • Analysis of a Drosophila amplicon in follicle cells highlights the diversity of metazoan replication origins.

    abstract：:To investigate the properties of metazoan replication origins, recent studies in cell culture have adopted the strategy of identifying origins using genome-wide approaches and assessing correlations with such features as transcription and histone modifications. Drosophila amplicon in follicle cells (DAFCs), genomic re...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1114209108

    authors： Kim JC,Orr-Weaver TL

    更新日期：2011-10-04 00:00:00

  • Rolling circle DNA replication in vitro by a complex of herpes simplex virus type 1-encoded enzymes.

    abstract：:Extracts of insect cells infected with baculoviruses recombinant for the herpes simplex virus 1 (HSV-1)-encoded enzymes that are required for its replication can promote the rolling circle replication of circular plasmid templates. Replication is independent of a HSV-1 origin of replication (oris) or the HSV-1 origin ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.91.22.10665

    authors： Skaliter R,Lehman IR

    更新日期：1994-10-25 00:00:00

  • Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formation.

    abstract：:Germinal centers (GCs) are specialized microenvironments in secondary lymphoid organs where high-affinity antibody-producing B cells are selected based on B-cell antigen receptor (BCR) signal strength. BCR signaling required for normal GC selection is uncertain. We have found that protein kinase N1 (PKN1, also known a...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1218925110

    authors： Yasui T,Sakakibara-Yada K,Nishimura T,Morita K,Tada S,Mosialos G,Kieff E,Kikutani H

    更新日期：2012-12-18 00:00:00

  • Proximity of the manganese cluster of photosystem II to the redox-active tyrosine YZ.

    abstract：:Electron spin echo electron-nuclear double resonance (ESE-ENDOR) experiments performed on a broad radical electron paramagnetic resonance (EPR) signal observed in photosystem II particles depleted of Ca2+ indicate that this signal arises from the redox-active tyrosine YZ. The tyrosine EPR signal width is increased rel...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.92.21.9545

    authors： Gilchrist ML Jr,Ball JA,Randall DW,Britt RD

    更新日期：1995-10-10 00:00:00

  • Hypoxia-activated cytotoxic agent tirapazamine enhances hepatic artery ligation-induced killing of liver tumor in HBx transgenic mice.

    abstract：:Transarterial chemoembolization (TACE) is the main treatment for intermediate stage hepatocellular carcinoma (HCC) with Barcelona Clinic Liver Cancer classification because of its exclusive arterial blood supply. Although TACE achieves substantial necrosis of the tumor, complete tumor necrosis is uncommon, and the res...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1613466113

    authors： Lin WH,Yeh SH,Yeh KH,Chen KW,Cheng YW,Su TH,Jao P,Ni LC,Chen PJ,Chen DS

    更新日期：2016-10-18 00:00:00

  • Human presence diminishes the importance of climate in driving fire activity across the United States.

    abstract：:Growing human and ecological costs due to increasing wildfire are an urgent concern in policy and management, particularly given projections of worsening fire conditions under climate change. Thus, understanding the relationship between climatic variation and fire activity is a critically important scientific question...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1713885114

    authors： Syphard AD,Keeley JE,Pfaff AH,Ferschweiler K

    更新日期：2017-12-26 00:00:00

  • IL-10 directly suppresses CD4 but not CD8 T cell effector and memory responses following acute viral infection.

    abstract：:Mounting effective T cell responses is critical for eliciting long-lasting immunity following viral infection and vaccination. A multitude of inhibitory and stimulatory factors are induced following infection, and it is the compilation of these signals that quantitatively and qualitatively program the ensuing effector...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0914500107

    authors： Brooks DG,Walsh KB,Elsaesser H,Oldstone MB

    更新日期：2010-02-16 00:00:00

  • Nucleotide sequence at the binding site for coat protein on RNA of bacteriophage R17.

    abstract：:The binding of a few molecules [1-6] of RNA bacteriophage coat protein to 1 molecule of RNA represses in vitro translation of the RNA synthetase cistron. Digestion of the complex, R17 coat protein-R17 RNA, by T1 RNase yields an RNA fragment bound to the coat protein. The nucleotide sequence of this fragment (59 residu...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.69.10.3033

    authors： Bernardi A,Spahr PF

    更新日期：1972-10-01 00:00:00

  • Conservation of nodulation genes between Rhizobium meliloti and a slow-growing Rhizobium strain that nodulates a nonlegume host.

    abstract：:Parasponia, a woody member of the elm family, is the only nonlegume genus whose members are known to form an effective nitrogen-fixing symbiosis with a Rhizobium species. The bacterial strain RP501 is a slow-growing strain of Rhizobium isolated from Parasponia nodules. Strain RP501 also nodulates the legumes siratro (...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.82.17.5841

    authors： Marvel DJ,Kuldau G,Hirsch A,Richards E,Torrey JG,Ausubel FM

    更新日期：1985-09-01 00:00:00

  • Control of A-system amino acid transport by a second regulatory gene R2 in Chinese hamster ovary cells CHO-K1 and the possible connection of this gene with insulin activity.

    abstract：:Evidence based on a study of alanine-resistant (Alar), constitutive mutants of CHO-K1 cells and the conditions that favor stimulation of the A system of amino acid activity supports the model that the A system of amino acid transport in these cells is repressible and under negative control of regulatory gene R1. In th...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.84.22.8040

    authors： Moffett J,Périer F,Jones M,Englesberg E

    更新日期：1987-11-01 00:00:00

  • Observation of an apparent first-order glass transition in ultrafragile Pt-Cu-P bulk metallic glasses.

    abstract：:An experimental study of the configurational thermodynamics for a series of near-eutectic Pt80-x Cu x P20 bulk metallic glass-forming alloys is reported where 14 < x < 27. The undercooled liquid alloys exhibit very high fragility that increases as x decreases, resulting in...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1916371117

    authors： Na JH,Corona SL,Hoff A,Johnson WL

    更新日期：2020-02-11 00:00:00