Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis.

abstract：:Activation of the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway is a frequent occurrence in human cancers and a major promoter of chemotherapeutic resistance. Inhibition of one downstream target in this pathway, mTORC1, has shown potential to improve chemosensitivity. However, the mechanisms and genetic m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mills JR,Hippo Y,Robert F,Chen SM,Malina A,Lin CJ,Trojahn U,Wendel HG,Charest A,Bronson RT,Kogan SC,Nadon R,Housman DE,Lowe SW,Pelletier J

更新日期：2008-08-05 00:00:00

abstract：:Electrophysiological and activity-dependent gene expression studies of birdsong have contributed to the understanding of the neural representation of natural sounds. However, we have limited knowledge about the overall spatial topography of song representation in the avian brain. Here, we adapt the noninvasive functio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Voss HU,Tabelow K,Polzehl J,Tchernichovski O,Maul KK,Salgado-Commissariat D,Ballon D,Helekar SA

更新日期：2007-06-19 00:00:00

abstract：:Colocalization of proteins that are part of the same signal transduction pathway via compartmentalization, scaffold, or anchor proteins is an essential aspect of the signal transduction system in eukaryotic cells. If interaction must occur via free diffusion, then the spatial separation between the sources of the two ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Batada NN,Shepp LA,Siegmund DO

更新日期：2004-04-27 00:00:00

abstract：:An enconuclease activity that reacts with x-irradiated DNA is present in extracts of E. coli. By using centrifugal methods to monitor the conversion of the supercoiled, circular double-stranded DNA for phage phi-x-174 (replicative form) or PM2 to the relaxed circular form it was possible to quantitate the rate of radi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strniste GF,Wallace SS

更新日期：1975-06-01 00:00:00

abstract：:Maltose-binding protein (MBP) is a two-domain protein that undergoes a ligand-mediated conformational rearrangement from an "open" to a "closed" structure on binding to maltooligosaccharides. To characterize the energy landscape associated with this transition, we have generated five variants of MBP with mutations loc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Millet O,Hudson RP,Kay LE

更新日期：2003-10-28 00:00:00

abstract：:Simian virus 40 (SV40)-transformed hamster cells were relatively resistant to the lytic effect of activated macrophages from animals with chronic intracellular infections. Conversely, SV40-transformed mouse and rat cells and adenovirus 2-transformed hamster cells were highly susceptible to destruction by tumoricidal a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cook JL,Hibbs JB Jr,Lewis AM Jr

更新日期：1980-11-01 00:00:00

abstract：:Mitochondrial ATP-sensitive K (mitoK(ATP)) channels play a central role in protecting the heart from injury in ischemic preconditioning. In isolated mitochondria exposed to elevated extramitochondrial Ca, P(i), and anoxia to simulate ischemic conditions, the selective mitoK(ATP) channel agonist diazoxide (25-50 microM...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Korge P,Honda HM,Weiss JN

更新日期：2002-03-05 00:00:00

abstract：:Despite the widespread occurrence of spliceosomal introns in the genomes of higher eukaryotes, their origin remains controversial. One model proposes that the duplication of small genomic portions could have provided the boundaries for new introns. If this mechanism has occurred recently, the 5' and 3' boundaries of e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhuo D,Madden R,Elela SA,Chabot B

更新日期：2007-01-16 00:00:00

abstract：:Nerve growth factor has been quantified by both bioassay and radial immunodiffusion in mouse saliva elicited by several secretagogues. The concentrations by bioassay of nerve growth factor in both epinephrine- and norepinephrine-induced saliva (3400 and 900 mug/ml, respectively) are higher than reported in any other s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wallace LJ,Partlow LM

更新日期：1976-11-01 00:00:00

abstract：:We previously demonstrated that the primary region of factor IX and IXa responsible for saturable specific binding to bovine aortic endothelial cells resides in residues 3-11 at the amino terminus of factor IX. We also demonstrated that mutations of lysine to alanine at residue 5, factor IX K5A, or valine to lysine at...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheung WF,van den Born J,Kühn K,Kjellén L,Hudson BG,Stafford DW

更新日期：1996-10-01 00:00:00

abstract：:Anthrax toxin is an intracellularly acting toxin in which sufficient information is available regarding the structure of its transmembrane channel, allowing for detailed investigation of models of translocation. Anthrax toxin, comprising three proteins-protective antigen (PA), lethal factor (LF), and edema factor-tran...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Das D,Krantz BA

更新日期：2016-08-23 00:00:00

abstract：:The number of large intramembrane particles associated with sites of synaptic vesicle release at the squid giant synapse was determined and compared to the average maximal presynaptic calcium current in order to derive an estimate of the conductance each particle would have if it were a calcium channel. This value, 0....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pumplin DW,Reese TS,Llinás R

更新日期：1981-11-01 00:00:00

abstract：:The activation of additional promoter sites by production of an alternative sigma subunit for RNA polymerase is a common strategy for the coordinate regulation of gene expression. Many alternative sigma factors control genes for specialized, and often narrowly distributed, functions. For example, most of the alternati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen YF,Helmann JD

更新日期：1992-06-01 00:00:00

abstract：:Induction of longstanding immunologic tolerance is essential for survival of transplanted organs and tissues. Despite recent advances in immunosuppression protocols, allograft damage inflicted by antibody specific for donor organs continues to represent a major obstacle to graft survival. Here we report that activatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Choi JY,Eskandari SK,Cai S,Sulkaj I,Assaker JP,Allos H,AlHaddad J,Muhsin SA,Alhussain E,Mansouri A,Yeung MY,Seelen MAJ,Kim HJ,Cantor H,Azzi JR

更新日期：2020-03-17 00:00:00

abstract：:A cell line has been developed from the imaginal wing discs of the lepidopteran insect Trichoplusia ni (Hübner). The cells grow in suspension as fluid-filled, multicellular vesicles. The cell line has been designated IAL-TND1. Two-dimensional electrophoresis (isoelectric focusing and sodium dodecyl sulfate/polyacrylam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lynn DE,Miller SG,Oberlander H

更新日期：1982-04-01 00:00:00

abstract：:We have determined the packing efficiency at the protein-water interface by calculating the volumes of atoms on the protein surface and nearby water molecules in 22 crystal structures. We find that an atom on the protein surface occupies, on average, a volume approximately 7% larger than an atom of equivalent chemical...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gerstein M,Chothia C

更新日期：1996-09-17 00:00:00

abstract：:Better understanding myelination of peripheral nerves would benefit patients affected by peripheral neuropathies, including Charcot-Marie-Tooth disease. Little is known about the role the Golgi compartment plays in Schwann cell (SC) functions. Here, we studied the role of Golgi in myelination of peripheral nerves in m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baba T,Alvarez-Prats A,Kim YJ,Abebe D,Wilson S,Aldworth Z,Stopfer MA,Heuser J,Balla T

更新日期：2020-11-10 00:00:00

abstract：:The liver plays a key role in the regulation of circulating levels of low density lipoproteins (LDL) because it is both the site for the production of and the major organ for the degradation of this class of lipoproteins. In this study, the effects of feeding polyunsaturated or saturated triacylglycerols on receptor-d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spady DK,Dietschy JM

更新日期：1985-07-01 00:00:00

abstract：:Type VI protein secretion system (T6SS) is important for bacterial competition through contact-dependent killing of competitors. T6SS delivers effectors to neighboring cells and corresponding antagonistic proteins confer immunity against effectors that are delivered by sister cells. Although T6SS has been found in mor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dong TG,Ho BT,Yoder-Himes DR,Mekalanos JJ

更新日期：2013-02-12 00:00:00

abstract：:Determinants of the recommended dietary allowance (RDA) for vitamin C include the relationship between vitamin C dose and steady-state plasma concentration, bioavailability, urinary excretion, cell concentration, and potential adverse effects. Because current data are inadequate, an in-hospital depletion-repletion stu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levine M,Conry-Cantilena C,Wang Y,Welch RW,Washko PW,Dhariwal KR,Park JB,Lazarev A,Graumlich JF,King J,Cantilena LR

更新日期：1996-04-16 00:00:00

abstract：:Emergence of antiestrogen-resistant cells in MCF-7 cells during suppression of estrogen signaling is a widely accepted model of acquired breast cancer resistance to endocrine therapy. To obtain insight into the genomic basis of endocrine therapy resistance, we characterized MCF-7 monoclonal sublines that survived 21-d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coser KR,Wittner BS,Rosenthal NF,Collins SC,Melas A,Smith SL,Mahoney CJ,Shioda K,Isselbacher KJ,Ramaswamy S,Shioda T

更新日期：2009-08-25 00:00:00

abstract：:Recent work using culture-independent methods suggests that the lungs of cystic fibrosis (CF) patients harbor a vast array of bacteria not conventionally implicated in CF lung disease. However, sampling lung secretions in living subjects requires that expectorated specimens or collection devices pass through the oroph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goddard AF,Staudinger BJ,Dowd SE,Joshi-Datar A,Wolcott RD,Aitken ML,Fligner CL,Singh PK

更新日期：2012-08-21 00:00:00

abstract：:What are the forces that shape the structure of prokaryotic genomes: the order of genes, their proximity, and their orientation? Coregulation and coordinated horizontal gene transfer are believed to promote the proximity of functionally related genes and the formation of operons. However, forces that influence the str...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kolesov G,Wunderlich Z,Laikova ON,Gelfand MS,Mirny LA

更新日期：2007-08-28 00:00:00

abstract：:We examined human immunodeficiency virus (HIV) production in cultured mononuclear cells from 36 seropositive homosexual males. Production was detected by using an HIV p24 antigen ELISA assay in blood mononuclear cells in 54% of asymptomatic, 71% of acquired immunodeficiency syndrome (AIDS)-related complex, and 100% of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McElrath MJ,Pruett JE,Cohn ZA

更新日期：1989-01-01 00:00:00

abstract：:The toxic, mutagenic, and carcinogenic effects of alkylating agents have been attributed to their ability to damage DNA. Reaction at the O6 position of guanine results in miscoding during DNA replication, has been shown to be mutagenic in both bacteriophage and bacteria, and may be responsible for malignant transforma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brennand J,Margison GP

更新日期：1986-09-01 00:00:00

abstract：:The electronic absorption spectra of oxidized and reduced spinach ferredoxins have been measured between 1200 and 600 nm at low temperature in D(2)O/ethylene glycol glasses. Relatively weak absorption bands are observed at 720, 820, and 920 nm in oxidized ferredoxin, and at 652, 820, and 920 nm in reduced ferredoxin. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rawlings J,Siiman O,Gray HB

更新日期：1974-01-01 00:00:00

abstract：:We have inserted the sequence 5'-AAG-GAGGU-3', which is complementary to the 3' terminus of Escherichia coli 16S rRNA, in a reading frame and analyzed its effect on the accuracy and overall rate of translation in vivo. Translation over the sequence yields a 50% ribosomal frameshift if the reading phase is A-AGG-AGG-U....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spanjaard RA,van Duin J

更新日期：1988-11-01 00:00:00

abstract：:Contemporary climate change is characterized both by increasing mean temperature and increasing climate variability such as heat waves, storms, and floods. How populations and communities cope with such climatic extremes is a question central to contemporary ecology and biodiversity conservation. Previous work has sho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reusch TB,Ehlers A,Hämmerli A,Worm B

更新日期：2005-02-22 00:00:00

abstract：:Telomere syndromes have their most common manifestation in lung disease that is recognized as idiopathic pulmonary fibrosis and emphysema. In both conditions, there is loss of alveolar integrity, but the underlying mechanisms are not known. We tested the capacity of alveolar epithelial and stromal cells from mice with...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alder JK,Barkauskas CE,Limjunyawong N,Stanley SE,Kembou F,Tuder RM,Hogan BL,Mitzner W,Armanios M

更新日期：2015-04-21 00:00:00

abstract：:Siglecs are a recently discovered family of animal lectins that belong to the Ig superfamily and recognize sialic acids (Sias). CD33-related Siglecs (CD33rSiglecs) are a subgroup with as-yet-unknown functions, characterized by sequence homology, expression on innate immune cells, conserved cytosolic tyrosine-based sig...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Angata T,Margulies EH,Green ED,Varki A

更新日期：2004-09-07 00:00:00