当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > Demonstration of inter- and intraspecies differences in serotonin binding sites by antibodies from an autistic child.

Demonstration of inter- and intraspecies differences in serotonin binding sites by antibodies from an autistic child.

Abstract：

:Serotonin (5-HT) binding sites from bovine and rat cerebral cortex membranes share pharmacological properties that allow both to be subclassified by the same criteria. We show here that [3H]5-HT binding sites from human cortex also possess pharmacological properties that follow the same subclassification scheme as for bovine and rat cortex. In addition, we show that solubilized 5-HT1 and 5-HT3 sites from all three species have an s20,w value of 3.4. Despite these similar pharmacological and physical characteristics, we can demonstrate antigenic differences between receptor types and species. Human 5-HT1A sites can be distinguished from human 5-HT1B, 5-HT2, and 5-HT3 sites and from equivalent sites in rat and bovine cortex. The anti-human 5-HT1A antibodies were discovered in the blood of an autistic child and may have clinical or etiologic significance for this disorder.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Todd RD,Ciaranello RD

doi

10.1073/pnas.82.2.612

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

612-6

issue

2

eissn

0027-8424

issn

1091-6490

journal_volume

82

pub_type

杂志文章

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