NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.

abstract：:Recent studies have suggested that Paleozoic hyperoxia enabled animal gigantism, and the subsequent hypoxia drove a reduction in animal size. This evolutionary hypothesis depends on the argument that gas exchange in many invertebrates and skin-breathing vertebrates becomes compromised at large sizes because of distanc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaiser A,Klok CJ,Socha JJ,Lee WK,Quinlan MC,Harrison JF

更新日期：2007-08-07 00:00:00

abstract：:Leucine analogs were tested in the Krebs II ascites cell-free translation system for the ability to inhibit preprotein cleavage by replacing leucine in nascent chains of bovine preprolactin, rat preprolactin, human placental prelactogen (pre-hPL), and pre-alpha subunit of human chorionic gonadotropin (alpha-hCG). In t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hortin G,Boime I

更新日期：1980-03-01 00:00:00

abstract：:Cryogenic fluorescent light microscopy of flash-frozen cells stands out by artifact-free fixation and very little photobleaching of the fluorophores used. To attain the highest level of resolution, aberration-free immersion objectives with accurately matched immersion media are required, but both do not exist for imag...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Faoro R,Bassu M,Mejia YX,Stephan T,Dudani N,Boeker C,Jakobs S,Burg TP

更新日期：2018-02-06 00:00:00

abstract：:The uterine epithelium of mice and humans undergoes cyclical waves of cell proliferation and differentiation under the regulation of estradiol-17β (E2) and progesterone (P4). These epithelial cells respond to E2 with increased protein and DNA synthesis, whereas P4 inhibits only the E2-induced DNA synthetic response. H...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,Zhu L,Kuokkanen S,Pollard JW

更新日期：2015-03-17 00:00:00

abstract：:G-protein-coupled receptors (GPCRs) have recently joined the list of cell surface receptors that dimerize. Dimerization has been shown to alter the ligand-binding, signaling, and trafficking properties of these receptors. Recent studies have shown that GPCRs heterodimerize with closely related members, resulting in th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jordan BA,Trapaidze N,Gomes I,Nivarthi R,Devi LA

更新日期：2001-01-02 00:00:00

abstract：:The three-dimensional structures of RNA enzymes form catalytic centers that include specific substrate binding sites. High-resolution determination of these and other RNA structures is essential for a detailed understanding of the function of RNA in biological systems. The crystal structures of only a few RNA molecule...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Doudna JA,Grosshans C,Gooding A,Kundrot CE

更新日期：1993-08-15 00:00:00

abstract：:Increased clouds and precipitation normally decrease the diurnal temperature range (DTR) and thus have commonly been offered as explanation for the trend of reduced DTR observed for many land areas over the last several decades. Observations show, however, that the DTR was reduced most in dry regions and especially in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou L,Dickinson RE,Tian Y,Vose RS,Dai Y

更新日期：2007-11-13 00:00:00

abstract：:Pin1 is a modular enzyme that accelerates the cis-trans isomerization of phosphorylated-Ser/Thr-Pro (pS/T-P) motifs found in numerous signaling proteins regulating cell growth and neuronal survival. We have used NMR to investigate the interaction of Pin1 with three related ligands that include a pS-P substrate peptide...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Namanja AT,Wang XJ,Xu B,Mercedes-Camacho AY,Wilson KA,Etzkorn FA,Peng JW

更新日期：2011-07-26 00:00:00

abstract：:Tephritid fruit flies belonging to the Rhagoletis pomonella sibling species complex are controversial because they have been proposed to diverge in sympatry (in the absence of geographic isolation) by shifting and adapting to new host plants. Here, we report evidence suggesting a surprising source of genetic variation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feder JL,Berlocher SH,Roethele JB,Dambroski H,Smith JJ,Perry WL,Gavrilovic V,Filchak KE,Rull J,Aluja M

更新日期：2003-09-02 00:00:00

abstract：:A mol of creatine kinase (EC 2.7.3.2), an enzyme with two identical subunits can be titrated very rapidly and stoichiometrically with 2 mol of 2-chloromercuri-4-nitrophenol, an environmentally sensitive chromophoric probe specific for thiols. Chemical modification does not inactivate the enzyme nor can the reaction be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Quiocho FE,Thomson JW

更新日期：1973-10-01 00:00:00

abstract：:Receptor tyrosine kinases (RTKs) are a class of cell surface receptors that, upon ligand binding, stimulate a variety of critical cellular functions. The orphan receptor anaplastic lymphoma kinase (ALK) is one of very few RTKs that remain without a firmly established protein ligand. Here we present a novel cytokine, F...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reshetnyak AV,Murray PB,Shi X,Mo ES,Mohanty J,Tome F,Bai H,Gunel M,Lax I,Schlessinger J

更新日期：2015-12-29 00:00:00

abstract：:Trimeric class I virus fusion proteins undergo a series of conformational rearrangements that leads to the association of C- and N-terminal heptad repeat domains in a "trimer-of-hairpins" structure, facilitating the apposition of viral and cellular membranes during fusion. This final fusion hairpin structure is sustai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cianci C,Langley DR,Dischino DD,Sun Y,Yu KL,Stanley A,Roach J,Li Z,Dalterio R,Colonno R,Meanwell NA,Krystal M

更新日期：2004-10-19 00:00:00

abstract：:Eukaryotic initiator proteins form origin recognition complexes (ORCs) that bind to replication origins during most of the cell cycle and direct assembly of prereplication complexes (pre-RCs) before the onset of S phase. In the eubacterium Escherichia coli, there is a temporally similar nucleoprotein complex comprisin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller DT,Grimwade JE,Betteridge T,Rozgaja T,Torgue JJ,Leonard AC

更新日期：2009-11-03 00:00:00

abstract：:We previously found that a minor fraction of single-stranded DNA (ss-DNA) isolated from native nuclear DNA of normal chicken embryonic cells and cells of other species hybridized with bulk nuclear DNA or cellular RNA in great excess. At least one-third of ss-DNA belonging to the nonrepetitious part of the cell genome ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leibovitch SA,Tapiero H,Harel J

更新日期：1977-09-01 00:00:00

abstract：:Skeletal muscle cells have served as a paradigm for understanding mechanisms leading to cellular differentiation. The proliferation and differentiation of muscle precursor cells require the concerted activity of myogenic regulatory factors including MyoD. In addition, chromatin modifiers mediate dynamic modifications ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ling BM,Bharathy N,Chung TK,Kok WK,Li S,Tan YH,Rao VK,Gopinadhan S,Sartorelli V,Walsh MJ,Taneja R

更新日期：2012-01-17 00:00:00

abstract：:In organisms possessing a dispersal phase the processes of mating, competition, feeding, and predation are often carried out within "trait-groups," defined as populations enclosed in areas smaller than the boundaries of the deme. A simple model shows that this can lead to the selection of "altruistic" traits that favo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wilson DS

更新日期：1975-01-01 00:00:00

abstract：:Direct reciprocity and conditional cooperation are important mechanisms to prevent free riding in social dilemmas. However, in large groups, these mechanisms may become ineffective because they require single individuals to have a substantial influence on their peers. However, the recent discovery of zero-determinant ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hilbe C,Wu B,Traulsen A,Nowak MA

更新日期：2014-11-18 00:00:00

abstract：:The temperature dependence of migration rate and of the thermotactic sensitivity of pseudoplasmodia of Dictyostelium discoideum has been measured. Migration rate increases with temperature to 20 degrees, is temperature insensitive from 20 degrees to 27.5 degrees, and decreases with temperature to 29 degrees, above whi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poff KL,Skokut M

更新日期：1977-05-01 00:00:00

abstract：:Histone deacetylases (HDACs) are key regulators of gene expression that require assembly into larger protein complexes for activity. Efforts to understand how associated proteins modulate the function of HDACs would benefit from new technologies that evaluate HDAC activity in native biological systems. Here, we descri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Salisbury CM,Cravatt BF

更新日期：2007-01-23 00:00:00

abstract：:Solar photovoltaic (PV) electricity generation is expanding rapidly in China, with total capacity projected to be 400 GW by 2030. However, severe aerosol pollution over China reduces solar radiation reaching the surface. We estimate the aerosol impact on solar PV electricity generation at the provincial and regional g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li X,Wagner F,Peng W,Yang J,Mauzerall DL

更新日期：2017-11-07 00:00:00

abstract：:Amnesia produced by protein synthesis inhibitors such as anisomycin provides major support for the prevalent view that the formation of long-lasting memories requires de novo protein synthesis. However, inhibition of protein synthesis might disrupt other neural functions to interfere with memory formation. Intraamygda...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Canal CE,Chang Q,Gold PE

更新日期：2007-07-24 00:00:00

abstract：:Striking taste disturbances are reported in cancer patients treated with Hedgehog (HH)-pathway inhibitor drugs, including sonidegib (LDE225), which block the HH pathway effector Smoothened (SMO). We tested the potential for molecular, cellular, and functional recovery in mice from the severe disruption of taste-organ ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kumari A,Ermilov AN,Grachtchouk M,Dlugosz AA,Allen BL,Bradley RM,Mistretta CM

更新日期：2017-11-28 00:00:00

abstract：:The embryonic sites in which progenitors of the hematopoietic lineages first emerge are ideal regions to characterize both the cells and environment needed to initiate blood cell development. For a number of years both the murine yolk sac and embryo have been recognized to contain progenitors of B lymphocytes. However...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cumano A,Furlonger C,Paige CJ

更新日期：1993-07-15 00:00:00

abstract：:Gene expression in higher organisms is thought to be regulated by a complex network of transcription factor binding and chromatin modifications, yet the relative importance of these two factors remains a matter of debate. Here, we show that a computational approach allows surprisingly accurate prediction of histone mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benveniste D,Sonntag HJ,Sanguinetti G,Sproul D

更新日期：2014-09-16 00:00:00

abstract：:The p53 protein is an attractive target for immunotherapy, because mutations in the p53 gene are the most common genetic alterations found in human tumors. These mutations result in high levels of p53 protein in the tumor cell, whereas the expression level of wild-type p53 in nonmalignant tissue is usually much lower....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roth J,Dittmer D,Rea D,Tartaglia J,Paoletti E,Levine AJ

更新日期：1996-05-14 00:00:00

abstract：:When the proximal and distal elements of wire-frame cubes are conflated, observers perceive illusory structures that no longer behave veridically. These phenomena suggest that what we normally see depends on visual associations generated by experience. The necessity of such learning may explain why the mammalian visua...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Purves D,Andrews TJ

更新日期：1997-06-10 00:00:00

abstract：:A Drosophila cDNA encoding a human transcription factor TFIIB homologue was isolated by PCR methods. The deduced amino acid sequence indicates 85% sequence similarity with human TFIIB, and the corresponding cDNA product expressed in Escherichia coli is interchangeable with human TFIIB for both basal and GAL4-VP16-indu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamashita S,Wada K,Horikoshi M,Gong DW,Kokubo T,Hisatake K,Yokotani N,Malik S,Roeder RG,Nakatani Y

更新日期：1992-04-01 00:00:00

abstract：:The 1H NMR signal from oxymyoglobin, a low-concentration diamagnetic protein, is visible in myocardial tissue. The methyl group of the Val-E11 resonates in a clear spectral region at -2.76 ppm and responds to dynamic changes in cellular oxygenation. With CO, the signal shifts to -2.4 ppm. The Val-E11 peak assignment a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kreutzer U,Wang DS,Jue T

更新日期：1992-05-15 00:00:00

abstract：:Microbes whose genomes are encoded by DNA and for which adequate information is available display similar genomic mutation rates (average 0.0034 mutations per chromosome replication, range 0.0025 to 0.0046). However, this value currently is based on only a few well characterized microbes reproducing within a narrow ra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grogan DW,Carver GT,Drake JW

更新日期：2001-07-03 00:00:00

abstract：:1-Aminocyclopropane-1-carboxylate (ACC) synthase (EC 4.4.1.14), extracted from tomato pericarp tissue, was purified 6500-fold by conventional and high-performance liquid chromatography. Two-dimensional gel electrophoresis of this preparation indicated that ACC synthase activity was associated with a protein band at 50...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bleecker AB,Kenyon WH,Somerville SC,Kende H

更新日期：1986-10-01 00:00:00