Roll maneuvers are essential for active reorientation of Caenorhabditis elegans in 3D media.

abstract：:The serum thymic factor (FTS) utilized in its synthetic or natural form loses its biological activity in a rosette assay after treatment with a metal ion-chelating agent, Chelex 100. This activity is restored by the addition of Zn salts and, to a lesser extent, certain other metal salts. FTS activation is secondary to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dardenne M,Pléau JM,Nabarra B,Lefrancier P,Derrien M,Choay J,Bach JF

更新日期：1982-09-01 00:00:00

abstract：:Never before have individuals had to adapt to social environments defined by such magnitudes of ethnic diversity and cultural differentiation. However, neurobiological evidence informing about strategies to reduce xenophobic sentiment and foster altruistic cooperation with outsiders is scarce. In a series of experimen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marsh N,Scheele D,Feinstein JS,Gerhardt H,Strang S,Maier W,Hurlemann R

更新日期：2017-08-29 00:00:00

abstract：:The proteasome is responsible for degradation of substrates of the ubiquitin pathway. 20S proteasomes are cylindrical particles with subunits arranged in a stack of four heptameric rings. The outer rings are composed of alpha subunits, and the inner rings are composed of beta subunits. A well-characterized archaeal pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arendt CS,Hochstrasser M

更新日期：1997-07-08 00:00:00

abstract：:Analysis, by the recovery of specific genetic "markers," of the effects of DNase I, physical shear, and temperature shock on DNA-cell complexes demonstrates that sequential attachment of both ends of bacteriophage SP82G DNA to Bacillus subtilis precedes entry of the DNA molecule into the cell, and that each attachment...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams GL,Green DM

更新日期：1972-06-01 00:00:00

abstract：:The androgen receptor (AR) binds to androgen response elements and regulates target genes via a mechanism involving coregulators. Here we demonstrate that the AR can interact with the testicular orphan receptor-4 (TR4) and function as a repressor to down-regulate the TR4 target genes by preventing the TR4 binding to i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee YF,Shyr CR,Thin TH,Lin WJ,Chang C

更新日期：1999-12-21 00:00:00

abstract：:To gain further insight into the mode of action of S-locus receptor kinase (SRK), a receptor-like kinase involved in the self-incompatibility response in Brassica, different recombinant SRK proteins have been expressed in a membranous environment using the insect cell/baculovirus system. Recombinant SRK proteins exhib...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giranton JL,Dumas C,Cock JM,Gaude T

更新日期：2000-03-28 00:00:00

abstract：:Recent studies with fibroblasts have shown that peptidylhydroxyproline formation begins toward the end of the log phase of growth and is an expression of the activity of the enzyme, collagen proline hydroxylase, which increase in late log-phase cells. This communication reports a two- to fivefold increase in hydroxyla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Comstock JP,Udenfriend S

更新日期：1970-06-01 00:00:00

abstract：:Evidence for perceptual periodicity emerges from studies showing periodic fluctuations in visual perception and decision making that are accompanied by neural oscillations in brain activity. We have uncovered signs of periodicity in the time course of binocular rivalry, a widely studied form of multistable perception....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cha O,Blake R

更新日期：2019-07-23 00:00:00

abstract：:Protocell models are used to investigate how cells might have first assembled on Earth. Some, like oil-in-water droplets, can be seemingly simple models, while able to exhibit complex and unpredictable behaviors. How such simple oil-in-water systems can come together to yield complex and life-like behaviors remains a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Points LJ,Taylor JW,Grizou J,Donkers K,Cronin L

更新日期：2018-01-30 00:00:00

abstract：:The expanding behavioral repertoire of the developing brain during childhood and adolescence is shaped by complex brain-environment interactions and flavored by unique life experiences. The transition into young adulthood offers opportunities for adaptation and growth but also increased susceptibility to environmental...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alnæs D,Kaufmann T,Marquand AF,Smith SM,Westlye LT

更新日期：2020-06-02 00:00:00

abstract：:In previous studies we showed that 5 days of treatment with granulocyte colony-stimulating factor (G-CSF) and stem cell factor (SCF) mobilized murine repopulating cells to the peripheral blood (PB) and that these cells could be efficiently transduced with retroviral vectors. We also found that, 7-14 days after cytokin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dunbar CE,Seidel NE,Doren S,Sellers S,Cline AP,Metzger ME,Agricola BA,Donahue RE,Bodine DM

更新日期：1996-10-15 00:00:00

abstract：:Genetic data in the mouse have shown that endothelin 3 (ET3) and its receptor B (ETRB) are essential for the development of two neural crest (NC) derivatives, the melanocytes and the enteric nervous system. We report here the effects of ET3 in vitro on the differentiation of quail trunk NC cells (NCC) in mass and clon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lahav R,Dupin E,Lecoin L,Glavieux C,Champeval D,Ziller C,Le Douarin NM

更新日期：1998-11-24 00:00:00

abstract：:The prediction of binding sites and the understanding of interfaces associated with protein complexation remains an open problem in molecular biophysics. This work shows that a crucial factor in predicting and rationalizing protein-protein interfaces can be inferred by assessing the extent of intramolecular desolvatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fernández A,Scheraga HA

更新日期：2003-01-07 00:00:00

abstract：:The transcription factor NFAT5/TonEBP, a member of the NFAT/Rel family of transcription factors, has been implicated in diverse cellular responses, including the response to osmotic stress, integrin-dependent cell migration, T cell activation, and the Ras pathway in Drosophila. To clarify the in vivo role of NFAT5, we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： López-Rodríguez C,Antos CL,Shelton JM,Richardson JA,Lin F,Novobrantseva TI,Bronson RT,Igarashi P,Rao A,Olson EN

更新日期：2004-02-24 00:00:00

abstract：:A hallmark of most neurodegenerative diseases, including those caused by polyglutamine expansion, is the formation of ubiquitin (Ub)-positive protein aggregates in affected neurons. This finding suggests that the Ub system may be involved in common mechanisms underlying these otherwise unrelated diseases. Here we repo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Donaldson KM,Li W,Ching KA,Batalov S,Tsai CC,Joazeiro CA

更新日期：2003-07-22 00:00:00

abstract：:The gluconate (gnt) operon of Bacillus subtilis consists of four gnt genes; the second and third genes code for gluconate kinase (gluconokinase, EC 2.7.1.12) and gluconate permease, respectively. A fragment carrying the promoter of this operon (gnt promoter) and the first gene (gntR) was subcloned into a promoter prob...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fujita Y,Fujita T

更新日期：1987-07-01 00:00:00

abstract：:Mouse teratocarcinoma cells induced to differentiate in vitro undergo a massive (30%) demethylation of DNA. A similar undermethylation is also observed in the mouse extraembryonic membranes, the yolk sac and placenta. In both cases, the decrease in methyl moieties occurs at a large number of CpG sites spread out over ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Razin A,Webb C,Szyf M,Yisraeli J,Rosenthal A,Naveh-Many T,Sciaky-Gallili N,Cedar H

更新日期：1984-04-01 00:00:00

abstract：:Many experiments in the past have demonstrated the requirement of de novo gene expression during the long-term retention of learning and memory. Although previous studies implicated individual genes or genetic pathways in learning and memory, they did not uncover the collective behaviors or patterns of the genes. We h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cavallaro S,D'Agata V,Manickam P,Dufour F,Alkon DL

更新日期：2002-12-10 00:00:00

abstract：:A series of anti-human placental uracil DNA glycosylase monoclonal antibodies was used to screen a human placental cDNA library in phage lambda gt11. Twenty-seven immunopositive plaques were detected and purified. One clone containing a 1.2-kilobase (kb) human cDNA insert was chosen for further study by insertion into...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vollberg TM,Siegler KM,Cool BL,Sirover MA

更新日期：1989-11-01 00:00:00

abstract：:By using harmonic radar, we report the complete flight paths of displaced bees. Test bees forage at a feeder or are recruited by a waggle dance indicating the feeder. The flights are recorded after the bees are captured when leaving the hive or the feeder and are released at an unexpected release site. A sequence of b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Menzel R,Greggers U,Smith A,Berger S,Brandt R,Brunke S,Bundrock G,Hülse S,Plümpe T,Schaupp F,Schüttler E,Stach S,Stindt J,Stollhoff N,Watzl S

更新日期：2005-02-22 00:00:00

abstract：:General control nonderepressible 2 (GCN2) plays a major role in the cellular response to amino acid limitation. Although maintenance of amino acid homeostasis is critical for tumor growth, the contribution of GCN2 to cancer cell survival and proliferation is poorly understood. In this study, we generated GCN2 inhibito...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakamura A,Nambu T,Ebara S,Hasegawa Y,Toyoshima K,Tsuchiya Y,Tomita D,Fujimoto J,Kurasawa O,Takahara C,Ando A,Nishigaki R,Satomi Y,Hata A,Hara T

更新日期：2018-08-14 00:00:00

abstract：:Phototropin is a blue light photoreceptor for tropic responses, relocation of chloroplasts, and stomata opening in plants. Phototropin has two chromophoric domains named light-oxygen-voltage-sensing (LOV) 1 and 2 in the N-terminal half, and a serine/threonine (Ser/Thr) protein kinase motif in the C-terminal half. Conc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matsuoka D,Tokutomi S

更新日期：2005-09-13 00:00:00

abstract：:Ribavirin is a nucleotide analog that can be incorporated by viral polymerases, causing mutations by allowing base mismatches. It is currently used therapeutically as an antiviral drug during hepatitis C virus infections. During the amplification of poliovirus genomic RNA or hepatitis C replicons, error frequency is k...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pfeiffer JK,Kirkegaard K

更新日期：2003-06-10 00:00:00

abstract：:Protein framework alterations in heritable Cu, Zn superoxide dismutase (SOD) mutants cause misassembly and aggregation in cells affected by the motor neuron disease ALS. However, the mechanistic relationship between superoxide dismutase 1 (SOD1) mutations and human disease is controversial, with many hypotheses postul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pratt AJ,Shin DS,Merz GE,Rambo RP,Lancaster WA,Dyer KN,Borbat PP,Poole FL 2nd,Adams MW,Freed JH,Crane BR,Tainer JA,Getzoff ED

更新日期：2014-10-28 00:00:00

abstract：:3-Methylcholanthrene (MCA) skin painting rapidly induced a 100% incidence of thymic lymphomas in RF/J mice. Tumors developed exclusively in cells of the T-lymphocyte lineage and displayed the surface phenotype: Thy-1+, Lyt-1+, Lyt-2+, Qa-1+, H-2K+, H-2D+, TL-, Ig-, Ia-. This phenotype resembled that of cortisone-resis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goodenow MM,Lilly F

更新日期：1984-12-01 00:00:00

abstract：:A primary muscle cell culture derived from newborn rabbit muscle and growing on microcarriers in suspension was established. When cultured for several weeks, the myotubes in this model develop the completely adult pattern of fast myosin light and heavy chains. When Ca2+ ionophore is added to the culture medium on day ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kubis HP,Haller EA,Wetzel P,Gros G

更新日期：1997-04-15 00:00:00

abstract：:Lysinuric protein intolerance (LPI) is an autosomal recessive phenotype consistent with impaired transport of cationic amino acids at the basolateral membrane of intestinal and renal epithelia. On the assumption that the basolateral membrane of epithelial cells and plasma membrane of parenchymal cells are functional a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith DW,Scriver CR,Tenenhouse HS,Simell O

更新日期：1987-11-01 00:00:00

abstract：:Vascular endothelial dysfunction underlies the genesis and progression of numerous diseases. Although the GATA transcription factor GATA-2 is expressed in endothelial cells and is implicated in coronary heart disease, it has been studied predominantly as a master regulator of hematopoiesis. Because many questions rega...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Linnemann AK,O'Geen H,Keles S,Farnham PJ,Bresnick EH

更新日期：2011-08-16 00:00:00

abstract：:The utility of adenovirus (Ad) vectors for gene transduction can be limited by receptor specificity. We developed a gene-delivery vehicle in which the potent Ad5 vector was genetically reengineered to display the mucosal-targeting sigma1 protein of reovirus type 3 Dearing (T3D). A sigma1 construct containing all but a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mercier GT,Campbell JA,Chappell JD,Stehle T,Dermody TS,Barry MA

更新日期：2004-04-20 00:00:00

abstract：:Recent advances in cell-free expression protocols have opened a new avenue toward high-resolution structural investigations of membrane proteins by x-ray crystallography and NMR spectroscopy. One of the biggest challenges for liquid-state NMR-based structural investigations of membrane proteins is the significant peak...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reckel S,Sobhanifar S,Schneider B,Junge F,Schwarz D,Durst F,Löhr F,Güntert P,Bernhard F,Dötsch V

更新日期：2008-06-17 00:00:00