Loss of the MYC gene amplified in human HL-60 cells after treatment with inhibitors of poly(ADP-ribose) polymerase or with dimethyl sulfoxide.

abstract：:Treatment of cultured human tumor cells with the chloroethylnitrosourea antitumor drug 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) selectively induces transcription and protein synthesis of a subset of the human heat shock or stress-induced genes (HSP90 and HSP70) with little effect on other stress genes or on express...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kroes RA,Abravaya K,Seidenfeld J,Morimoto RI

更新日期：1991-06-01 00:00:00

abstract：:A genetic complementation system was developed in which tobacco etch virus (TEV) polymerase (NIb)-expressing transgenic plants or protoplasts were inoculated with NIb-defective TEV mutants. A beta-glucuronidase (GUS) reporter gene integrated into the genomes of parental and four mutant viruses was used to assay RNA am...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li XH,Carrington JC

更新日期：1995-01-17 00:00:00

abstract：:Failure of embryo implantation accounts for a significant percentage of female infertility. Exquisitely coordinated molecular programs govern the interaction between the competent blastocyst and the receptive uterus. Decidualization, the rapid proliferation and differentiation of endometrial stromal cells into decidua...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haller M,Yin Y,Ma L

更新日期：2019-09-24 00:00:00

abstract：:Glutamine-dependent carbamylphosphate synthetase (Escherichia coli) is composed of a heavy subunit (molecular weight about 130,000) and a light subunit (molecular weight about 42,000), which can be separated with retention of catalytic activities. The separated heavy subunit can catalyze activation of CO(2) by ATP and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trotta PP,Wellner VP,Pinkus LM,Meister A

更新日期：1973-10-01 00:00:00

abstract：:A sequence of 14 nucleotides in one human diversity (D) minigene (D2) is identical with a sequence in complementarity-determining region 2 (CDR2) of one human gene for the variable region of the heavy chain of immunoglobulin. The finding that nucleotide segments present in a D minigene can appear in CDR2 raises the po...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu TT,Kabat EA

更新日期：1982-08-01 00:00:00

abstract：:Memory formation requires the placement of experienced events in the same order in which they appeared. A large body of evidence from human studies indicates that structures in the medial temporal lobe are critically involved in forming and maintaining such memories, and complementing evidence from lesion and electrop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paz R,Gelbard-Sagiv H,Mukamel R,Harel M,Malach R,Fried I

更新日期：2010-03-30 00:00:00

abstract：:Cholera vibrios produce a single polymeric protein that (i) causes hemagglutination; (ii) appears to participate in their attachment to gut epithelium; (iii) may mediate their detachment from gut epithelium; and (iv) is a protease that hydrolyzes fibronectin and mucin, cleaves lactoferrin, and nicks the A subunit of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Finkelstein RA,Boesman-Finkelstein M,Holt P

更新日期：1983-02-01 00:00:00

abstract：:Elucidating the lineage relationships among different cell types is key to understanding human brain development. Here we developed parallel RNA and DNA analysis after deep sequencing (PRDD-seq), which combines RNA analysis of neuronal cell types with analysis of nested spontaneous DNA somatic mutations as cell lineag...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang AY,Li P,Rodin RE,Kim SN,Dou Y,Kenny CJ,Akula SK,Hodge RD,Bakken TE,Miller JA,Lein ES,Park PJ,Lee EA,Walsh CA

更新日期：2020-06-23 00:00:00

abstract：:Viruses are obligatory intracellular parasites that suffer strong evolutionary pressure from the host immune system. Rapidly evolving viral genomes can adapt to this pressure by acquiring genes that counteract host defense mechanisms. For example, many vertebrate DNA viruses have hijacked cellular genes encoding cytok...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lamiable O,Kellenberger C,Kemp C,Troxler L,Pelte N,Boutros M,Marques JT,Daeffler L,Hoffmann JA,Roussel A,Imler JL

更新日期：2016-01-19 00:00:00

abstract：:Young male baboons born in captivity were immunized with an attenuated, cryopreserved schistosomular vaccine derived from gamma-irradiated (50 krad) cercariae of the Puerto Rican strain of Schistosoma mansoni. Protection against a heterologous Kenyan strain of S. mansoni, after percutaneous infection, was assessed. Pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Damian RT,Roberts ML,Powell MR,Clark JD,Lewis FA,Stirewalt MA

更新日期：1984-06-01 00:00:00

abstract：:The development of seeds in flowering plants is placed under complex interactions between maternal tissues, the embryo, and the endosperm. The endosperm plays a major role in the regulation of seed size. In Arabidopsis thaliana, endosperm size depends on the coordination of the genetic pathway HAIKU (IKU) with epigene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li J,Nie X,Tan JL,Berger F

更新日期：2013-09-17 00:00:00

abstract：:Previous studies have shown that the effect of language on categorical perception of color is stronger when stimuli are presented in the right visual field than in the left. To examine whether this lateralized effect occurs preattentively at an early stage of processing, we monitored the visual mismatch negativity, wh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mo L,Xu G,Kay P,Tan LH

更新日期：2011-08-23 00:00:00

abstract：:MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) are protein-serine/threonine kinases that are activated by ERK or p38 and phosphorylate eIF4E, which is involved in cap-dependent translation initiation. However, Mnk1/2 double knockout (Mnk-DKO) mice show normal cell growth and development despite an absence of eI...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ueda T,Sasaki M,Elia AJ,Chio II,Hamada K,Fukunaga R,Mak TW

更新日期：2010-08-10 00:00:00

abstract：:We previously have identified a subpopulation of contact-insensitive (CS-) cells which lacks density-dependent inhibition of cell division in primary and low-passage cultures of Syrian hamster embryonic (SHE) fibroblastic cells. Further, we have shown that the proportion of these CS- cells declines as a result of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakano S,Ueo H,Bruce SA,Ts'o PO

更新日期：1985-08-01 00:00:00

abstract：:Splenic lymphocytes from a Lewis rat, immunized with purified estradiol-receptor complex of calf uterine nuclei, were fused with cells of three different mouse myeloma lines (P3-X63-Ag8, P3-NSI/I-Ag4-1, and Sp2/0-Ag14) to yield hybridoma cultures, 9% of which produced antibodies to the receptor protein (estrophilin). ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Greene GL,Fitch FW,Jensen EV

更新日期：1980-01-01 00:00:00

abstract：:The starting point for the study of adverse experiences is that some have enduring consequences that continue after the period of exposure to the adversity. That raises four basic issues: whether social adversities can be considered homogeneous, whether the crucial effect lies in the "objective" or subjectively percei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rutter M

更新日期：2012-10-16 00:00:00

abstract：:Diabetes mellitus is characterized by either the inability to produce insulin (type 1 diabetes) or as insensitivity to insulin secreted by the body (type 2 diabetes). In either case, the body is unable to move blood glucose efficiently across cell membranes to be used. This leads to a variety of local and systemic det...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alipio Z,Liao W,Roemer EJ,Waner M,Fink LM,Ward DC,Ma Y

更新日期：2010-07-27 00:00:00

abstract：:We reported previously that Go-deficient mice develop severe neurological defects that include hyperalgesia, a generalized tremor, lack of coordination, and a turning syndrome somewhat reminiscent of unilateral lesions of the dopaminergic nigro-striatal pathway. By using frozen coronal sections of serially sectioned b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jiang M,Spicher K,Boulay G,Wang Y,Birnbaumer L

更新日期：2001-03-13 00:00:00

abstract：:The receptor for granulocyte-macrophage colony-stimulating factor (GM-CSF) is composed of an alpha and beta subunit, which together form the high-affinity receptor. The alpha subunit by itself binds ligand at low affinity, whereas the isolated beta subunit does not bind GM-CSF. It is generally believed that the high-a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ding DX,Rivas CI,Heaney ML,Raines MA,Vera JC,Golde DW

更新日期：1994-03-29 00:00:00

abstract：:A defect in the yeast GEF1 gene, a CLC chloride channel homolog leads to an iron requirement and cation sensitivity. The iron requirement is due to a failure to load Cu2+ onto a component of the iron uptake system, Fet3. This process, which requires both Gef1 and the Menkes disease Cu2+-ATPase yeast homolog Ccc2, occu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gaxiola RA,Yuan DS,Klausner RD,Fink GR

更新日期：1998-03-31 00:00:00

abstract：:Circadian rhythms describe biological phenomena that oscillate with an approximately 24-hour cycle. These rhythms include blood pressure, body temperature, hormone levels, the number of immune cells in blood, and the sleep-wake cycle. In this paper, we will focus on common genes between species that are responsible fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishida N,Kaneko M,Allada R

更新日期：1999-08-03 00:00:00

abstract：:Dimerization of human immunodeficiency virus type 1 protease (HIV-1 PR) monomers is an essential prerequisite for viral proteolytic activity and the subsequent generation of infectious virus particles. Disruption of the dimer interface inhibits this activity as does formation of heterodimers between wild-type and defe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McPhee F,Good AC,Kuntz ID,Craik CS

更新日期：1996-10-15 00:00:00

abstract：:A set of at least 30 proteins disappears from the two-dimensional electrophoretic pattern of human lymphoid cells treated with various antimitochondrial agents. This set is similar to the set of proteins found in isolated mitochondria (except for the presence of action in the latter group), indicating that the inhibit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anderson L

更新日期：1981-04-01 00:00:00

abstract：:Direct measurements of the intracellular level of lambda repressor have been made by a DNA-filter assay and a radioimmune assay. Transcription of cI, the structural gene for repressor, appears to initiate at two different promoters, prm and pre. Promoter pre is activated during the establishment of lysogeny by the act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reichardt L,Kaiser AD

更新日期：1971-09-01 00:00:00

abstract：:Inspite of several stimulating developments in gene therapy, the formulation of a targeted gene delivery "vector" is still far from ideal. We have demonstrated the potential of reconstituted Sendai viral envelopes containing only the fusion glycoprotein (F-virosomes) in targeted delivery of reporter genes to liver cel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramani K,Hassan Q,Venkaiah B,Hasnain SE,Sarkar DP

更新日期：1998-09-29 00:00:00

abstract：:Chromosomes condense during mitotic entry to facilitate their segregation. Condensation is typically assayed in fixed preparations, limiting analysis of contributing factors. Here, we describe a quantitative method to monitor condensation kinetics in living cells expressing GFP fused to a core histone. We demonstrate ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maddox PS,Portier N,Desai A,Oegema K

更新日期：2006-10-10 00:00:00

abstract：:We advance a theory of resilience as it applies to the challenges of international development. The conceptualization we advance for development resilience focuses on the stochastic dynamics of individual and collective human well-being, especially on the avoidance of and escape from chronic poverty over time in the f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barrett CB,Constas MA

更新日期：2014-10-07 00:00:00

abstract：:We examined iron nitrosylation of non-heme protein and enzymatic activity of the Fe-S cluster protein, aconitase, in acute cardiac allograft rejection. Heterotopic transplantation of donor hearts was performed in histocompatibility matched (isografts: Lewis --> Lewis) and mismatched (allografts: Wistar-Furth --> Lewis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pieper GM,Halligan NL,Hilton G,Konorev EA,Felix CC,Roza AM,Adams MB,Griffith OW

更新日期：2003-03-18 00:00:00

abstract：:There is increasing, but largely indirect, evidence pointing to an effect of commensal gut microbiota on the central nervous system (CNS). However, it is unknown whether lactic acid bacteria such as Lactobacillus rhamnosus could have a direct effect on neurotransmitter receptors in the CNS in normal, healthy animals. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bravo JA,Forsythe P,Chew MV,Escaravage E,Savignac HM,Dinan TG,Bienenstock J,Cryan JF

更新日期：2011-09-20 00:00:00

abstract：:The Escherichia coli chaperonins GroEL and GroES facilitate the refolding of polypeptide chains in an ATP hydrolysis-dependent reaction. The elementary steps in the binding and release of polypeptide substrates to GroEL were investigated in surface plasmon resonance studies to measure the rates of binding and dissocia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin Z,Eisenstein E

更新日期：1996-03-05 00:00:00