Monoclonal antibodies to estrophilin: probes for the study of estrogen receptors.

abstract：:We are only just beginning to catalog the vast diversity of cell types in the cerebral cortex. Such categorization is a first step toward understanding how diversification relates to function. All cortical projection neurons arise from a uniform pool of progenitor cells that lines the ventricles of the forebrain. It i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heavner WE,Ji S,Notwell JH,Dyer ES,Tseng AM,Birgmeier J,Yoo B,Bejerano G,McConnell SK

更新日期：2020-10-06 00:00:00

abstract：:The poly(A) site of bovine prolactin (bPRL) mRNA was examined by phased priming of cDNA synthesis with oligodeoxynucleotides of the general sequence d(pT8-N-N'). The existence of multiple poly(A)-adjacent sequences in bPRL mRNA was indicated by the production of specific chain-termination fragments with at least three...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sasavage NL,Smith M,Gillam S,Woychik RP,Rottman FM

更新日期：1982-01-01 00:00:00

abstract：:The superficial gray layer of the superior colliculus contains a map that represents the visual field, whereas the underlying intermediate gray layer contains a vector map of the saccades that shift the direction of gaze. These two maps are aligned so that a particular region of the visual field is represented directl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee PH,Helms MC,Augustine GJ,Hall WC

更新日期：1997-11-25 00:00:00

abstract：:The mitogen-activated kinase activating death domain protein (MADD) that is differentially expressed in neoplastic vs. normal cells (DENN) was identified as a substrate for c-Jun N-terminal kinase 3, the first demonstration of such an activity for this stress-activated kinase that is predominantly expressed in the bra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Y,Zhou L,Miller CA

更新日期：1998-03-03 00:00:00

abstract：:Controlling calorie intake (CCI) extends healthful life-span by a mechanism that may involve reduced rates of cell division without detriment to inducible cellular responses. To test whether inducible cellular proliferation is preserved by CCI and whether the mRNA expression levels of oncogenes activated by cell divis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Himeno Y,Engelman RW,Good RA

更新日期：1992-06-15 00:00:00

abstract：:Many fatal neurodegenerative diseases such as Alzheimer's, Parkinson, the prion-related diseases, and non-neurodegenerative disorders such as type II diabetes are characterized by abnormal amyloid fiber aggregates, suggesting a common mechanism of pathogenesis. We have discovered that a class of systematically designe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hauser CA,Deng R,Mishra A,Loo Y,Khoe U,Zhuang F,Cheong DW,Accardo A,Sullivan MB,Riekel C,Ying JY,Hauser UA

更新日期：2011-01-25 00:00:00

abstract：:Four polyimidazoles were used in the binding and cleavage studies with poly(U). The two polydisperse polyvinylimidazoles were previously described by others, while the other two new polymers of polyethyleneimines were prepared by cationic polymerization of oxazolines. The latter had imidazole units attached to each ni...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheng L,Abhilash KG,Breslow R

更新日期：2012-08-07 00:00:00

abstract：:The demonstration of enzymatic capabilities of certain RNAs, in addition to their well-known template properties, has led to the recognition that RNAs are the only biological macromolecules that can function both as genotype and phenotype, hence raising the possibility of Darwinian selection and precellular evolution ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Diener TO

更新日期：1989-12-01 00:00:00

abstract：:Prostate-specific membrane antigen (PSMA) is a type 2 integral membrane glycoprotein that serves as an attractive target for cancer immunotherapy by virtue of its abundant and restricted expression on the surface of prostate carcinomas and the neovasculature of most other solid tumors. However, relatively little is kn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schülke N,Varlamova OA,Donovan GP,Ma D,Gardner JP,Morrissey DM,Arrigale RR,Zhan C,Chodera AJ,Surowitz KG,Maddon PJ,Heston WD,Olson WC

更新日期：2003-10-28 00:00:00

abstract：:Many neurotransmitters are known to regulate neuronal cell function by means of activation of cAMP-dependent protein kinase (PKA) and phosphorylation of neuronal substrate proteins, including transcription factors and ion channels. Here, we have characterized the gene expression of two isoforms of a protein kinase inh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seasholtz AF,Gamm DM,Ballestero RP,Scarpetta MA,Uhler MD

更新日期：1995-02-28 00:00:00

abstract：:Micrometeorites with diameter approximately 100-200 microm dominate the flux of extraterrestrial matter on Earth. The vast majority of micrometeorites are chemically, mineralogically, and isotopically related to carbonaceous chondrites, which amount to only 2.5% of meteorite falls. Here, we report the discovery of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gounelle M,Chaussidon M,Morbidelli A,Barrat JA,Engrand C,Zolensky ME,McKeegan KD

更新日期：2009-04-28 00:00:00

abstract：:The prefrontal cortex continues to mature after puberty and into early adulthood, mirroring the time course of maturation of cognitive abilities. However, the way in which prefrontal activity changes during peri- and postpubertal cortical maturation is largely unknown. To address this question, we evaluated the develo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou X,Zhu D,Katsuki F,Qi XL,Lees CJ,Bennett AJ,Salinas E,Stanford TR,Constantinidis C

更新日期：2014-03-11 00:00:00

abstract：:MicroRNAs (miRNAs) are small 19- to 24-nt noncoding RNAs that have the capacity to regulate fundamental biological processes essential for cancer initiation and progression. In cancer, miRNAs may function as oncogenes or tumor suppressors. Here, we conducted global profiling for miRNAs in a cohort of stage 1 nonsmall ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peng Y,Dai Y,Hitchcock C,Yang X,Kassis ES,Liu L,Luo Z,Sun HL,Cui R,Wei H,Kim T,Lee TJ,Jeon YJ,Nuovo GJ,Volinia S,He Q,Yu J,Nana-Sinkam P,Croce CM

更新日期：2013-09-10 00:00:00

abstract：:Human malignant pleural mesothelioma (MPM) is considered a rare tumor, but recent estimations indicate that one-quarter million people will die of this neoplasm in Europe in the next three decades. The mineral asbestos is considered the main causative agent of this neoplasm. MPM is largely unresponsive to conventional...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mazzoni E,Corallini A,Cristaudo A,Taronna A,Tassi G,Manfrini M,Comar M,Bovenzi M,Guaschino R,Vaniglia F,Magnani C,Casali F,Rezza G,Barbanti-Brodano G,Martini F,Tognon MG

更新日期：2012-10-30 00:00:00

abstract：:Base excision repair (BER) removes at least 20,000 DNA lesions per human cell per day and is critical for the maintenance of genomic stability. We hypothesize that aberrant BER, resulting from mutations in BER genes, can lead to genomic instability and cancer. The first step in BER is catalyzed by DNA N-glycosylases. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Galick HA,Kathe S,Liu M,Robey-Bond S,Kidane D,Wallace SS,Sweasy JB

更新日期：2013-08-27 00:00:00

abstract：:Computers are organized into hardware and software. Using a theoretical approach to identify patterns in gene expression in a variety of species, organs, and cell types, we found that biological systems similarly are comprised of a relatively unchanging hardware-like gene pattern. Orthogonal patterns of software-like ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kravchenko-Balasha N,Levitzki A,Goldstein A,Rotter V,Gross A,Remacle F,Levine RD

更新日期：2012-03-20 00:00:00

abstract：:Mucopolysaccharidosis type VII is a lysosomal storage disorder resulting from inherited deficiency of beta-glucuronidase (GUS). Mucopolysaccharidosis type VII is characterized by glycosaminoglycan storage in most tissues, including brain. In these disorders, enzyme delivery across the blood-brain barrier (BBB) is the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Urayama A,Grubb JH,Sly WS,Banks WA

更新日期：2004-08-24 00:00:00

abstract：:A complementary DNA (cDNA) clone from a human placenta cDNA library encoding extracellular superoxide dismutase (EC-SOD; superoxide:superoxide oxidoreductase, EC 1.15.1.1) has been isolated and the nucleotide sequence determined. The cDNA has a very high G+C content. EC-SOD is synthesized with a putative 18-amino acid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hjalmarsson K,Marklund SL,Engström A,Edlund T

更新日期：1987-09-01 00:00:00

abstract：:Nitric oxide (NO), synthesized from L-arginine by NO synthases (NOS), plays an essential role in the regulation of cerebrovascular tone. Adenoviral vectors have been widely used to transfer recombinant genes to different vascular beds. To determine whether the recombinant endothelial NOS (eNOS) gene can be delivered i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen AF,Jiang SW,Crotty TB,Tsutsui M,Smith LA,O'Brien T,Katusic ZS

更新日期：1997-11-11 00:00:00

abstract：:During neurogenesis of the mammalian neocortex, neural progenitor cells divide to generate daughter cells that either become neurons or remain as progenitor cells. The mouse numb (m-numb) gene encodes a membrane-associated protein that is asymmetrically localized to the apical cell membrane of dividing cortical progen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhong W,Jiang MM,Schonemann MD,Meneses JJ,Pedersen RA,Jan LY,Jan YN

更新日期：2000-06-06 00:00:00

abstract：:Acquired resistance against antimalarial drugs has further increased the need for an effective malaria vaccine. The current leading candidate, RTS,S, is a recombinant circumsporozoite protein (CSP)-based vaccine against Plasmodium falciparum that contains 19 NANP repeats followed by a thrombospondin repeat domain. Alt...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oyen D,Torres JL,Wille-Reece U,Ockenhouse CF,Emerling D,Glanville J,Volkmuth W,Flores-Garcia Y,Zavala F,Ward AB,King CR,Wilson IA

更新日期：2017-11-28 00:00:00

abstract：:Transmembrane (TM) domains of integral membrane proteins are generally thought to be helical. However, a Gly-Pro sequence within the TM domain of the insulin receptor is predicted to act as a helix breaker. CD analyses of model TM peptides in a lipid-like environment show that substitution of Gly and Pro by Ala enhanc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goncalves E,Yamada K,Thatte HS,Backer JM,Golan DE,Kahn CR,Shoelson SE

更新日期：1993-06-15 00:00:00

abstract：:Bacteriophage lambda encodes a number of genes involved in the recombinational repair of DNA double-strand breaks. The product of one of these genes, rap, has been purified. Truncated Rap proteins that copurify with the full-length form are derived, at least in part, from a rho-dependent transcription terminator locat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharples GJ,Corbett LM,Graham IR

更新日期：1998-11-10 00:00:00

abstract：:The human cytokine I-309 is a small glycoprotein secreted by activated T lymphocytes and structurally related to a number of inflammatory cytokines. To investigate the biological activities of I-309 protein, we produced a stable Chinese hamster ovary cell transfectant, CDI.10, which constitutively secretes I-309 prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller MD,Krangel MS

更新日期：1992-04-01 00:00:00

abstract：:Fast lateral proton migration along membranes is of vital importance for cellular energy homeostasis and various proton-coupled transport processes. It can only occur if attractive forces keep the proton at the interface. How to reconcile this high affinity to the membrane surface with high proton mobility is unclear....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang C,Knyazev DG,Vereshaga YA,Ippoliti E,Nguyen TH,Carloni P,Pohl P

更新日期：2012-06-19 00:00:00

abstract：:Natural resistance-associated macrophage protein (Nramp) family transporters catalyze uptake of essential divalent transition metals like iron and manganese. To discriminate against abundant competitors, the Nramp metal-binding site should favor softer transition metals, which interact either covalently or ionically w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bozzi AT,Bane LB,Weihofen WA,McCabe AL,Singharoy A,Chipot CJ,Schulten K,Gaudet R

更新日期：2016-09-13 00:00:00

abstract：:Protein functions require conformational motions. We show here that the dominant conformational motions are slaved by the hydration shell and the bulk solvent. The protein contributes the structure necessary for function. We formulate a model that is based on experiments, insights from the physics of glass-forming liq...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frauenfelder H,Chen G,Berendzen J,Fenimore PW,Jansson H,McMahon BH,Stroe IR,Swenson J,Young RD

更新日期：2009-03-31 00:00:00

abstract：:Due to intrinsic aggressiveness and lack of effective therapies, prognosis of pancreatic cancer remains dismal. Because the only molecular targeted drug approved for pancreatic ductal adenocarcinoma is a kinase inhibitor specific to the epidermal growth factor receptor (EGFR), and this receptor collaborates with anoth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maron R,Schechter B,Mancini M,Mahlknecht G,Yarden Y,Sela M

更新日期：2013-09-17 00:00:00

abstract：:Members of the order Nidovirales express their structural protein ORFs from a nested set of 3' subgenomic mRNAs (sg mRNAs), and for most of these ORFs, a single genomic transcription regulatory sequence (TRS) was identified. Nine TRSs were previously reported for the arterivirus Simian hemorrhagic fever virus (SHFV). ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Di H,Madden JC Jr,Morantz EK,Tang HY,Graham RL,Baric RS,Brinton MA

更新日期：2017-10-17 00:00:00

abstract：:Peripheral blood leukocytes, obtained from volunteers after vaccination or natural illness with influenza, were assayed for cytotoxicity against influenza virus-infected cells. Approximately 7 days after vaccination or the onset of respiratory illness, peak cytotoxicity was demonstrated in a chromium-release assay. Se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Greenberg SB,Six HR,Drake S,Couch RB

更新日期：1979-09-01 00:00:00