Mouse numb is an essential gene involved in cortical neurogenesis.

abstract：:The alpha and beta subunits of Na-K-ATPase are up-regulated by hypertonicity in inner-medullary collecting duct cells adapted to survive in hypertonic conditions. We examined the regulation of the gamma subunit by hypertonicity. Although cultured inner-medullary collecting duct cells lacked the gamma subunits, both va...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Capasso JM,Rivard C,Berl T

更新日期：2001-11-06 00:00:00

abstract：:A new nondefective hybrid virus has been plaque-isolated from the Ad.2-SV40 hybrid population. This virus replicates efficiently with one-hit kinetics in both human embryonic kidney and African green monkey kidney cells, induces an SV40 specific antigen which is detectable by immunofluorescence and complement-fixation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lewis AM Jr,Levin MJ,Wiese WH,Crumpacker CS,Henry PH

更新日期：1969-08-01 00:00:00

abstract：:After treatment with nitrite, Japanese soy sauce was strongly mutagenic to Salmonella typhimurium TA100 without S9 mixture. Two precursors of the mutagen were isolated from Japanese soy sauce, and these were identified as (-)-(1S,3S)-1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid [(-)-(1S,3S)-MTCA] and i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wakabayashi K,Ochiai M,Saitô H,Tsuda M,Suwa Y,Nagao M,Sugimura T

更新日期：1983-05-01 00:00:00

abstract：:Fluorescence imaging in the second near-infrared window (NIR-II, 1,000-1,700 nm) features deep tissue penetration, reduced tissue scattering, and diminishing tissue autofluorescence. Here, NIR-II fluorescent probes, including down-conversion nanoparticles, quantum dots, single-walled carbon nanotubes, and organic dyes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dang X,Gu L,Qi J,Correa S,Zhang G,Belcher AM,Hammond PT

更新日期：2016-05-10 00:00:00

abstract：:The structural requirements of E. coli formylmethionine tRNA for aminoacylation have been examined by chemical modification of the tRNA, followed by separation of the modified molecules into active and inactive components. Photooxidation of tRNA(fMet) at 50 degrees in the presence of methylene blue results in modifica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schulman LH

更新日期：1972-12-01 00:00:00

abstract：:Normal rat kidney cells were nonproductively infected either with CP27, a mutant of Moloney sarcoma virus that is temperature-sensitive for maintenance of transformation, or with the parental wild-type virus. The nonproducer cells were inoculated into the tails of athymic nude mice that were subsequently incubated at ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klarlund JK,Forchhammer J

更新日期：1980-03-01 00:00:00

abstract：:The emergence of resistance to multiple unrelated chemotherapeutic drugs impedes the treatment of several cancers. Although the involvement of ATP-binding cassette transporters has long been known, there is no in situ method capable of tracking this transporter-related resistance at the single-cell level without inter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kuss S,Polcari D,Geissler M,Brassard D,Mauzeroll J

更新日期：2013-06-04 00:00:00

abstract：:In Huntington's disease (HD), mutation of huntingtin causes selective neurodegeneration of dopaminoceptive striatal medium spiny neurons. Transgenic HD model mice that express a portion of the disease-causing form of human huntingtin develop a behavioral phenotype that suggests dysfunction of dopaminergic neurotransmi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bibb JA,Yan Z,Svenningsson P,Snyder GL,Pieribone VA,Horiuchi A,Nairn AC,Messer A,Greengard P

更新日期：2000-06-06 00:00:00

abstract：:Energy-coupling factor (ECF) transporters are a recently discovered family of primary active transporters for micronutrients and vitamins, such as biotin, thiamine, and riboflavin. Found exclusively in archaea and bacteria, including the human pathogens Listeria, Streptococcus, and Staphylococcus, ECF transporters may...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karpowich NK,Wang DN

更新日期：2013-02-12 00:00:00

abstract：:Human X chromosome DNA was partially purified from a mouse-human hybrid cell line containing a single human chromosome, the X. Enrichment of such DNA was accomplished by two sequential reassociations of radiolabeled hybrid cell DNA with large excesses of mouse DNA. Unreassociated hybrid cell DNA was used as a probe fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmeckpeper BJ,Smith KD,Dorman BP,Ruddle FH,Talbot CC Jr

更新日期：1979-12-01 00:00:00

abstract：:Fodrin, a protein composed of two polypeptides with molecular weights of 250,000 and 240,000, is concentrated in the cortical cytoplasm of neurons, and moves down the axons by the process of axonal transport. We have used immunofluorescence techniques to determine whether fodrin antigens also move in non-neuronal cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levine J,Willard M

更新日期：1983-01-01 00:00:00

abstract：:The evolutionary transition from single cells toward multicellular forms of life represents one of the major transitions in the evolution of complex organisms. In this transition, single autonomously reproducing cells became parts of larger reproducing entities that eventually constituted a new unit of selection. The ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pfeiffer T,Bonhoeffer S

更新日期：2003-02-04 00:00:00

abstract：:After decades of robust growth, the rise in US life expectancy stalled after 2010. Explanations for the stall have focused on rising drug-related deaths. Here we show that a stagnating decline in cardiovascular disease (CVD) mortality was the main culprit, outpacing and overshadowing the effects of all other causes of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mehta NK,Abrams LR,Myrskylä M

更新日期：2020-03-31 00:00:00

abstract：:In the absence of any overt task performance, it has been shown that spontaneous, intrinsic brain activity is expressed as systemwide, resting-state networks in the adult brain. However, the route to adult patterns of resting-state activity through neuronal development in the human brain is currently unknown. Therefor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fransson P,Skiöld B,Horsch S,Nordell A,Blennow M,Lagercrantz H,Aden U

更新日期：2007-09-25 00:00:00

abstract：:One mechanism of silver resistance in microorganisms is accumulation of the metal ions in the cell. Here, we report on the phenomenon of biosynthesis of silver-based single crystals with well-defined compositions and shapes, such as equilateral triangles and hexagons, in Pseudomonas stutzeri AG259. The crystals were u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klaus T,Joerger R,Olsson E,Granqvist CG

更新日期：1999-11-23 00:00:00

abstract：:Etioplasts isolated from barley leaves and purified on a Sephadex G-50 (coarse) column were characterized by electron microscopy and nucleic acid analysis. The majority of etioplasts retained an intact outer envelope, and contamination by other fragments was extremely low. The level of gibberellin-like substances extr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Evans A,Smith H

更新日期：1976-01-01 00:00:00

abstract：:Current knowledge of the evolution of the postcranial skeleton in the genus Homo is hampered by a geographically and chronologically scattered fossil record. Here we present a complete characterization of the postcranium of the middle Pleistocene paleodeme from the Sima de los Huesos (SH) and its paleobiological impli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arsuaga JL,Carretero JM,Lorenzo C,Gómez-Olivencia A,Pablos A,Rodríguez L,García-González R,Bonmatí A,Quam RM,Pantoja-Pérez A,Martínez I,Aranburu A,Gracia-Téllez A,Poza-Rey E,Sala N,García N,Alcázar de Velasco A,Cuenca-B

更新日期：2015-09-15 00:00:00

abstract：:Midbrain dopamine (DA) neurons respond to sensory stimuli associated with future rewards. When reward is delivered probabilistically, DA neurons reflect this uncertainty by increasing their firing rates in a period between the sensory cue and reward delivery time. Probability of reward, however, has been externally co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de Lafuente V,Romo R

更新日期：2011-12-06 00:00:00

abstract：:The techniques of electrophoresis were used in a search for evidence of mutation affecting protein structure, the indicators being hemoglobin and a set of serum proteins and erythrocyte enzymes. Among 94,796 locus tests on Amerindians from Central and South America, there was no evidence for mutation. Among 105,649 lo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Neel JV,Mohrenweiser HW,Meisler MH

更新日期：1980-10-01 00:00:00

abstract：:The sea anemone, Nematostella vectensis, has become an attractive new model organism for comparative genomics and evolutionary developmental biology. Over the last few years, many genes have been isolated and their expression patterns studied to gain insight into their function. More recently, functional tools have be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Renfer E,Amon-Hassenzahl A,Steinmetz PR,Technau U

更新日期：2010-01-05 00:00:00

abstract：:Prey in natural communities are usually shared by many predator species. How predators coexist while competing for the same prey is one of the fundamental questions in ecology. Here, we show that competing predator species may not only coexist on a single prey but even help each other to persist if they specialize on ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Roos AM,Schellekens T,Van Kooten T,Persson L

更新日期：2008-09-16 00:00:00

abstract：:Reducible compounds that participate in crosslinking were analyzed in hydroxylysine-deficient collagens of patients with a heritable disorder of connective tissue. After treatment with [(3)H]sodium borohydride, new compounds, as well as a totally different pattern of tritiated compounds, were found in hydroxylysine-de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eyre DR,Glimcher MJ

更新日期：1972-09-01 00:00:00

abstract：:Herpesvirus saimiri (HVS) is the prototype member of a distinctive subset of lymphotropic herpesviruses (the gamma 2 subgroup) with A+T-rich coding sequences. In this paper, we show that cells productively infected with HVS contain high concentrations of a virus-specified thymidylate synthase (5,10-methylenetetrahydro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Honess RW,Bodemer W,Cameron KR,Niller HH,Fleckenstein B,Randall RE

更新日期：1986-06-01 00:00:00

abstract：:Real-world studies show that the facial expressions produced during pain and orgasm-two different and intense affective experiences-are virtually indistinguishable. However, this finding is counterintuitive, because facial expressions are widely considered to be a powerful tool for social interaction. Consequently, de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen C,Crivelli C,Garrod OGB,Schyns PG,Fernández-Dols JM,Jack RE

更新日期：2018-10-23 00:00:00

abstract：:The O(2)-reaction chemistry of 1:1 mixtures of (F(8))Fe(II) (1; F(8) = tetrakis(2,6-diflurorophenyl)porphyrinate) and [(L(Me(2))N)Cu(I)](+) (2; L(Me(2))N = N,N-bis(2-[2-(N',N'-4-dimethylamino)pyridyl]ethyl)methylamine) is described, to model aspects of the chemistry occurring in cytochrome c oxidase. Spectroscopic inv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim E,Helton ME,Wasser IM,Karlin KD,Lu S,Huang HW,Moenne-Loccoz P,Incarvito CD,Rheingold AL,Honecker M,Kaderli S,Zuberbuhler AD

更新日期：2003-04-01 00:00:00

abstract：:Recent studies show that plant organ positioning may be mediated by localized concentrations of the plant hormone auxin. Auxin patterning in the shoot apical meristem is in turn brought about by the subcellular polar distribution of the putative auxin efflux mediator, PIN1. However, the question of what signals determ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jönsson H,Heisler MG,Shapiro BE,Meyerowitz EM,Mjolsness E

更新日期：2006-01-31 00:00:00

abstract：:Defining the molecules that regulate tumor cell survival is an essential prerequisite for the development of targeted approaches to cancer treatment. Whereas many studies aimed at identifying such targets use human tumor cells grown in vitro or as s.c. xenografts, it is unclear whether such experimental models replica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Camphausen K,Purow B,Sproull M,Scott T,Ozawa T,Deen DF,Tofilon PJ

更新日期：2005-06-07 00:00:00

abstract：:Homozygous lymphoblastoid cell lines representing Dw subtypes of the DR2 serotype were studied for structural polymorphism at DR beta. These subtypes included Dw2, Dw12, and non-Dw2/non-Dw12. Analysis by two-dimensional gel electrophoresis showed that two DR beta genes were expressed in each cell line studied. One of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee BS,Rust NA,McMichael AJ,McDevitt HO

更新日期：1987-07-01 00:00:00

abstract：:I summarize recent computational and experimental work that addresses the inherent variability in the synaptic and intrinsic conductances in normal healthy brains and shows that multiple solutions (sets of parameters) can produce similar circuit performance. I then discuss a number of issues raised by this observation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marder E

更新日期：2011-09-13 00:00:00

abstract：:We are only just beginning to catalog the vast diversity of cell types in the cerebral cortex. Such categorization is a first step toward understanding how diversification relates to function. All cortical projection neurons arise from a uniform pool of progenitor cells that lines the ventricles of the forebrain. It i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heavner WE,Ji S,Notwell JH,Dyer ES,Tseng AM,Birgmeier J,Yoo B,Bejerano G,McConnell SK

更新日期：2020-10-06 00:00:00