Resting-state networks in the infant brain.

abstract：:Volumetric detection and accurate quantification of fluorescent proteins in entire animals would greatly enhance our ability to monitor biological processes in vivo. Here we present a quantitative tomographic technique for visualization of superficial and deep-seated (>2-3 mm) fluorescent protein activity in vivo. We ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zacharakis G,Kambara H,Shih H,Ripoll J,Grimm J,Saeki Y,Weissleder R,Ntziachristos V

更新日期：2005-12-20 00:00:00

abstract：:The prefrontal cortex (PFC) is assumed to contribute to goal-directed episodic encoding by exerting cognitive control on medial temporal lobe (MTL) memory processes. However, it is thus far unclear to what extent the contribution of PFC-MTL interactions to memory manifests at a structural anatomical level. We combined...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schott BH,Niklas C,Kaufmann J,Bodammer NC,Machts J,Schütze H,Düzel E

更新日期：2011-03-29 00:00:00

abstract：:We previously purified a 48-kDa protein (p48) that specifically reacts with an antiserum directed against the 12 carboxyl-terminal amino acids of the c-myc gene product. Using an antiserum directed against the purified p48, we have cloned a cDNA from a human expression library. This cDNA hybrid-selects an mRNA that tr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giallongo A,Feo S,Moore R,Croce CM,Showe LC

更新日期：1986-09-01 00:00:00

abstract：:For many years, the Neanderthals have been recognized as a distinctive extinct hominid group that occupied Europe and western Asia between about 200,000 and 30,000 years ago. It is still debated, however, whether these hominids belong in their own species, Homo neanderthalensis, or represent an extinct variant of Homo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwartz JH,Tattersall I

更新日期：1996-10-01 00:00:00

abstract：:Urodeles and fetal mammals are capable of impressive epimorphic regeneration in a variety of tissues, whereas the typical default response to injury in adult mammals consists of inflammation and scar tissue formation. One component of epimorphic regeneration is the recruitment of resident progenitor and stem cells to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Agrawal V,Johnson SA,Reing J,Zhang L,Tottey S,Wang G,Hirschi KK,Braunhut S,Gudas LJ,Badylak SF

更新日期：2010-02-23 00:00:00

abstract：:Biological polymers such as nucleic acids and proteins are constructed of only one-the d or l-of the two possible nonsuperimposable mirror images (enantiomers) of selected organic compounds. However, before the advent of life, it is generally assumed that chemical reactions produced 50:50 (racemic) mixtures of enantio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cooper G,Rios AC

更新日期：2016-06-14 00:00:00

abstract：:Although mathematical models and laboratory experiments have shown that species interactions can generate chaos, field evidence of chaos in natural ecosystems is rare. We report on a pristine rocky intertidal community located in one of the world's oldest marine reserves that has displayed a complex cyclic succession ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benincà E,Ballantine B,Ellner SP,Huisman J

更新日期：2015-05-19 00:00:00

abstract：:IL-33, a cytokine of the IL-1 family, is closely associated with type II T cell responses. Here, we report an unexpected proinflammatory role of IL-33 in inflammatory arthritis. IL-33 was expressed in synovial fibroblasts from patients with rheumatoid arthritis (RA). Expression was markedly elevated in vitro by inflam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu D,Jiang HR,Kewin P,Li Y,Mu R,Fraser AR,Pitman N,Kurowska-Stolarska M,McKenzie AN,McInnes IB,Liew FY

更新日期：2008-08-05 00:00:00

abstract：:A key barrier to the realization of personalized medicine for cancer is the identification of biomarkers. Here we describe a two-stage strategy for the discovery of serum biomarker signatures corresponding to specific cancer-causing mutations and its application to prostate cancer (PCa) in the context of the commonly ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cima I,Schiess R,Wild P,Kaelin M,Schüffler P,Lange V,Picotti P,Ossola R,Templeton A,Schubert O,Fuchs T,Leippold T,Wyler S,Zehetner J,Jochum W,Buhmann J,Cerny T,Moch H,Gillessen S,Aebersold R,Krek W

更新日期：2011-02-22 00:00:00

abstract：:Multiple epiphyseal dysplasia (MED) is a degenerative cartilage condition shown in some cases to be caused by mutations in genes encoding cartilage oligomeric matrix protein or type IX collagen. We studied a family with autosomal dominant MED affecting predominantly the knee joints and a mild proximal myopathy. Geneti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bönnemann CG,Cox GF,Shapiro F,Wu JJ,Feener CA,Thompson TG,Anthony DC,Eyre DR,Darras BT,Kunkel LM

更新日期：2000-02-01 00:00:00

abstract：:Carbon can exist as isolated dumbbell, 1D chain, 2D plane, and 3D network in carbon solids or carbon-based compounds, which attributes to its rich chemical binding way, including sp-, sp(2)-, and sp(3)-hybridized bonds. sp(2)-hybridizing carbon always captures special attention due to its unique physical and chemical ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li YL,Luo W,Zeng Z,Lin HQ,Mao HK,Ahuja R

更新日期：2013-06-04 00:00:00

abstract：:CCR5 encodes a cell surface chemokine receptor molecule that serves as the principal coreceptor, with CD4, for HIV-type 1 (HIV-1). Varied HIV-1 susceptibility and time to progression to AIDS have been associated with polymorphisms in CCR5. Many of these polymorphisms are located in the 5' cis-regulatory region of CCR5...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bamshad MJ,Mummidi S,Gonzalez E,Ahuja SS,Dunn DM,Watkins WS,Wooding S,Stone AC,Jorde LB,Weiss RB,Ahuja SK

更新日期：2002-08-06 00:00:00

abstract：:The affinity and stoichiometry of DNA binding by Escherichia coli trp repressor were studied by electrophoresis in nondenaturing gels. The ability of trp repressor to retard the electrophoretic mobility of an operator DNA fragment depends on the pH of the gel system. Above the pI of the protein, little retardation of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carey J

更新日期：1988-02-01 00:00:00

abstract：:The AML1 gene, located on chromosome 21, is involved in several distinct chromosomal translocations in human leukemia. In t(8;21) acute myelogenous leukemia (AML), the AML1 gene is juxtaposed to the ETO gene located on chromosome 8, generating an AML1/ETO fusion protein. Both AML1/ETO and the AML1 proteins recognize t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klampfer L,Zhang J,Zelenetz AO,Uchida H,Nimer SD

更新日期：1996-11-26 00:00:00

abstract：:Independent transgene insertions differ in expression based on their location in the genome; these position effects are of interest because they reflect the influence of genome organization on gene regulation. Position effects also represent potentially insurmountable obstacles to the rigorous functional comparison of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Siegal ML,Hartl DL

更新日期：1998-12-22 00:00:00

abstract：:Embryonic stem cells (ESCs) represent an important research tool and a potential resource for regenerative medicine. Generally, ESCs are cocultured with a supportive feeder cell layer of murine embryonic fibroblasts, which maintain the ESCs' capacity for self-renewal and block spontaneous differentiation. These cumber...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miyabayashi T,Teo JL,Yamamoto M,McMillan M,Nguyen C,Kahn M

更新日期：2007-03-27 00:00:00

abstract：:Mechanisms of bacterial pathogenesis have become an increasingly important subject as pathogens have become increasingly resistant to current antibiotics. The adhesion of microorganisms to the surface of host tissue is often a first step in pathogenesis and is a plausible target for new antiinfective agents. Examinati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liang MN,Smith SP,Metallo SJ,Choi IS,Prentiss M,Whitesides GM

更新日期：2000-11-21 00:00:00

abstract：:Confluent cultures of human fetal lung fibroblasts degrade approximately 10% of their newly synthesized collagen within the cell prior to secretion. This basal level of intracellular degradation could not be inhibited by colchicine or cytochalasin B, inhibitors of microtubular and microfilament function, respectively,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berg RA,Schwartz ML,Crystal RG

更新日期：1980-08-01 00:00:00

abstract：:Infected-cell protein 4 (ICP4), the major regulatory protein specified by herpes simplex virus 1 in infected cells, binds to homologs of the sequence ATCGTCnnnnYCGRC (A sites, where n is any nucleotide, Y is a pyrimidine, and R is a purine) and to unrelated sequences for which no consensus sequence has been derived (B...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Michael N,Roizman B

更新日期：1989-12-01 00:00:00

abstract：:An Escherichia coli chromosomal DNA fragment cloned on a multicopy plasmid conferred resistance to carbonylcyanide m-chlorophenylhydrazone, nalidixic acid, and a number of other toxic compounds. The sequence of the cloned emr locus located at minute 57.5 of the chromosome revealed two open reading frames, emrA and emr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lomovskaya O,Lewis K

更新日期：1992-10-01 00:00:00

abstract：:The world's oceans are undergoing profound changes as a result of human activities. However, the consequences of escalating human impacts on marine mammal biodiversity remain poorly understood. The International Union for the Conservation of Nature (IUCN) identifies 25% of marine mammals as at risk of extinction, but ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davidson AD,Boyer AG,Kim H,Pompa-Mansilla S,Hamilton MJ,Costa DP,Ceballos G,Brown JH

更新日期：2012-02-28 00:00:00

abstract：:Cell cycle-controlled human histone genes are coordinately expressed during S phase, and transcriptional regulation involves a series of trans-acting factors (HiNFs). The proliferation-specific factor HiNF-D interacts with multiple recognition motifs in histone H4, H3, and H1 promoters. Using gel shift immunoassays, w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Wijnen AJ,Aziz F,Graña X,De Luca A,Desai RK,Jaarsveld K,Last TJ,Soprano K,Giordano A,Lian JB

更新日期：1994-12-20 00:00:00

abstract：:In movies or on TV, a wheel can seem to rotate backwards, due to the temporal subsampling inherent in the recording process (the wagon wheel illusion). Surprisingly, this effect has also been reported under continuous light, suggesting that our visual system, too, might sample motion in discrete "snapshots." Recently,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： VanRullen R,Reddy L,Koch C

更新日期：2005-04-05 00:00:00

abstract：:A glycoprotein, termed amphiregulin (AR), inhibits growth of several human carcinoma cells in culture and stimulates proliferation of human fibroblasts and certain other tumor cells. It has been purified to apparent homogeneity from serum-free conditioned medium of MCF-7 human breast carcinoma cells that had been trea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shoyab M,McDonald VL,Bradley JG,Todaro GJ

更新日期：1988-09-01 00:00:00

abstract：:Thyroid hormone receptors (TRs) are members of the nuclear hormone receptor superfamily that act as ligand-dependent transcription factors. Here we identified the ten-eleven translocation protein 3 (TET3) as a TR interacting protein increasing cell sensitivity to T3. The interaction between TET3 and TRs is independent...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guan W,Guyot R,Samarut J,Flamant F,Wong J,Gauthier KC

更新日期：2017-08-01 00:00:00

abstract：:The substitution pattern of anthocyanin pigments is a main determinant of flower color. Flavonoid 3',5'-hydroxylase (F3'5'H) is a cytochrome P450 enzyme (Cyt P450) that catalyzes the 3', 5'-hydroxylation of dihydroflavonols, the precursors of purple anthocyanins. Species such as rose and carnation lack F3'5'H activity...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de Vetten N,ter Horst J,van Schaik HP,de Boer A,Mol J,Koes R

更新日期：1999-01-19 00:00:00

abstract：:Plants, although sessile, can reorient growth axes in response to changing environmental conditions. Phototropism and gravitropism represent adaptive growth responses induced by changes in light direction and growth axis orientation relative to gravitational direction, respectively. The nearly 80-year-old Cholodny-Wen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Esmon CA,Tinsley AG,Ljung K,Sandberg G,Hearne LB,Liscum E

更新日期：2006-01-03 00:00:00

abstract：:Drosophila melanogaster Polo kinase physically interacts with, and is repressed by, the Matrimony (Mtrm) protein during oogenesis. Females heterozygous for a deletion of the mtrm gene display defects in chromosome segregation at meiosis I. However, a complete absence of Mtrm results in both meiotic catastrophe and fem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bonner AM,Hughes SE,Chisholm JA,Smith SK,Slaughter BD,Unruh JR,Collins KA,Friederichs JM,Florens L,Swanson SK,Pelot MC,Miller DE,Washburn MP,Jaspersen SL,Hawley RS

更新日期：2013-03-26 00:00:00

abstract：:Assessing temporal variability in extreme rainfall events before the historical era is complicated by the sparsity of long-term "direct" storm proxies. Here we present a 2,200-y-long, accurate, and precisely dated record of cave flooding events from the northwest Australian tropics that we interpret, based on an integ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Denniston RF,Villarini G,Gonzales AN,Wyrwoll KH,Polyak VJ,Ummenhofer CC,Lachniet MS,Wanamaker AD Jr,Humphreys WF,Woods D,Cugley J

更新日期：2015-04-14 00:00:00

abstract：:Glutamine-dependent carbamylphosphate synthetase (Escherichia coli) is composed of a heavy subunit (molecular weight about 130,000) and a light subunit (molecular weight about 42,000), which can be separated with retention of catalytic activities. The separated heavy subunit can catalyze activation of CO(2) by ATP and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trotta PP,Wellner VP,Pinkus LM,Meister A

更新日期：1973-10-01 00:00:00