Binding of the herpes simplex virus major regulatory protein to viral DNA.

abstract：:In Epstein-Barr virus (EBV)-positive Burkitt lymphoma (BL) the role of EBV in the translocation and deregulation of the MYC oncogene remains unknown. By utilizing an EBV-negative BL (BJAB) and several EBV-positive sublines derived from it by in vitro infection, it was possible to show that the presence of the virus wa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lacy J,Summers WP,Watson M,Glazer PM,Summers WC

更新日期：1987-08-01 00:00:00

abstract：:The highly aggressive character of melanoma makes it an excellent model for probing the mechanisms underlying metastasis, which remains one of the most difficult challenges in treating cancer. We find that miR-182, member of a miRNA cluster in a chromosomal locus (7q31-34) frequently amplified in melanoma, is commonly...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Segura MF,Hanniford D,Menendez S,Reavie L,Zou X,Alvarez-Diaz S,Zakrzewski J,Blochin E,Rose A,Bogunovic D,Polsky D,Wei J,Lee P,Belitskaya-Levy I,Bhardwaj N,Osman I,Hernando E

更新日期：2009-02-10 00:00:00

abstract：:When an unusually high frequency of an allele is encountered in a population, "founder effect" is often invoked as an explanation. As usually used, the term implies the disproportionate increase through chance (rather than selection) of an allele contributed to the population by a particular ancestor. While genetic th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thompson EA,Neel JV

更新日期：1978-03-01 00:00:00

abstract：:Defining the links between cell division and DNA replication is essential for understanding normal cell cycle progression and tumorigenesis. In this report we explore the effect of phosphorylation of cell division cycle 6 (Cdc6), a DNA replication initiation factor, by polo-like kinase 1 (Plk1) on the regulation of ch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yim H,Erikson RL

更新日期：2010-11-16 00:00:00

abstract：:Functional recovery after stroke has been associated with brain plasticity; however, the exact relationship is unknown. We performed behavioral tests, functional MRI, and histology in a rat stroke model to assess the correlation between temporal changes in sensorimotor function, brain activation patterns, cerebral isc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dijkhuizen RM,Ren J,Mandeville JB,Wu O,Ozdag FM,Moskowitz MA,Rosen BR,Finklestein SP

更新日期：2001-10-23 00:00:00

abstract：:Tangier disease is a familial disorder characterized by orange tonsils, cholesterol ester deposition in reticuloendothelial cells, abnormal chylomicron remnants, and a marked reduction in high density lipoproteins. Plasma concentrations of the apolipoproteins apo-A-I and apoA-II in patients with Tangier disease are ap...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kay LL,Ronan R,Schaefer EJ,Brewer HB Jr

更新日期：1982-04-01 00:00:00

abstract：:A panel of 26 mouse-human somatic cell hybrids containing different human chromosome complements was analyzed with a cloned human pepsinogen cDNA probe to determine the chromosomal location and the number of genes encoding these proteins. A complex containing variable numbers of pepsinogen genes was localized to the c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taggart RT,Mohandas TK,Shows TB,Bell GI

更新日期：1985-09-01 00:00:00

abstract：:The Paramyxoviridae family of enveloped viruses enters cells through the concerted action of two viral glycoproteins. The receptor-binding protein, hemagglutinin-neuraminidase (HN), H, or G, binds its cellular receptor and activates the fusion protein, F, which, through an extensive refolding event, brings viral and c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bose S,Zokarkar A,Welch BD,Leser GP,Jardetzky TS,Lamb RA

更新日期：2012-09-25 00:00:00

abstract：:Adoptive cellular immunotherapy, infusions of interleukin 2 (IL-2) in conjunction with in vitro-activated killer cells, has brought new hope to patients with cancer. The broad application of this strategy, however, is constrained by the need for repeated leukapheresis and by the labor-intensive process of in vitro act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakajima F,Khanna A,Xu G,Lagman M,Haschemeyer R,Mouradian J,Wang JC,Stenzel KH,Rubin AL,Suthanthiran M

更新日期：1994-08-16 00:00:00

abstract：:In addition to their roles in desensitization and signaling of seven-membrane-spanning receptors, beta-arrestins have been more recently implicated in regulating non-seven-membrane-spanning receptor pathways. By using a yeast two-hybrid screen, we identified the inhibitor of NF-kappaB, IkappaBalpha, as a binding partn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Witherow DS,Garrison TR,Miller WE,Lefkowitz RJ

更新日期：2004-06-08 00:00:00

abstract：:In the human, cone photoreceptors (L, M, and S) and the melanopsin-containing, intrinsically photosensitive retinal ganglion cells (ipRGCs) are active at daytime light intensities. Signals from cones are combined both additively and in opposition to create the perception of overall light and color. Similar mechanisms ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spitschan M,Jain S,Brainard DH,Aguirre GK

更新日期：2014-10-28 00:00:00

abstract：:Patients with systemic lupus erythematosus (SLE) have accelerated atherosclerosis. The underlying mechanisms are poorly understood, and investigations have been hampered by the absence of animal models that reflect the human condition of generalized atherosclerosis and lupus. We addressed this problem by transferring ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stanic AK,Stein CM,Morgan AC,Fazio S,Linton MF,Wakeland EK,Olsen NJ,Major AS

更新日期：2006-05-02 00:00:00

abstract：:The nanoscale distributions of electron density and electric fields in GaAs semiconductor devices are displayed with NMR experiments. The spectra are sensitive to the changes to the nuclear-spin Hamiltonian that are induced by perturbations delivered in synchrony with a line-narrowing pulse sequence. This POWER (pertu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kempf JG,Miller MA,Weitekamp DP

更新日期：2008-12-23 00:00:00

abstract：:Cell signaling systems sense and respond to ligands that bind cell surface receptors. These systems often respond to changes in the concentration of extracellular ligand more rapidly than the ligand equilibrates with its receptor. We demonstrate, by modeling and experiment, a general "systems level" mechanism cells us...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ventura AC,Bush A,Vasen G,Goldín MA,Burkinshaw B,Bhattacharjee N,Folch A,Brent R,Chernomoretz A,Colman-Lerner A

更新日期：2014-09-16 00:00:00

abstract：:Cranial neural crest cells (crNCCs) migrate from the neural tube to the pharyngeal arches (PAs) of the developing embryo and, subsequently, differentiate into bone and connective tissue to form the mandible. Within the PAs, crNCCs respond to local signaling cues to partition into the proximo-distally oriented subdomai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vincentz JW,Casasnovas JJ,Barnes RM,Que J,Clouthier DE,Wang J,Firulli AB

更新日期：2016-07-05 00:00:00

abstract：:Most B lymphocytes in normal individuals express two classes of cell-surface immunoglobulins, IgM and IgD. The specificity of the two antigen receptors is identical since they are produced by transcription and differential splicing of the same variable region gene segment to the heavy-chain constant region gene segmen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Irsch J,Irlenbusch S,Radl J,Burrows PD,Cooper MD,Radbruch AH

更新日期：1994-02-15 00:00:00

abstract：:The ability of bacteria to regulate gene expression in response to changes in cell density is termed quorum sensing. This behavior involves the synthesis and recognition of extracellular, hormone-like compounds known as autoinducers. Here we report the structure of an autoinducer synthase, LuxS from Bacillus subtilis,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hilgers MT,Ludwig ML

更新日期：2001-09-25 00:00:00

abstract：:In contrast with speciation in terrestrial organisms, marine plankton frequently display gradual morphological change without lineage division (e.g., phyletic gradualism or gradual evolution), which has raised the possibility that a different mode of evolution dominates within pelagic environments. Here, we reexamine ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hull PM,Norris RD

更新日期：2009-12-15 00:00:00

abstract：:The effects of UV irradiation on the incorporation of [3H]uridine in HeLa (human) cell mRNA, rRNA, heterogeneous nuclear RNA (hnRNA) and early mRNA from adenovirus type 2 have been compared. The UV target size of cell mRNA is at least 3 times larger than the average size of the mRNA itself and larger than the adenovir...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldberg S,Schwartz H,Darnell JE Jr

更新日期：1977-10-01 00:00:00

abstract：:Nitrogen limitation imposes a major transition in the lifestyle of nondiazotrophic cyanobacteria that is controlled by a complex interplay of regulatory factors involving the pervasive signal processor PII Immediately upon nitrogen limitation, newly fixed carbon is redirected toward glycogen synthesis. How the metabol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Orthwein T,Scholl J,Spät P,Lucius S,Koch M,Macek B,Hagemann M,Forchhammer K

更新日期：2021-02-09 00:00:00

abstract：:We describe the mechanical separation of the two complementary strands of a single molecule of bacteriophage lambda DNA. The 3' and 5' extremities on one end of the molecule are pulled progressively apart, and this leads to the opening of the double helix. The typical forces along the opening are in the range of 10-15...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Essevaz-Roulet B,Bockelmann U,Heslot F

更新日期：1997-10-28 00:00:00

abstract：:Striga is a major biotic constraint to sorghum production in semiarid tropical Africa and Asia. Genetic resistance to this parasitic weed is the most economically feasible control measure. Mutant alleles at the LGS1 (LOW GERMINATION STIMULANT 1) locus drastically reduce Striga germination stimulant activity. We provid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gobena D,Shimels M,Rich PJ,Ruyter-Spira C,Bouwmeester H,Kanuganti S,Mengiste T,Ejeta G

更新日期：2017-04-25 00:00:00

abstract：:Infectious diseases of domesticated animals impact human well-being via food insecurity, loss of livelihoods, and human infections. While much research has focused on parasites that infect single host species, most parasites of domesticated mammals infect multiple species. The impact of multihost parasites varies acro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Farrell MJ,Davies TJ

更新日期：2019-04-16 00:00:00

abstract：:Membrane lipids were once thought to be homogenously distributed in the 2D surface of a membrane, but the lipid raft theory suggests that cholesterol and sphingolipids partition away from other membrane lipids. Lipid raft theory further implicates these cholesterol-rich domains in many processes such as signaling and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Foster LJ,De Hoog CL,Mann M

更新日期：2003-05-13 00:00:00

abstract：:A number of recent studies have shown that iron dissolution in Fe-containing dust aerosol can be linked to source material (mineral or anthropogenic), mineralogy, and iron speciation. All of these factors need to be incorporated into atmospheric chemistry models if these models are to accurately predict the impact of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rubasinghege G,Lentz RW,Scherer MM,Grassian VH

更新日期：2010-04-13 00:00:00

abstract：:neurogenin2 (ngn2) encodes a basic helix-loop-helix transcription factor and plays an important role in neurogenesis from migratory neural crest cells. Its role in retinal development is poorly understood. We observed that in the developing chick retina, ngn2 was expressed in a subpopulation of proliferating progenito...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan RT,Ma WX,Wang SZ

更新日期：2001-12-18 00:00:00

abstract：:Water-biomolecule interactions have been extensively studied in dilute solutions, crystals, and rehydrated powders, but none of these model systems may capture the behavior of water in the highly organized intracellular milieu. Because of the experimental difficulty of selectively probing the structure and dynamics of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Persson E,Halle B

更新日期：2008-04-29 00:00:00

abstract：:Changes in the amount, intensity, and timing of precipitation are increasing hydrologic variability in many regions, but we have little understanding of how these changes are affecting freshwater species. Stream-breeding amphibians-a diverse group in North America-may be particularly sensitive to hydrologic variabilit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lowe WH,Swartz LK,Addis BR,Likens GE

更新日期：2019-09-24 00:00:00

abstract：:Theoretical models suggest that social networks influence the evolution of cooperation, but to date there have been few experimental studies. Observational data suggest that a wide variety of behaviors may spread in human social networks, but subjects in such studies can choose to befriend people with similar behavior...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fowler JH,Christakis NA

更新日期：2010-03-23 00:00:00

abstract：:Inflammation is a major factor in heart disease. IκB kinase (IKK) and its downstream target NF-κB are regulators of inflammation and are activated in cardiac disorders, but their precise contributions and targets are unclear. We analyzed IKK/NF-κB function in the heart by a gain-of-function approach, generating an ind...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maier HJ,Schips TG,Wietelmann A,Krüger M,Brunner C,Sauter M,Klingel K,Böttger T,Braun T,Wirth T

更新日期：2012-07-17 00:00:00