Abstract:
:Functional recovery after stroke has been associated with brain plasticity; however, the exact relationship is unknown. We performed behavioral tests, functional MRI, and histology in a rat stroke model to assess the correlation between temporal changes in sensorimotor function, brain activation patterns, cerebral ischemic damage, and cerebrovascular reactivity. Unilateral stroke induced a large ipsilateral infarct and acute dysfunction of the contralateral forelimb, which significantly recovered at later stages. Forelimb impairment was accompanied by loss of stimulus-induced activation in the ipsilesional sensorimotor cortex; however, local tissue and perfusion were only moderately affected and cerebrovascular reactivity was preserved in this area. At 3 days after stroke, extensive activation-induced responses were detected in the contralesional hemisphere. After 14 days, we found reduced involvement of the contralesional hemisphere, and significant responses in the infarction periphery. Our data suggest that limb dysfunction is related to loss of brain activation in the ipsilesional sensorimotor cortex and that restoration of function is associated with biphasic recruitment of peri- and contralesional functional fields in the brain.
journal_name
Proc Natl Acad Sci U S Aauthors
Dijkhuizen RM,Ren J,Mandeville JB,Wu O,Ozdag FM,Moskowitz MA,Rosen BR,Finklestein SPdoi
10.1073/pnas.231235598keywords:
subject
Has Abstractpub_date
2001-10-23 00:00:00pages
12766-71issue
22eissn
0027-8424issn
1091-6490pii
231235598journal_volume
98pub_type
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