The role of SOS and flap processing in microsatellite instability in Escherichia coli.

abstract：:Inhibition of protein synthesis in rabbit reticulocyte lysates by double-stranded RNA is caused by the inactivation of IF-3, an initiation factor required for the recycling of ribosomes and for their binding to messenger RNA. The evidence for this is that (i) the inhibition can be overcome by addition of exogenous If-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaempfer R,Kaufman J

更新日期：1973-04-01 00:00:00

abstract：:β subunits of high voltage-gated Ca2+ (CaV) channels promote cell-surface expression of pore-forming α1 subunits and regulate channel gating through binding to the α-interaction domain (AID) in the first intracellular loop. We addressed the stability of CaV α1B-β interactions by rapamycin-translocatable CaV β subunits...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeon JH,Park CG,Hille B,Suh BC

更新日期：2018-10-16 00:00:00

abstract：:The generation of diverse neuronal types and subtypes from multipotent progenitors during development is crucial for assembling functional neural circuits in the adult central nervous system. During mouse retinogenesis, early retinal progenitors give rise to several cell types, including ganglion, amacrine, horizontal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luo H,Jin K,Xie Z,Qiu F,Li S,Zou M,Cai L,Hozumi K,Shima DT,Xiang M

更新日期：2012-02-28 00:00:00

abstract：:Nascent replicative form type II (RFII) DNA of coliphage M13 synthesized in an Escherichia coli mutant deficient in the 5' leads to 3' exonuclease associated uith DNA polymerase I contains ribonucleotides that are retained in the covalently closed RFI DNA sealed in vitro by the joint action of T5 phage DNA polymerase ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dasgupta S,Mitra S

更新日期：1978-01-01 00:00:00

abstract：:Mechanoelectrical transduction in the inner ear is a biophysical process underlying the senses of hearing and balance. The key players involved in this process are mechanosensitive ion channels. They are located in the stereocilia of hair cells and opened by the tension in specialized molecular springs, the tip links,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gianoli F,Risler T,Kozlov AS

更新日期：2017-12-19 00:00:00

abstract：:In MtrF, an outer-membrane multiheme cytochrome, the 10 heme groups are arranged in heme binding domains II and IV along the pseudo-C2 axis, forming the electron transfer (ET) pathways. Previous reports based on molecular dynamics simulations showed that the redox potential (Em) values for the heme pairs located in sy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watanabe HC,Yamashita Y,Ishikita H

更新日期：2017-03-14 00:00:00

abstract：:The primary DNA lesion induced by malondialdehyde, a byproduct of lipid peroxidation and prostaglandin synthesis, is 3-(2'-deoxy-beta-D-erythro-pentofuranosyl)-pyrimido[1, 2-a]purin-10(3H)-one (M1G). When placed opposite cytosine (underlined) at neutral pH in either the d(GGTMTCCG).d(CGGACACC) or d(ATCGCMCGGCATG). d(C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mao H,Schnetz-Boutaud NC,Weisenseel JP,Marnett LJ,Stone MP

更新日期：1999-06-08 00:00:00

abstract：:Protein tyrosine phosphorylation in purified synaptic vesicles from rat forebrain has been studied in the presence of Mn2+ and orthovanadate. High levels of endogenous protein tyrosine phosphorylation were observed. Four major phosphoproteins, with apparent molecular masses of 105, 94, 38, and 30 kDa, were shown to co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pang DT,Wang JK,Valtorta F,Benfenati F,Greengard P

更新日期：1988-02-01 00:00:00

abstract：:Although the p53 network has been intensively studied, genetic analyses long hinted at the existence of components that remained elusive. Recent studies have shown regulation of p53 at the mRNA level mediated via both the 5' and the 3' untranslated regions and affecting the stability and translation efficiency of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Devany E,Zhang X,Park JY,Tian B,Kleiman FE

更新日期：2013-02-26 00:00:00

abstract：:Productive T cell recognition of antigen-presenting cells (APCs) is normally accompanied by the formation of a cell-cell contact called the "immunological synapse." Our understanding of the steps leading up to this formation has been limited by the absence of tools for analyzing 3D surfaces and surface distributions a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moss WC,Irvine DJ,Davis MM,Krummel MF

更新日期：2002-11-12 00:00:00

abstract：:We examined human immunodeficiency virus (HIV) production in cultured mononuclear cells from 36 seropositive homosexual males. Production was detected by using an HIV p24 antigen ELISA assay in blood mononuclear cells in 54% of asymptomatic, 71% of acquired immunodeficiency syndrome (AIDS)-related complex, and 100% of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McElrath MJ,Pruett JE,Cohn ZA

更新日期：1989-01-01 00:00:00

abstract：:A comparison of the monoclinic and orthorhombic crystal structures of the uncomplexed double-stranded, antiparallel, left-handed beta-helix (5.6 amino acid residues per turn) (increases decreases beta 5.6) conformers of gramicidin A reveals marked differences in the tryptophan side-chain orientations and the degree of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Langs DA,Smith GD,Courseille C,Précigoux G,Hospital M

更新日期：1991-06-15 00:00:00

abstract：:Innate immunity is the primary and most ancient defense against infection. Although critical to survival, coordinating protection against a foreign organism is energetically costly, creating the need to reallocate substrates from nonessential functions, such as growth and nutrient storage. However, the mechanism by wh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DiAngelo JR,Bland ML,Bambina S,Cherry S,Birnbaum MJ

更新日期：2009-12-08 00:00:00

abstract：:We previously reported that short-term immobilization stress of rats causes increased colonic mucin release, goblet cell depletion, prostaglandin E2 secretion, and colonic mast cell activation, as well as increased colonic motility. The purpose of this study was to investigate whether neurotensin (NT), a peptide expre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Castagliuolo I,Leeman SE,Bartolak-Suki E,Nikulasson S,Qiu B,Carraway RE,Pothoulakis C

更新日期：1996-10-29 00:00:00

abstract：:The structural and functional organization of the Cct complex was addressed by genetic analyses of subunit interactions and catalytic cooperativity among five of the eight different essential subunits, Cct1p-Cct8p, in the yeast Saccharomyces cerevisiae. The cct1-1, cct2-3, and cct3-1 alleles, containing mutations at t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin P,Sherman F

更新日期：1997-09-30 00:00:00

abstract：:In human financial and social systems, exchanges of information among individuals cause speculative bubbles, behavioral cascades, and other correlated actions that profoundly influence system-level function. Exchanges of information are also widespread in ecological systems, but their effects on ecosystem-level proces...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gil MA,Hein AM

更新日期：2017-05-02 00:00:00

abstract：:The relative importance of local ecological and larger-scale historical processes in causing differences in species richness across the globe remains keenly debated. To gain insight into these questions, we investigated the assembly of plant diversity in the Cerrado in South America, the world's most species-rich trop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Simon MF,Grether R,de Queiroz LP,Skema C,Pennington RT,Hughes CE

更新日期：2009-12-01 00:00:00

abstract：:Stearoyl-acyl-carrier-protein-desaturase-mediated conversion of stearic acid (18:0) to oleic acid (18:1) is a key step, which regulates levels of unsaturated fatty acids in cells. We previously showed that stearoyl-acyl-carrier-protein-desaturase mutants ssi2/fab2 carrying a loss-of-function mutation in the plastidial...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kachroo A,Venugopal SC,Lapchyk L,Falcone D,Hildebrand D,Kachroo P

更新日期：2004-04-06 00:00:00

abstract：:Eukaryotic translation initiation factor (eIF) 5 is crucial for the assembly of the eukaryotic preinitiation complex. This activity is mediated by the ability of its C-terminal HEAT domain to interact with eIF1, eIF2, and eIF3 in the multifactor complex and with eIF4G in the 48S complex. However, the binding sites for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamamoto Y,Singh CR,Marintchev A,Hall NS,Hannig EM,Wagner G,Asano K

更新日期：2005-11-08 00:00:00

abstract：:Sex determination in mammals is governed by antagonistic interactions of two genetic pathways, imbalance in which may lead to disorders/differences of sex development (DSD) in human. Among 46,XX individuals with testicular DSD (TDSD) or ovotesticular DSD (OTDSD), testicular tissue is present in the gonad. Although the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eozenou C,Gonen N,Touzon MS,Jorgensen A,Yatsenko SA,Fusee L,Kamel AK,Gellen B,Guercio G,Singh P,Witchel S,Berman AJ,Mainpal R,Totonchi M,Mohseni Meybodi A,Askari M,Merel-Chali T,Bignon-Topalovic J,Migale R,Costanzo

更新日期：2020-06-16 00:00:00

abstract：:The immunity protein to colicin A (Cai), which is constitutively expressed at a very low level in Escherichia coli strains, has been studied in recombinant plasmid constructs allowing expression of various immunity fusion proteins under the control of inducible promoters. The 13-amino acid NH2-terminal region of Cai w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Geli V,Baty D,Lazdunski C

更新日期：1988-02-01 00:00:00

abstract：:Lipid interactions with the integral membrane protein Na,K-ATPase (ATP phosphohydrolase, EC 3.6.1.3) purified from the electric organ of Electrophorus electricus were studied by spin labeling. A protein-associated component (boundary layer) in equilibrium with the fluid bilayer is clearly evident in the electron spin ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brotherus JR,Jost PC,Griffith OH,Keana JF,Hokin LE

更新日期：1980-01-01 00:00:00

abstract：:Hermansky-Pudlak syndrome (HPS) defines a group of autosomal recessive disorders characterized by deficiencies in lysosome-related organelles such as melanosomes and platelet-dense granules. Several HPS genes encode proteins of unknown function including HPS1, HPS3, and HPS4. Here we have identified and characterized ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nazarian R,Falcón-Pérez JM,Dell'Angelica EC

更新日期：2003-07-22 00:00:00

abstract：:Myosin-binding protein C (MyBP-C) is a thick filament protein playing an essential role in muscle contraction, and MyBP-C mutations cause heart and skeletal muscle disease in millions worldwide. Despite its discovery 40 y ago, the mechanism of MyBP-C function remains unknown. In vitro studies suggest that MyBP-C could...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luther PK,Winkler H,Taylor K,Zoghbi ME,Craig R,Padrón R,Squire JM,Liu J

更新日期：2011-07-12 00:00:00

abstract：:Telomerase activity was identified in extracts from several different mouse cell lines. Addition of telomeric TTAGGG repeats was specific to telomeric oligonucleotide primers and sensitive to pretreatment with RNase A. In contrast to the hundreds of repeats synthesized by the human and Tetrahymena telomerase enzymes i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prowse KR,Avilion AA,Greider CW

更新日期：1993-02-15 00:00:00

abstract：:Bufonid anurans of the genus Atelopus contain both steroidal bufadienolides and various guanidinium alkaloids of the tetrodotoxin class. The former inhibit sodium-potassium ATPases, whereas the latter block voltage-dependent sodium channels. The structure of one guanidinium alkaloid, zetekitoxin AB, has remained a mys...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yotsu-Yamashita M,Kim YH,Dudley SC Jr,Choudhary G,Pfahnl A,Oshima Y,Daly JW

更新日期：2004-03-30 00:00:00

abstract：:Groundwater arsenic (As) is elevated in the shallow Holocene aquifers of Bangladesh. In the dry season, the shallow groundwater discharges to major rivers. This process may influence the chemistry of the river and the hyporheic zone sediment. To assess the fate of As during discharge, surface (0-5 cm) and subsurface (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Datta S,Mailloux B,Jung HB,Hoque MA,Stute M,Ahmed KM,Zheng Y

更新日期：2009-10-06 00:00:00

abstract：:Mind wandering represents the human capacity for internally focused thought and relies upon the brain's default network and its interactions with attentional networks. Studies have characterized mind wandering in healthy people, yet there is limited understanding of how this capacity is affected in clinical population...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Callaghan C,Shine JM,Hodges JR,Andrews-Hanna JR,Irish M

更新日期：2019-02-19 00:00:00

abstract：:Calls for the eradication of malaria require the development of global and regional strategies based on a strong and consistent evidence base. Evidence from the previous global malaria eradication program and more recent transborder control campaigns have shown the importance of accounting for human movement in introd...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tatem AJ,Smith DL

更新日期：2010-07-06 00:00:00

abstract：:An unusual cAMP signaling system mediates many of the events that prepare spermatozoa to meet the egg. Its components include the atypical, bicarbonate-stimulated, sperm adenylyl cyclase and a cAMP-dependent protein kinase (PKA) with the unique catalytic subunit termed Calpha(2) or C(s). We generated mice that lack Ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nolan MA,Babcock DF,Wennemuth G,Brown W,Burton KA,McKnight GS

更新日期：2004-09-14 00:00:00