A new form of cerebellar long-term potentiation is postsynaptic and depends on nitric oxide but not cAMP.

Abstract:

:Long-term depression (LTD) at cerebellar parallel fiber (PF)-Purkinje cell synapses must be balanced by long-term potentiation (LTP) to prevent saturation and allow reversal of motor learning. The only previously analyzed form of cerebellar LTP is induced by 4-8 Hz PF stimulation and requires cAMP but not nitric oxide. It is a poor candidate to reverse LTD because it is presynaptically expressed whereas LTD is postsynaptic. We now characterize a new form of LTP induced by 1 Hz PF stimulation for at least 300 s. This LTP is postsynaptically expressed, enhanced by chelating postsynaptic Ca(2+), and depends on nitric oxide but not cAMP or cGMP, making it a plausible anti-Hebbian counterpart to Hebbian LTD.

authors

Lev-Ram V,Wong ST,Storm DR,Tsien RY

doi

10.1073/pnas.122206399

keywords:

subject

Has Abstract

pub_date

2002-06-11 00:00:00

pages

8389-93

issue

12

eissn

0027-8424

issn

1091-6490

pii

122206399

journal_volume

99

pub_type

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