Abstract:
:Stem cell therapy has emerged as a promising tool for the treatment of a variety of diseases. Previously, we have shown that Akt-modified mesenchymal stem cells mediate tissue repair through paracrine mechanisms. Using a comprehensive functional genomic strategy, we show that secreted frizzled related protein 2 (Sfrp2) is the key stem cell paracrine factor that mediates myocardial survival and repair after ischemic injury. Sfrp2 is known to modulate Wnt signaling, and we demonstrate that cardiomyocytes treated with secreted frizzled related protein increase cellular beta-catenin and up-regulate expression of antiapoptotic genes. These findings reveal the key role played by Sfrp2 in mediating the paracrine effects of Akt-mesenchymal stem cells on tissue repair and identify modulation of Wnt signaling as a therapeutic target for heart disease.
journal_name
Proc Natl Acad Sci U S Aauthors
Mirotsou M,Zhang Z,Deb A,Zhang L,Gnecchi M,Noiseux N,Mu H,Pachori A,Dzau Vdoi
10.1073/pnas.0610024104subject
Has Abstractpub_date
2007-01-30 00:00:00pages
1643-8issue
5eissn
0027-8424issn
1091-6490pii
0610024104journal_volume
104pub_type
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