Hyphal development in Neurospora crassa: involvement of a two-component histidine kinase.

abstract：:A hierarchy of residue density assessments and packing properties in protein structures are contrasted, including a regular density, a variety of charge densities, a hydrophobic density, a polar density, and an aromatic density. These densities are investigated by alternative distance measures and also at the interfac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baud F,Karlin S

更新日期：1999-10-26 00:00:00

abstract：:During the past several decades, numerous reports from disparate geographical areas have documented an increased frequency of "bleaching" in reef-forming corals. The phenomenon, triggered by increased sea surface temperatures, occurs when the cnidarian hosts digest and/or expel their intracellular, photosynthetic dino...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tchernov D,Kvitt H,Haramaty L,Bibby TS,Gorbunov MY,Rosenfeld H,Falkowski PG

更新日期：2011-06-14 00:00:00

abstract：:The nature of chemical bonds of ruthenium(Ru)-quinine(Q) complexes, mononuclear [Ru(trpy)(3,5-t-Bu(2)Q)(OH(2))](ClO(4))(2) (trpy = 2,2':6',2''-terpyridine, 3,5-di-tert-butyl-1,2-benzoquinone) (1), and binuclear [Ru(2)(btpyan)(3,6-di-Bu(2)Q)(2)(OH(2))](2+) (btpyan = 1,8-bis(2,2':6',2''-terpyrid-4'-yl)anthracene, 3,6-t-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tanaka K,Isobe H,Yamanaka S,Yamaguchi K

更新日期：2012-09-25 00:00:00

abstract：:Matrix-assisted laser desorption/ionization (MALDI) time of flight mass spectrometry was used to detect and order DNA fragments generated by Sanger dideoxy cycle sequencing. This was accomplished by improving the sensitivity and resolution of the MALDI method using a delayed ion extraction technique (DE-MALDI). The cy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roskey MT,Juhasz P,Smirnov IP,Takach EJ,Martin SA,Haff LA

更新日期：1996-05-14 00:00:00

abstract：:Meiotic recombination in the yeast Saccharomyces cerevisiae is initiated by programmed double-strand breaks at selected sites throughout the genome (hotspots). alpha-Hotspots are binding sites for transcription factors. Double-strand breaks at alpha-hotspots require binding of transcription factor but not high levels ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Abdullah MF,Borts RH

更新日期：2001-12-04 00:00:00

abstract：:This communication reports a modulating effect of intracellular ATP on the steady-state and kinetic properties of the delayed rectifier of the giant axon of the squid. When internally dialyzed or perfused giant axons from Loligo plei or Loligo pealei are voltage clamped at -60 mV and washed free of ATP, the potassium ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bezanilla F,Caputo C,DiPolo R,Rojas H

更新日期：1986-04-01 00:00:00

abstract：:In animals, successful production of the visual chromophore (11-cis-retinal or derivatives thereof such as 11-cis-3-hydroxy-retinal) is essential for photoreceptor cell function and survival. These carotenoid-derived compounds must combine with a protein moiety (the opsin) to establish functional visual pigments. Evid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oberhauser V,Voolstra O,Bangert A,von Lintig J,Vogt K

更新日期：2008-12-02 00:00:00

abstract：:B-1a cells, an anatomically, phenotypically, and functionally distinct subset of B cells that produce the bulk of natural serum IgM and much of gut-associated IgA, are an important component of the early response to pathogens. Because the induced expression of CD5, a hallmark of B-1a cells, requires a nuclear factor o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berland R,Wortis HH

更新日期：2003-11-11 00:00:00

abstract：:Autism spectrum disorders (ASDs) comprise a highly heritable, multifarious group of neurodevelopmental disorders, which are characterized by repetitive behaviors and impairments in social interactions. Point mutations have been identified in X-linked Neuroligin (NLGN) 3 and 4X genes in patients with ASDs and all of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bemben MA,Nguyen QA,Wang T,Li Y,Nicoll RA,Roche KW

更新日期：2015-02-24 00:00:00

abstract：:Spin-polarized charge currents induce magnetic tunnel junction (MTJ) switching by virtue of spin-transfer torque (STT). Recently, by taking advantage of the spin-dependent thermoelectric properties of magnetic materials, novel means of generating spin currents from temperature gradients, and their associated thermal-s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pushp A,Phung T,Rettner C,Hughes BP,Yang SH,Parkin SS

更新日期：2015-05-26 00:00:00

abstract：:Understanding protein-protein interactions is central to our understanding of almost all complex biological processes. Computational tools exploiting rapidly growing genomic databases to characterize protein-protein interactions are urgently needed. Such methods should connect multiple scales from evolutionary conserv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gueudré T,Baldassi C,Zamparo M,Weigt M,Pagnani A

更新日期：2016-10-25 00:00:00

abstract：:Neural crest stem cells can be isolated from differentiated cultures of human pluripotent stem cells, but the process is inefficient and requires cell sorting to obtain a highly enriched population. No specific method for directed differentiation of human pluripotent cells toward neural crest stem cells has yet been r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Menendez L,Yatskievych TA,Antin PB,Dalton S

更新日期：2011-11-29 00:00:00

abstract：:A gamma-trace variant protein is the major constituent of the amyloid fibrils in patients from Iceland with hereditary cerebral hemorrhage with amyloidosis. The protein consists of 110 residues and is similar to human urinary gamma-trace basic protein (or cystatin C) beginning at its 11th amino-terminal residue. It ha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ghiso J,Jensson O,Frangione B

更新日期：1986-05-01 00:00:00

abstract：:Coat components localize to specific membrane domains, where they sort selected transmembrane proteins. To study how clathrin coats are stabilized on such domains and to identify the protein networks involved, we combined proteomic screens and in vitro liposome-based assays that recapitulate the fidelity of protein so...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baust T,Czupalla C,Krause E,Bourel-Bonnet L,Hoflack B

更新日期：2006-02-28 00:00:00

abstract：:We have previously identified two species of the low-affinity human Fc receptor for IgE, Fc epsilon RIIa and Fc epsilon RIIb, which differ only in a short stretch of amino acids at the N-terminal cytoplasmic end. Their differential expressions on B cells and monocytes suggest that Fc epsilon RIIa and Fc epsilon RIIb a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yokota A,Yukawa K,Yamamoto A,Sugiyama K,Suemura M,Tashiro Y,Kishimoto T,Kikutani H

更新日期：1992-06-01 00:00:00

abstract：:There exists a properly embedded minimal surface of genus one with a single end asymptotic to the end of the helicoid. This genus-one helicoid is constructed as the limit of a continuous one-parameter family of screw-motion invariant minimal surfaces, also asymptotic to the helicoid, that have genus equal to one in th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weber M,Hoffman D,Wolf M

更新日期：2005-11-15 00:00:00

abstract：:Studies of natural killer (NK) cell function in vivo have been challenging primarily due to the lack of animal models in which NK cells are genetically and selectively deficient. Here, we describe a transgenic mouse with defective natural killing and selective deficiency in NK1.1(+) CD3(-) cells. Despite functionally ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim S,Iizuka K,Aguila HL,Weissman IL,Yokoyama WM

更新日期：2000-03-14 00:00:00

abstract：:There is an important medical need for new antifungal agents with novel mechanisms of action to treat the increasing number of patients with life-threatening systemic fungal disease and to overcome the growing problem of resistance to current therapies. F901318, the leading representative of a novel class of drug, the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oliver JD,Sibley GEM,Beckmann N,Dobb KS,Slater MJ,McEntee L,du Pré S,Livermore J,Bromley MJ,Wiederhold NP,Hope WW,Kennedy AJ,Law D,Birch M

更新日期：2016-11-08 00:00:00

abstract：:In multicellular organisms, the higher order organization of chromatin during interphase and the reassembly of the nuclear envelope during mitosis are thought to involve an interaction between the nuclear lamina and chromatin. The nuclear distribution of lamins and of peripheral chromatin is highly correlated in vivo,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldberg M,Harel A,Brandeis M,Rechsteiner T,Richmond TJ,Weiss AM,Gruenbaum Y

更新日期：1999-03-16 00:00:00

abstract：:Historically, the biodiversity and composition of species in a locality was thought to be influenced primarily by deterministic factors. In such cases, species' niches create differential responses to environmental conditions and interspecific interactions, which combine to determine that locality's biodiversity and s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chase JM

更新日期：2007-10-30 00:00:00

abstract：:Brief incubation of partially purified preparations of hormone-sensitive lipase from rat epididymal fat pads with ATP, Mg(++), cyclic adenosine 3':5'-monophosphate and rabbit muscle protein kinase (phosphorylase b kinase kinase) resulted in enhancement of lipolytic activity (44-93%). Little or no activation was observ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huttunen JK,Steinberg D,Mayer SE

更新日期：1970-09-01 00:00:00

abstract：:A fundamental mystery of plant cell biology is the occurrence of "stromules," stroma-filled tubular extensions from plastids (such as chloroplasts) that are universally observed in plants but whose functions are, in effect, completely unknown. One prevalent hypothesis is that stromules exchange signals or metabolites ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brunkard JO,Runkel AM,Zambryski PC

更新日期：2015-08-11 00:00:00

abstract：:Using an expression cloning approach, we have isolated a cDNA encoding GD3 synthase (CMP-NeuAc:NeuAc alpha 2-3Gal beta 1-4Glc beta 1-1'Cer alpha 2,8-sialyltransferase, EC 2.4.99.8), which is a key regulatory enzyme determining the prominence of the ganglioside biosynthesis pathway. The cloned cDNA encodes a 341-amino ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nara K,Watanabe Y,Maruyama K,Kasahara K,Nagai Y,Sanai Y

更新日期：1994-08-16 00:00:00

abstract：:Highly expanded Cretaceous-Paleogene (K-Pg) boundary section from the Chicxulub peak ring, recovered by International Ocean Discovery Program (IODP)-International Continental Scientific Drilling Program (ICDP) Expedition 364, provides an unprecedented window into the immediate aftermath of the impact. Site M0077 inclu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gulick SPS,Bralower TJ,Ormö J,Hall B,Grice K,Schaefer B,Lyons S,Freeman KH,Morgan JV,Artemieva N,Kaskes P,de Graaff SJ,Whalen MT,Collins GS,Tikoo SM,Verhagen C,Christeson GL,Claeys P,Coolen MJL,Goderis S,Goto K,

更新日期：2019-09-24 00:00:00

abstract：:Activation of p53 tumor suppressor by antagonizing its negative regulator murine double minute (MDM)2 has been considered an attractive strategy for cancer therapy and several classes of p53-MDM2 binding inhibitors have been developed. However, these compounds do not inhibit the p53-MDMX interaction, and their effecti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Graves B,Thompson T,Xia M,Janson C,Lukacs C,Deo D,Di Lello P,Fry D,Garvie C,Huang KS,Gao L,Tovar C,Lovey A,Wanner J,Vassilev LT

更新日期：2012-07-17 00:00:00

abstract：:Membrane lipids were once thought to be homogenously distributed in the 2D surface of a membrane, but the lipid raft theory suggests that cholesterol and sphingolipids partition away from other membrane lipids. Lipid raft theory further implicates these cholesterol-rich domains in many processes such as signaling and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Foster LJ,De Hoog CL,Mann M

更新日期：2003-05-13 00:00:00

abstract：:The importance of dystrophin and its associated proteins in normal muscle function is now well established. Many of these proteins are expressed in nonmuscle tissues, particularly the brain. Here we describe the characterization of beta-dystrobrevin, a dystrophin-related protein that is abundantly expressed in brain a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blake DJ,Nawrotzki R,Loh NY,Górecki DC,Davies KE

更新日期：1998-01-06 00:00:00

abstract：:The Rev protein of HIV-1, which facilitates the nuclear export of HIV-1 pre-mRNAs, has been a target for antiviral therapy. Here we describe a new strategy for inhibiting Rev function and HIV-1 replication. In contrast to previous approaches, we use a wild-type rather than a mutant Rev protein and covalently link this...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qian XY,Chen ZY,Zhang J,Rabson AB,Krug RM

更新日期：1996-08-20 00:00:00

abstract：:Many insects are dependent on bacterial symbionts that provide essential nutrients (ex. aphid-Buchnera and tsetse-Wiglesworthia associations), wherein the symbionts are harbored in specific cells called bacteriocytes that constitute a symbiotic organ bacteriome. Facultative and parasitic bacterial symbionts like Wolba...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hosokawa T,Koga R,Kikuchi Y,Meng XY,Fukatsu T

更新日期：2010-01-12 00:00:00

abstract：:Alzheimer's disease is characterized by two primary pathological features: amyloid plaques and neurofibrillary tangles. The interconnection between amyloid and tau aggregates is of intense interest, but mouse models have yet to reveal a direct interrelationship. We now show that NO may be a key factor that connects am...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Colton CA,Vitek MP,Wink DA,Xu Q,Cantillana V,Previti ML,Van Nostrand WE,Weinberg JB,Dawson H

更新日期：2006-08-22 00:00:00