Abstract:
:In a passive dendritic tree, inhibitory synaptic inputs activating ionic conductances with an equilibrium potential near the resting potential can effectively veto excitatory inputs. Analog interactions of this type can be very powerful if the inputs are appropriately timed and occur at certain locations. We examine with computer simulations the precise conditions required for strong and specific interactions in the case of a delta-like ganglion cell of the cat retina. We find some critical conditions to be that (i) the peak inhibitory conductance changes must be sufficiently large (i.e., approximately equal to 50 nS or more), (ii) inhibition must be on the direct path from the location of excitation to the soma, and (iii) the time course of excitation and inhibition must substantially overlap. Analog AND-NOT operations realized by satisfying these conditions may underlie direction selectivity in ganglion cells.
journal_name
Proc Natl Acad Sci U S Aauthors
Koch C,Poggio T,Torre Vdoi
10.1073/pnas.80.9.2799subject
Has Abstractpub_date
1983-05-01 00:00:00pages
2799-802issue
9eissn
0027-8424issn
1091-6490journal_volume
80pub_type
杂志文章abstract::2-Isopropylmalate synthase (EC 4.1.3.12) of yeast is a mitochondrial enzyme. We now provide evidence showing that a large part of the 2-isopropylmalate synthase activity that is associated with the mitochondria is located in the mitochondrial matrix. In vitro translation of total yeast RNA followed by immunoprecipitat...
journal_title:Proceedings of the National Academy of Sciences of the United States of America
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doi:10.1073/pnas.80.5.1270
更新日期:1983-03-01 00:00:00
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journal_title:Proceedings of the National Academy of Sciences of the United States of America
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journal_title:Proceedings of the National Academy of Sciences of the United States of America
pub_type: 杂志文章
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abstract::Epstein-Barr virus (EBV) and Kaposi's sarcoma herpesvirus (KSHV) cause ∼2% of all human cancers. RNase R-resistant RNA sequencing revealed that both gammaherpesviruses encode multiple, uniquely stable, circular RNAs (circRNA). EBV abundantly expressed both exon-only and exon-intron circRNAs from the BamHI A rightward ...
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更新日期:1987-07-01 00:00:00
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更新日期:1979-04-01 00:00:00
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journal_title:Proceedings of the National Academy of Sciences of the United States of America
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更新日期:1996-12-24 00:00:00
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journal_title:Proceedings of the National Academy of Sciences of the United States of America
pub_type: 历史文章,杂志文章
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更新日期:2013-01-22 00:00:00
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journal_title:Proceedings of the National Academy of Sciences of the United States of America
pub_type: 杂志文章
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更新日期:2012-08-21 00:00:00
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journal_title:Proceedings of the National Academy of Sciences of the United States of America
pub_type: 杂志文章
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更新日期:1990-06-01 00:00:00
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journal_title:Proceedings of the National Academy of Sciences of the United States of America
pub_type: 杂志文章
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更新日期:1981-03-01 00:00:00
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journal_title:Proceedings of the National Academy of Sciences of the United States of America
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更新日期:1990-01-01 00:00:00
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更新日期:1982-07-01 00:00:00
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journal_title:Proceedings of the National Academy of Sciences of the United States of America
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更新日期:1980-01-01 00:00:00
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更新日期:1995-04-11 00:00:00
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更新日期:2004-10-05 00:00:00
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更新日期:1996-03-19 00:00:00
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journal_title:Proceedings of the National Academy of Sciences of the United States of America
pub_type: 杂志文章
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更新日期:2016-12-27 00:00:00