Nonlinear interactions in a dendritic tree: localization, timing, and role in information processing.

Abstract:

:In a passive dendritic tree, inhibitory synaptic inputs activating ionic conductances with an equilibrium potential near the resting potential can effectively veto excitatory inputs. Analog interactions of this type can be very powerful if the inputs are appropriately timed and occur at certain locations. We examine with computer simulations the precise conditions required for strong and specific interactions in the case of a delta-like ganglion cell of the cat retina. We find some critical conditions to be that (i) the peak inhibitory conductance changes must be sufficiently large (i.e., approximately equal to 50 nS or more), (ii) inhibition must be on the direct path from the location of excitation to the soma, and (iii) the time course of excitation and inhibition must substantially overlap. Analog AND-NOT operations realized by satisfying these conditions may underlie direction selectivity in ganglion cells.

authors

Koch C,Poggio T,Torre V

doi

10.1073/pnas.80.9.2799

subject

Has Abstract

pub_date

1983-05-01 00:00:00

pages

2799-802

issue

9

eissn

0027-8424

issn

1091-6490

journal_volume

80

pub_type

杂志文章
  • Submitochondrial localization, cell-free synthesis, and mitochondrial import of 2-isopropylmalate synthase of yeast.

    abstract::2-Isopropylmalate synthase (EC 4.1.3.12) of yeast is a mitochondrial enzyme. We now provide evidence showing that a large part of the 2-isopropylmalate synthase activity that is associated with the mitochondria is located in the mitochondrial matrix. In vitro translation of total yeast RNA followed by immunoprecipitat...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.80.5.1270

    authors: Hampsey DM,Lewin AS,Kohlhaw GB

    更新日期:1983-03-01 00:00:00

  • Evidence for neural rhythms embedded within binocular rivalry.

    abstract::Evidence for perceptual periodicity emerges from studies showing periodic fluctuations in visual perception and decision making that are accompanied by neural oscillations in brain activity. We have uncovered signs of periodicity in the time course of binocular rivalry, a widely studied form of multistable perception....

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1905174116

    authors: Cha O,Blake R

    更新日期:2019-07-23 00:00:00

  • Androgen-induced proliferative quiescence in prostate cancer cells: the role of AS3 as its mediator.

    abstract::In the prostate gland of adult mammals, most epithelial cells are in a state of proliferative quiescence. Androgens regulate this effect by inducing cell cycle arrest in the G(0)/G(1) phase. Potential mediators of this androgen-induced proliferative shutoff were identified by means of subtracted cDNA libraries. The ex...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.97.18.10185

    authors: Geck P,Maffini MV,Szelei J,Sonnenschein C,Soto AM

    更新日期:2000-08-29 00:00:00

  • Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF-induced neutrophil recruitment.

    abstract::Granulocyte-colony stimulating factor (G-CSF) promotes mobilization of CD11b(+)Gr1(+) myeloid cells and has been implicated in resistance to anti-VEGF therapy in mouse models. High G-CSF production has been associated with a poor prognosis in cancer patients. Here we show that activation of the RAS/MEK/ERK pathway reg...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1303302110

    authors: Phan VT,Wu X,Cheng JH,Sheng RX,Chung AS,Zhuang G,Tran C,Song Q,Kowanetz M,Sambrone A,Tan M,Meng YG,Jackson EL,Peale FV,Junttila MR,Ferrara N

    更新日期:2013-04-09 00:00:00

  • Phospholipase D is present on Golgi-enriched membranes and its activation by ADP ribosylation factor is sensitive to brefeldin A.

    abstract::ADP ribosylation factor (ARF) is a small guanosine triphosphate (GTP)-binding protein that regulates the binding of coat proteins to membranes and is required for several stages of vesicular transport. ARF also stimulates phospholipase D (PLD) activity, which can alter the lipid content of membranes by conversion of p...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.92.11.4952

    authors: Ktistakis NT,Brown HA,Sternweis PC,Roth MG

    更新日期:1995-05-23 00:00:00

  • Circular DNA tumor viruses make circular RNAs.

    abstract::Epstein-Barr virus (EBV) and Kaposi's sarcoma herpesvirus (KSHV) cause ∼2% of all human cancers. RNase R-resistant RNA sequencing revealed that both gammaherpesviruses encode multiple, uniquely stable, circular RNAs (circRNA). EBV abundantly expressed both exon-only and exon-intron circRNAs from the BamHI A rightward ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1811728115

    authors: Toptan T,Abere B,Nalesnik MA,Swerdlow SH,Ranganathan S,Lee N,Shair KH,Moore PS,Chang Y

    更新日期:2018-09-11 00:00:00

  • Iridescence in nematics: Photonic liquid crystals of nanoplates in absence of long-range periodicity.

    abstract::Photonic materials with positionally ordered structure can interact strongly with light to produce brilliant structural colors. Here, we found that the nonperiodic nematic liquid crystals of nanoplates can also display structural color with only significant orientational order. Owing to the loose stacking of the nemat...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1906511116

    authors: Zeng M,King D,Huang D,Do C,Wang L,Chen M,Lei S,Lin P,Chen Y,Cheng Z

    更新日期:2019-09-10 00:00:00

  • Genetic instability in Drosophila melanogaster: cytogenetic analysis of MR-induced X-chromosome deficiencies.

    abstract::We present data that demonstrate that three MR elements isolated from wild populations of Drosophila melanogaster on two continents can cause large deletions of the X chromosome in males. The deleted chromosomes, termed mini-X chromosomes, are induced at a frequency of approximately 1:4000 in chromosomes that are init...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.84.13.4533

    authors: Green MM,Yamamoto MT,Miklos GL

    更新日期:1987-07-01 00:00:00

  • Increasing intracellular magnesium levels with the 31-amino acid MgtS protein.

    abstract::Synthesis of the 31-amino acid, inner membrane protein MgtS (formerly denoted YneM) is induced by very low Mg2+ in a PhoPQ-dependent manner in Escherichia coli Here we report that MgtS acts to increase intracellular Mg2+ levels and maintain cell integrity upon Mg2+ depletion. Upon development of a functional tagged de...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1703415114

    authors: Wang H,Yin X,Wu Orr M,Dambach M,Curtis R,Storz G

    更新日期:2017-05-30 00:00:00

  • Cytotoxic T cells: Lyt phenotype and blocking of killing activity by Lyt antisera.

    abstract::WE REEXAMINED TWO QUESTIONS CONCERNING LYT ANTIGENS OF CYTOTOXIC T CELLS OF THE MOUSE: is Lyt-1 antigen expressed on cytotoxic effector cells and can cytotoxicity be blocked by antibody to Lyt antigens in the absence of added complement? A 3-hr (51)Cr-release assay with splenic effector cells and leukemia or myeloma t...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.76.4.1977

    authors: Nakayama E,Shiku H,Stockert E,Oettgen HF,Old LJ

    更新日期:1979-04-01 00:00:00

  • Similar DNA recognition properties of alternatively spliced Drosophila POU factors.

    abstract::The POU-IV or "Brn-3" class of POU-domain transcription factors is represented in Drosophila by I-POU and twin-of-I-POU, alternative splice products of the I-POU gene. I-POU has been previously reported to inhibit DNA binding by the POU-III class factor drifter/Cf1a via the formation of heterodimeric complexes. Here w...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.93.26.15097

    authors: Turner EE

    更新日期:1996-12-24 00:00:00

  • Macropredatory ichthyosaur from the Middle Triassic and the origin of modern trophic networks.

    abstract::The biotic recovery from Earth's most severe extinction event at the Permian-Triassic boundary largely reestablished the preextinction structure of marine trophic networks, with marine reptiles assuming the predator roles. However, the highest trophic level of today's marine ecosystems, i.e., macropredatory tetrapods ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 历史文章,杂志文章

    doi:10.1073/pnas.1216750110

    authors: Fröbisch NB,Fröbisch J,Sander PM,Schmitz L,Rieppel O

    更新日期:2013-01-22 00:00:00

  • Chronic reduction in inhibition reduces receptive field size in mouse auditory cortex.

    abstract::Inhibitory interneurons regulate the responses of cortical circuits. In auditory cortical areas, inhibition from these neurons narrows spectral tuning and shapes response dynamics. Acute disruptions of inhibition expand spectral receptive fields. However, the effects of long-term perturbations of inhibitory circuitry ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1205909109

    authors: Seybold BA,Stanco A,Cho KK,Potter GB,Kim C,Sohal VS,Rubenstein JL,Schreiner CE

    更新日期:2012-08-21 00:00:00

  • A murine fibroblast growth factor (FGF) receptor expressed in CHO cells is activated by basic FGF and Kaposi FGF.

    abstract::We have cloned a murine cDNA encoding a tyrosine kinase receptor with about 90% similarity to the chicken fibroblast growth factor (FGF) receptor and the human fms-like gene (FLG) tyrosine kinase. This mouse receptor lacks 88 amino acids in the extracellular portion, leaving only two immunoglobulin-like domains compar...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.87.11.4378

    authors: Mansukhani A,Moscatelli D,Talarico D,Levytska V,Basilico C

    更新日期:1990-06-01 00:00:00

  • Nucleotide sequence at the termini of the DNA of Bacillus subtilis phage phi 29.

    abstract::Phage phi 29 DNA cannot be phosphorylated with polynucleotide kinase and [gamma-32P]ATP because of the presence of a viral protein covalently linked to the 5' termini. The 5' ends can, however, be made susceptible to phosphorylation by treatment with alkali and alkaline phosphatase. Restriction fragments Hpa II C and ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.78.3.1446

    authors: Escarmís C,Salas M

    更新日期:1981-03-01 00:00:00

  • Metastable intermediates in myoglobin at low pH.

    abstract::Resonance Raman and optical absorption spectra of ligand-free (deoxy) myoglobin and CO-bound myoglobin (MbCO) at pH 2.6 have been measured by using continuous-flow/rapid-mixing techniques. The spectra of deoxy myoglobin at low pH within 6 ms of the pH drop demonstrate that the iron-histidine bond has been ruptured but...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.87.1.205

    authors: Han S,Rousseau DL,Giacometti G,Brunori M

    更新日期:1990-01-01 00:00:00

  • Responses in the brain of estrogen receptor alpha-disrupted mice.

    abstract::These studies sought to determine if neurons in the estrogen receptor-alpha knockout (ERalphaKO) mouse brain concentrated 16alpha-[125I]iodo-11beta-methoxy-17beta-estradiol (125I-estrogen), and if so, whether estrogen binding augmented the expression of progesterone receptor (PR) mRNA. Mice were injected with 125I-est...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.94.20.11008

    authors: Shughrue PJ,Lubahn DB,Negro-Vilar A,Korach KS,Merchenthaler I

    更新日期:1997-09-30 00:00:00

  • From the Cover: Strong profiling is not mathematically optimal for discovering rare malfeasors.

    abstract::The use of profiling by ethnicity or nationality to trigger secondary security screening is a controversial social and political issue. Overlooked is the question of whether such actuarial methods are in fact mathematically justified, even under the most idealized assumptions of completely accurate prior probabilities...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0813202106

    authors: Press WH

    更新日期:2009-02-10 00:00:00

  • Synergistically stimulated (Na+,K+)-adenosine triphosphatase from plasma membrane of a marine diatom.

    abstract::An ATP-hydrolyzing activity with the properties of a Mg(2+)-dependent (Na(+),K(+))-ATPase (ATP phosphohydrolase, EC 3.6.1.3) from a 20-fold purified plasma membrane fraction of the marine diatom, Nitzschia alba is described. The basal activity requires Mg(2+) and further stimulation by Na(+) or Na(+) plus K(+) is depe...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.71.11.4376

    authors: Sullivan CW,Volcani BE

    更新日期:1974-11-01 00:00:00

  • Antagonism of microRNA-126 suppresses the effector function of TH2 cells and the development of allergic airways disease.

    abstract::Allergic asthma is an inflammatory disease of the lung characterized by abnormal T helper-2 (T(H)2) lymphocyte responses to inhaled antigens. The molecular mechanisms leading to the generation of T(H)2 responses remain unclear, although toll-like receptors (TLRs) present on innate immune cells play a pivotal role in s...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0905063106

    authors: Mattes J,Collison A,Plank M,Phipps S,Foster PS

    更新日期:2009-11-03 00:00:00

  • Regulation of the in vitro antibody response by neuroendocrine hormones.

    abstract::Treatment of lymphocytes with inducers of interferon alpha (IFN-alpha) results in the production of corticotropin (ACTH) and endorphin-like activities. The pro-opiomelanocortin-derived hormones ACTH and alpha-, beta-, and gamma-endorphin and the structurally related hormones [Leu]- and [Met]enkephalin were therefore t...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.79.13.4171

    authors: Johnson HM,Smith EM,Torres BA,Blalock JE

    更新日期:1982-07-01 00:00:00

  • T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo.

    abstract::Organ graft rejection is a T-cell-dependent process. The activation of alloreactive T cells requires stimulation of the T-cell receptor/CD3 complex by foreign major histocompatibility complex (MHC)-encoded gene products. However, accumulating evidence suggests that, in addition to T-cell receptor occupancy, other cost...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.89.22.11102

    authors: Turka LA,Linsley PS,Lin H,Brady W,Leiden JM,Wei RQ,Gibson ML,Zheng XG,Myrdal S,Gordon D

    更新日期:1992-11-15 00:00:00

  • A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responses.

    abstract::To examine the in vivo role(s) of type I interferons (IFNs) and to determine the role of a component of the type I IFN receptor (IFNAR1) in mediating responses to these IFNs, we generated mice with a null mutation (-/-) in the IFNAR1 gene. Despite compelling evidence for modulation of cell proliferation and differenti...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.92.24.11284

    authors: Hwang SY,Hertzog PJ,Holland KA,Sumarsono SH,Tymms MJ,Hamilton JA,Whitty G,Bertoncello I,Kola I

    更新日期:1995-11-21 00:00:00

  • ChIP-on-chip significance analysis reveals large-scale binding and regulation by human transcription factor oncogenes.

    abstract::ChIP-on-chip has emerged as a powerful tool to dissect the complex network of regulatory interactions between transcription factors and their targets. However, most ChIP-on-chip analysis methods use conservative approaches aimed at minimizing false-positive transcription factor targets. We present a model with improve...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0806445106

    authors: Margolin AA,Palomero T,Sumazin P,Califano A,Ferrando AA,Stolovitzky G

    更新日期:2009-01-06 00:00:00

  • Switch recombination in normal IgA1+ B lymphocytes.

    abstract::Most B lymphocytes in normal individuals express two classes of cell-surface immunoglobulins, IgM and IgD. The specificity of the two antigen receptors is identical since they are produced by transcription and differential splicing of the same variable region gene segment to the heavy-chain constant region gene segmen...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.91.4.1323

    authors: Irsch J,Irlenbusch S,Radl J,Burrows PD,Cooper MD,Radbruch AH

    更新日期:1994-02-15 00:00:00

  • Chromosomal mutations of Escherichia coli that alter expression of conjugative plasmid functions.

    abstract::We have identified two chromosomal genes of Escherichia coli K12 that are required for the expression of conjugative plasmid functions in the presence of normal plasmid DNA. Hfr cells with mutations in both of these genes are resistant to donor-specific bacteriophage and defective as conjugal donors. These characteris...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.77.1.513

    authors: McEwen J,Silverman P

    更新日期:1980-01-01 00:00:00

  • Reconstitution of p53-ubiquitinylation reactions from purified components: the role of human ubiquitin-conjugating enzyme UBC4 and E6-associated protein (E6AP).

    abstract::The E6 protein of the high-risk human papillomaviruses inactivates the tumor suppressor protein p53 by stimulating its ubiquitinylation and subsequent degradation. Ubiquitinylation is a multistep process involving a ubiquitin-activating enzyme, one of many distinct ubiquitin-conjugating enzymes, and in certain cases, ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.92.8.3264

    authors: Rolfe M,Beer-Romero P,Glass S,Eckstein J,Berdo I,Theodoras A,Pagano M,Draetta G

    更新日期:1995-04-11 00:00:00

  • Distinct ontogenic and regional expressions of newly identified Cajal-Retzius cell-specific genes during neocorticogenesis.

    abstract::Cajal-Retzius (CR) cells are early-generated transient neurons and are important in the regulation of cortical neuronal migration and cortical laminar formation. Molecular entities characterizing the CR cell identity, however, remain largely elusive. We purified mouse cortical CR cells expressing GFP to homogeneity by...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0406295101

    authors: Yamazaki H,Sekiguchi M,Takamatsu M,Tanabe Y,Nakanishi S

    更新日期:2004-10-05 00:00:00

  • Ligand occupancy of the alpha-V-beta3 integrin is necessary for smooth muscle cells to migrate in response to insulin-like growth factor.

    abstract::Smooth muscle cells (SMCs) have been shown to migrate in response to insulin-like growth factor I (IGF-I). However, the mechanism mediating this response has not been determined. The migration rates of porcine and human vascular SMCs were assessed in a monolayer wounding assay. IGF-I and IGF-II induced increases of 14...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.93.6.2482

    authors: Jones JI,Prevette T,Gockerman A,Clemmons DR

    更新日期:1996-03-19 00:00:00

  • Revealing the dual streams of speech processing.

    abstract::Several dual route models of human speech processing have been proposed suggesting a large-scale anatomical division between cortical regions that support motor-phonological aspects vs. lexical-semantic aspects of speech processing. However, to date, there is no complete agreement on what areas subserve each route or ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1614038114

    authors: Fridriksson J,Yourganov G,Bonilha L,Basilakos A,Den Ouden DB,Rorden C

    更新日期:2016-12-27 00:00:00