Histone H2B monoubiquitination regulates heart development via epigenetic control of cilia motility.

abstract：:Combined intracellular and microfluorometric recording techniques were used to evaluate whether the inhibition by cholinergic or adrenergic transmitters of the Ca2(+)-activated potassium current (IAHP) in hippocampal CA3 pyramidal cells was mediated by an alteration of depolarization-induced change in cytosolic free C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knöpfel T,Vranesic I,Gähwiler BH,Brown DA

更新日期：1990-06-01 00:00:00

abstract：:Paclitaxel has emerged as a front line treatment for aggressive malignancies of the breast, lung, and ovary. Successful therapy of cancer is frequently undermined by the development of paclitaxel resistance. There is a growing need to find other therapeutic targets to facilitate treatment of drug-resistant cancers. Us...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patel N,Chatterjee SK,Vrbanac V,Chung I,Mu CJ,Olsen RR,Waghorne C,Zetter BR

更新日期：2010-02-09 00:00:00

abstract：:Monoclonal antibodies (mAbs) have been used to treat malignancies in humans with varying degrees of success. Progress has been hindered by the lack of suitable animal models, which would ideally consist of immunocompetent animals that are tolerant to tumor-associated antigens. Suitable models would allow the study and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wilkinson RW,Ross EL,Poulsom R,Ilyas M,Straub J,Snary D,Bodmer WF,Mather SJ

更新日期：2001-08-28 00:00:00

abstract：:Total heterogeneous nuclear RNA from HeLa cells infected with adenovirus for 18-20 hr stimulates amino acid incorporation into protein in a cell-free system from Ehrlich ascites tumors. This stimulation of protein synthesis by the nuclear RNA requires intact nuclei. The role of nuclei in this system is unknown, but ev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chatterjee NK,Weissbach H

更新日期：1974-08-01 00:00:00

abstract：:Somatic cell hybrids have been prepared at high frequency between the rat muscle cell line L6 and human fetal muscle cells. The hybrid cells express several human gene products including an antigen, 12E7, controlled by the human X chromosome, Thy-1, and several human isoenzymes. In addition, one clone (37-11) expresse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Quinn CA,Goodfellow PN,Povey S,Walsh FS

更新日期：1981-08-01 00:00:00

abstract：:Rivers around the world are being regulated by dams to accommodate the needs of a rapidly growing global population. These regulatory efforts usually oppose the natural tendency of rivers to flood, move sediment, and migrate. Although an economic benefit, river regulation has come at unforeseen and unevaluated cumulat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trush WJ,McBain SM,Leopold LB

更新日期：2000-10-24 00:00:00

abstract：:The 89-kDa cell surface glycoprotein, P3.58, is detectable on advanced human melanomas in situ but not on benign melanocytes or early melanomas. cDNA cloning of P3.58 from melanoma cells was accomplished by screening a lambda zap expression vector library with monoclonal antibodies produced against the denatured antig...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johnson JP,Stade BG,Holzmann B,Schwäble W,Riethmüller G

更新日期：1989-01-01 00:00:00

abstract：:Little is known about how genetic variation and epigenetic marks interact to shape differences in behavior. The foraging (for) gene regulates behavioral differences between the rover and sitter Drosophila melanogaster strains, but the molecular mechanisms through which it does so have remained elusive. We show that th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anreiter I,Kramer JM,Sokolowski MB

更新日期：2017-11-21 00:00:00

abstract：:We have tested the effect of increased ribosomal fidelity on a modified version of the programmed release factor 2 (RF2) translational frameshift. In the constructs tested, the original UGA codon at the site of the shift was replaced by either of two sense codons, UGG (tryptophan), which allows a frameshift of approxi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sipley J,Goldman E

更新日期：1993-03-15 00:00:00

abstract：:We have purified a protein from Necturus maculosus gallbladder cells that forms chloride channels in an artificial membrane. The same protein apparently can form channels that are highly selective for chloride but can have conductances varying from 9 to about 150 pS. The high-conductance channels are blocked by the mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Finn AL,Dillard M,Gaido M

更新日期：1993-06-15 00:00:00

abstract：:Current models of the formation and distribution of gold deposits on Earth are based on the long-standing paradigm that hydrogen sulfide and chloride are the ligands responsible for gold mobilization and precipitation by fluids across the lithosphere. Here we challenge this view by demonstrating, using in situ X-ray a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pokrovski GS,Kokh MA,Guillaume D,Borisova AY,Gisquet P,Hazemann JL,Lahera E,Del Net W,Proux O,Testemale D,Haigis V,Jonchière R,Seitsonen AP,Ferlat G,Vuilleumier R,Saitta AM,Boiron MC,Dubessy J

更新日期：2015-11-03 00:00:00

abstract：:MicroRNAs (miRNAs) are small, 18-22 nt long, noncoding RNAs that act as potent negative gene regulators in a variety of physiological and pathological processes. To repress gene expression, miRNAs are packaged into RNA-induced silencing complexes (RISCs) that target mRNAs for degradation and/or translational repressio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen AK,Sengupta P,Waki K,Van Engelenburg SB,Ochiya T,Ablan SD,Freed EO,Lippincott-Schwartz J

更新日期：2014-07-01 00:00:00

abstract：:Earth's water cycle enables the incorporation of water (hydration) in mantle minerals that can influence the physical properties of the mantle. Lattice thermal conductivity of mantle minerals is critical for controlling the temperature profile and dynamics of the mantle and subducting slabs. However, the effect of hyd...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang YY,Hsieh WP,Tan E,Chen J

更新日期：2017-04-18 00:00:00

abstract：:Brefeldin A, a fungal metabolite that inhibits membrane transport, induces the mono(ADP-ribosyl)ation of two cytosolic proteins of 38 and 50 kDa as judged by SDS/PAGE. The 38-kDa substrate has been previously identified as glyceraldehyde-3-phosphate dehydrogenase (GAPDH). We report that the 50-kDa BFA-induced ADP-ribo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Di Girolamo M,Silletta MG,De Matteis MA,Braca A,Colanzi A,Pawlak D,Rasenick MM,Luini A,Corda D

更新日期：1995-07-18 00:00:00

abstract：:In facultative photoperiodic flowering plants, noninductive photoperiods result in a delay in flowering, but such plants eventually flower, illustrating plasticity in an important developmental transition, flowering. The model plant, Arabidopsis, has a facultative photoperiod response. Although the inductive flowering...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim DH,Sung S

更新日期：2010-09-28 00:00:00

abstract：:Mutations in the low density lipoprotein (LDL) receptor (LDLR) cause hypercholesterolemia because of inefficient LDL clearance from the circulation. In addition, there is a paradoxical oversecretion of the metabolic precursor of LDL, very low density lipoprotein (VLDL). We recently demonstrated that the LDLR mediates ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gillian-Daniel DL,Bates PW,Tebon A,Attie AD

更新日期：2002-04-02 00:00:00

abstract：:The trace metals nickel and platinum, which are not substrates for ferrochelatase and thus do not form heme in biological systems, were found to act similaryl to cobalt, and heme itself, in regulating heme metabolism in liver and kidney. These metals induced heme oxygenase activity in both organs with the peak of indu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maines MD,Kappas A

更新日期：1977-05-01 00:00:00

abstract：:Under various conditions, specific genetic areas of the phage T4 DNA molecule are preferentially and repeatedly replicated, resulting in the amplification of these areas. These areas are found to lie in the vicinity of the known origins of DNA replication. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kozinski AW,Ling SK,Hutchinson N,Halpern ME,Mattson T

更新日期：1980-09-01 00:00:00

abstract：:We have studied the expression of simian virus 40 (SV40) specific tumor antigen (T-antigen) and viral RNA in SV40-transformed mouse 3T3 cells that are temperature-sensitive for the expression of the transformed phenotype (ts SV3T3). Although transformed by wild-type SV40, ts SV3T3 cells at 32 degrees behave like stand...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Basilico C,Zouzias D

更新日期：1976-06-01 00:00:00

abstract：:The immunity protein to colicin A (Cai), which is constitutively expressed at a very low level in Escherichia coli strains, has been studied in recombinant plasmid constructs allowing expression of various immunity fusion proteins under the control of inducible promoters. The 13-amino acid NH2-terminal region of Cai w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Geli V,Baty D,Lazdunski C

更新日期：1988-02-01 00:00:00

abstract：:We studied mutants of E. coli originally identified as being deficient in either endonuclease II (deoxyribonucleate oligonucleotidohydrolase, EC 3.1.4.30) or exonuclease III [deoxyribonucleate (double-stranded) 5'-nucleotidohydrolase, EC 3.1.4.27] activity. Twelve independently derived mutants were tested, including t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yajko DM,Weiss B

更新日期：1975-02-01 00:00:00

abstract：:For almost a century the plant hormone auxin has been central to theories on apical dominance, whereby the growing shoot tip suppresses the growth of the axillary buds below. According to the classic model, the auxin indole-3-acetic acid is produced in the shoot tip and transported down the stem, where it inhibits bud...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mason MG,Ross JJ,Babst BA,Wienclaw BN,Beveridge CA

更新日期：2014-04-22 00:00:00

abstract：:Intercropping, which grows at least two crop species on the same pieces of land at the same time, can increase grain yields greatly. Legume-grass intercrops are known to overyield because of legume nitrogen fixation. However, many agricultural soils are deficient in phosphorus. Here we show that a new mechanism of ove...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li L,Li SM,Sun JH,Zhou LL,Bao XG,Zhang HG,Zhang FS

更新日期：2007-07-03 00:00:00

abstract：:The internal dynamics of bacteriorhodopsin, the light-driven proton pump in the purple membrane of Halobacterium halobium, has been studied by inelastic neutron scattering for various conditions of temperature and hydration. Light activation can take place when the membrane is vibrating harmonically. The ability of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ferrand M,Dianoux AJ,Petry W,Zaccaï G

更新日期：1993-10-15 00:00:00

abstract：:The cellular response to ionizing radiation (IR) includes induction of the c-jun and EGR1 early response genes. The present work has examined potential cytoplasmic signaling cascades that transduce IR-induced signals to the nucleus. The results demonstrate activation of the 40S ribosomal protein S6 kinase, pp90rsk, in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kharbanda S,Saleem A,Shafman T,Emoto Y,Weichselbaum R,Kufe D

更新日期：1994-06-07 00:00:00

abstract：:Changes in tree growth rates can affect tree mortality and forest feedbacks to the global carbon cycle. As air temperature increases, evaporative demand also increases, increasing effective drought in forest ecosystems. Using a spatially comprehensive network of Douglas fir (Pseudotsuga menziesii) chronologies from 12...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Restaino CM,Peterson DL,Littell J

更新日期：2016-08-23 00:00:00

abstract：:Naive CD4 T cells differentiate into several effector lineages, which generate a stronger and more rapid response to previously encountered immunological challenges. Although effector function is a key feature of adaptive immunity, the molecular basis of this process is poorly understood. Here, we investigated the spa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zorca CE,Kim LK,Kim YJ,Krause MR,Zenklusen D,Spilianakis CG,Flavell RA

更新日期：2015-03-31 00:00:00

abstract：:cGMP is a key regulatory molecule in visual transduction, integration of neuronal response to excitatory neurotransmitters, relaxation of smooth muscle, intestinal secretion of water and salt, and reabsorption of sodium and water in the distal tubules of the nephron. Some of these cellular functions are associated wit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruth P,Wang GX,Boekhoff I,May B,Pfeifer A,Penner R,Korth M,Breer H,Hofmann F

更新日期：1993-04-01 00:00:00

abstract：:microRNAs comprise a few percent of animal genes and have been recognized as important regulators of a diverse range of biological processes. Understanding the biological functions of miRNAs requires effective means to identify their targets. Combined efforts from computational prediction, miRNA over-expression or dep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hong X,Hammell M,Ambros V,Cohen SM

更新日期：2009-09-01 00:00:00

abstract：:Extracellular cAMP plays a crucial role in regulating the developmental program of Dictyostelium discoideum, functioning as a chemotactic agent, as well as a signal that regulates expression of developmentally expressed genes. These activities appear to be mediated by a cell-surface receptor for cAMP. We have studied ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chisholm RL,Hopkinson S,Lodish HF

更新日期：1987-02-01 00:00:00