Muscarinic and beta-adrenergic depression of the slow Ca2(+)-activated potassium conductance in hippocampal CA3 pyramidal cells is not mediated by a reduction of depolarization-induced cytosolic Ca2+ transients.

abstract：:Parasitic plants share a common anatomical feature, the haustorium. Haustoria enable both infection and nutrient transfer, which often leads to growth penalties for host plants and yield reduction in crop species. Haustoria also reciprocally transfer substances, such as RNA and proteins, from parasite to host, but the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spallek T,Melnyk CW,Wakatake T,Zhang J,Sakamoto Y,Kiba T,Yoshida S,Matsunaga S,Sakakibara H,Shirasu K

更新日期：2017-05-16 00:00:00

abstract：:MacArthur and Wilson [MacArthur, R. H. & Wilson, E. O. (1967) The Theory of Island Biogeography (Princeton Univ. Press, Princeton, NJ)] used the rate of recolonization of the Krakatau Islands (sterilized in the cataclysmic 1883 eruption) by birds and vascular plants to test their equilibrium model of immigration and e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thornton IW,Zann RA,Rawlinson PA,Tidemann CR,Adikerana AS,Widjoya AH

更新日期：1988-01-01 00:00:00

abstract：:Stress-induced impairments in extinction learning are believed to sustain posttraumatic stress disorder (PTSD). Noradrenergic signaling may contribute to extinction impairments by modulating medial prefrontal cortex (mPFC) circuits involved in fear regulation. Here we demonstrate that aversive fear conditioning rapidl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fitzgerald PJ,Giustino TF,Seemann JR,Maren S

更新日期：2015-07-14 00:00:00

abstract：:The androgen receptor (AR) plays an essential role in prostate cancer, and suppression of its signaling with androgen deprivation therapy (ADT) has been the mainstay of treatment for metastatic hormone-sensitive prostate cancer for more than 70 y. Chemotherapy has been reserved for metastatic castration-resistant pros...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Komura K,Jeong SH,Hinohara K,Qu F,Wang X,Hiraki M,Azuma H,Lee GS,Kantoff PW,Sweeney CJ

更新日期：2016-05-31 00:00:00

abstract：:The stator ring of the bacterial flagellar motor is composed of the MotA and MotB proteins that act together to generate a turning force (torque) acting on the FliG ring of the rotor. The C-terminal domain of MotB (MotB-C) is believed to anchor the MotA/MotB complex to peptidoglycan (PG) of the cell wall. The first cr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roujeinikova A

更新日期：2008-07-29 00:00:00

abstract：:Dimers of bacteriochlorophyll a (Bchla) with optical absorption maximum at 853 nm and a nonconservative circular dichroism spectrum are formed in a solution of formamide/water that contains micelles of Triton X-100. The apparent equilibrium constant and the corresponding Gibbs energy change for the Bchl self-organizat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scherz A,Rosenbach-Belkin V

更新日期：1989-03-01 00:00:00

abstract：:Expression of glucokinase in hepatocytes and pancreatic 6-cells is of major physiologic importance to mammalian glucose homeostasis. Liver glucokinase catalyzes the first committed step in the disposal of glucose, and beta-cell glucokinase catalyzes a rate-limiting step required for glucose-regulated insulin release. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heimberg H,De Vos A,Moens K,Quartier E,Bouwens L,Pipeleers D,Van Schaftingen E,Madsen O,Schuit F

更新日期：1996-07-09 00:00:00

abstract：:An inwardly rectifying, ATP-regulated K+ channel with a distinctive molecular architecture, ROMK1, was recently cloned from rat kidney. Using patch clamp techniques, we have investigated the regulation of ROMK1 with particular emphasis on phosphorylation/dephosphorylation processes. Spontaneous channel rundown occurre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McNicholas CM,Wang W,Ho K,Hebert SC,Giebisch G

更新日期：1994-08-16 00:00:00

abstract：:Human tyrosyl-DNA phosphodiesterase (TDP1) hydrolyzes the phosphodiester bond at a DNA 3'-end linked to a tyrosyl moiety and has been implicated in the repair of topoisomerase I (Top1)-DNA covalent complexes. TDP1 can also hydrolyze other 3'-end DNA alterations including 3'-phosphoglycolate and 3'-abasic sites, and ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Das BB,Dexheimer TS,Maddali K,Pommier Y

更新日期：2010-11-16 00:00:00

abstract：:We have engineered the ecdysone-inducible mammalian expression system for general retroviral delivery to cultured mammalian cells. We inducibly expressed PTEN in the glioblastoma cell line, U87MG, lacking this gene. Because nearly all cells are recruited on induction, we find both up- and down-regulated genes by cDNA ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stolarov J,Chang K,Reiner A,Rodgers L,Hannon GJ,Wigler MH,Mittal V

更新日期：2001-11-06 00:00:00

abstract：:Modified bovine leukemia virus (BLV) glycoproteins were expressed by using vaccinia virus recombinants, and their fusogenic capacities were examined by a syncytia-formation assay. This analysis indicates that (i) both BLV envelope glycoproteins gp51 and gp30 are necessary for cell fusion; (ii) insertion of the N-termi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vonèche V,Portetelle D,Kettmann R,Willems L,Limbach K,Paoletti E,Ruysschaert JM,Burny A,Brasseur R

更新日期：1992-05-01 00:00:00

abstract：:Two functional domains in the primary structure of basic fibroblast growth factor (FGF) have been identified on the basis of their ability to interact with the FGF receptor, bind radiolabeled heparin, and modulate the cellular response to FGF. Peptides derived from these two functional domains can act as partial agoni...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baird A,Schubert D,Ling N,Guillemin R

更新日期：1988-04-01 00:00:00

abstract：:A novel type I transmembrane protein of COPI-coated vesicles, p23, has been demonstrated to be localized mainly to the Golgi complex. This protein and p24, another member of the p24 family, have been shown to bind coatomer via their short cytoplasmic tails. Here we demonstrate that p23 continuously cycles through the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nickel W,Sohn K,Bünning C,Wieland FT

更新日期：1997-10-14 00:00:00

abstract：:Chemosensory proteins (CSPs) have been proposed to transport hydrophobic chemicals from air to olfactory or taste receptors. They have been isolated from several sensory organs of a wide range of insect species. The x-ray structure of CSPMbraA6, a 112-aa antennal protein from the moth Mamestra brassicae (Mbra), was sh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Campanacci V,Lartigue A,Hällberg BM,Jones TA,Giudici-Orticoni MT,Tegoni M,Cambillau C

更新日期：2003-04-29 00:00:00

abstract：:The Nod-like receptor family in man contains proteins that recognize invasive bacteria. Nod1, a member of this family, is activated by specific peptidoglycan-derived muropeptides that contain meso-diaminopimelic acid. Plants contain a large family of proteins known as resistance (R) proteins that have common structura...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： da Silva Correia J,Miranda Y,Leonard N,Ulevitch R

更新日期：2007-04-17 00:00:00

abstract：:Fluorescence photobleaching recovery and immunofluorescence methods have been used to study the lateral mobility and topographical distribution of a major cell surface glycoprotein (CSP). Both endogenous CSP and fluorescent-labeled exogenous CSP bind to the cell surface in a fibrillar pattern and are immobile on the e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schlessinger J,Barak LS,Hammes GG,Yamada KM,Pastan I,Webb WW,Elson EL

更新日期：1977-07-01 00:00:00

abstract：:Ca2+, pheromones, sweet taste compounds, and the main neurotransmitters glutamate and gamma-aminobutyric acid activate G protein-coupled receptors (GPCRs) that constitute the GPCR family 3. These receptors are dimers, and each subunit has a large extracellular domain called a Venus flytrap module (VFTM), where agonist...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bessis AS,Rondard P,Gaven F,Brabet I,Triballeau N,Prezeau L,Acher F,Pin JP

更新日期：2002-08-20 00:00:00

abstract：:Magnitudes of the larger Soviet underground nuclear weapons tests from the start of the Threshold Test Ban Treaty in 1976 through 1982 are determined for short- and long-period seismic waves. Yields are calculated from the surface wave magnitude for those explosions at the eastern Kazakh test site that triggered a sma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sykes LR,Cifuentes IL

更新日期：1984-03-01 00:00:00

abstract：:Transcription termination is a critical step in the control of gene expression. One of the major termination mechanisms is mediated by Rho factor that dissociates the complex mRNA-DNA-RNA polymerase upon binding with RNA polymerase. Rho promotes termination at the end of operons, but it can also terminate transcriptio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Silva IJ,Barahona S,Eyraud A,Lalaouna D,Figueroa-Bossi N,Massé E,Arraiano CM

更新日期：2019-02-19 00:00:00

abstract：:Memory CD8 T cells provide durable protection against diverse intracellular pathogens and can be broadly segregated into distinct circulating and tissue-resident populations. Paradigmatic studies have demonstrated that circulating memory cells can be further divided into effector memory (Tem) and central memory (Tcm) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Milner JJ,Nguyen H,Omilusik K,Reina-Campos M,Tsai M,Toma C,Delpoux A,Boland BS,Hedrick SM,Chang JT,Goldrath AW

更新日期：2020-10-13 00:00:00

abstract：:A sensitive and rapid in situ method was developed to visualize sites of single-stranded (ss) DNA in cultured cells and in experimental test animals. Anti-bromodeoxyuridine antibody recognizes the halogenated base analog incorporated into chromosomal DNA only when substituted DNA is in the single strand form. After tr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raderschall E,Golub EI,Haaf T

更新日期：1999-03-02 00:00:00

abstract：:That tumors cause changes in surrounding tissues is well documented, but whether they also affect distant tissues is uncertain. Such knowledge may be important in understanding the relationship between cancer and overall patient health. To address this question, we examined tissues distant to sites of implanted tumors...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Redon CE,Dickey JS,Nakamura AJ,Kareva IG,Naf D,Nowsheen S,Kryston TB,Bonner WM,Georgakilas AG,Sedelnikova OA

更新日期：2010-10-19 00:00:00

abstract：:Thymic epithelial cells (TECs), the major component of the thymic microenvironment, can be modulated by pituitary hormones. We have shown previously that prolactin (PRL) can influence the endocrine activity of TECs and stimulate TEC proliferation as well as cytokeratin expression, suggesting the existence of PRL recep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dardenne M,Kelly PA,Bach JF,Savino W

更新日期：1991-11-01 00:00:00

abstract：:Intestinal CD103(-) dendritic cells (DCs) are pathogenic for colitis. Unveiling molecular mechanisms that render these cells proinflammatory is important for the design of specific immunotherapies. In this report, we demonstrated that mesenteric lymph node CD103(-) DCs express, among other proinflammatory cytokines, h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kourepini E,Aggelakopoulou M,Alissafi T,Paschalidis N,Simoes DC,Panoutsakopoulou V

更新日期：2014-03-04 00:00:00

abstract：:Histone H3 phosphorylation is a critical step that couples signal transduction pathways to gene regulation. To specifically assess the transcriptional regulatory functions of H3 phosphorylation, we developed an in vivo targeting approach and found that the H3 kinase MSK1 is a direct and potent transcriptional activato...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lau PN,Cheung P

更新日期：2011-02-15 00:00:00

abstract：:Global increases in population, consumption, and gross domestic product raise concerns about the sustainability of the current and future use of natural resources. The human appropriation of net primary production (HANPP) provides a useful measure of human intervention into the biosphere. The productive capacity of la...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krausmann F,Erb KH,Gingrich S,Haberl H,Bondeau A,Gaube V,Lauk C,Plutzar C,Searchinger TD

更新日期：2013-06-18 00:00:00

abstract：:Reactive oxygen species (ROS) are known to be important signal molecules that are involved in biotic and abiotic stress responses as well as in growth regulation. However, the molecular mechanisms by which ROS act as a growth regulator, as well as how ROS-dependent growth regulation relates to its roles in stress resp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mabuchi K,Maki H,Itaya T,Suzuki T,Nomoto M,Sakaoka S,Morikami A,Higashiyama T,Tada Y,Busch W,Tsukagoshi H

更新日期：2018-05-15 00:00:00

abstract：:The statistics of extrasolar planetary systems indicate that the default mode of planet formation generates planets with orbital periods shorter than 100 days and masses substantially exceeding that of the Earth. When viewed in this context, the Solar System is unusual. Here, we present simulations which show that a p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Batygin K,Laughlin G

更新日期：2015-04-07 00:00:00

abstract：:Vascular endothelial cells (ECs) at arterial branches and curvatures experience disturbed blood flow and induce a quiescent-to-activated phenotypic transition of the adjacent smooth muscle cells (SMCs) and a subsequent smooth muscle hyperplasia. However, the mechanism underlying the flow pattern-specific initiation of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu JJ,Liu YF,Zhang YP,Zhao CR,Yao WJ,Li YS,Wang KC,Huang TS,Pang W,Wang XF,Wang X,Chien S,Zhou J

更新日期：2017-08-01 00:00:00

abstract：:During performance of attention-demanding cognitive tasks, certain regions of the brain routinely increase activity, whereas others routinely decrease activity. In this study, we investigate the extent to which this task-related dichotomy is represented intrinsically in the resting human brain through examination of s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fox MD,Snyder AZ,Vincent JL,Corbetta M,Van Essen DC,Raichle ME

更新日期：2005-07-05 00:00:00