Resistance to docetaxel in prostate cancer is associated with androgen receptor activation and loss of KDM5D expression.

abstract：:Synapsins are abundant synaptic-vesicle phosphoproteins that are known to regulate neurotransmitter release but whose precise function has been difficult to pinpoint. Here, we use knockout mice to analyze the role of synapsins 1 and 2 in the calyx of Held synapse, allowing precise measurements of neurotransmitter rele...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun J,Bronk P,Liu X,Han W,Südhof TC

更新日期：2006-02-21 00:00:00

abstract：:Misfolding and aggregation of Cu, Zn superoxide dismutase (SOD1) is implicated in neuronal death in amyotrophic lateral sclerosis. Each SOD1 monomer binds to 1 copper and 1 zinc ion and maintains its disulfide bond (Cys-57-Cys-146) in the reducing cytoplasm of cell. Mounting experimental evidence suggests that metal l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ding F,Dokholyan NV

更新日期：2008-12-16 00:00:00

abstract：:We have developed an efficient, versatile, and user-friendly viral engineering and expression system that is based on in planta assembly of functional viral vectors from separate pro-vector modules. With this new system, instead of supplying a plant cell with a complete viral vector as a mature viral particle, an RNA ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marillonnet S,Giritch A,Gils M,Kandzia R,Klimyuk V,Gleba Y

更新日期：2004-05-04 00:00:00

abstract：:Physical biochemical techniques are used to establish the structure, subunit stoichiometry, and assembly pathway of the primosome complex of the bacteriophage T4 DNA replication system. Analytical ultracentrifugation and fluorescence anisotropy methods show that the functional T4 primosome consists of six gp41 helicas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jose D,Weitzel SE,Jing D,von Hippel PH

更新日期：2012-08-21 00:00:00

abstract：:The bifunctional Neurospora crassa mitochondrial tyrosyl-tRNA synthetase (CYT-18 protein) both aminoacylates mitochondrial tRNA(Tyr) and acts as a structure-stabilizing splicing cofactor for group I introns. Previous studies showed that CYT-18 has distinct tRNA(Tyr) and group I intron-binding sites, with the latter fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paukstelis PJ,Lambowitz AM

更新日期：2008-04-22 00:00:00

abstract：:Kinesin-1 is a molecular motor protein that transports cargo along microtubules. Inside cells, the vast majority of kinesin-1 is regulated to conserve ATP and to ensure its proper intracellular distribution and coordination with other molecular motors. Regulated kinesin-1 folds in half at a hinge in its coiled-coil st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dietrich KA,Sindelar CV,Brewer PD,Downing KH,Cremo CR,Rice SE

更新日期：2008-07-01 00:00:00

abstract：:Streptococcus pneumoniae cause considerable morbidity and mortality, with persistent neurological sequelae, particularly in young children and the elderly. It is widely assumed that carriage occurs through direct mucosal colonization from the environment whereas meningitis results from invasion from the blood. However...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Ginkel FW,McGhee JR,Watt JM,Campos-Torres A,Parish LA,Briles DE

更新日期：2003-11-25 00:00:00

abstract：:An immature state of cellular differentiation--characterized by stem cell-like tendencies and impaired differentiation--is a hallmark of cancer. Using glioblastoma multiforme (GBM) as a model system, we sought to determine whether molecular determinants that drive cells toward terminal differentiation are also genetic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu J,Ho AL,Yuan L,Hu B,Hua S,Hwang SS,Zhang J,Hu T,Zheng H,Gan B,Wu G,Wang YA,Chin L,DePinho RA

更新日期：2013-09-03 00:00:00

abstract：:Protein tyrosine phosphatase (PTP)σ (PTPRS) was shown previously to be associated with susceptibility to inflammatory bowel disease (IBD). PTPσ(-/-) mice exhibit an IBD-like phenotype in the intestine and show increased susceptibility to acute models of murine colitis. However, the function of PTPσ in the intestine is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murchie R,Guo CH,Persaud A,Muise A,Rotin D

更新日期：2014-01-14 00:00:00

abstract：:Due to its remarkably long half-life, together with its wide in vivo distribution and its lack of enzymatic or immunological functions, human serum albumin (HSA) represents an optimal carrier for therapeutic peptides/proteins aimed at interacting with cellular or molecular components of the vascular and interstitial c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeh P,Landais D,Lemaître M,Maury I,Crenne JY,Becquart J,Murry-Brelier A,Boucher F,Montay G,Fleer R

更新日期：1992-03-01 00:00:00

abstract：:Fetal cerebral neurons at the initiation of active neurite outgrowth in culture incorporate 4-fold more [3H]glucosamine into glycoproteins than into the cellular lipid fraction. After 8 days or longer, when a well-developed fiber network is apparent, lipids are labeled more extensively than the glycoproteins. Labeling...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yavin E,Richter-Landsberg C,Duksin D,Yavin Z

更新日期：1984-09-01 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) is a multifunctional protein that participates in signaling pathways initiated by various growth factors and cytokines. It exists in multiple forms including those phosphorylated on Tyr(705) (pYSTAT3) or Ser(727) (pSSTAT3) as well as the unphosphorylated prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koo MY,Park J,Lim JM,Joo SY,Shin SP,Shim HB,Chung J,Kang D,Woo HA,Rhee SG

更新日期：2014-04-29 00:00:00

abstract：:The heptadecapeptide orphanin FQ (OFQ) is a recently discovered neuropeptide that exhibits structural features reminiscent of the opioid peptides and that is an endogenous ligand to a G protein-coupled receptor sequentially related to the opioid receptors. We have cloned both the human and rat cDNAs encoding the OFQ p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nothacker HP,Reinscheid RK,Mansour A,Henningsen RA,Ardati A,Monsma FJ Jr,Watson SJ,Civelli O

更新日期：1996-08-06 00:00:00

abstract：:Transposition is a multistep process in which a transposable element DNA sequence moves from its original genetic location to a new site. Early steps in this process include the formation of a transposition complex in which the end sequences of the transposable element are brought together in a structurally precise fa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goryshin IYu,Kil YV,Reznikoff WS

更新日期：1994-11-08 00:00:00

abstract：:The plant vascular system provides transport and support capabilities that are essential for plant growth and development, yet the mechanisms directing the arrangement of vascular bundles within the shoot inflorescence stem remain unknown. We used computational and experimental biology to evaluate the role of auxin an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ibañes M,Fàbregas N,Chory J,Caño-Delgado AI

更新日期：2009-08-11 00:00:00

abstract：:In the preceding paper we described an experiment that determined the in vivo forward mutation rate in a single replication cycle for spleen necrosis virus. In addition to substitutions, frameshifts, and hypermutations, the mutated proviruses contained two classes of deletions. One class of deletions contained short d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pathak VK,Temin HM

更新日期：1990-08-01 00:00:00

abstract：:Repeat proteins contain short, tandem arrays of simple structural motifs (20-40 aa). These stack together to form nonglobular structures that are stabilized by short-range interactions from residues close in primary sequence. Unlike globular proteins, they have few, if any, long-range nonlocal stabilizing interactions...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Javadi Y,Main ER

更新日期：2009-10-13 00:00:00

abstract：:Glycogen synthase kinase 3 (GSK-3) is implicated in multiple biological processes including metabolism, gene expression, cell fate determination, proliferation, and survival. GSK-3 activity is inhibited through phosphorylation of serine 21 in GSK-3 alpha and serine 9 in GSK-3 beta. These serine residues of GSK-3 have ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fang X,Yu SX,Lu Y,Bast RC Jr,Woodgett JR,Mills GB

更新日期：2000-10-24 00:00:00

abstract：:N6-methyladenosine (m6A) represents one of the most common RNA modifications in eukaryotes. Specific m6A writer, eraser, and reader proteins have been identified. As an m6A eraser, ALKBH5 specifically removes m6A from target mRNAs and inactivation of Alkbh5 leads to male infertility in mice. However, the underlying mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tang C,Klukovich R,Peng H,Wang Z,Yu T,Zhang Y,Zheng H,Klungland A,Yan W

更新日期：2018-01-09 00:00:00

abstract：:We demonstrate that the receptor binding moiety of Escherichia coli heat-labile enterotoxin (EtxB) can completely prevent autoimmune disease in a murine model of arthritis. Injection of male DBA/1 mice at the base of the tail with type II collagen in the presence of complete Freund's adjuvant normally leads to arthrit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams NA,Stasiuk LM,Nashar TO,Richards CM,Lang AK,Day MJ,Hirst TR

更新日期：1997-05-13 00:00:00

abstract：:Establishing quantitative relationships between molecular structure and broad biological effects has been a longstanding challenge in science. Currently, no method exists for forecasting broad biological activity profiles of medicinal agents even within narrow boundaries of structurally similar molecules. Starting fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fliri AF,Loging WT,Thadeio PF,Volkmann RA

更新日期：2005-01-11 00:00:00

abstract：:Interleukin 10 (IL-10) inhibits interferon gamma-induced macrophage activation for cytotoxicity against larvae of the human parasite Schistosoma mansoni by suppressing production of the toxic effector molecule nitric oxide (NO). In this study, the mechanism of IL-10 action was identified as inhibition of endogenous tu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oswald IP,Wynn TA,Sher A,James SL

更新日期：1992-09-15 00:00:00

abstract：:Although much evidence suggests that the plasma membrane of eukaryotic cells is not homogenous, the precise architecture of this important structure has not been clear. Here we use transmission electron microscopy of plasma membrane sheets and specific probes to show that most or all plasma membrane-associated protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lillemeier BF,Pfeiffer JR,Surviladze Z,Wilson BS,Davis MM

更新日期：2006-12-12 00:00:00

abstract：:The effects of messages initiated by one receptor on the covalent modification of a second receptor were studied by use of a technique for rapidly separating the receptors. Methylation of the bacterial-chemotactic serine receptor increases as a result of aspartate binding to the aspartate receptor. The aspartate-induc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sanders DA,Koshland DE Jr

更新日期：1988-11-01 00:00:00

abstract：:Terminal oligopyrimidine (TOP) motifs are sequences at the 5' ends of mRNAs that link their translation to the mTOR Complex 1 (mTORC1) nutrient-sensing signaling pathway. They are commonly regarded as discrete elements that reside on ∼100 mRNAs that mostly encode translation factors. However, the full spectrum of TOP ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Philippe L,van den Elzen AMG,Watson MJ,Thoreen CC

更新日期：2020-03-10 00:00:00

abstract：:Two strains that overproduce endonuclease III were found in a colony bank containing hybrid ColE1-Escherichia coli plasmids. The enzyme was identified in crude extracts by the degradation of partially depyrimidinated DNA in the presence of EDTA, by its sedimentation velocity, and by its associated thymine glycol-DNA g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cunningham RP,Weiss B

更新日期：1985-01-01 00:00:00

abstract：:Let X(0) be an unknown M by N matrix. In matrix recovery, one takes n < MN linear measurements y(1),…,y(n) of X(0), where y(i) = Tr(A(T)iX(0)) and each A(i) is an M by N matrix. A popular approach for matrix recovery is nuclear norm minimization (NNM): solving the convex optimization problem min ||X||*subject to y(i) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Donoho DL,Gavish M,Montanari A

更新日期：2013-05-21 00:00:00

abstract：:Facial expressions of emotion in humans are believed to be produced by contracting one's facial muscles, generally called action units. However, the surface of the face is also innervated with a large network of blood vessels. Blood flow variations in these vessels yield visible color changes on the face. Here, we stu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benitez-Quiroz CF,Srinivasan R,Martinez AM

更新日期：2018-04-03 00:00:00

abstract：:Clostridium botulinum neurotoxins (BoNTs), the most potent toxins known, disrupt neurotransmission through proteolysis of proteins involved in neuroexocytosis. The light chains of BoNTs are unique zinc proteases that have stringent substrate specificity and require exceptionally long substrates. We have determined the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Segelke B,Knapp M,Kadkhodayan S,Balhorn R,Rupp B

更新日期：2004-05-04 00:00:00

abstract：:The complete amino acid sequence of Xenopus laevis nonmuscle myosin heavy chain B (MHC-B) has been deduced from overlapping cDNA clones isolated from an XTC cell library. RNA blots of various developmental stages, adult tissues, and XTC cells detect a single transcript of 7.5 kb which is expressed at similar levels th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhatia-Dey N,Adelstein RS,Dawid IB

更新日期：1993-04-01 00:00:00