当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > Delineation of a molecularly distinct terminally differentiated memory CD8 T cell population.

Delineation of a molecularly distinct terminally differentiated memory CD8 T cell population.

Abstract：

:Memory CD8 T cells provide durable protection against diverse intracellular pathogens and can be broadly segregated into distinct circulating and tissue-resident populations. Paradigmatic studies have demonstrated that circulating memory cells can be further divided into effector memory (Tem) and central memory (Tcm) populations based on discrete functional characteristics. Following resolution of infection, we identified a persisting antigen-specific CD8 T cell population that was terminally fated with potent effector function but maintained memory T cell qualities and conferred robust protection against reinfection. Notably, this terminally differentiated effector memory CD8 T cell population (terminal-Tem) was conflated within the conventional Tem population, prompting redefinition of the classical characteristics of Tem cells. Murine terminal-Tem were transcriptionally, functionally, and developmentally unique compared to Tem cells. Through mass cytometry and single-cell RNA sequencing (RNA-seq) analyses of human peripheral blood from healthy individuals, we also identified an analogous terminal-Tem population of CD8 T cells that was transcriptionally distinct from Tem and Tcm Key findings from this study show that parsing of terminal-Tem from conventionally defined Tem challenge the reported characteristics of Tem biology, including enhanced presence in lymphoid tissues, robust IL-2 production, and recall potential, greater than expected homeostatic fitness, refined transcription factor dependencies, and a distinct molecular phenotype. Classification of terminal-Tem and clarification of Tem biology hold broad implications for understanding the molecular regulation of memory cell states and harnessing immunological memory to improve immunotherapies.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Milner JJ,Nguyen H,Omilusik K,Reina-Campos M,Tsai M,Toma C,Delpoux A,Boland BS,Hedrick SM,Chang JT,Goldrath AW

doi

10.1073/pnas.2008571117

subject

Has Abstract

pub_date

2020-10-13 00:00:00

pages

25667-25678

issue

41

eissn

0027-8424

issn

1091-6490

pii

2008571117

journal_volume

117

pub_type

杂志文章

相关文献

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA文献大全
  • Organization of the gene encoding common acute lymphoblastic leukemia antigen (neutral endopeptidase 24.11): multiple miniexons and separate 5' untranslated regions.

    abstract：:The common acute lymphoblastic leukemia antigen (CALLA) is a 749-amino acid type II integral membrane protein that has been identified recently as the neutral endopeptidase 24.11 [NEP (EC 3.4.24.11)]. Herein, we characterize the organization of the human CALLA/NEP gene and show that it spans more than 80 kilobases (kb...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.86.18.7103

    authors： D'Adamio L,Shipp MA,Masteller EL,Reinherz EL

    更新日期：1989-09-01 00:00:00

  • Distinct frontal systems for response inhibition, attentional capture, and error processing.

    abstract：:Stopping an action in response to an unexpected event requires both that the event is attended to, and that the action is inhibited. Previous neuroimaging investigations of stopping have failed to adequately separate these cognitive elements. Here we used a version of the widely used Stop Signal Task that controls for...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1000175107

    authors： Sharp DJ,Bonnelle V,De Boissezon X,Beckmann CF,James SG,Patel MC,Mehta MA

    更新日期：2010-03-30 00:00:00

  • Protein kinase CK2 governs the molecular decision between encephalitogenic TH17 cell and Treg cell development.

    abstract：:T helper 17 (TH17) cells represent a discrete TH cell subset instrumental in the immune response to extracellular bacteria and fungi. However, TH17 cells are considered to be detrimentally involved in autoimmune diseases like multiple sclerosis (MS). In contrast to TH17 cells, regulatory T (Treg) cells were shown to b...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1523869113

    authors： Ulges A,Witsch EJ,Pramanik G,Klein M,Birkner K,Bühler U,Wasser B,Luessi F,Stergiou N,Dietzen S,Brühl TJ,Bohn T,Bündgen G,Kunz H,Waisman A,Schild H,Schmitt E,Zipp F,Bopp T

    更新日期：2016-09-06 00:00:00

  • The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors.

    abstract：:Alterations of human chromosome 8p occur frequently in many tumors. We identified a 1.5-Mb common region of allelic loss on 8p22 by allelotype analysis. cDNA selection allowed isolation of several genes, including FEZ1. The predicted Fez1 protein contained a leucine-zipper region with similarity to the DNA-binding dom...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.96.7.3928

    authors： Ishii H,Baffa R,Numata SI,Murakumo Y,Rattan S,Inoue H,Mori M,Fidanza V,Alder H,Croce CM

    更新日期：1999-03-30 00:00:00

  • Secretion of human hepatitis B virus is inhibited by the imino sugar N-butyldeoxynojirimycin.

    abstract：:The imino sugar N-butyldeoxynojirimycin (NBDNJ) is a potent inhibitor of the oligosaccharide-trimming enzyme alpha-glucosidase I. Hepatitis B virus (HBV) contains three surface proteins (HBs proteins) of different sizes that are singly or doubly N-glycosylated and are essential for the formation of infectious virus. T...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.91.6.2235

    authors： Block TM,Lu X,Platt FM,Foster GR,Gerlich WH,Blumberg BS,Dwek RA

    更新日期：1994-03-15 00:00:00

  • IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation.

    abstract：:Pathogenic infections and tissue injuries trigger the assembly of inflammasomes, cytosolic protein complexes that activate caspase-1, leading to cleavage of pro-IL-1β and pro-IL-18 and to pyroptosis, a proinflammatory cell death program. Although microbial recognition by Toll-like receptors (TLRs) is known to induce t...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1320294111

    authors： Lin KM,Hu W,Troutman TD,Jennings M,Brewer T,Li X,Nanda S,Cohen P,Thomas JA,Pasare C

    更新日期：2014-01-14 00:00:00

  • Local modulation of plus-end transport targets herpesvirus entry and egress in sensory axons.

    abstract：:The core structures of many viruses move within cells by association with host cytoskeletal motor proteins; however, the mechanisms by which intracellular viral particles are transported toward sites of replication or the cell periphery at distinct stages of infection remain to be understood. The regulation of herpesv...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0404686101

    authors： Smith GA,Pomeranz L,Gross SP,Enquist LW

    更新日期：2004-11-09 00:00:00

  • Evidence for pro-beta-nerve growth factor, a biosynthetic precursor to beta-nerve growth factor.

    abstract：:The biosynthesis of beta-nerve growth factor (betaNGF) was studied in mouse submaxillary glands incubated with L-[(35)S]cystine. betaNGF was isolated from tissue extracts by the addition of antiserum against betaNGF and the washed immunoprecipitates were analyzed by sodium dodecyl sulfate gel electrophoresis. With sho...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.74.9.3647

    authors： Berger EA,Shooter EM

    更新日期：1977-09-01 00:00:00

  • Inelastic electron tunneling spectroscopy of nucleic acid derivatives.

    abstract：:Inelastic electron tunneling spectra of nucleosides and nucleotides are presented which show that detailed information on the vibrational spectra of these molecules can be obtained from a few micrograms of material. A series of studies on adenine derivatives demonstrates that unambiguous identification of a large numb...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.73.5.1598

    authors： Clark JM,Coleman RV

    更新日期：1976-05-01 00:00:00

  • Conserved behavioral circuits govern high-speed decision-making in wild fish shoals.

    abstract：:To evade their predators, animals must quickly detect potential threats, gauge risk, and mount a response. Putative neural circuits responsible for these tasks have been isolated in laboratory studies. However, it is unclear whether and how these circuits combine to generate the flexible, dynamic sequences of evasion ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1809140115

    authors： Hein AM,Gil MA,Twomey CR,Couzin ID,Levin SA

    更新日期：2018-11-27 00:00:00

  • Diverse conjugative elements silence natural transformation in Legionella species.

    abstract：:Natural transformation (i.e., the uptake of DNA and its stable integration in the chromosome) is a major mechanism of horizontal gene transfer in bacteria. Although the vast majority of bacterial genomes carry the genes involved in natural transformation, close relatives of naturally transformable species often appear...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1909374116

    authors： Durieux I,Ginevra C,Attaiech L,Picq K,Juan PA,Jarraud S,Charpentier X

    更新日期：2019-09-10 00:00:00

  • Nuclear receptor RORα regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation.

    abstract：:Pathologic ocular angiogenesis is a leading cause of blindness, influenced by both dysregulated lipid metabolism and inflammation. Retinoic-acid-receptor-related orphan receptor alpha (RORα) is a lipid-sensing nuclear receptor with diverse biologic function including regulation of lipid metabolism and inflammation; ho...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1504387112

    authors： Sun Y,Liu CH,SanGiovanni JP,Evans LP,Tian KT,Zhang B,Stahl A,Pu WT,Kamenecka TM,Solt LA,Chen J

    更新日期：2015-08-18 00:00:00

  • Quon 3D language for quantum information.

    abstract：:We present a 3D topological picture-language for quantum information. Our approach combines charged excitations carried by strings, with topological properties that arise from embedding the strings in the interior of a 3D manifold with boundary. A quon is a composite that acts as a particle. Specifically, a quon is a ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1621345114

    authors： Liu Z,Wozniakowski A,Jaffe AM

    更新日期：2017-03-07 00:00:00

  • ADP-ribosylation factor 1 dependent clathrin-coat assembly on synthetic liposomes.

    abstract：:The assembly of clathrin-coated vesicles on Golgi membranes is initiated by the GTP-binding protein ADP ribosylation factor (ARF), which generates high-affinity membrane-binding sites for the heterotetrameric AP-1 adaptor complex. Once bound, the AP-1 recruits clathrin triskelia, which polymerize to form the coat. We ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.96.9.5013

    authors： Zhu Y,Drake MT,Kornfeld S

    更新日期：1999-04-27 00:00:00

  • HMT, encoded by H-2M3, is a neoclassical major histocompatibility class I antigen.

    abstract：:H-2M3 encodes HMT, the major histocompatibility complex (MHC) class I heavy chain of the maternally transmitted antigen (Mta). Like classical MHC class I genes, the expression of M3 can be stimulated by gamma-interferon and its message can be detected from mid-gestational embryos (day 8) through adulthood. HMTb, a non...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.90.7.2784

    authors： Wang CR,Lindahl KF

    更新日期：1993-04-01 00:00:00

  • Hemorrhage in lesions caused by cowpox virus is induced by a viral protein that is related to plasma protein inhibitors of serine proteases.

    abstract：:Several recombinant cowpox viruses were constructed and used to identify a viral gene that controls the production of hemorrhage in lesions caused by the Brighton Red strain of cowpox virus (CPV-BR). This gene is located in the KpnD fragment of CPV-BR DNA, between 31 and 32 kilobases from the end of the genome. This p...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.83.20.7698

    authors： Pickup DJ,Ink BS,Hu W,Ray CA,Joklik WK

    更新日期：1986-10-01 00:00:00

  • L-Fucose-terminated glycoconjugates are recognized by pinocytosis receptors on macrophages.

    abstract：:125I-Labeled L-fucose-albumin complex and rat preputial beta-glucuronidase are rapidly cleared from plasma after intravenous infusion. L-Fucose-albumin retards the plasma clearance of beta-glucuronidase whereas D-fucose-albumin is inactive. In vitro, 125I-labeled L-fucose-albumin is taken up into rat or rabbit alveola...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.78.2.1019

    authors： Shepherd VL,Lee YC,Schlesinger PH,Stahl PD

    更新日期：1981-02-01 00:00:00

  • Discrete fracture patterns of virus shells reveal mechanical building blocks.

    abstract：:Viral shells are self-assembled protein nanocontainers with remarkable material properties. They combine simplicity of construction with toughness and complex functionality. These properties make them interesting for bionanotechnology. To date we know little about how virus structure determines assembly pathways and s...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1105586108

    authors： Ivanovska IL,Miranda R,Carrascosa JL,Wuite GJ,Schmidt CF

    更新日期：2011-08-02 00:00:00

  • Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies.

    abstract：:Human cells express thousands of different surface proteins that can be used for cell classification, or to distinguish healthy and disease conditions. A method capable of profiling a substantial fraction of the surface proteome simultaneously and inexpensively would enable more accurate and complete classification of...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1721899115

    authors： Pollock SB,Hu A,Mou Y,Martinko AJ,Julien O,Hornsby M,Ploder L,Adams JJ,Geng H,Müschen M,Sidhu SS,Moffat J,Wells JA

    更新日期：2018-03-13 00:00:00

  • LSD1 activates a lethal prostate cancer gene network independently of its demethylase function.

    abstract：:Medical castration that interferes with androgen receptor (AR) function is the principal treatment for advanced prostate cancer. However, clinical progression is universal, and tumors with AR-independent resistance mechanisms appear to be increasing in frequency. Consequently, there is an urgent need to develop new tr...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1719168115

    authors： Sehrawat A,Gao L,Wang Y,Bankhead A 3rd,McWeeney SK,King CJ,Schwartzman J,Urrutia J,Bisson WH,Coleman DJ,Joshi SK,Kim DH,Sampson DA,Weinmann S,Kallakury BVS,Berry DL,Haque R,Van Den Eeden SK,Sharma S,Bearss J,Beer

    更新日期：2018-05-01 00:00:00

  • Optimal functionalization of a molecular electrocatalyst for hydride transfer.

    abstract：:Optimization of hydride transfer (HT) catalysts to enhance rates and selectivities of (photo)electroreduction reactions could be a crucial component of a sustainable chemical industry. Here, we analyze how ring functionalization of the adsorbed transient intermediate 2-pyridinide (2-PyH-*)-predicted to form in situ fr...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1911948116

    authors： Xu S,Carter EA

    更新日期：2019-11-12 00:00:00

  • Floodplains as an Achilles' heel of Amazonian forest resilience.

    abstract：:The massive forests of central Amazonia are often considered relatively resilient against climatic variation, but this view is challenged by the wildfires invoked by recent droughts. The impact of such fires that spread from pervasive sources of ignition may reveal where forests are less likely to persist in a drier f...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1617988114

    authors： Flores BM,Holmgren M,Xu C,van Nes EH,Jakovac CC,Mesquita RCG,Scheffer M

    更新日期：2017-04-25 00:00:00

  • Genomic analysis of uncultured marine viral communities.

    abstract：:Viruses are the most common biological entities in the oceans by an order of magnitude. However, very little is known about their diversity. Here we report a genomic analysis of two uncultured marine viral communities. Over 65% of the sequences were not significantly similar to previously reported sequences, suggestin...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.202488399

    authors： Breitbart M,Salamon P,Andresen B,Mahaffy JM,Segall AM,Mead D,Azam F,Rohwer F

    更新日期：2002-10-29 00:00:00

  • Rhythms of Drosophila period gene expression in culture.

    abstract：:The Drosophila clock genes period (per) and timeless (tim) have been studied behaviorally and biochemically, but to date there has been no viable culture system for studying the cell biology of the Drosophila clock. We have cultured pupal ring glands attached to the central nervous system and observed rhythms of perio...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.94.8.4092

    authors： Emery IF,Noveral JM,Jamison CF,Siwicki KK

    更新日期：1997-04-15 00:00:00

  • Drosophila as a model for studying cystic fibrosis pathophysiology of the gastrointestinal system.

    abstract：:Cystic fibrosis (CF) is a recessive disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. The most common symptoms include progressive lung disease and chronic digestive conditions. CF is the first human genetic disease to benefit from having five different species of animal models. De...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1913127117

    authors： Kim K,Lane EA,Saftien A,Wang H,Xu Y,Wirtz-Peitz F,Perrimon N

    更新日期：2020-05-12 00:00:00

  • Microbes vs. chemistry in the origin of the anaerobic gut lumen.

    abstract：:The succession from aerobic and facultative anaerobic bacteria to obligate anaerobes in the infant gut along with the differences between the compositions of the mucosally adherent vs. luminal microbiota suggests that the gut microbes consume oxygen, which diffuses into the lumen from the intestinal tissue, maintainin...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1718635115

    authors： Friedman ES,Bittinger K,Esipova TV,Hou L,Chau L,Jiang J,Mesaros C,Lund PJ,Liang X,FitzGerald GA,Goulian M,Lee D,Garcia BA,Blair IA,Vinogradov SA,Wu GD

    更新日期：2018-04-17 00:00:00

  • Prospective measurements of dehydroepiandrosterone sulfate in a cohort of elderly subjects: relationship to gender, subjective health, smoking habits, and 10-year mortality.

    abstract：:The decrease with age of the adrenal-secreted dehydroepiandrosterone sulfate (DHEAS) in serum has suggested that it may be causally related to longevity. For the PAQUID [People (Personnes) Aged (Agées) About What (Quid, in Latin)] cohort of elderly subjects, we have previously reported higher DHEAS in men than in wome...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.121177998

    authors： Mazat L,Lafont S,Berr C,Debuire B,Tessier JF,Dartigues JF,Baulieu EE

    更新日期：2001-07-03 00:00:00

  • Global environmental impacts of agricultural expansion: the need for sustainable and efficient practices.

    abstract：:The recent intensification of agriculture, and the prospects of future intensification, will have major detrimental impacts on the nonagricultural terrestrial and aquatic ecosystems of the world. The doubling of agricultural food production during the past 35 years was associated with a 6.87-fold increase in nitrogen ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.96.11.5995

    authors： Tilman D

    更新日期：1999-05-25 00:00:00

  • Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras.

    abstract：:Several findings suggest that signals from tyrosine kinases are transduced, at least in part, through ras proteins. These findings include (i) blockage of the transforming activity of constitutively active tyrosine kinases by inhibiting ras function and (ii) genetic screens in Caenorhabditis elegans and in Drosophila ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.89.14.6511

    authors： Bowtell D,Fu P,Simon M,Senior P

    更新日期：1992-07-15 00:00:00

  • Somatic integration of an oncogene-harboring Sleeping Beauty transposon models liver tumor development in the mouse.

    abstract：:The Sleeping Beauty (SB) transposon system can integrate foreign sequences of DNA in the genome of mouse somatic cells eliciting long-term expression in vivo. This technology holds great promise for human gene therapy as a nonviral technology to deliver therapeutic genes. SB also provides a means to study the effects ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0502974102

    authors： Carlson CM,Frandsen JL,Kirchhof N,McIvor RS,Largaespada DA

    更新日期：2005-11-22 00:00:00