Hemorrhage in lesions caused by cowpox virus is induced by a viral protein that is related to plasma protein inhibitors of serine proteases.

abstract：:We present a model for transposition that allows a choice between cointegrate formation (replicon fusion) and direct transposition. We propose that initiation of the process occurs by invasion of the target DNA by a single-stranded end of the transposable element. This leads to nicking of one of the DNA strands of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Galas DJ,Chandler M

更新日期：1981-08-01 00:00:00

abstract：:The primary obstacle to producing renewable fuels from lignocellulosic biomass is a plant's recalcitrance to releasing sugars bound in the cell wall. From a sample set of wood cores representing 1,100 individual undomesticated Populus trichocarpa trees, 47 extreme phenotypes were selected across measured lignin conten...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Studer MH,DeMartini JD,Davis MF,Sykes RW,Davison B,Keller M,Tuskan GA,Wyman CE

更新日期：2011-04-12 00:00:00

abstract：:Poliovirus type 1 cDNA sequences coding for viral capsid polypeptide VP1 were inserted into the beta-lactamase sequence of Escherichia coli plasmid pBR322. Resulting recombinant plasmid pSW119 expressed in Escherichia coli a VP1-beta-lactamase fusion protein that reacted with antibodies raised against poliovirus capsi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van der Werf S,Wychowski C,Bruneau P,Blondel B,Crainic R,Horodniceanu F,Girard M

更新日期：1983-08-01 00:00:00

abstract：:Prostate cancer is a heterogeneous disease composed of divergent molecular and histologic subtypes, including prostate adenocarcinoma (PrAd) and neuroendocrine prostate cancer (NEPC). While PrAd is the major histology in prostate cancer, NEPC can evolve from PrAd as a mechanism of treatment resistance that involves a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee JK,Bangayan NJ,Chai T,Smith BA,Pariva TE,Yun S,Vashisht A,Zhang Q,Park JW,Corey E,Huang J,Graeber TG,Wohlschlegel J,Witte ON

更新日期：2018-05-08 00:00:00

abstract：:We determined the crystal structure of the Escherichia coli nucleoid-associated HUalphabeta protein by x-ray diffraction and observed that the heterodimers form multimers with octameric units in three potential arrangements, which may serve specialized roles in different DNA transaction reactions. It is of special imp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guo F,Adhya S

更新日期：2007-03-13 00:00:00

abstract：:The Ten-Eleven-Translocation 2 (TET2) gene encodes a member of TET family enzymes that alters the epigenetic status of DNA by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine (5hmC). Somatic loss-of-function mutations of TET2 are frequently observed in patients with diverse myeloid malignancies, including myelody...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ko M,Bandukwala HS,An J,Lamperti ED,Thompson EC,Hastie R,Tsangaratou A,Rajewsky K,Koralov SB,Rao A

更新日期：2011-08-30 00:00:00

abstract：:In an autoshaping experiment, food-deprived pigeons pecked rapidly at a moving dot that preceded the delivery of food. When the moving dot and food were no longer correlated, the rate of pecking dropped nearly to zero. When, subsequently, no food was given, pecking reappeared at a high rate (nearly 200 pecks per min f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Epstein R,Skinner BF

更新日期：1980-10-01 00:00:00

abstract：:Arguably the most foundational principle in perception research is that our experience of the world goes beyond the retinal image; we perceive the distal environment itself, not the proximal stimulation it causes. Shape may be the paradigm case of such "unconscious inference": When a coin is rotated in depth, we infer...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morales J,Bax A,Firestone C

更新日期：2020-06-30 00:00:00

abstract：:The 5'-phosphoinositol phosphatase SHIP negatively regulates signaling pathways triggered by antigen, cytokine and Fc receptors in both lymphocytes and myeloid cells. Mice with germ-line (null) deletion of SHIP develop a myeloproliferative-like syndrome that causes early lethality. Lymphocyte anomalies have been obser...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tarasenko T,Kole HK,Chi AW,Mentink-Kane MM,Wynn TA,Bolland S

更新日期：2007-07-03 00:00:00

abstract：:Excessive activation of poly(ADP-ribose) polymerase 1 (PARP1) leads to NAD(+) depletion and cell death during ischemia and other conditions that generate extensive DNA damage. When activated by DNA strand breaks, PARP1 uses NAD(+) as substrate to form ADP-ribose polymers on specific acceptor proteins. These polymers a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ying W,Sevigny MB,Chen Y,Swanson RA

更新日期：2001-10-09 00:00:00

abstract：:An enzymatic activity, having the properties expected of a B-specific host-controlled modification enzyme, has been purified from an extract of Escherichia coli strain B. This activity renders the unmodified replicative form of phage fd resistant to B-specific restriction and is only present in strains carrying intact...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kühnlein U,Linn S,Arber W

更新日期：1969-06-01 00:00:00

abstract：:A tandemly repeated DNA sequence organized predominantly, if not entirely, in a specific manner on the human X chromosome has been cloned in pBR322 and characterized. The sequence was detected as a 2-kilobase band in ethidium bromide-stained agarose gels of BamHI-digested total human nuclear DNA. Although in situ hybr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang TP,Hansen SK,Oishi KK,Ryder OA,Hamkalo BA

更新日期：1982-11-01 00:00:00

abstract：:Activation of eukaryotic class II gene expression involves the formation of a transcription initiation complex that includes RNA polymerase II, general transcription factors, and SRB components of the holoenzyme. Negative regulators of transcription have been described, but it is not clear whether any are general repr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gadbois EL,Chao DM,Reese JC,Green MR,Young RA

更新日期：1997-04-01 00:00:00

abstract：:A nuclear protein, termed leucine-rich acidic nuclear protein (LANP), has been isolated from among rat cerebellar proteins whose expression was transiently increased during an early stage of postnatal development. The amino acid sequence, deduced from its cDNA, showed that LANP contains 247 amino acids consisting of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matsuoka K,Taoka M,Satozawa N,Nakayama H,Ichimura T,Takahashi N,Yamakuni T,Song SY,Isobe T

更新日期：1994-10-11 00:00:00

abstract：:X-chromosome inactivation (XCI) is initiated by the long noncoding RNA Xist, which coats the inactive X (Xi) and targets Polycomb repressive complex 2 (PRC2) in cis. Epigenomic analyses have provided significant insight into Xist binding patterns and chromatin organization of the Xi. However, such epigenomic analyses ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sunwoo H,Wu JY,Lee JT

更新日期：2015-08-04 00:00:00

abstract：:Lampreys are one of the two surviving jawless vertebrate groups and one of a few vertebrate groups with the best exemplified metamorphosis during their life cycle, which consists of a long-lasting larval stage, a peculiar metamorphosis, and a relatively short adulthood with a markedly different anatomy. Although the f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang MM,Wu F,Miao D,Zhang J

更新日期：2014-10-28 00:00:00

abstract：:During the developmental process of the Gram-negative soil bacterium Myxococcus xanthus, vegetatively growing rod cells differentiate to ultimately become metabolically quiescent and environmentally resistant myxospores encased within fruiting bodies. This program, initiated by nutrient deprivation, is propagated by b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tzeng L,Singer M

更新日期：2005-10-04 00:00:00

abstract：:The Late Quaternary glacial-interglacial transitions represent the highest amplitude climate changes over the last million years. Unraveling the sequence of events and feedbacks at Termination III (T-III), including potential abrupt climate reversals similar to those of the last Termination, has been particularly chal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pérez-Mejías C,Moreno A,Sancho C,Bartolomé M,Stoll H,Cacho I,Cheng H,Edwards RL

更新日期：2017-09-19 00:00:00

abstract：:Organic hydroperoxide resistance (Ohr) enzymes are unique Cys-based, lipoyl-dependent peroxidases. Here, we investigated the involvement of Ohr in bacterial responses toward distinct hydroperoxides. In silico results indicated that fatty acid (but not cholesterol) hydroperoxides docked well into the active site of Ohr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alegria TG,Meireles DA,Cussiol JR,Hugo M,Trujillo M,de Oliveira MA,Miyamoto S,Queiroz RF,Valadares NF,Garratt RC,Radi R,Di Mascio P,Augusto O,Netto LE

更新日期：2017-01-10 00:00:00

abstract：:Injection of rat kidney cortex mRNA into Xenopus laevis oocytes leads to a stimulation of Na(+)-dependent SO4(2-) uptake. Based on this information, we have isolated from a corresponding library a cDNA (NaSi-1) that is most likely related to a Na+/SO4(2-) cotransport system. NaSi-1 cRNA leads in a time- and dose-depen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Markovich D,Forgo J,Stange G,Biber J,Murer H

更新日期：1993-09-01 00:00:00

abstract：:Comparisons were made of the T1 ribonuclease digests of 32P-labeled nucleolar 45S RNA of intact Novikoff hepatoma cells and the RNA synthesized in vitro by isolated nucleoli. Approximately 200 oligonucleotide spots were found in the two-dimensional chromatogram of 45S nucleolar RNA labeled in vivo, which includes frag...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ballal NR,Choi YC,Mouche R,Busche H

更新日期：1977-06-01 00:00:00

abstract：:Let t --> gamma(t), 0

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stein EM,Wainger S

更新日期：1976-12-01 00:00:00

abstract：:BCL6 encodes a transcriptional repressor that is essential for the germinal center (GC) reaction and important in lymphomagenesis. Although its promoter has been well studied, little is known concerning its possible regulation by more distal elements. To gain such information, we mapped critical histone modifications ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramachandrareddy H,Bouska A,Shen Y,Ji M,Rizzino A,Chan WC,McKeithan TW

更新日期：2010-06-29 00:00:00

abstract：:Anti-idiotype antibodies (Ab2) were purified from a cancer patient treated with NP-4, a murine monoclonal antibody to carcinoembryonic antigen (CEA). These Ab2 were specific for NP-4 and inhibited the binding between NP-4 and CEA. BALB/c mice immunized with these human Ab2 produced anti-Ab2 antibodies that were also r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Losman MJ,Hansen HJ,Sharkey RM,Goldenberg DM,Monestier M

更新日期：1991-04-15 00:00:00

abstract：:The structure of the proline-specific aminopeptidase (EC 3.4.11.9) from Escherichia coli has been solved and refined for crystals of the native enzyme at a 2.0-A resolution, for a dipeptide-inhibited complex at 2.3-A resolution, and for a low-pH inactive form at 2.7-A resolution. The protein crystallizes as a tetramer...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wilce MC,Bond CS,Dixon NE,Freeman HC,Guss JM,Lilley PE,Wilce JA

更新日期：1998-03-31 00:00:00

abstract：:Double-stranded DNA break repair by homologous recombination is initiated by resection of free DNA ends to produce a 3'-ssDNA overhang. In bacteria, this reaction is catalyzed by helicase-nuclease complexes such as AddAB in a manner regulated by specific recombination hotspot sequences called Crossover hotspot instiga...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carrasco C,Gilhooly NS,Dillingham MS,Moreno-Herrero F

更新日期：2013-07-09 00:00:00

abstract：:Twelve zeolitic imidazolate frameworks (ZIFs; termed ZIF-1 to -12) have been synthesized as crystals by copolymerization of either Zn(II) (ZIF-1 to -4, -6 to -8, and -10 to -11) or Co(II) (ZIF-9 and -12) with imidazolate-type links. The ZIF crystal structures are based on the nets of seven distinct aluminosilicate zeo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park KS,Ni Z,Côté AP,Choi JY,Huang R,Uribe-Romo FJ,Chae HK,O'Keeffe M,Yaghi OM

更新日期：2006-07-05 00:00:00

abstract：:An extracellular matrix protein, cytotactin, with widespread tissue distribution has been identified, isolated, and partially characterized. Cytotactin mediates glia-neuron adhesion in vitro, but unlike Ng-CAM, the neuron-glia cell-adhesion molecule, it is absent from neurons. Cytotactin was isolated from 14-day embry...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grumet M,Hoffman S,Crossin KL,Edelman GM

更新日期：1985-12-01 00:00:00

abstract：:Located within the brain's ventricles, the choroid plexus produces cerebrospinal fluid and forms an important barrier between the central nervous system and the blood. For unknown reasons, the choroid plexus produces high levels of the protein klotho. Here, we show that these levels naturally decline with aging. Deple...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu L,Stein LR,Kim D,Ho K,Yu GQ,Zhan L,Larsson TE,Mucke L

更新日期：2018-11-27 00:00:00

abstract：:We have identified a gene, rig (rat insulinoma gene), that is activated in chemically induced rat insulinomas but not in normal pancreatic islets or in regenerating islets. In the present study, we have found that the insulinoma gene was activated in a BK virus-induced hamster insulinoma cell line and in a spontaneous...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Inoue C,Shiga K,Takasawa S,Kitagawa M,Yamamoto H,Okamoto H

更新日期：1987-10-01 00:00:00