VAMP3 and SNAP23 mediate the disturbed flow-induced endothelial microRNA secretion and smooth muscle hyperplasia.

abstract：:Animal epithelial tissue becomes reproducibly colonized by specific environmental bacteria. The bacteria (microbiota) perform critical functions for the host's tissue development, immune system development, and nutrition; yet the processes by which bacterial diversity in the environment is selected to assemble the cor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brooks JF 2nd,Gyllborg MC,Cronin DC,Quillin SJ,Mallama CA,Foxall R,Whistler C,Goodman AL,Mandel MJ

更新日期：2014-12-02 00:00:00

abstract：:Resistance to ionizing radiation (IR), which is a conventional treatment for osteosarcoma that cannot be resected, undermines the efficacy of this therapy. However, the mechanism by which IR induces radioresistance in osteosarcoma is not defined. Here, we report that CR6-interacting factor-1 (CRIF1) is highly expresse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ran Q,Jin F,Xiang Y,Xiang L,Wang Q,Li F,Chen L,Zhang Y,Wu C,Zhou L,Xiao Y,Chen L,Wu J,Zhong JF,Li SC,Li Z

更新日期：2019-10-08 00:00:00

abstract：:The human amygdala plays a key role in recognizing facial emotions and neurons in the monkey and human amygdala respond to the emotional expression of faces. However, it remains unknown whether these responses are driven primarily by properties of the stimulus or by the perceptual judgments of the perceiver. We invest...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang S,Tudusciuc O,Mamelak AN,Ross IB,Adolphs R,Rutishauser U

更新日期：2014-07-29 00:00:00

abstract：:The liver plays a critical role in inducing systemic immune tolerance, for example, during limiting hypersensitivity to food allergy and in rendering acceptance of allotransplant or even hepatotropic pathogens. We investigated the unknown mechanisms of liver tolerance by using an established hepatitis B virus (HBV)-ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu L,Yin W,Sun R,Wei H,Tian Z

更新日期：2013-10-15 00:00:00

abstract：:The formation of complex superstructures via hydrogen bonding of two ditopic building blocks, diazadibenzoperylenes 1a,b and isophthalic acid 2, has been investigated. It was found that only the phenoxy-substituted diazadibenzoperylene 1a forms extended assemblies with 2 in complexes of a 1:1 stoichiometry, whereas fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sautter A,Thalacker C,Heise B,Wurthner F

更新日期：2002-04-16 00:00:00

abstract：:Humans shift their gaze to a new location several times per second. It is still unclear what determines where they look next. Fixation behavior is influenced by the low-level salience of the visual stimulus, such as luminance, contrast, and color, but also by high-level task demands and prior knowledge. Under natural ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schütz AC,Trommershäuser J,Gegenfurtner KR

更新日期：2012-05-08 00:00:00

abstract：:Partial, unilateral nigrostriatal lesions of varying severity were produced in rats by injecting graded doses of 6-hydroxydopamine into the substantia nigra. Formation of the dopamine metabolites dihydroxyphenylacetic acid and homovanillic acid in each surviving nigrostriatal neuron (estimated by the ratios of dihydro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Melamed E,Hefti F,Wurtman RJ

更新日期：1980-07-01 00:00:00

abstract：:The human forkhead box O3A gene (FOXO3A) encodes an evolutionarily conserved key regulator of the insulin-IGF1 signaling pathway that is known to influence metabolism and lifespan in model organisms. A recent study described 3 SNPs in the FOXO3A gene that were statistically significantly associated with longevity in a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Flachsbart F,Caliebe A,Kleindorp R,Blanché H,von Eller-Eberstein H,Nikolaus S,Schreiber S,Nebel A

更新日期：2009-02-24 00:00:00

abstract：:Most guanine nucleotide binding protein (G protein)-coupled receptors have a conserved cysteine in the C-terminal cytoplasmic tail near the seventh transmembrane spanning region. This cysteine is known to be palmitoylated in rhodopsin, the beta 2-adrenergic receptor (beta 2AR) and the alpha 2A-adrenergic receptor (alp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eason MG,Jacinto MT,Theiss CT,Liggett SB

更新日期：1994-11-08 00:00:00

abstract：:Peptides from the three type I repeats of human endothelial cell thrombospondin, containing the consensus sequence-Trp-Ser-Xaa-Trp-, bind to sulfated glycoconjugates including heparin and sulfatide. The peptides are potent inhibitors for the binding of thrombospondin, laminin, or apolipoprotein E to these ligands. The...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guo NH,Krutzsch HC,Nègre E,Vogel T,Blake DA,Roberts DD

更新日期：1992-04-01 00:00:00

abstract：:Wild-type newborn mice are characterized by the ability of certain liver-specific genes encoding various enzymes and mapping on different chromosomes to respond to glucocorticoid induction. Newborn mice homozygous for deletions at and around the albino locus on chromosome 7 fail to develop this competence for hormone-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DeFranco D,Bali D,Torres R,DePinho RA,Erickson RP,Gluecksohn-Waelsch S

更新日期：1991-07-01 00:00:00

abstract：:It has been shown that the pituitary contains a cytotropic factor (CTF) that stimulates the secretion of catecholamines by dopaminergic neurons of the hypothalamus. In the present study, CTF was purified from rat pituitaries and found by means of mass spectrometric analysis to be adenosine. This finding was corroborat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Porter JC,Ijames CF,Wang TC,Markey SP

更新日期：1995-06-06 00:00:00

abstract：:Oil spills can lead to irreversible environmental degradation and are a potential hazard to human health. We study how onshore oil spills affect neonatal and infant mortality by combining spatial data from the Nigerian Oil Spill Monitor with Demographic and Health Surveys. To identify a causal effect, we compare sibli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bruederle A,Hodler R

更新日期：2019-03-19 00:00:00

abstract：:Emerging evidence suggests that tissue plasminogen activator (tPA), currently the only FDA-approved medication for ischemic stroke, exerts important biological actions on the CNS besides its well-known thrombolytic effect. In this study, we investigated the role of tPA on primary neurons in culture and on brain recove...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pu H,Shi Y,Zhang L,Lu Z,Ye Q,Leak RK,Xu F,Ma S,Mu H,Wei Z,Xu N,Xia Y,Hu X,Hitchens TK,Bennett MVL,Chen J

更新日期：2019-04-30 00:00:00

abstract：:In vivo, G protein-coupled receptors (GPCR) for neurotransmitters undergo complex intracellular trafficking that contribute to regulate their abundance at the cell surface. Here, we report a previously undescribed alteration in the subcellular localization of D1 dopamine receptor (D1R) that occurs in vivo in striatal ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dumartin B,Jaber M,Gonon F,Caron MG,Giros B,Bloch B

更新日期：2000-02-15 00:00:00

abstract：:Preferential phosphorylation of specific proteins by cAMP-dependent protein kinase (PKA) may be mediated in part by the anchoring of PKA to a family of A-kinase anchor proteins (AKAPs) positioned in close proximity to target proteins. This interaction is thought to depend on binding of the type II regulatory (RII) sub...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burton KA,Johnson BD,Hausken ZE,Westenbroek RE,Idzerda RL,Scheuer T,Scott JD,Catterall WA,McKnight GS

更新日期：1997-09-30 00:00:00

abstract：:Converging TGF-beta and insulin-like neuroendocrine signaling pathways regulate whether Caenorhabditis elegans develops reproductively or arrests at the dauer larval stage. We examined whether neurotransmitters act in the dauer entry or recovery pathways. Muscarinic agonists promote recovery from dauer arrest induced ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tissenbaum HA,Hawdon J,Perregaux M,Hotez P,Guarente L,Ruvkun G

更新日期：2000-01-04 00:00:00

abstract：:Vertebrates, from zebra fish to humans, have an innate immune recognition of many bacterial flagellins. This involves a conserved eight-amino acid epitope in flagellin recognized by the Toll-like receptor 5 (TLR5). Several important human pathogens, such as Helicobacter pylori and Campylobacter jejuni, have escaped TL...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kreutzberger MAB,Ewing C,Poly F,Wang F,Egelman EH

更新日期：2020-07-21 00:00:00

abstract：:To complete the set of synthetic analogs of the three recognized types of active sites in iron-sulfur redox proteins, the compound (Et4N)[Fe((SCH2)2C6H4)2], derived from o-xylyl-alpha,alpha'-dithiol, has been prepared and its structure has been determined by x-ray diffraction. The bischelate anion contains a near-tetr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lane RW,Ibers JA,Frankel RB,Holm RH

更新日期：1975-08-01 00:00:00

abstract：:Insulin-degrading enzyme (IDE) selectively degrades the monomer of amyloidogenic peptides and contributes to clearance of amyloid β (Aβ). Thus, IDE retards the progression of Alzheimer's disease. IDE possesses an enclosed catalytic chamber that engulfs and degrades its peptide substrates; however, the molecular mechan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McCord LA,Liang WG,Dowdell E,Kalas V,Hoey RJ,Koide A,Koide S,Tang WJ

更新日期：2013-08-20 00:00:00

abstract：:Tomato plants overexpressing a prosystemin gene that encodes the precursor of a mobile wound signal called systemin have been shown previously to constitutively synthesize extraordinarily high levels of two defensive proteinase inhibitor proteins in leaves in the absence of wounding. We herein report that leaves of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Constabel CP,Bergey DR,Ryan CA

更新日期：1995-01-17 00:00:00

abstract：:A single, modified nucleoside in Escherichia coli tRNA, 6-(3-methyl-2-butenylamino)-2-methyl-thio-9-beta-D-ribofuranosylpurine, has been desulfurized with Raney nickel to afford its probable biosynthetic precursor. The limitations of the reaction at the nucleoside and tRNA levels and its lack of inhibition of the amin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hecht SM,Kirkegaard LH,Bock RM

更新日期：1971-01-01 00:00:00

abstract：:Environmental cues are transmitted to the interior of the cell via a complex network of signaling hubs. Receptor tyrosine kinases (RTKs) and trimeric G proteins are two such major signaling hubs in eukaryotes. Conventionally, canonical signal transduction via trimeric G proteins is thought to be triggered exclusively ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Midde KK,Aznar N,Laederich MB,Ma GS,Kunkel MT,Newton AC,Ghosh P

更新日期：2015-03-03 00:00:00

abstract：:Most human cancers are aneuploid and have chromosomal instability, which contrasts to the inability of human cells to normally tolerate aneuploidy. Noting that aneuploidy in human breast cancer correlates with increased expression levels of the Mps1 checkpoint gene, we investigated whether these high levels of Mps1 co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Daniel J,Coulter J,Woo JH,Wilsbach K,Gabrielson E

更新日期：2011-03-29 00:00:00

abstract：:The Alzheimer A beta amyloid peptide (A beta) is the principal proteinaceous component of amyloid associated with Alzheimer disease (AD). We have determined the relative abundance of A beta structural variants present in amyloid from brains of 10 individuals with sporadic AD, 2 individuals with familial AD carrying sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Näslund J,Schierhorn A,Hellman U,Lannfelt L,Roses AD,Tjernberg LO,Silberring J,Gandy SE,Winblad B,Greengard P

更新日期：1994-08-30 00:00:00

abstract：:The sustainability of irrigated agriculture in many arid and semiarid areas of the world is at risk because of a combination of several interrelated factors, including lack of fresh water, lack of drainage, the presence of high water tables, and salinization of soil and groundwater resources. Nowhere in the United Sta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schoups G,Hopmans JW,Young CA,Vrugt JA,Wallender WW,Tanji KK,Panday S

更新日期：2005-10-25 00:00:00

abstract：:Transthyretin (TTR) is a globular tetrameric transport protein in plasma. Nearly 140 single amino acid substitutions in TTR cause life-threatening amyloid disease. We report a one-of-a-kind pathological variant featuring a Glu51, Ser52 duplication mutation (Glu51_Ser52dup). The proband, heterozygous for the mutation, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klimtchuk ES,Prokaeva T,Frame NM,Abdullahi HA,Spencer B,Dasari S,Cui H,Berk JL,Kurtin PJ,Connors LH,Gursky O

更新日期：2018-07-10 00:00:00

abstract：:The 93-residue transmembrane protein CrgA in Mycobacterium tuberculosis is a central component of the divisome, a large macromolecular machine responsible for cell division. Through interactions with multiple other components including FtsZ, FtsQ, FtsI (PBPB), PBPA, and CwsA, CrgA facilitates the recruitment of the pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Das N,Dai J,Hung I,Rajagopalan MR,Zhou HX,Cross TA

更新日期：2015-01-13 00:00:00

abstract：:Administration of epidermal growth factor (EGF) to neonatal mice resulted in rapid tyrosine phosphorylation of a number of specific substrates in liver, kidney, lung, bladder, skin, and brain as detected by Western blot analysis of tissue homogenates with anti-phosphotyrosine antibodies. In the liver, three prominent ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Donaldson RW,Cohen S

更新日期：1992-09-15 00:00:00

abstract：:Stimulation of the region antero-ventral to the third cerebral ventricle (AV3V) by a cholinergic drug, carbachol, and lesions of the AV3V have been demonstrated in previous studies to either augment or decrease sodium excretion, respectively. Atrial natriuretic peptide (ANP) dramatically increases renal sodium excreti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baldissera S,Menani JW,dos Santos LF,Favaretto AL,Gutkowska J,Turrin MQ,McCann SM,Antunes-Rodrigues J

更新日期：1989-12-01 00:00:00