A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum.

abstract：:Selected aspects of the evolutionary process and more specifically of the genetic variation are considered, with an emphasis in studies performed by my group. One key aspect of evolution seems to be the concomitant occurrence of dichotomic, contradictory (dialect) processes. Genetic variation is structured, and the dy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Salzano FM

更新日期：2000-05-09 00:00:00

abstract：:The thesis is developed that a low oxygen level Precambrian atmosphere presented early-evolving metazoan organisms with physiological connective tissue priorities resulting from the important molecular oxygen requirements in the biosynthesis of collagen hydroxyproline. Shells, cuticles, and carapaces which are not man...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Towe KM

更新日期：1970-04-01 00:00:00

abstract：:Bitemporal injections of puromycin that primarily affect the hippocampal-entorhinal area induce amnesia of aversive maze-learning in mice for 3 days after training but are ineffective 6 or more days after training. At these later times, additional puromycin sites covering widespread forebrain areas are necessary to in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Flexner JB,Flexner LB,Church AC,Rainbow TC,Brunswick DJ

更新日期：1985-11-01 00:00:00

abstract：:Orchids employing sexual deceit attract males of their pollinator species through specific volatile signals that mimic female-released sex pheromones. One of these signals proved to be 2-ethyl-5-propylcyclohexan-1,3-dione (chiloglottone1), a new natural product that was shown to be most important in the relations betw...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Franke S,Ibarra F,Schulz CM,Twele R,Poldy J,Barrow RA,Peakall R,Schiestl FP,Francke W

更新日期：2009-06-02 00:00:00

abstract：:A highly specific radioimmunoassay for one of the putative adrenomedullary [Met]enkephalin precursors, BAM-12P (Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-Gly-Arg-Pro-Glu-OH), has been developed. The BAM-12P antibodies recognize the COOH-terminal fragment of the peptide from Arg7 to Glu12 and do not crossreact with [Met5]- or [L...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baird A,Ling N,Böhlen P,Benoit R,Klepper R,Guillemin R

更新日期：1982-03-01 00:00:00

abstract：:An explicitly polarizable force field based exclusively on quantum data is applied to calculations of relative binding affinities of ligands to proteins. Five ligands, differing by replacement of an atom or functional group, in complexes with three serine proteases-trypsin, thrombin, and urokinase-type plasminogen act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khoruzhii O,Donchev AG,Galkin N,Illarionov A,Olevanov M,Ozrin V,Queen C,Tarasov V

更新日期：2008-07-29 00:00:00

abstract：:HU, the major DNA binding protein of Escherichia coli, exists in solution as a heterodimer composed of two highly homologous subunits: HU1, encoded by hupB; HU2, encoded by hupA. The purification of the HU protein from hupA- or hupB- bacteria showed that the hupB mutant strains synthesize normal amounts of the HU2 sub...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bonnefoy E,Almeida A,Rouviere-Yaniv J

更新日期：1989-10-01 00:00:00

abstract：:Previous studies have shown that the effect of language on categorical perception of color is stronger when stimuli are presented in the right visual field than in the left. To examine whether this lateralized effect occurs preattentively at an early stage of processing, we monitored the visual mismatch negativity, wh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mo L,Xu G,Kay P,Tan LH

更新日期：2011-08-23 00:00:00

abstract：:This work argues that, in a polarized environment, scientists can minimize the likelihood that the audience's biased processing will lead to rejection of their message if they not only eschew advocacy but also, convey that they are sharers of knowledge faithful to science's way of knowing and respectful of the audienc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jamieson KH,Hardy BW

更新日期：2014-09-16 00:00:00

abstract：:Mass-independent isotope fractionations driven by differences in volumes and shapes of nuclei (the field shift effect) are known in several elements and are likely to be found in more. All-electron relativistic electronic structure calculations can predict this effect but at present are computationally intensive and l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schauble EA

更新日期：2013-10-29 00:00:00

abstract：:The autoimmune dermatologic disease pemphigus vulgaris (PV) is associated with the HLA serotypes DR4 and DRw6. Susceptibility to PV could be conferred either by sequences shared between the DR4 and DRw6 haplotypes or by different sequences in these haplotypes. We have examined the distribution of DR and DQ beta-chain ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scharf SJ,Friedmann A,Brautbar C,Szafer F,Steinman L,Horn G,Gyllensten U,Erlich HA

更新日期：1988-05-01 00:00:00

abstract：:Transient expression of either alpha or alpha + beta subunits of the high-conductance Ca2+-activated K+ (maxi-K) channel has been achieved in COS-1 cells. Expression has been studied using charybdotoxin (ChTX), a peptidyl inhibitor that binds in the pore on the alpha subunit. Although some properties of monoiodotyrosi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hanner M,Schmalhofer WA,Munujos P,Knaus HG,Kaczorowski GJ,Garcia ML

更新日期：1997-04-01 00:00:00

abstract：:Tata Element Modulatory Factor (TMF/ARA160) is a multifunctional Golgi-associated protein, which accumulates in colonic enterocytes and goblet cells. Mice lacking TMF/ARA160 (TMF(-/-)) produce thick and uniform colonic mucus that resists adherent bacterial colonization and diminishes susceptibility of these mice to in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bel S,Elkis Y,Elifantz H,Koren O,Ben-Hamo R,Lerer-Goldshtein T,Rahimi R,Ben Horin S,Nyska A,Shpungin S,Nir U

更新日期：2014-04-01 00:00:00

abstract：:During CsCl isopycnic centrifugation at 20 mM Mg(++), Escherichia coli 30S ribosomal subunits specifically lose proteins S1, S2, S3, S5, S9, S10, and S14. The resultant 30S core is unable to stimulate the GTPase activity of EF-G in the presence of 50S subunits. Activity could be restored to a small extent by adding ba...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marsh RC,Parmeggiani A

更新日期：1973-01-01 00:00:00

abstract：:Human plasma has been shown to contain an apolipoprotein that mediates the transport of cholesteryl ester from high density lipoprotein (HDL) to very low density lipoprotein (VLDL) or low density lipoprotein (LDL). This activity, confined to the density greater than 1.063 g/ml interval, has been isolated from HDL and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chajek T,Fielding CJ

更新日期：1978-07-01 00:00:00

abstract：:The crystal structure of Escherichia coli ornithine transcarbamoylase (OTCase, EC 2.1.3.3) complexed with the bisubstrate analog N-(phosphonacetyl)-L-ornithine (PALO) has been determined at 2.8-A resolution. This research on the structure of a transcarbamoylase catalytic trimer with a substrate analog bound provides n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ha Y,McCann MT,Tuchman M,Allewell NM

更新日期：1997-09-02 00:00:00

abstract：:An open question remains as to what coordinates cell behavior during organogenesis, permitting organs to reach their appropriate size and shape. The Arabidopsis gene STRUBBELIG (SUB) defines a receptor-mediated signaling pathway in plants. SUB encodes a putative leucine-rich repeat transmembrane receptor-like kinase. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chevalier D,Batoux M,Fulton L,Pfister K,Yadav RK,Schellenberg M,Schneitz K

更新日期：2005-06-21 00:00:00

abstract：:The role of rising atmospheric CO2 in modulating estuarine carbonate system dynamics remains poorly characterized, likely due to myriad processes driving the complex chemistry in these habitats. We reconstructed the full carbonate system of an estuarine seagrass habitat for a summer period of 2.5 months utilizing a co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pacella SR,Brown CA,Waldbusser GG,Labiosa RG,Hales B

更新日期：2018-04-10 00:00:00

abstract：:FUS3 is functionally redundant with KSS1, a homologous yeast protein kinase, for a step(s) in signal transduction between the beta subunit of the guanine nucleotide binding protein (G protein), STE4, and the mating type-specific transcriptional activator, STE12. Either FUS3 or KSS1 can execute this function; when neit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Elion EA,Brill JA,Fink GR

更新日期：1991-11-01 00:00:00

abstract：:We have identified a cDNA from a human phytohemagglutinin-activated lymphoblast library encoding a protein that binds 125I-labeled human interleukin 12 (125I-huIL-12) with a Kd of about 5 nM when expressed in COS-7 cells. When coexpressed in COS-7 cells with the previously identified IL-12 beta receptor (IL-12R beta) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Presky DH,Yang H,Minetti LJ,Chua AO,Nabavi N,Wu CY,Gately MK,Gubler U

更新日期：1996-11-26 00:00:00

abstract：:DsRed, a brilliantly red fluorescent protein, was recently cloned from Discosoma coral by homology to the green fluorescent protein (GFP) from the jellyfish Aequorea. A core question in the biochemistry of DsRed is the mechanism by which the GFP-like 475-nm excitation and 500-nm emission maxima of immature DsRed are r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gross LA,Baird GS,Hoffman RC,Baldridge KK,Tsien RY

更新日期：2000-10-24 00:00:00

abstract：:Since the demonstration that the sequence of a protein encodes its structure, the prediction of structure from sequence remains an outstanding problem that impacts numerous scientific disciplines, including many genome projects. By iteratively fixing secondary structure assignments of residues during Monte Carlo simul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DeBartolo J,Colubri A,Jha AK,Fitzgerald JE,Freed KF,Sosnick TR

更新日期：2009-03-10 00:00:00

abstract：:High levels of D-serine occur in mammalian brain, where it appears to be an endogenous ligand of the glycine site of N-methyl-D-aspartate receptors. In glial cultures of rat cerebral cortex, D-serine is enriched in type II astrocytes and is released upon stimulation with agonists of non-N-methyl-D-aspartate glutamate ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wolosker H,Sheth KN,Takahashi M,Mothet JP,Brady RO Jr,Ferris CD,Snyder SH

更新日期：1999-01-19 00:00:00

abstract：:The HLA class II-associated invariant chain (Ii)-derived peptide (CLIP) occupies the peptide binding groove during assembly in the endoplasmic reticulum, travels with HLA class II to endosomal compartments, and is subsequently released to allow binding of antigenic peptides. We investigated whether the exchange of CLI...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Bergen J,Schoenberger SP,Verreck F,Amons R,Offringa R,Koning F

更新日期：1997-07-08 00:00:00

abstract：:Staphylococcus aureus is a major cause of community-acquired and nosocomial infections including the life-threatening conditions endocarditis, necrotizing pneumonia, necrotizing fasciitis, and septicemia. Toll-like receptor (TLR)-2, a membrane-bound microbial sensor, detects staphylococcal components, but macrophages ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hruz P,Zinkernagel AS,Jenikova G,Botwin GJ,Hugot JP,Karin M,Nizet V,Eckmann L

更新日期：2009-08-04 00:00:00

abstract：:Perceptual decisions are better when they take uncertainty into account. Uncertainty arises not only from the properties of sensory input but also from cognitive sources, such as different levels of attention. However, it is unknown whether humans appropriately adjust for such cognitive sources of uncertainty during p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Denison RN,Adler WT,Carrasco M,Ma WJ

更新日期：2018-10-23 00:00:00

abstract：:The major auxin-binding protein in maize membranes is thought to function as a physiological receptor. From earlier information, including the use of site-directed irreversible inhibitors, several of the amino acids likely to form part of the active auxin-binding site were provisionally assigned. Inspection of the ami...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Venis MA,Napier RM,Barbier-Brygoo H,Maurel C,Perrot-Rechenmann C,Guern J

更新日期：1992-08-01 00:00:00

abstract：:Thalassemia is a heritable human anemia caused by a variety of mutations that affect expression of the alpha- or the beta-chain of hemoglobin. The expressivity of the phenotype is likely to be influenced by unlinked modifying genes. Indeed, by using a mouse model of alpha-thalassemia, we find that its phenotype is str...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leder A,Wiener E,Lee MJ,Wickramasinghe SN,Leder P

更新日期：1999-05-25 00:00:00

abstract：:Injection of 3':5'-cyclic AMP (cAMP) into larvae of the fly Sarcophaga bullata 3-4 hr before the beginning of puparium formation (red-spiracle stage) greatly accelerates the onset of tanning without affecting initiation of puparium formation (anterior retraction). Accelerated tanning resembles real tanning in two impo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fraenkel G,Blechl A,Blechl J,Herman P,Seligman MI

更新日期：1977-05-01 00:00:00

abstract：:Messenger RNA from rat liver was partially purified by chromatography on cellulose on the basis of its poly(A) content. Microgram amounts of this RNA stimulate protein synthesis manyfold in a heterologous cell-free system, derived from Krebs ascites cells supplemented with reticulocyte initiation factors. The messenge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schutz G,Beato M,Feigelson P

更新日期：1973-04-01 00:00:00