Dopamine tone regulates D1 receptor trafficking and delivery in striatal neurons in dopamine transporter-deficient mice.

abstract：:Recent studies show that plant organ positioning may be mediated by localized concentrations of the plant hormone auxin. Auxin patterning in the shoot apical meristem is in turn brought about by the subcellular polar distribution of the putative auxin efflux mediator, PIN1. However, the question of what signals determ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jönsson H,Heisler MG,Shapiro BE,Meyerowitz EM,Mjolsness E

更新日期：2006-01-31 00:00:00

abstract：:We discuss the generic time behavior of reaction-diffusion processes capable of modeling various types of biological transport processes, such as ligand migration in proteins and gating fluctuations in ion channel proteins. The main observable in these two cases, the fraction of unbound ligands and the probability of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nadler W,Stein DL

更新日期：1991-08-01 00:00:00

abstract：:Three enzyme reactions have been reported to catalyze the synthesis of phosphoribosylamine in eukaryotic cells. These activities are glutamine phosphoribosylpyrophosphate (P-Rib-P-P) amidotransferase [amidophosphoribosyl-transferase; 5-phosphoribosylamine: pyrophosphate phosphoribosyltransferase (glutamate-amidating) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holmes EW,King GL,Leyva A,Singer SC

更新日期：1976-07-01 00:00:00

abstract：:The use of fluorescent probes to give continuous readouts of the structural states of mitochondrial membranes during energy coupling seems a logical extension of their use in the study of protein structural changes. A clear correlation of the probes' fluorescence characteristics with the acquisition of energy coupling...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chance B

更新日期：1970-10-01 00:00:00

abstract：:Toxin-antitoxin systems are found in many bacterial chromosomes and plasmids with roles ranging from plasmid stabilization to biofilm formation and persistence. In these systems, the expression/activity of the toxin is counteracted by an antitoxin, which, in type I systems, is an antisense RNA. While the regulatory me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： El Mortaji L,Tejada-Arranz A,Rifflet A,Boneca IG,Pehau-Arnaudet G,Radicella JP,Marsin S,De Reuse H

更新日期：2020-12-08 00:00:00

abstract：:In the 7 years since dynamin was first isolated from bovine brain in search of novel microtubule-based motors, our understanding of this enzyme has expanded significantly. We now know that brain dynamin belongs to a family of large GTPases, which mediate vesicle trafficking. Furthermore, this enzymatic activity is mar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Urrutia R,Henley JR,Cook T,McNiven MA

更新日期：1997-01-21 00:00:00

abstract：:A 10-aa motif in transmembrane helix 1 of diphtheria toxin that is conserved in anthrax edema factor, anthrax lethal factor, and botulinum neurotoxin serotypes A, C, and D was identified by blast, clustal w, and meme computational analysis. Using the diphtheria toxin-related fusion protein toxin DAB(389)IL-2, we demon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ratts R,Trujillo C,Bharti A,vanderSpek J,Harrison R,Murphy JR

更新日期：2005-10-25 00:00:00

abstract：:In the traditional Z scheme of photosynthesis the Emerson effects of red drop (decline in yield of photosynthesis in far-red light) and enhancement (of far-red yield by supplementary short-wavelength light) are taken to be evidence for the coupling in series of two photosystems that absorb unsymmetrically in the far-r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Warner JW,Berry RS

更新日期：1987-06-01 00:00:00

abstract：:Golgi-associated cytoplasmic proteins, such as the coatomer protein complex, are required for vesicle budding and trafficking. We have previously described a cytoplasmic phosphoprotein, p200, which binds dynamically and specifically to Golgi membranes. The p200 protein is dissociated from Golgi membranes in the presen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Narula N,Stow JL

更新日期：1995-03-28 00:00:00

abstract：:By examining many alternative arrangements of cortical areas, we have found that the arrangement actually present in the brain minimizes the volume of the axons required for interconnecting the areas. Our observations support the notion that the organization of cortical areas has evolved to optimize interareal connect...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klyachko VA,Stevens CF

更新日期：2003-06-24 00:00:00

abstract：:In earlier papers L.W. introduced two sequences of higher-rank zeta functions associated to a smooth projective curve over a finite field, both of them generalizing the Artin zeta function of the curve. One of these zeta functions is defined geometrically in terms of semistable vector bundles of rank n over the curve ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weng L,Zagier D

更新日期：2020-03-24 00:00:00

abstract：:Escherichia coli DnaJ functions as a typical molecular chaperone in coordination with other heat shock proteins such as DnaK and GrpE in a variety of cellular processes. In this study, it was found that E. coli possesses an analogue of DnaJ, as judged from not only its primary structure but also its possible function....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ueguchi C,Kakeda M,Yamada H,Mizuno T

更新日期：1994-02-01 00:00:00

abstract：:Heterozygous mutations in the CD95 (APO-1/Fas) receptor occur in most individuals with autoimmune lymphoproliferative syndrome (ALPS) and dominantly interfere with apoptosis by an unknown mechanism. We show that local or global alterations in the structure of the cytoplasmic death domain from nine independent ALPS CD9...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martin DA,Zheng L,Siegel RM,Huang B,Fisher GH,Wang J,Jackson CE,Puck JM,Dale J,Straus SE,Peter ME,Krammer PH,Fesik S,Lenardo MJ

更新日期：1999-04-13 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF), a cognate ligand for the tyrosine kinase receptor B (TrkB) receptor, mediates neuronal survival, differentiation, synaptic plasticity, and neurogenesis. However, BDNF has a poor pharmacokinetic profile that limits its therapeutic potential. Here we report the identification of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jang SW,Liu X,Yepes M,Shepherd KR,Miller GW,Liu Y,Wilson WD,Xiao G,Blanchi B,Sun YE,Ye K

更新日期：2010-02-09 00:00:00

abstract：:The development of distinct regions in the amniote vertebral column results from somite formation and Hox gene expression, with the adult morphology displaying remarkable variation among lineages. Mammalian regionalization is reportedly very conservative or even constrained, but there has been no study investigating v...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Müller J,Scheyer TM,Head JJ,Barrett PM,Werneburg I,Ericson PG,Pol D,Sánchez-Villagra MR

更新日期：2010-02-02 00:00:00

abstract：:Modern functional imaging techniques of the brain measure local hemodynamic responses evoked by neuronal activity. Capillary pericytes recently were suggested to mediate neurovascular coupling in brain slices, but their role in vivo remains unexplored. We used two-photon microscopy to study in real time pericytes and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fernández-Klett F,Offenhauser N,Dirnagl U,Priller J,Lindauer U

更新日期：2010-12-21 00:00:00

abstract：:Transforming growth factor beta (TGF-beta) signals through a receptor complex containing the type I (TGF-beta RI) and type II (TGF-beta RII) receptors. We describe here biochemical studies on early events in the TGF-beta signaling pathways. TGF-beta RII is highly phosphorylated when expressed alone in COS-1 cells; its...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen F,Weinberg RA

更新日期：1995-02-28 00:00:00

abstract：:The effects of UV irradiation on the incorporation of [3H]uridine in HeLa (human) cell mRNA, rRNA, heterogeneous nuclear RNA (hnRNA) and early mRNA from adenovirus type 2 have been compared. The UV target size of cell mRNA is at least 3 times larger than the average size of the mRNA itself and larger than the adenovir...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldberg S,Schwartz H,Darnell JE Jr

更新日期：1977-10-01 00:00:00

abstract：:The "WD40" domain is a widespread recognition module for linking partner proteins in intracellular networks of signaling and sorting. The clathrin amino-terminal domain, which directs incorporation of cargo into coated pits, is a beta-propeller closely related in structure to WD40 modules. The crystallographically det...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： ter Haar E,Harrison SC,Kirchhausen T

更新日期：2000-02-01 00:00:00

abstract：:The binding protein for the K+-channel toxin dendrotoxin I was purified from a detergent extract of rat brain membranes. The purification procedure utilized chromatography on DEAE-Trisacryl, affinity chromatography on a dendrotoxin-I-Aca 22 column, and wheat germ agglutinin-Affigel 10 with a final 3800- to 4600-fold e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rehm H,Lazdunski M

更新日期：1988-07-01 00:00:00

abstract：:A structural gene for the alpha-subunit of RNA polymerase (nucleosidetriphosphate:RNA nucleotidyltransferase; EC 2.7.7.6) has been identified and mapped between spcA and trkA, near 64 min on the E. coli chromosome. It appears to be coordinately expressed and possibly cotranscribed with the genes for ribosomal proteins...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jaskunas SR,Burgess RR,Nomura M

更新日期：1975-12-01 00:00:00

abstract：:Hematologic malignancies are frequently associated with cardiac pathologies. Mutations of isocitrate dehydrogenase 1 and 2 (IDH1/2) occur in a subset of acute myeloid leukemia patients, causing metabolic and epigenetic derangements. We have now discovered that altered metabolism in leukemic cells has a profound effect...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karlstaedt A,Zhang X,Vitrac H,Harmancey R,Vasquez H,Wang JH,Goodell MA,Taegtmeyer H

更新日期：2016-09-13 00:00:00

abstract：:In recent years, the field of psychology has begun to conduct replication tests on a large scale. Here, we show that "replicator degrees of freedom" make it far too easy to obtain and publish false-negative replication results, even while appearing to adhere to strict methodological standards. Specifically, using data...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bryan CJ,Yeager DS,O'Brien JM

更新日期：2019-12-17 00:00:00

abstract：:The classical Euler-Poisson equations describing the motion of a heavy rigid body about a fixed point are generalized to arbitrary Lie algebras as Hamiltonian systems on coad-joint orbits of a tangent bundle Lie group. the N-dimensional Lagrange and symmetric heavy top are thereby shown to be completely integrable. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ratiu T

更新日期：1981-03-01 00:00:00

abstract：:In multicellular organisms, the higher order organization of chromatin during interphase and the reassembly of the nuclear envelope during mitosis are thought to involve an interaction between the nuclear lamina and chromatin. The nuclear distribution of lamins and of peripheral chromatin is highly correlated in vivo,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldberg M,Harel A,Brandeis M,Rechsteiner T,Richmond TJ,Weiss AM,Gruenbaum Y

更新日期：1999-03-16 00:00:00

abstract：:Establishing quantitative relationships between molecular structure and broad biological effects has been a longstanding challenge in science. Currently, no method exists for forecasting broad biological activity profiles of medicinal agents even within narrow boundaries of structurally similar molecules. Starting fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fliri AF,Loging WT,Thadeio PF,Volkmann RA

更新日期：2005-01-11 00:00:00

abstract：:Prior incubation of quiescent cultures of Swiss 3T3 cells with vasopressin leads to loss of mitogenic stimulation on its subsequent addition in the presence of a synergistic growth factor. This desensitization is selective for vasopressin, requires prolonged incubation (half-maximal desensitization after 12 hr of trea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Collins MK,Rozengurt E

更新日期：1983-04-01 00:00:00

abstract：:Imaging reporter gene expression in living subjects is a rapidly evolving area of molecular imaging research. Studies have validated the use of reporter genes with positron emission tomography (PET), single photon emission computed tomography (SPECT), MRI, fluorescence with wild-type and mutants of green fluorescent p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhaumik S,Gambhir SS

更新日期：2002-01-08 00:00:00

abstract：:Large-scale analysis of the GC-content distribution at the gene level reveals both common features and basic differences in genomes of different groups of species. Sharp changes in GC content are detected at the transcription boundaries for all species analyzed, including human, mouse, rat, chicken, fruit fly, and wor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang L,Kasif S,Cantor CR,Broude NE

更新日期：2004-11-30 00:00:00

abstract：:Targeted gene modification mediated by single-stranded oligonucleotides (SSOs) holds great potential for widespread use in a number of biological and biomedical fields, including functional genomics and gene therapy. By using this approach, specific genetic changes have been created in a number of prokaryotic and euka...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu XS,Xin L,Yin WX,Shang XY,Lu L,Watt RM,Cheah KS,Huang JD,Liu DP,Liang CC

更新日期：2005-02-15 00:00:00