Pericytes in capillaries are contractile in vivo, but arterioles mediate functional hyperemia in the mouse brain.

abstract：:Cells are dynamical systems of biomolecular interactions that process information from their environment to mount diverse yet specific responses. A key property of many self-organized systems is that of criticality: a state of a system in which, on average, perturbations are neither dampened nor amplified, but are pro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nykter M,Price ND,Aldana M,Ramsey SA,Kauffman SA,Hood LE,Yli-Harja O,Shmulevich I

更新日期：2008-02-12 00:00:00

abstract：:We have isolated from vaccinia virus cores an enzyme, 5'-phosphate-polyribonucleotide kinase, that in the presence of ATP and Mg2+ catalyzes the conversion of 5'-phosphate and 5'-diphosphate termini of RNA to the 5'-triphosphate species. With the exception of dATP, other nucleoside triphosphates were inactive as phosp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spencer E,Loring D,Hurwitz J,Monroy G

更新日期：1978-10-01 00:00:00

abstract：:Accurate replication in the presence of DNA damage is essential to genome stability and viability in all cells. In Escherichia coli, DNA replication forks blocked by UV-induced damage undergo a partial resection and RecF-catalyzed regression before synthesis resumes. These processing events generate distinct structura...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jeiranian HA,Schalow BJ,Courcelle CT,Courcelle J

更新日期：2013-07-09 00:00:00

abstract：:The Snf1 protein kinase family has been conserved in eukaryotes. In the yeast Saccharomyces cerevisiae, Snf1 is essential for transcription of glucose-repressed genes in response to glucose starvation. The direct interaction between Snf1 and its activating subunit, Snf4, within the kinase complex is regulated by the g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ludin K,Jiang R,Carlson M

更新日期：1998-05-26 00:00:00

abstract：:Two RNA fractions have been isolated and purified from both oncogenic and nononcogenic strains of Agrobacterium tumefaciens. Both RNAs are capable of inducing the formation of transplantable tumors when introduced at wound sites in stems of Datura stramonium plants. One of these RNA fractions was found to be bound to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beljanski M,Aaron-da Cunha MI,Beljanski MS,Manigault P,Bourgarel P

更新日期：1974-05-01 00:00:00

abstract：:Members of the tumor necrosis factor receptor (TNFR) superfamily are important for cell growth and survival. In addition to providing costimulatory signals for cell proliferation, ligation of both TNFR1 and Fas can result in programmed cell death or apoptosis. The underlying mechanism requires an intact 80-aa stretch ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prasad KV,Ao Z,Yoon Y,Wu MX,Rizk M,Jacquot S,Schlossman SF

更新日期：1997-06-10 00:00:00

abstract：:Heme A is an essential cofactor for respiratory terminal oxidases and vital for respiration in aerobic organisms. The final step of heme A biosynthesis is formylation of the C-8 methyl group of heme molecule by heme A synthase (HAS). HAS is a heme-containing integral membrane protein, and its structure and reaction me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Niwa S,Takeda K,Kosugi M,Tsutsumi E,Mogi T,Miki K

更新日期：2018-11-20 00:00:00

abstract：:The stoichiometry of J chain in pentamer IgM has been determined by measuring the radiolabeled thiols in the constituent chains after complete reduction and alkylation of the polymer. One mole of J was found to be disulfide bonded to 1 mol of pentamer. The linkage of J chain in IgM has been determined by correlating t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chapuis RM,Koshland ME

更新日期：1974-03-01 00:00:00

abstract：:Antibodies may bind to bacterial pathogens or their toxins to control infections, and their effector activity is mediated through the recruitment of complement component C1q or the engagement with Fcγ receptors (FcγRs). For bacterial pathogens that rely on a single toxin to cause disease, immunity correlates with toxi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen X,Shi M,Tong X,Kim HK,Wang LX,Schneewind O,Missiakas D

更新日期：2020-09-15 00:00:00

abstract：:Neutron diffraction maps have been used to assign the rotor conformations of the hydroxyl hydrogens in trypsin. Knowledge of these conformations is used to assess the relative importance of steric and electrostatic effects in conferring the H-bonding geometries of these groups. A general finding was that most hydroxyl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kossiakoff AA,Shpungin J,Sintchak MD

更新日期：1990-06-01 00:00:00

abstract：:We introduce a new genetic distance for microsatellite loci, incorporating features of the stepwise mutation model, and test its performance on microsatellite polymorphisms in humans, chimpanzees, and gorillas. We find that it performs well in determining the relations among the primates, but less well than other dist...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldstein DB,Ruiz Linares A,Cavalli-Sforza LL,Feldman MW

更新日期：1995-07-18 00:00:00

abstract：:In the mammalian visual system, the terminal arbors of retinal ganglion cell axons from the two eyes are restricted to mutually exclusive territories within their thalamic target, the lateral geniculate nucleus (LGN). Here we have investigated some of the factors that determine the adult morphology of terminal arbors ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Garraghty PE,Shatz CJ,Sretavan DW,Sur M

更新日期：1988-10-01 00:00:00

abstract：:Inositol polyphosphate 4-phosphatase (4-phosphatase) is an enzyme that catalyses the hydrolysis of the 4-position phosphate from phosphatidylinositol 3,4-bisphosphate [PtdIns(3,4)P2]. In human platelets the formation of this phosphatidylinositol, by the actions of phosphatidylinositol 3-kinase (PI 3-kinase), correlate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Munday AD,Norris FA,Caldwell KK,Brown S,Majerus PW,Mitchell CA

更新日期：1999-03-30 00:00:00

abstract：:A nongenetic, transgenerational effect of parental age on offspring fitness has been described in many taxa in the laboratory. Such a transgenerational fitness effect will have important influences on population dynamics, population age structure, and the evolution of aging and lifespan. However, effects of parental a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schroeder J,Nakagawa S,Rees M,Mannarelli ME,Burke T

更新日期：2015-03-31 00:00:00

abstract：:Plasmids that contain synthetic genes coding for small oligoribonucleotides called external guide sequences (EGSs) have been introduced into strains of Escherichia coli harboring antibiotic resistance genes. The EGSs direct RNase P to cleave the mRNAs transcribed from these genes thereby converting the phenotype of dr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guerrier-Takada C,Salavati R,Altman S

更新日期：1997-08-05 00:00:00

abstract：:To study the origin of and the degree of T-cell antigen receptor (TCR) diversity of Thy-1+ dendritic epidermal cells (Thy-1+ dECs) in mice, we have developed a monoclonal antibody (mAb 536) to the gamma delta TCR. mAb 536 binds to and stimulates interleukin 2 secretion from Thy-1+ dEC but not cells that express TCR co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Havran WL,Grell S,Duwe G,Kimura J,Wilson A,Kruisbeek AM,O'Brien RL,Born W,Tigelaar RE,Allison JP

更新日期：1989-06-01 00:00:00

abstract：:Host factor protein Cyclophilin A (CypA) regulates HIV-1 viral infectivity through direct interactions with the viral capsid, by an unknown mechanism. CypA can either promote or inhibit viral infection, depending on host cell type and HIV-1 capsid (CA) protein sequence. We have examined the role of conformational dyna...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu M,Hou G,Zhang H,Suiter CL,Ahn J,Byeon IJ,Perilla JR,Langmead CJ,Hung I,Gor'kov PL,Gan Z,Brey W,Aiken C,Zhang P,Schulten K,Gronenborn AM,Polenova T

更新日期：2015-11-24 00:00:00

abstract：:Bacterial populations are subject to complex processes of diversification that involve mutation and horizontal DNA transfer mediated by transformation, transduction, or conjugation. Tracing the evolutionary events leading to genetic changes allows us to infer the history of a microbe. Here, we combine experimental and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brochet M,Rusniok C,Couvé E,Dramsi S,Poyart C,Trieu-Cuot P,Kunst F,Glaser P

更新日期：2008-10-14 00:00:00

abstract：:Seemingly similar individuals often experience drastically different success trajectories, with some repeatedly failing and others consistently succeeding. One explanation is preexisting variability along unobserved fitness dimensions that is revealed gradually through differential achievement. Alternatively, positive...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van de Rijt A,Kang SM,Restivo M,Patil A

更新日期：2014-05-13 00:00:00

abstract：:The way general anesthetics cause their clinically useful effects on the nervous system is not known. Since the principal determinant of the potency of these agents is their solubility in oil, the role of chemical structure in affecting anesthetic targets has been obscured. In this work, we use an intense beam of ligh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Campbell DB,Nash HA

更新日期：1994-03-15 00:00:00

abstract：:We have examined the role of a cell surface galactosyltransferase, laminin, and laminin-binding protein (receptor) in the invasion of clonal derivatives of a murine adrenal carcinoma cell line. Although a 10-fold variation was found in the ability to invade a reconstituted basement membrane matrix, levels of intracell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Penno MB,Passaniti A,Fridman R,Hart GW,Jordan C,Kumar S,Scott AF

更新日期：1989-08-01 00:00:00

abstract：:West Nile virus, which is transmitted by Culex mosquitoes while feeding on birds and humans, has emerged as the dominant vector borne disease in North America. We have identified natural compounds from humans and birds, which are detected with extreme sensitivity by olfactory receptor neurons (ORNs) on the antennae of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Syed Z,Leal WS

更新日期：2009-11-03 00:00:00

abstract：:Alzheimer's disease (AD) comprises multifactorial ailments for which current therapeutic strategies remain insufficient to broadly address the underlying pathophysiology. Epigenetic gene regulation relies upon multifactorial processes that regulate multiple gene and protein pathways, including those involved in AD. We...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Volmar CH,Salah-Uddin H,Janczura KJ,Halley P,Lambert G,Wodrich A,Manoah S,Patel NH,Sartor GC,Mehta N,Miles NTH,Desse S,Dorcius D,Cameron MD,Brothers SP,Wahlestedt C

更新日期：2017-10-24 00:00:00

abstract：:Transmural stimulation of the isolated adrenal gland of the rat and guinea pig results in secretion of catecholamine. The secretion is due to activation of cholinergic receptors of the adrenal medulla by acetylcholine released from splanchnic nerve terminals after transmural stimulation. Our aim was to see whether the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wakade AR,Wakade TD

更新日期：1982-05-01 00:00:00

abstract：:Synaptobrevin/vesicle-associated membrane protein (VAMP) and syntaxin are potential vesicle donor and target membrane receptors of a docking complex that requires N-ethylmaleimide-sensitive factor (NSF) and soluble NSF-attachment proteins as soluble factors for vesicle fusion with target membranes. Members of this doc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamasaki S,Hu Y,Binz T,Kalkuhl A,Kurazono H,Tamura T,Jahn R,Kandel E,Niemann H

更新日期：1994-05-24 00:00:00

abstract：:Sour taste is detected by a subset of taste cells on the tongue and palate epithelium that respond to acids with trains of action potentials. Entry of protons through a Zn(2+)-sensitive proton conductance that is specific to sour taste cells has been shown to be the initial event in sour taste transduction. Whether th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ye W,Chang RB,Bushman JD,Tu YH,Mulhall EM,Wilson CE,Cooper AJ,Chick WS,Hill-Eubanks DC,Nelson MT,Kinnamon SC,Liman ER

更新日期：2016-01-12 00:00:00

abstract：:Previous studies have identified lipid-poor high density lipoproteins with electrophoretic pre-beta mobility as the initial acceptors of cell-derived cholesterol in human plasma. These lipoproteins contain apolipoprotein A-I (apo A-I) as their sole apolipoprotein. In the present study, incubation of human plasma with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang Y,von Eckardstein A,Wu S,Maeda N,Assmann G

更新日期：1994-03-01 00:00:00

abstract：:New advances in polarized light microscopy were used to image Congo red-stained cerebral amyloidosis in sharp relief. The rotating-polarizer method was used to separate the optical effects of transmission, linear birefringence, extinction, linear dichroism, and orientation of the electric dipole transition moments and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jin LW,Claborn KA,Kurimoto M,Geday MA,Maezawa I,Sohraby F,Estrada M,Kaminksy W,Kahr B

更新日期：2003-12-23 00:00:00

abstract：:Scholander and his coworkers have described in These Proceedings several experiments in which the osmotic pressure exerted by colloidal particles appears to be altered when the particles are subject to an external force; they interpret the experiments as showing that the traditional explanation of osmotic pressure is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hobbie RK

更新日期：1974-08-01 00:00:00

abstract：:In facultative photoperiodic flowering plants, noninductive photoperiods result in a delay in flowering, but such plants eventually flower, illustrating plasticity in an important developmental transition, flowering. The model plant, Arabidopsis, has a facultative photoperiod response. Although the inductive flowering...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim DH,Sung S

更新日期：2010-09-28 00:00:00