Dynamic allostery governs cyclophilin A-HIV capsid interplay.

abstract：:Gold nanoparticles (NPs) wrapped in a membrane can be utilized as artificial virus nanoparticles (AVNs) that combine the large nonblinking or bleaching optical cross-section of the NP core with the biological surface properties and functionalities provided by a self-assembled lipid membrane. We used these hybrid nanom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu F,Bandara A,Akiyama H,Eshaghi B,Stelter D,Keyes T,Straub JE,Gummuluru S,Reinhard BM

更新日期：2018-09-25 00:00:00

abstract：:Chromogranin A (CGA) is a secretory protein present in the adrenal medulla and in a variety of endocrine organs. This protein may serve as precursor for pancreastatin (PST) and for other biologically active peptides. Recently, chromostatin (CST), a CGA derivative, has been identified that possesses high biological act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cetin Y,Aunis D,Bader MF,Galindo E,Jörns A,Bargsten G,Grube D

更新日期：1993-03-15 00:00:00

abstract：:Coxiella burnetti, the etiologic agent of Q fever, is an oligate intracellular parasite of eukaryotes. Unlike the majority of successful bacterial parasites, which escape the bactericidal environment of the phagolysosome by various means, C. burnetii multiplies only in the phagolysosome. In view of the relatively hars...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hackstadt T,Williams JC

更新日期：1981-05-01 00:00:00

abstract：:The plant kingdom contains vastly untapped natural product chemistry, which has been traditionally explored through the activity-guided approach. Here, we describe a gene-guided approach to discover and engineer a class of plant ribosomal peptides, the branched cyclic lyciumins. Initially isolated from the Chinese wol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kersten RD,Weng JK

更新日期：2018-11-13 00:00:00

abstract：:Metals in one spatial dimension are described at the lowest energy scales by the Luttinger liquid theory. It is well understood that this free theory, and even interacting integrable models, can support ballistic transport of conserved quantities including energy. In contrast, realistic one-dimensional metals, even wi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bulchandani VB,Karrasch C,Moore JE

更新日期：2020-06-09 00:00:00

abstract：:The programmed activation/repression of transcription factors in early hematopoietic differentiation has not yet been explored. The DNA-binding protein GATA-1 is required for normal erythroid development and regulates erythroid-expressed genes in maturing erythroblasts. We analyzed GATA-1 expression in early human adu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sposi NM,Zon LI,Carè A,Valtieri M,Testa U,Gabbianelli M,Mariani G,Bottero L,Mather C,Orkin SH

更新日期：1992-07-15 00:00:00

abstract：:Transforming growth factor alpha (TGF-alpha) is generated by cleavage of a membrane-anchored precursor protein, proTGF-alpha. ProTGF-alpha is cleaved at a slow rate and accumulates on the cell surface, thereby mediating cell-cell adhesion and mitogenic stimulation. We show here that cleavage of membrane proTGF-alpha b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pandiella A,Massagué J

更新日期：1991-03-01 00:00:00

abstract：:Methane seeps are widespread seafloor ecosystems shaped by the emission of gas from seabed reservoirs. The microorganisms inhabiting methane seeps transform the chemical energy in methane to products that sustain rich benthic communities around the gas leaks. Despite the biogeochemical relevance of microbial methane r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruff SE,Biddle JF,Teske AP,Knittel K,Boetius A,Ramette A

更新日期：2015-03-31 00:00:00

abstract：:We show that epidermal growth factor (EGF) receptor can be transferred in a biologically active orientation from donor hepatic membranes to recipient receptorless fibroblast cells. The recipient cells (NR-6) normally lack EGF receptors and are biologically unresponsive to EGF. The transfer of receptors from donor plas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bishayee S,Feinman J,Pittenger M,Michael H,Das M

更新日期：1982-03-01 00:00:00

abstract：:The histidine periplasmic permease of Salmonella typhimurium has been partially purified and reconstituted into proteoliposomes. In this in vitro preparation, transport activity is completely dependent on the presence of all four permease proteins (HisJ, HisQ, HisM, and HisP) and on internal ATP. The reconstituted sys...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bishop L,Agbayani R Jr,Ambudkar SV,Maloney PC,Ames GF

更新日期：1989-09-01 00:00:00

abstract：:The nucleotide sequence of the recognition site for the restriction-modification enzyme of Escherichia coli B (SB site) has been determined. The recognition site is a 15-nucleotide sequence consisting of the trimer 5'TGA3', followed by an 8-nucleotide domain of variable sequence, which in turn is followed by tetramer ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ravetch JV,Horiuchi K,Zinder ND

更新日期：1978-05-01 00:00:00

abstract：:Evolutionary processes leading to adaptive radiation regularly occur too fast to be accurately recorded in the fossil record but too slowly to be readily observed in living biota. The study of evolutionary radiations is thereby confronted with an epistemological gap between the timescales and approaches used by neonto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van Bocxlaer B,Hunt G

更新日期：2013-08-20 00:00:00

abstract：:Egg laying hormone, a peptide neurohormone with an approximate molecular weight of 6000, was isolated from the region of the abdominal ganglion of Aplysia that contains the neuroendocrine bag cells and purified by gel filtration chromatography, isoelectric focusing, and dialysis. A 1-min local application of egg layin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Branton WD,Arch S,Smock T,Mayeri E

更新日期：1978-11-01 00:00:00

abstract：:DNA "breathing" is a thermally driven process in which base-paired DNA sequences transiently adopt local conformations that depart from their most stable structures. Polymerases and other proteins of genome expression require access to single-stranded DNA coding templates located in the double-stranded DNA "interior,"...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Phelps C,Lee W,Jose D,von Hippel PH,Marcus AH

更新日期：2013-10-22 00:00:00

abstract：:Mammalian nervous system function involves billions of neurons which are interconnected in a multitude of neural circuits. Here we describe a genetic approach to chart neural circuits. By using an olfactory-specific promoter, we selectively expressed barley lectin in sensory neurons in the olfactory epithelium and vom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horowitz LF,Montmayeur JP,Echelard Y,Buck LB

更新日期：1999-03-16 00:00:00

abstract：:Ultraviolet photosensitivity of the single-stranded forms of poly(A) and poly(dA) is compared. In contrast to poly(A), poly(dA) is rather sensitive to ultraviolet irradiation. Relatively low doses of ultraviolet light lead to characteristic changes of the ultraviolet and circular dichroism spectra of poly(dA), suggest...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pörschke D

更新日期：1973-09-01 00:00:00

abstract：:Pneumococcal peptidoglycan amidase (N-acetylmuramoyl-L-alanine amidase, EC 3.5.1.28) and phage CPL1 lysozyme degrade a common substrate (choline-containing pneumococcal cell walls); the former hydrolyzes the bond between muramic acid and alanine, whereas the latter breaks down the linkage between muramic acid and gluc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Díaz E,López R,García JL

更新日期：1990-10-01 00:00:00

abstract：:Protein tyrosine phosphorylation in purified synaptic vesicles from rat forebrain has been studied in the presence of Mn2+ and orthovanadate. High levels of endogenous protein tyrosine phosphorylation were observed. Four major phosphoproteins, with apparent molecular masses of 105, 94, 38, and 30 kDa, were shown to co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pang DT,Wang JK,Valtorta F,Benfenati F,Greengard P

更新日期：1988-02-01 00:00:00

abstract：:Mammalian visual systems are characterized by their ability to recognize stimuli invariant to various transformations. Here, we investigate the hypothesis that this ability is achieved by the temporal encoding of visual stimuli. By using a model of a cortical network, we show that this encoding is invariant to several...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wyss R,Konig P,Verschure PF

更新日期：2003-01-07 00:00:00

abstract：:West Nile virus, which is transmitted by Culex mosquitoes while feeding on birds and humans, has emerged as the dominant vector borne disease in North America. We have identified natural compounds from humans and birds, which are detected with extreme sensitivity by olfactory receptor neurons (ORNs) on the antennae of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Syed Z,Leal WS

更新日期：2009-11-03 00:00:00

abstract：:The ubiquitin ligase Siah2 has been shown to regulate prolyl hydroxylase 3 (PHD3) stability with concomitant effect on HIF-1alpha availability. Because HIF-1alpha is implicated in tumorigenesis and metastasis, we used SW1 mouse melanoma cells, which develop primary tumors with a propensity to metastasize, in a syngene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qi J,Nakayama K,Gaitonde S,Goydos JS,Krajewski S,Eroshkin A,Bar-Sagi D,Bowtell D,Ronai Z

更新日期：2008-10-28 00:00:00

abstract：:The conserved Ndc80 complex is an essential microtubule-binding component of the kinetochore. Recent findings suggest that the Ndc80 complex influences microtubule dynamics at kinetochores in vivo. However, it was unclear if the Ndc80 complex mediates these effects directly, or by affecting other factors localized at ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Umbreit NT,Gestaut DR,Tien JF,Vollmar BS,Gonen T,Asbury CL,Davis TN

更新日期：2012-10-02 00:00:00

abstract：:It has been proposed that extensive wildfires occurred after the Cretaceous-Tertiary (K-T) impact event. An abundance of soot and pyrosynthetic polycyclic aromatic hydrocarbons (pPAHs) in marine K-T boundary impact rocks (BIRs) have been considered support for this hypothesis. However, nonmarine K-T BIRs, from across ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Belcher CM,Finch P,Collinson ME,Scott AC,Grassineau NV

更新日期：2009-03-17 00:00:00

abstract：:We have sequenced the mutant beta-actin gene of a tumorigenic human fibroblast cell line (HuT-14T) and found that it carries three mutations that alter the amino acids at positions 36, 83, and 244 as well as a 22-base-pair "insertion" sequence, in the 5' intron, not present in a wild-type gene. The less tumorigenic ce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin CS,Ng SY,Gunning P,Kedes L,Leavitt J

更新日期：1985-10-01 00:00:00

abstract：:Infectious tolerance describes the process of CD4(+) regulatory T cells (Tregs) converting naïve T cells to become additional Tregs. We show that antigen-specific Tregs induce, within skin grafts and dendritic cells, the expression of enzymes that consume at least 5 different essential amino acids (EAAs). T cells fail...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cobbold SP,Adams E,Farquhar CA,Nolan KF,Howie D,Lui KO,Fairchild PJ,Mellor AL,Ron D,Waldmann H

更新日期：2009-07-21 00:00:00

abstract：:We have used in vitro selection techniques to characterize DNA sequences that are ligated efficiently by T4 RNA ligase. We find that the ensemble of selected sequences ligated about 10 times as efficiently as the random mixture of sequences used as the input for selection. Surprisingly, the majority of the selected se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harada K,Orgel LE

更新日期：1993-02-15 00:00:00

abstract：:Poliovirus mRNA and mRNA transcribed from vesicular stomatitis virus and reovirus genomes efficiently direct protein synthesis in vivo under experimental conditions where the initiation of host protein synthesis is selectively blocked. The selective blockage of host peptide chain initiation after exposure to hypertoni...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nuss DL,Oppermann H,Koch G

更新日期：1975-04-01 00:00:00

abstract：:Single-nucleotide polymorphisms (SNPs) in the human ether-a-go-go-related gene 1, hERG1, are associated with cardiac arrhythmias. The Kv11.1 channels encoded by hERG1 are also essential for rhythmic excitability of the pituitary, where they are regulated by thyroid hormone through a signal transduction cascade involvi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gentile S,Martin N,Scappini E,Williams J,Erxleben C,Armstrong DL

更新日期：2008-09-23 00:00:00

abstract：:Archaea (archaebacteria) are a phenotypically diverse group of microorganisms that share a common evolutionary history. There are four general phenotypic groups of archaea: the methanogens, the extreme halophiles, the sulfate-reducing archaea, and the extreme thermophiles. In the marine environment, archaeal habitats ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DeLong EF

更新日期：1992-06-15 00:00:00

abstract：:Parathyroid hormone-related protein (PTHrP) is synthesized in the brain, and a single type of cloned receptor for the N-terminal portion of PTHrP and PTH is present in the central nervous system. Nothing is known about the physiological actions or signaling pathways used by PTHrP in the brain. Using cultured rat hippo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fukayama S,Tashjian AH Jr,Davis JN,Chisholm JC

更新日期：1995-10-24 00:00:00