Infectious tolerance via the consumption of essential amino acids and mTOR signaling.

abstract：:We prove theorems on the structure of the fundamental group of a compact riemannian manifold of non-positive curvature. In particular, a conjecture of J. Wolf [J. Differential Geometry, 2, 421-446 (1968)] is proved. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yau ST

更新日期：1970-10-01 00:00:00

abstract：:Protein prenylation with farnesyl or geranylgeranyl moieties is an important posttranslational modification that affects the activity of such diverse proteins as the nuclear lamins, the yeast mating factor mata, and the ras oncogene products. In this article, we show that whole retinal cultures incorporate radioactive...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lai RK,Perez-Sala D,Cañada FJ,Rando RR

更新日期：1990-10-01 00:00:00

abstract：:Poliovirus type 1 cDNA sequences coding for viral capsid polypeptide VP1 were inserted into the beta-lactamase sequence of Escherichia coli plasmid pBR322. Resulting recombinant plasmid pSW119 expressed in Escherichia coli a VP1-beta-lactamase fusion protein that reacted with antibodies raised against poliovirus capsi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van der Werf S,Wychowski C,Bruneau P,Blondel B,Crainic R,Horodniceanu F,Girard M

更新日期：1983-08-01 00:00:00

abstract：:Vertebrate dentitions are extraordinarily diverse in both morphology and regenerative capacity. The teleost order Tetraodontiformes exhibits an exceptional array of novel dental morphologies, epitomized by constrained beak-like dentitions in several families, i.e., porcupinefishes, three-toothed pufferfishes, ocean su...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thiery AP,Shono T,Kurokawa D,Britz R,Johanson Z,Fraser GJ

更新日期：2017-05-30 00:00:00

abstract：:Signaling through Janus kinases (JAKs) and signal transducers and activators of transcription (STATs) is central to the responses to the majority of cytokines and some growth factors, including the interferons (IFNs) and the IL-6 family of cytokines. The biological responses to stimulation through the widely distribut...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Costa-Pereira AP,Tininini S,Strobl B,Alonzi T,Schlaak JF,Is'harc H,Gesualdo I,Newman SJ,Kerr IM,Poli V

更新日期：2002-06-11 00:00:00

abstract：:Apoptotic cells contain nuclear autoantigens that may initiate a systemic autoimmune response. To explore the mechanism of antibody binding to apoptotic cells, 3H9, a murine autoantibody with dual specificity for phospholipids and DNA, was used. H chain mutants of 3H9 were constructed, expressed as single-chain Fv (sc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cocca BA,Seal SN,D'Agnillo P,Mueller YM,Katsikis PD,Rauch J,Weigert M,Radic MZ

更新日期：2001-11-20 00:00:00

abstract：:Basophils are powerful mediators of Th2 immunity and are present in increased numbers during allergic inflammation and helminth infection. Despite their ability to potentiate Th2 immunity the mechanisms regulating basophil development remain largely unknown. We have found a unique role for isotype-switched antibodies ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Herbst T,Esser J,Prati M,Kulagin M,Stettler R,Zaiss MM,Hewitson JP,Merky P,Verbeek JS,Bourquin C,Camberis M,Prout M,Maizels RM,Le Gros G,Harris NL

更新日期：2012-09-11 00:00:00

abstract：:In Trimenia moorei, an extant member of the ancient angiosperm clade Austrobaileyales, we found a remarkable pattern of female gametophyte (egg-producing structure) development that strikingly resembles that of pollen tubes and their intrasexual competition within the maternal pollen tube transmitting tissues of most ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bachelier JB,Friedman WE

更新日期：2011-07-26 00:00:00

abstract：:We have developed a technology for analysis and sorting of live cells according to secreted molecules. An artificial affinity matrix, specific for the secreted product of interest, is created on the cell surface, and the cells are allowed to secrete for a defined time period. The secreted molecules bind to the affinit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Manz R,Assenmacher M,Pflüger E,Miltenyi S,Radbruch A

更新日期：1995-03-14 00:00:00

abstract：:Humans assess the credibility of information gained from others on a daily basis; this ongoing assessment is especially crucial for avoiding exploitation by others. We used a repeated, two-person bargaining game and a cognitive hierarchy model to test how subjects judge the information sent asymmetrically from one pla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhatt MA,Lohrenz T,Camerer CF,Montague PR

更新日期：2012-05-29 00:00:00

abstract：:Liver fibrosis interferes with normal liver function and facilitates hepatocellular carcinoma (HCC) development, representing a major threat to human health. Here, we present a comprehensive perspective of microRNA (miRNA) function on targeting the fibrotic microenvironment. Starting from a murine HCC model, we identi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Winkler I,Bitter C,Winkler S,Weichenhan D,Thavamani A,Hengstler JG,Borkham-Kamphorst E,Kohlbacher O,Plass C,Geffers R,Weiskirchen R,Nordheim A

更新日期：2020-01-07 00:00:00

abstract：:In order to define the protease domain of human immunodeficiency virus 1, various regions of the pol open reading frame were cloned and expressed in Escherichia coli. Antiserum directed against the conserved retroviral protease active site was used to identify pol precursor and processed species containing the presume...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Graves MC,Lim JJ,Heimer EP,Kramer RA

更新日期：1988-04-01 00:00:00

abstract：:Gene conversion and conversion-associated reciprocal recombination have been studied in various Saccharomyces cerevisiae hybrids. In a sample of 11,023 unselected meiotic tetrads, 907 conversions were observed at the arg4, thr3, his1, and SUP6 loci. Of these conversions, 445 (or 49.1%) were associated with reciprocal ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hurst DD,Fogel S,Mortimer RK

更新日期：1972-01-01 00:00:00

abstract：:P201 is a short (eight-residue) nonacidic peptide that comprises a strong transcriptional activating region when tethered to DNA in yeast. Here we identify the mediator protein Gal11 as an essential target of P201. Deletion of Gal11, which modestly decreases activation elicited by the typical acidic yeast activator, a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu Z,Ansari AZ,Lu X,Ogirala A,Ptashne M

更新日期：2002-06-25 00:00:00

abstract：:Nicks within one strand of the bacteriophage T5 DNA molecule act as " weak points" for a novel kind mechanical breakage that can be utilized for "dissecting" the genome. The products from sheared T5(+) DNA include five unique double-stranded segments of the molecule and various combinations of adjacent segments. These...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hayward GS

更新日期：1974-05-01 00:00:00

abstract：:The 1,25-dihydroxyvitamin D3 [1,25-(OH)2vitamin D3] analog KH1060 exerts very potent effects on cell proliferation and cell differentiation via the vitamin D receptor (VDR). However, the activities of KH1060 are not associated with an increased affinity for the VDR. We now show that increased stabilization of the VDR-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van den Bemd GC,Pols HA,Birkenhäger JC,van Leeuwen JP

更新日期：1996-10-01 00:00:00

abstract：:The regulatory photoreceptor phytochrome controls the transcription of its own phy genes in a negative feedback fashion. We have exploited microprojectile-mediated gene transfer to develop a rapid transient expression assay system for the study of DNA sequences involved in the phytochrome-regulated expression of these...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bruce WB,Christensen AH,Klein T,Fromm M,Quail PH

更新日期：1989-12-01 00:00:00

abstract：:Previous research has implicated a large network of brain regions in the processing of risk during decision making. However, it has not yet been determined if activity in these regions is predictive of choices on future risky decisions. Here, we examined functional MRI data from a large sample of healthy subjects perf...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Helfinstein SM,Schonberg T,Congdon E,Karlsgodt KH,Mumford JA,Sabb FW,Cannon TD,London ED,Bilder RM,Poldrack RA

更新日期：2014-02-18 00:00:00

abstract：:Two prominent timekeeping systems, the cell cycle, which controls cell division, and the circadian system, which controls 24-h rhythms of physiology and behavior, are found in nearly all living organisms. A distinct feature of circadian rhythms is that they are temperature-compensated such that the period of the rhyth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeom M,Pendergast JS,Ohmiya Y,Yamazaki S

更新日期：2010-05-25 00:00:00

abstract：:Ferroelectricity and antiferroelectricity are widely seen in various types of condensed matter and are of technological significance not only due to their electrical switchability but also due to intriguing cross-coupling effects such as electro-mechanical and electro-caloric effects. The control of the two types of d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takae K,Tanaka H

更新日期：2018-10-02 00:00:00

abstract：:We have isolated a protein from Saccharomyces cerevisiae that binds specifically to a nucleotide sequence associated with the autonomously replicating sequence (ARS) ARS120, located in the telomeric region of a yeast chromosome. "Footprinting" analysis revealed that a 26-base-pair DNA sequence, 5'-CAAGTGCCGTGCATAATGAT...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eisenberg S,Civalier C,Tye BK

更新日期：1988-02-01 00:00:00

abstract：:With high-dimensional data, variable-by-variable statistical testing is often used to select variables whose behavior differs across conditions. Such an approach requires adjustment for multiple testing, which can result in low statistical power. A two-stage approach that first filters variables by a criterion indepen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bourgon R,Gentleman R,Huber W

更新日期：2010-05-25 00:00:00

abstract：:Determining the principal energy-transfer pathways responsible for allosteric communication in biomolecules remains challenging, partially due to the intrinsic complexity of the systems and the lack of effective characterization methods. In this work, we introduce the eigenvector centrality metric based on mutual info...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Negre CFA,Morzan UN,Hendrickson HP,Pal R,Lisi GP,Loria JP,Rivalta I,Ho J,Batista VS

更新日期：2018-12-26 00:00:00

abstract：:The peripheral axonal branch of primary sensory neurons readily regenerates after peripheral nerve injury, but the central branch, which courses in the dorsal columns of the spinal cord, does not. However, if a peripheral nerve is transected before a spinal cord injury, sensory neurons that course in the dorsal column...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Neumann S,Skinner K,Basbaum AI

更新日期：2005-11-15 00:00:00

abstract：:Overaccumulation of abnormally organized mitochondria in so-called "ragged-red" skeletal muscle fibers is a morphological hallmark of mitochondrial myopathies, in particular of mitochondrial encephalomyopathies. Characteristic for the abnormal mitochondria is the occurrence of highly ordered crystalline inclusions. Im...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stadhouders AM,Jap PH,Winkler HP,Eppenberger HM,Wallimann T

更新日期：1994-05-24 00:00:00

abstract：:We present the use of our recently described multiple-loci polymorphic DNA markers ("alumorphs") for linkage mapping of the human genome. By using the polymerase chain reaction (PCR) with an Alu-specific primer we could reveal, in a single experiment, up to 20 genomic polymorphisms seen as the presence or absence of a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zietkiewicz E,Labuda M,Sinnett D,Glorieux FH,Labuda D

更新日期：1992-09-15 00:00:00

abstract：:The site-specific recombination system (FLP) encoded by the yeast plasmid 2-micron circle can also act in yeast on the inverted repeats of the bacterial transposon Tn5. The efficiency of this recombination is dependent on the location of Tn5 within the 2-micron circle genome but can be as high as that observed for 2-m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jayaram M,Broach JR

更新日期：1983-12-01 00:00:00

abstract：:beta 2-Glycoprotein I (beta 2-GPI), a phospholipid-binding plasma protein, is an absolute requirement (cofactor) for the binding of autoimmune-type anti-cardiolipin (aCL) antibodies to cardiolipin (CL). The nature of this cofactor activity and the specific regions of the molecule involved have not yet been determined....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hunt JE,Simpson RJ,Krilis SA

更新日期：1993-03-15 00:00:00

abstract：:In vivo, G protein-coupled receptors (GPCR) for neurotransmitters undergo complex intracellular trafficking that contribute to regulate their abundance at the cell surface. Here, we report a previously undescribed alteration in the subcellular localization of D1 dopamine receptor (D1R) that occurs in vivo in striatal ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dumartin B,Jaber M,Gonon F,Caron MG,Giros B,Bloch B

更新日期：2000-02-15 00:00:00

abstract：:Mussels adhere to a variety of surfaces by depositing a highly specific ensemble of 3,4-dihydroxyphenyl-l-alanine (DOPA) containing proteins. The adhesive properties of Mytilus edulis foot proteins mfp-1 and mfp-3 were directly measured at the nano-scale by using a surface forces apparatus (SFA). An adhesion energy of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin Q,Gourdon D,Sun C,Holten-Andersen N,Anderson TH,Waite JH,Israelachvili JN

更新日期：2007-03-06 00:00:00