Conversion-associated recombination in yeast (hybrids-meiosis-tetrads-marker loci-models).

abstract：:Dysregulation of cyclin-dependent kinase 5 (cdk5) per relative concentrations of its activators p35 and p25 is implicated in neurodegenerative diseases. P35 has a short t½ and undergoes rapid proteasomal degradation in its membrane-bound myristoylated form. P35 is converted by calpain to p25, which, along with an exte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsai SY,Pokrass MJ,Klauer NR,Nohara H,Su TP

更新日期：2015-05-26 00:00:00

abstract：:An approach combining signal detection theory and precise 3D reconstructions from serial section electron microscopy (3DEM) was used to investigate synaptic plasticity and information storage capacity at medial perforant path synapses in adult hippocampal dentate gyrus in vivo. Induction of long-term potentiation (LTP...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bromer C,Bartol TM,Bowden JB,Hubbard DD,Hanka DC,Gonzalez PV,Kuwajima M,Mendenhall JM,Parker PH,Abraham WC,Sejnowski TJ,Harris KM

更新日期：2018-03-06 00:00:00

abstract：:The immunity protein to colicin A (Cai), which is constitutively expressed at a very low level in Escherichia coli strains, has been studied in recombinant plasmid constructs allowing expression of various immunity fusion proteins under the control of inducible promoters. The 13-amino acid NH2-terminal region of Cai w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Geli V,Baty D,Lazdunski C

更新日期：1988-02-01 00:00:00

abstract：:The biosynthesis of beta-nerve growth factor (betaNGF) was studied in mouse submaxillary glands incubated with L-[(35)S]cystine. betaNGF was isolated from tissue extracts by the addition of antiserum against betaNGF and the washed immunoprecipitates were analyzed by sodium dodecyl sulfate gel electrophoresis. With sho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berger EA,Shooter EM

更新日期：1977-09-01 00:00:00

abstract：:The fate of two recently described human B lymphocyte-specific antigens (B1 and B2) was studied after B-cell activation in vivo and in vitro. Whereas both B1 and B2 were present on virtually all B cells from normal lymph nodes, B2 was absent from approximately 50% of B cells from hyperplastic lymph nodes. When B cells...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stashenko P,Nadler LM,Hardy R,Schlossman SF

更新日期：1981-06-01 00:00:00

abstract：:The binding of a few molecules [1-6] of RNA bacteriophage coat protein to 1 molecule of RNA represses in vitro translation of the RNA synthetase cistron. Digestion of the complex, R17 coat protein-R17 RNA, by T1 RNase yields an RNA fragment bound to the coat protein. The nucleotide sequence of this fragment (59 residu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bernardi A,Spahr PF

更新日期：1972-10-01 00:00:00

abstract：:A spectroscopic interpretation of incoherent neutron scattering experiments is presented which is based on Franck-Condon-type probabilities for scattering-induced transitions between quantum states of the target. The resulting expressions for the scattering functions enable an energy landscape-oriented analysis of neu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kneller GR

更新日期：2018-09-18 00:00:00

abstract：:Adult cardiomyocytes are irreversibly postmitotic but respond to a variety of stimuli by hypertrophic growth, which is associated with an increase in cell size and protein content, organization of sarcomeres, and activation of a fetal gene program. Recently, we described a novel cardiac helicase activated by MEF2 prot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu ZP,Olson EN

更新日期：2002-02-19 00:00:00

abstract：:We have investigated the biochemical basis for negative regulation of interleukin 2 receptor alpha-chain (IL-2R alpha) gene expression. Transient transfection studies employing internally deleted forms of the IL-2R alpha promoter localized a negative regulatory element (NRE) between nucleotides -400 and -368 relative ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith MR,Greene WC

更新日期：1989-11-01 00:00:00

abstract：:RNA interference (RNAi) is a widely used method for analysis of gene function in tissue culture cells. However, to date there has been no reliable method for testing the specificity of any particular RNAi experiment. The ideal experiment is to rescue the phenotype by expression of the target gene in a form refractory ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kittler R,Pelletier L,Ma C,Poser I,Fischer S,Hyman AA,Buchholz F

更新日期：2005-02-15 00:00:00

abstract：:We report here the identification of a pollen-specific gene from Zea mays that contains multiple Ser-(Pro)n repeats, the motif found in the cell wall-associated extensins. Sequence analysis reveals that the encoded protein has a putative globular domain at the N terminus and an extensin-like domain at the C terminus. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rubinstein AL,Broadwater AH,Lowrey KB,Bedinger PA

更新日期：1995-04-11 00:00:00

abstract：:Pathway proteomics strategies measure protein expression changes in specific cellular processes that carry out related functions. Using targeted tandem mass tags-based sample multiplexing, hundreds of proteins can be quantified across 10 or more samples simultaneously. To facilitate these highly complex experiments, w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu Q,Xiao H,Jedrychowski MP,Schweppe DK,Navarrete-Perea J,Knott J,Rogers J,Chouchani ET,Gygi SP

更新日期：2020-05-05 00:00:00

abstract：:The ubiquitin ligase Siah2 has been shown to regulate prolyl hydroxylase 3 (PHD3) stability with concomitant effect on HIF-1alpha availability. Because HIF-1alpha is implicated in tumorigenesis and metastasis, we used SW1 mouse melanoma cells, which develop primary tumors with a propensity to metastasize, in a syngene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qi J,Nakayama K,Gaitonde S,Goydos JS,Krajewski S,Eroshkin A,Bar-Sagi D,Bowtell D,Ronai Z

更新日期：2008-10-28 00:00:00

abstract：:T-regulatory cells (Treg) and mast cells (MC) are abundant in colorectal cancer (CRC) tumors. Interaction between the two is known to promote immune suppression or loss of Treg functions and autoimmunity. Here, we demonstrate that in both human CRC and murine polyposis the outcome of this interaction is the generation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blatner NR,Bonertz A,Beckhove P,Cheon EC,Krantz SB,Strouch M,Weitz J,Koch M,Halverson AL,Bentrem DJ,Khazaie K

更新日期：2010-04-06 00:00:00

abstract：:Various reconstructive procedures have been attempted to restore a cosmetically acceptable phallus that would allow normal reproductive, sexual, and urinary function in patients requiring penile reconstruction. However, these procedures are limited by a shortage of native penile tissue. We previously demonstrated that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen KL,Eberli D,Yoo JJ,Atala A

更新日期：2010-02-23 00:00:00

abstract：:EF-hand Ca(II) binding sites share a conserved architecture and are prevalent in Ca(II) signaling pathways. The ion binding kinetics of these sites are carefully tuned to provide the physiologically appropriate activation and inactivation time scales. Here we examine kinetic tuning by the side chain at the ninth posit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Renner M,Danielson MA,Falke JJ

更新日期：1993-07-15 00:00:00

abstract：:Gonadotropin-releasing hormone (GnRH) is important in reproduction, although the mechanism of central hypogonadism in humans remains unclear. Because the GnRH neuron originates from the olfactory placode and migrates to the hypothalamus during development, central hypogonadism in humans could be caused by failure in n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Radovick S,Wray S,Lee E,Nicols DK,Nakayama Y,Weintraub BD,Westphal H,Cutler GB Jr,Wondisford FE

更新日期：1991-04-15 00:00:00

abstract：:Maximum likelihood analysis for linkage between autosomal dominant aniridia and 12 biochemical and serological markers in a single large family showed a probable linkage between autosomal dominant aniridia and the enzyme acid phosphatase-1. The presence of an autosomal dominant aniridia gene linked to acid phosphatase...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ferrell RE,Chakravarti A,Hittner HM,Riccardi VM

更新日期：1980-03-01 00:00:00

abstract：:A density-shift method is described for analyzing insulin receptor synthesis and turnover in cultured cells labeled with "heavy" amino acids (2H, 13C, and 15N). Solubilized newly synthesized heavy and old "light" receptors are separated by isopycnic banding on CsCl gradients and then quantitated. Insulin receptor synt...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reed BC,Lane MD

更新日期：1980-01-01 00:00:00

abstract：:The notion of stability of a local ring arises naturally in investigating completed moduli spaces via geometric invariant theory. A scheme corresponding to a boundary point of a moduli space of nonsingular varieties cannot have unstable singular points. This paper reports some results concerning the stability of surfa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shah J

更新日期：1978-09-01 00:00:00

abstract：:The subventricular zone remains mitotically active throughout life in rodents. Studies with tritiated thymidine, which is incorporated into the DNA of mitotic cells, have revealed that the rodent subventricular zone produces neuroblasts that migrate toward the olfactory bulb along the rostral migratory stream. A simil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bernier PJ,Bedard A,Vinet J,Levesque M,Parent A

更新日期：2002-08-20 00:00:00

abstract：:Brain function depends on adaptive self-organization of large-scale neural assemblies, but little is known about quantitative network parameters governing these processes in humans. Here, we describe the topology and synchronizability of frequency-specific brain functional networks using wavelet decomposition of magne...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bassett DS,Meyer-Lindenberg A,Achard S,Duke T,Bullmore E

更新日期：2006-12-19 00:00:00

abstract：:A 3- to 5-year cycle of vole abundances is a characteristic phenomenon in the ecology of northern regions, and their explanation stands as a central theoretical challenge in population ecology. Although many species of voles usually coexist and are in severe competition for food and breeding space, the role of intersp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hansen TF,Stenseth NC,Henttonen H,Tast J

更新日期：1999-02-02 00:00:00

abstract：:Ecological character displacement describes a pattern where morphological differences between sympatric species are enhanced through interspecific competition. Although widely considered a pervasive force in evolutionary ecology, few clear-cut examples have been documented. Here we report a case of ecological characte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Adams DC,Rohlf FJ

更新日期：2000-04-11 00:00:00

abstract：:Stroke patients with small central nervous system infarcts often demonstrate an acute dysexecutive syndrome characterized by difficulty with attention, concentration, and processing speed, independent of lesion size or location. We use magnetoencephalography (MEG) to show that disruption of network dynamics may be res...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marsh EB,Brodbeck C,Llinas RH,Mallick D,Kulasingham JP,Simon JZ,Llinás RR

更新日期：2020-12-29 00:00:00

abstract：:Serine is the only amino acid that is encoded by two disjoint codon sets so that a tandem substitution of two nucleotides is required to switch between the two sets. Previously published evidence suggests that, for the most evolutionarily conserved serines, the codon set switch occurs by simultaneous substitution of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rogozin IB,Belinky F,Pavlenko V,Shabalina SA,Kristensen DM,Koonin EV

更新日期：2016-11-15 00:00:00

abstract：:Among the myriad complications involved in the current food crisis, the relationship between agriculture and the rest of nature is one of the most important yet remains only incompletely analyzed. Particularly in tropical areas, agriculture is frequently seen as the antithesis of the natural world, where the problem i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Perfecto I,Vandermeer J

更新日期：2010-03-30 00:00:00

abstract：:It is proved that the well known Nagata automorphism of the polynomial ring in three variables over a field of characteristic zero is wild, that is, it can not be decomposed into a product of elementary automorphisms. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shestakov IP,Umirbaev UU

更新日期：2003-10-28 00:00:00

abstract：:The identities between homogeneous expressions in rank 1 vectors and rank n - 1 covectors in a Grassmann-Cayley algebra of rank n, in which one set occurs multilinearly, are shown to represent a set of dimension-independent identities. The theorem yields an infinite set of nontrivial geometric identities from a given ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hawrylycz M

更新日期：1995-03-14 00:00:00

abstract：:The zinc finger transcription factor Miz1 is a negative regulator of TNFalpha-induced JNK activation and cell death through inhibition of TRAF2 K63-polyubiquitination in a transcription-independent manner. Upon TNFalpha stimulation, Miz1 undergoes K48-linked polyubiquitination and proteasomal degradation, thereby reli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang Y,Do H,Tian X,Zhang C,Liu X,Dada LA,Sznajder JI,Liu J

更新日期：2010-07-27 00:00:00